JPS6279064A - Apparatus for stabilizing polarograph sensor - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a stabilizing device for a polarography sensor used in a portable artificial pancreatic islet or the like.

Prior art and its problems A portable artificial pancreatic islet that measures the blood sugar level (glucose concentration) of a diabetic patient by placing a polarography sensor in the living body and supplies an amount of insulin to the patient's living body according to this measured value. is being developed. When using a polarographic sensor, it is necessary to stabilize the sensor by immersing the electrodes of the sensor in a standard solution for sensor stabilization (electrolytic solution) and applying a predetermined voltage between the electrodes. Furthermore, since each sensor has a different sensitivity, when replacing the sensor of a portable artificial pancreatic islet, it is necessary to calibrate the glucose concentration measuring section of the portable artificial pancreatic islet.

When stabilizing a polarographic sensor or calibrating the glucose concentration individual part of a portable artificial pancreatic islet, conventionally, a predetermined DC voltage was applied to a constant temperature bath, a test tube containing a standard solution for sensor stabilization, and the sensor. They prepared an AC/DC converter to measure the output current, a measuring device to measure the output current of the sensor, etc., connected the appropriate wiring, and assembled the stabilizing device on a table or the like. For this reason, preparations for stabilizing the polarography sensor and calibrating the glucose concentration measurement unit of the portable artificial pancreatic islet are cumbersome, and the stabilization device is bulky.
There is a problem that the stabilizing device is difficult to move.

An object of the present invention is to provide a stabilizing device for a polarography sensor that can solve the above problems.

Means for Solving the Problems A stabilizing device for a polarography sensor according to the present invention includes a first standard solution and a second standard solution for stabilizing a polarography sensor, each having a different concentration of a substance to be detected by the polarography sensor. are respectively entered in the first
a standard solution storage tank, a second standard solution storage tank, a temperature adjustment device for adjusting the internal temperature of both storage tanks to a predetermined set temperature;
A connector for connecting a polarography sensor, a polarography circuit for applying a predetermined voltage between the electrodes of the polarography sensor connected to the connector, and a polarography circuit for displaying the current flowing between the electrodes of the polarography sensor connected to the connector. The case is characterized in that a display is built into the case, as well as a measurement display circuit for measuring the current flowing between the electrodes of the polarographic sensor connected to the connector and displaying the measured value on the display.

Embodiment FIG. 1 shows the appearance of a stabilizing device for a polarography sensor used in a portable artificial pancreatic islet. This stabilization device is capable of connecting and stabilizing up to four polarographic sensors at one time.

On the top surface (operation surface) of the stabilizing device case (1), there is an aluminum constant temperature block (3) with eight tanks (2) formed in one direction, eight connectors (4), and four A display changeover switch (5) and a liquid crystal display (6) are provided.

The constant temperature block (3) is provided on the left side of the operation surface. The eight tanks (2) are arranged in two rows of four on the left and right. In the left tank (2), the glucose concentration is Qm
The first standard solution for sensor stabilization of g/d/ is placed in the tank on the right (
2) is adapted to contain a second standard solution with a glucose concentration of 200 mg/d/. That is, in the constant temperature block (3), four pairs of a first standard solution storage tank (2) and a second standard solution storage tank (2) are formed at equal intervals in the front-rear direction. For convenience of explanation, the first standard solution storage tank (2
) and the second standard solution storage tank (2) will be referred to as first, second, third, and fourth storage tank pairs (2) in order from the front side.

The eight connectors (4) are arranged on the right side of the constant temperature block (3) in two rows of four on the left and right. The connector on the left (4) is for the negative pole, and the connector on the right (4)
) is for the positive electrode. That is, four pairs of positive electrode connectors (4) and negative electrode connectors (4) are provided at equal intervals in the front-rear direction. The four pairs of the positive electrode connector (4) and the negative electrode connector (4) will be referred to as first, second, third, and fourth connector pairs (4) in order from the front side. The first to fourth connector pairs (4) are the first to fourth connector pairs, respectively.
It is located right next to the storage tank pair (2).

