JPS6258332B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a method for manufacturing a transparent adhesive patch, and more specifically, it relates to a new transparent adhesive patch that uses a polyurethane film as a support and a special copolymer instead of conventional crude rubber as a plaster base. Pertains to drug manufacturing methods. The conventional patch medicine called Hatsuka gum plaster is
It is manufactured by a method in which raw rubber is used as a paste base material, a softener, a tackifying resin, and a filler are blended into this, and a kneaded product containing a paste base ingredient is applied and spread on sfumos or nonwoven fabric. There is. However, since this adhesive patch uses raw rubber as a base material, if it is applied to people with idiosyncratic constitutions, allergic symptoms may occur due to impurities (proteins, etc.) in the raw rubber. Even if you have a normal constitution, if you repeatedly apply the adhesive to the same area, there is a risk that the epidermis will be damaged when you remove it, and if you apply it to areas with thick hair, it will be quite painful to remove it. It is customary. In addition to these disadvantages in use, the above-mentioned adhesive patches require a series of complex and diverse steps to prepare the plaster base, starting from mastication of raw rubber, and the costs associated with this process account for a major portion of the manufacturing cost. I can't escape the disadvantage. The present invention solves the various drawbacks of the conventional patch medicines mentioned above by using a special copolymer instead of raw rubber as the base material of the plaster. To provide a method for producing a new transparent patch using Accordingly, the method for producing the transparent patch according to the present invention uses an olefin-based adhesive selected from 40 to 60% by weight of natural rubber or synthetic isoprene rubber, low-density polyethylene, polyisobutylene, polyethylene ethyl acrylate, and ethylene/isobutyl acrylate copolymer. Polymer 10-30% by weight, triisocyanate 20%
An undercoat layer is formed by coating a polyurethane film with an organic solvent solution of ~40% by weight of the composition and drying it, followed by styrene/
Isoprene/styrene block copolymer (A), styrene/butadiene/styrene block copolymer (B), and modified copolymer obtained by graft polymerizing methyl methacrylate to the above block copolymer (A) or (B). a base material selected from the group consisting of: a modifier selected from low density polyethylene, polyisobutylene, polyethylene ethyl acrylate and ethylene/isobutyl acrylate copolymer, and further contains liquid paraffin and a tackifying resin. The method consists of adding a paste base to the mixture, kneading it homogeneously, and applying and spreading the kneaded product on the undercoat layer. When planning to produce a transparent patch, it is natural to use a transparent plastic film as the support instead of the conventional sfumos or non-woven fabric, but due to the nature of the patch, the support must be breathable. must be maintained. Therefore, in the present invention, a polyurethane film that does not contain a plasticizer and whose flexibility hardly changes due to temperature changes is used as a support. However, if a kneaded product containing a paste base ingredient is directly applied and spread on a polyurethane film, the adhesion between the two is insufficient, making it impossible to obtain a satisfactory patch. According to the present invention, an undercoat layer is formed on the support polyurethane film. The undercoat layer is
40-60% by weight of natural rubber or synthetic isoprene rubber,
Olefinic polymer selected from low density polyethylene, polyisobutylene, polyethylene acrylate and ethylene/isobutyl acrylate copolymer 10-30% by weight, triisocyanate 20-40%
% by weight of the composition in an organic solvent is applied onto a polyurethane film and dried. As the organic solvent in this case, rubber volatile oil, n-hexane, benzene, ethyl acetate, acetone, etc. can be used. Once the undercoat layer is formed on the polyurethane film in this way, a kneaded material is then coated and spread on the undercoat layer. A mixture containing a base material selected from the coalescence (B) or a methyl methacrylate modified copolymer thereof, a modifier selected from the polyolefin polymers mentioned above, liquid paraffin and a tackifying resin, It is prepared by blending the base ingredients and kneading them homogeneously. In the present invention, the block copolymer or its modified copolymer used as the plaster base material both contains a segment consisting of a crystalline phase (styrene) and a segment consisting of an amorphous phase (isoprene or butadiene). It is a thermoplastic synthetic rubber that becomes fluid when heated and hardens into a semi-solid and exhibits viscoelasticity when cooled. And a styrene/isoprene/styrene block copolymer, hereinafter abbreviated as SIS.
(A) is a styrene/butadiene/styrene block copolymer with the trade name CALIFLEX TR1107 (manufactured by Ciel Chemical Co., Ltd.), also abbreviated as SBS.
(B) are both available on the market under the trade name Califrex TR1101 or TR1102 (ibid.). In addition, the modified copolymer of the present invention abbreviated as SIS-MMA or SBS-MMA is the above-mentioned SIS or SBS
Methyl methacrylate (MMA) is graft-polymerized using a radiation polymerization method.
Generally, 90 to 95 parts by weight of SIS or SBS and 10 parts of MMA are added.
Graft polymerization in a proportion of ~5 parts by weight is acceptable. As plaster base materials, SIS, SBS, SIS-
One or more of MMA and SBS-MMA can be used, but the amount of the plaster base material is preferably in the range of 20 to 35% by weight of the above-mentioned mixture. Olefinic polymers such as low-density polyethylene, polyisobutylene, polyethylene ethyl acrylate, and ethylene/isobutylene copolymers are also used in subbing layers, but when used in the above mixtures, they are used as modifiers for the plaster base material. Function.
By the way, the test patch manufactured without the modifier had an elastic modulus of 0.08 at 200% elongation.
The adhesive strength to the skin is high at ~0.8Kg/ ^cm2 , but the adhesive strength to the skin is weak, whereas patches manufactured with modifiers have a
The elastic modulus at % elongation is 0.03 to 0.3 Kg/cm ² , and the adhesive strength to the skin is equivalent to or higher than that of conventional patch drugs. The blending amount of the modifier can range from 1 to 10% by weight of the above-mentioned mixture. In the present invention, liquid paraffin is used as a softening agent, and the amount used is not substantially different from the amount of polybutene or process oil used as a softening agent in conventional shell gum plasters. As the tackifier base agent, those conventionally used in the art are used in conventional amounts. For example, tackifying resins include polyterpene resins (e.g., YS-resin), linear hydrocarbon resins (e.g., Escorets), hydrogenated rosin esters (e.g., ester gum), and base ingredients for plasters include methyl salicylate and salicylic acid. Glycol, camphor, l-menthol, capsicum (extract), capsaicin, nonylic acid vanillylamide, adrenal corticosteroids, skin protectants, etc. are used. In addition, since the present invention aims to produce a transparent adhesive patch, white pigments such as zinc oxide or titanium dioxide, which are commonly used in conventional adhesive plasters, are not used. Since the transparent patch of the present invention uses a special block copolymer or its modified copolymer as its base material, 3 to 20% by weight of water is blended in the presence of a surfactant. be able to. By adding water, the skin irritation of the patch is enhanced, so it exhibits the effect of promoting skin blood flow. In this case, the surfactant may be sorbitan monooleate, sorbitan monostearate, polyoxyethylene stearyl alcohol ether, etc.
The amount used is preferably in the range of 1.5 to 15.0% by weight of the kneaded product. It is also recommended to use humectants such as propylene glycol and glycerin. As a precaution, there are no examples of conventional adhesive patches that use raw rubber as a base material to include water. Examples will now be presented. Example 1 Composition 4.0 of 60% by weight natural rubber, 20% by weight olefinic polymer, 20% by weight triisocyanate
Dissolve g in 40 ml of n-hexane, apply this solution to a polyurethane film and dry it at 50 to 60°C.
A subbing layer was formed on the polyurethane film by aging. Next, a kneaded product having the composition shown in Table 1 was coated and spread on the undercoat layer to obtain a transparent patch. A liner such as cellophane, polyethylene film, polypropylene film, or release paper was pasted on the surface of the patch.

[Table] Each of the patches thus obtained was subjected to abuse at 55°C for more than 500 hours with the gear open, but no abnormalities were observed in any of them in terms of their medicinal efficacy or otherwise. Example 2 4.0 g of a composition of 50% by weight of synthetic isoprene rubber, 10% by weight of olefinic polymer, and 40% by weight of triisocyanate was dissolved in 40ml of n-hexane, and this solution was applied to a polyurethane film and heated at 50 to 60°C.
After drying, the film was aged to form an undercoat layer on the polyurethane film. Next, a kneaded product having the composition shown in Table 2 was coated and spread on the undercoat layer, and a liner was pasted thereon to obtain a transparent patch.

[Table] Each patch thus obtained was abused in the same manner as in Example 1, but as in Example 1, no abnormality was observed. Example 3 Composition 4.0 of 40% by weight natural rubber, 30% by weight olefinic polymer, and 30% by weight triisocyanate
Dissolve g in 40 ml of n-hexane, apply this solution to a polyurethane film and dry it at 50 to 60°C.
It was aged to obtain a subbing layer. Next, a kneaded product having the composition shown in Table 3 was coated and spread on the undercoat layer, and a liner was pasted thereon to obtain a transparent water-containing patch.

【table】

[Table] When the thus obtained transparent water-containing patch was abused in the same manner as in Example 1, the same results as in Example 1 were obtained.

Claims (1)

[Scope of Claims] 1 40 to 60% by weight of natural rubber or synthetic isoprene rubber, 10 to 30% by weight of an olefinic polymer selected from low density polyethylene, polyisobutylene, polyethylene ethyl acrylate and ethylene/isobutyl acrylate copolymer, An undercoat layer is formed by applying an organic solvent solution of a composition containing 20 to 40% by weight of isocyanate onto a polyurethane film and drying it, and then applying a styrene/isoprene/styrene block copolymer.
(A), styrene/butadiene/styrene block copolymer (B), and the above block copolymer (A) or (B)
a plaster base material selected from the group consisting of a modified copolymer obtained by graft-polymerizing methyl methacrylate to
A paste base ingredient is blended into a mixture containing a modifier selected from low-density polyethylene, polyisobutylene, polyethylene ethyl acrylate, and ethylene/isobutyl acrylate copolymer, as well as liquid paraffin and a tackifying resin, and the mixture is homogeneously kneaded. and a method for producing a transparent patch, which comprises coating and spreading this kneaded product on the undercoat layer. 2 The amount of plaster base material in the above mixture is 20 to 35% by weight.
The method for producing a transparent adhesive patch according to claim 1, wherein the amount of the modifier is 1 to 10% by weight. 3 In the above kneaded material, 1.5 to 15.0% by weight of a surfactant selected from sorbitan monooleate, sorbitan monostearate, and polyoxyethylene stearyl alcohol ether, and 3 to 3% of water.
Claim 1 or 2 containing 20% by weight
Method for manufacturing transparent patch medicines described in Section 1.