The connection plug (8a) of the polarography sensor (8) is connected to one of the first to fourth connector pairs (4), and the storage tank pair ( 2), the electrode portion is inserted into one of the storage tanks (2).

Four display changeover switches (5) are arranged side by side on the front of the operation surface. These display changeover switches (5
) will be referred to as first, second, third, and fourth display changeover switches (5) in order from the left. The first to fourth display changeover switches (5) correspond to the first to fourth connector pairs (4), respectively. When the display changeover switch (5) is switched to the display side (in this example, when it is pushed to the rear), as will be described later, the connector pair (5) corresponding to the switch (5)
The inter-electrode current value (output current value) of the polarography sensor (8) connected to the sensor (4) is displayed on the display (6).

The display (6) is provided at the rear of the right half of the operation surface.

A recorder terminal (path shown) is provided on the rear surface of the case (1). As will be described later, a voltage corresponding to the current value displayed on the display (6) appears at the recorder terminal. Therefore, the output current value of the polarography sensor can also be known by monitoring the output voltage of the recorder terminal. A power cord (7) is drawn out from the rear surface of the case (1).

2 and 3 show the electrical configuration of the stabilizing device, with FIG. 2 showing the temperature adjustment circuit of the constant temperature block, and FIG. 3 showing the sensor stabilization and characteristic measurement circuit, respectively.

In FIG. 2, a temperature adjustment circuit (10) detects the temperature of a constant temperature block heater (12) and a constant temperature block (3) connected between AC power supply terminals (11) via a switching means (13). The temperature sensor (14) is provided with a control circuit (15) that controls the switching means (13) based on the temperature detected by the temperature sensor (14). The control circuit (15) turns on the switching means (13) when the temperature detected by the humidity detector (14) is below a predetermined set temperature, and when the temperature detected by the temperature detector (14) exceeds the set temperature. When the switching means (1
3) is turned off.

In Figure 3, the sensor stabilization and characteristic measurement circuit (2
0) is a predetermined voltage (for example 0.65) between the electrodes of the polarographic sensor (8) connected to the connector pair (4).
It is equipped with a polarography circuit (21) for applying V) and a measurement display circuit (22) for measuring the output current of the polarography sensor (8) and displaying it on the display (6). The measurement display circuit (22) includes a first to fourth display changeover switch (5) and a first to fourth display changeover switch (5).
Polarography sensor (8) connected to the connector pair (1) corresponding to the one switched to the display side.
T/V converter circuit (23) that converts the output current into voltage;
an amplifier circuit (2) that amplifies the output of the I/V conversion circuit (23);
4) The output of the polarography sensor (8) is based on the output signals of the Δy/D conversion circuit (21) and the A'/D conversion circuit (25), which convert the output signal of the amplifier circuit (24) into a digital signal. A display control circuit (26) is provided for displaying the current value on the display (6). The output voltage of the amplifier circuit (24) is also sent to the recorder terminal.

The above stabilizing device is used for medical examination! It is placed at the bedside of a patient carrying an artificial pancreatic islet, and one to four polarographic sensors (8) are stabilized as follows. 1st
The first standard solution is put into the standard solution storage tank (2), and the second standard solution is put into the second standard solution storage tank (2). Power cord (7
) into the outlet (path shown) and turn on the power switch (path shown) of the stabilizing device. As a result, the temperature adjustment circuit (10) is activated, and after a predetermined period of time, the temperature of each standard solution reaches the set temperature and is maintained at this temperature.

After that, insert the electrode part of the polarography sensor (8) into the first standard solution storage tank (2) of one of the storage tank pairs (2), and insert the plug (8a) of this sensor (8) into the storage tank. Connect to connector pair (4) corresponding to pair (2). Here, in this way, four sensors (8) are connected to the first to fourth sensors.
It is assumed that they are respectively connected to connector pair (4). A predetermined voltage is applied between the electrodes of each sensor (8) by a polarography circuit (21).

The display changeover switch (5) corresponding to the connector pair (4) to which the sensor (8) to be used next as a sensor for a portable artificial pancreatic islet is connected is switched to the display side. Here, it is assumed that the first changeover switch (5) is switched to the display side. Then, the output current value of the sensor (8) connected to the first connector pair (4) is displayed on the display (6) by the measurement display circuit (22). The output current value of the sensor (8) becomes stable within several hours after the voltage is applied between the electrodes of the sensor (8).

When replacing the polarography sensor for an artificial pancreatic islet carried by a patient, first select the sensor (8) to be used next as a sensor for the artificial pancreatic islet based on the display on the display (6) or the output from the recorder terminal. (In this case, the first
Confirm that the output current value of the sensor (8) connected to the connector pair (4) is stable at a constant value. Thereafter, the connection plug (8a) of this sensor (8) is connected to the artificial pancreatic islet while the electrode part remains inserted into the storage tank (2). Then, the measurement value of the glucose concentration measuring section of the artificial pancreatic islet is adjusted to Omo/d1.

Next, connect the connecting plug (8a) of this sensor (8) again to the first connector pair (4) of the stabilizing device, and
) of the second standard solution storage tank (2) of the first storage tank pair (2).
2) Insert it inside. Then, wait until the output current value of the sensor (8) stabilizes to a constant value. In this case, the sensor (
The output current of 8) becomes stable in about 5 to 30 minutes. When the output current of the sensor (8) is stabilized, the connection plug (8a) of this sensor (8) is connected to the artificial islet with the electrode part still inserted into the storage tank (2), and the glucose in the artificial islet is Adjust the measured value of the concentration measurement unit to 200 mg/d/.

Effects of the Invention The stabilizing device for a polarography sensor according to the present invention includes a first standard solution and a second standard solution for stabilizing a polarography sensor, each containing a first standard solution and a second standard solution having different concentrations of substances to be detected by the polarography sensor. 1
A standard solution storage tank and a second standard solution storage tank, a temperature adjustment device for adjusting the internal temperature of both storage tanks to a predetermined set temperature, a connector for connecting a polarography sensor, and a polarography sensor connected to the connector. A polarography circuit for applying a predetermined voltage between the electrodes, an indicator for displaying the current flowing between the electrodes of the polarography sensor connected to the connector, and a polarography circuit for applying a predetermined voltage between the electrodes of the polarography sensor connected to the connector. A measurement and display circuit for measuring the flowing current and displaying the measured value on a display is built into the case.

Therefore, just by preparing one stabilization device, it is possible to stabilize the polarography sensor and calibrate the glucose concentration measuring section of the artificial pancreatic islet. This greatly simplifies the preparation for calibrating the parts. Since this stabilization device is built into the case as described above, it is not bulky and can be carried around, making it easy to calibrate glucose concentration measurements of artificial islets, such as when carrying artificial islets. It is extremely convenient as it can be taken to the patient's bedside or to the examination room.

[Brief explanation of drawings]

The drawings show an embodiment of the present invention, in which Fig. 1 is a perspective view showing the external appearance of a polarography sensor stabilization device, Fig. 2 is an electric circuit diagram showing a temperature adjustment circuit, and Fig. 3 is a sensor stabilization and characteristic measurement. FIG. 2 is an electrical circuit diagram showing the circuit. (1) Case, (2) Tank, (4) Connector, (6) Display, (8) Polarography sensor, (10) Temperature Adjustment circuit, (20)
...Sensor stabilization and characteristic measurement circuit, (21)...
- Polarography circuit, (22)...measurement display circuit. that's all

Claims (1)

[Scope of Claims] A first standard solution storage tank and a second standard solution containing a first standard solution and a second standard solution for polarography sensor stabilization having different concentrations of substances to be detected by the polarography sensor, respectively. Standard solution storage tank, temperature adjustment device to adjust the internal temperature of both storage tanks to a predetermined set temperature, connector for polarography sensor connection, and application of a predetermined voltage between the electrodes of the polarography sensor connected to the connector. a polarography circuit for measuring the current flowing between the electrodes of the polarography sensor connected to the connector; and a display device for measuring and displaying the current flowing between the electrodes of the polarography sensor connected to the connector. A polarography sensor stabilization device that has a measurement display circuit built into the case to display measured values.