JPS6254502B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a denture fixing adhesive. Conventionally, if the stability of the denture against the gingival surface is poor, the denture may move during conversation, eating, etc., or in severe cases may fall off, which not only makes daily life uncomfortable, but also damages the oral mucosa. Damage was also common. For this reason, denture fixing adhesives are widely desired in many cases, such as when there is a jaw defect due to a tumor, malformation, or trauma, when there are many missing teeth and the bone marrow of the remaining teeth is poor, or when there are bad chewing habits. It was rare. When the denture fixing adhesive comes into contact with saliva, it immediately becomes wet, and by adhering the denture base to the gingival surface, it maintains the stability of the denture for a long time, and also provides stress buffering, especially in the case of jaw prosthetic dentures. It is desirable that the gel forms a gel that has properties and can prevent various damage to the gingival surface due to contact between the two. Note that the formation of the gel also creates a vacuum seal between the denture and the gingival surface, which has the effect of further increasing the adhesion between the two. Many materials have been tried so far to be used as fixing adhesives for dentures that satisfy the above-mentioned performance, but none have been found to be satisfactory. Specifically, natural gums such as guar gum, xanthan gum, gum tragacanth, gum arabic, and sodium alginate, and semisynthetic polymers such as methylcellulose, hydroxymethylcellulose, and carboxymethylcellulose have been mainly investigated, but none of these Due to its weak adhesive strength and short duration, it was unsuitable as a denture fixing adhesive. Furthermore, a complete denture fixative using polyethylene oxide, which is a homopolymer of ethylene oxide, is disclosed in JP-A-47-44895, but the adhesiveness of this agent is still insufficient and its duration is short. Furthermore, the stability of the produced gel is also insufficient. Under the above circumstances, the present inventors conducted intensive studies on materials that have the performance as a denture fixing adhesive from a practical point of view, and found that the use of polyacrylic acid metal salt powder has high adhesiveness and long-lasting properties. The present invention was completed by discovering that a stable elastic gel can be formed over a long period of time. The polyacrylic acid metal salts used in the present invention are alkali metal salts, alkaline earth metal salts, and trivalent metal salts with an average molecular weight of 3 million to 10 million, but preferably polyacrylic acid salts with an average molecular weight of 5 million to 8 million. Alkali metal salts of acids and salts in which about 40% or less of the total number of moles of carboxyl groups present are substituted with alkaline earth or trivalent metals, and 60% or more are substituted with alkali metals. The particle size of the alkali metal salt polyacrylate powder is preferably finer than 100 mesh. In carrying out the present invention, it is sufficient to use only the powder of polyacrylic acid metal salt alone, but menthol or the like may be added as a flavoring agent.
Furthermore, polyacrylic acid metal salts are used as glidants.
Dry starch, talc, metal salts of stearic acid, silicic anhydride, fine powder of higher fatty acids, etc. are added at a ratio of 0.01 to 5%, and sodium alginate, methyl cellulose, etc. are added at a ratio of 0.01 to 10% as adhesive enhancers. It's okay. In addition, antibiotics such as fradiomycin, local anesthetics such as xylocaine, astringents such as borax, anticancer agents such as bleomycin, etc. may be appropriately blended with the denture fixing adhesive of the present invention to treat alveolar pyorrhea and surrounding areas. It can also be used for therapeutic purposes such as cancer and stomatitis. To use the denture fixing adhesive of the present invention, sprinkle an appropriate amount on the surface of a denture base moistened with water, gently set it on the tooth pad, and lightly bite it for 2 to 3 minutes. Among the metal salts of polyacrylic acid, sodium polyacrylate is a substance whose safety has been confirmed and is listed in the Japan Food Additives Standard and the Cosmetic Raw Materials Standards. Next, the excellent performance of the denture fixing adhesive of the present invention will be specifically explained using experimental examples. Experimental Example 1 Measurement of the adhesive strength of the denture fixing adhesive of the present invention. (1) Preparation of samples Samples Nos. 1 to 13 were prepared based on the recipe shown in Table 1, and Nos. 14 to 13 were the samples of the present invention.
22 is the control sample. (2) Experimental method Measurements were carried out using the apparatus shown in Figure 1. That is, a piece of cow skin A moistened with water was fixed to the bottom of a thermostatic cell D that could circulate running water at 37°C, and ² cm 2 of 500 mg of denture fixing adhesive was placed on top of it.
Place the spindle C connected to a Fudo Kogyo rheometer with a stainless steel disc on the tip, and apply a pressure of about 1 kg/cm ² to the spindle C. Add for 2 minutes to fully adhere A and C in Figure 1 with B. Next, reflux of running water at 37°C is started, and after 2 minutes, the support base E of the rheometer is raised at a speed of 5 cm/min, and the force required to separate the spindle C from the cow's skin A, i.e., fixing the denture. The adhesive force (g/cm ² ) of the adhesive was measured. (3) Results Table 1 shows the adhesive strength of each sample.

【table】

[Table] From this table, it can be seen that the adhesive strength of the denture fixing adhesives of the present invention No. 1 to 13 is superior to that of the control samples No. 14 to 22. Experimental example 2 Measurement of stress buffering properties (viscoelasticity) of wet gel of denture fixing adhesive (1) Sample preparation 500 mg of the sample with the formulation shown in Table 2 was set on a glass flat plate to a thickness of about 3 mm. , then water 1.2
ml was added and left to stand for 24 hours, and used as a sample. sample
Nos. 1 to 4 are samples of the present invention, and Nos. 5 to 7 are control samples. (2) Test method Measurements were performed using the apparatus shown in Figure 2.
That is, the support E of the rheometer is moved at a speed of 2 mm/sec toward the surface I of the wet gel, and the movement is continued while the rod-shaped spindle G is pressed against the surface I of the gel with a pressure of Px ₁ . An apparatus was used, which was set so that the movement of the support base E of the rheometer was automatically stopped when the tip of the shaped spindle F came into contact with the surface I of the gel (the state shown in FIG. 3). A repulsive force Px ₂ based on the viscoelasticity of the gel is applied to the tip of the disc terminal H that is stopped in the state shown in FIG. The higher the value of Px ₂ , the higher the viscoelasticity of the gel. In this way, the viscoelasticity of each sample at 37°C was measured. (3) Results Table 2 shows Px ₂ based on the viscoelasticity of the wet gel of the denture fixing adhesive.

【table】

[Table] From Table 2, the Px ₂ of samples Nos. 1 to 4 of the present invention are higher than those of control samples Nos. 5 to 7 by more than 30%. In other words, the denture fixing adhesive of the present invention has higher viscoelasticity than known ones, so it has high contact stress buffering properties between the gingiva and denture, and therefore can prevent various damage to the gingival surface due to contact between the two. Very easy to use. Experimental Example 3 Adhesion duration test of denture fixing adhesive (1) Sample preparation Samples with the formulations shown in Table 2 were used. (2) Test method Five denture users used each sample of fixing adhesive after dinner, and measured the duration of its effect. (3) Results Table 3 shows the adhesion duration of the dentures.

[Table] * Average value of 5 users From Table 3, the duration of the samples of the present invention (Nos. 1 to 4) is extremely long, more than 5 times that of the control samples (Nos. 5 to 7). , it can be seen that the effect is excellent. Next, the method for producing the adhesive of the present invention will be explained with reference to Examples. Example 1 A powder of 100 to 200 meshes of sodium polyacrylate with an average molecular weight of about 8 million was heated at 140°C for 5 minutes.
Let dry for a while and fill into sealed bottles. Example 2 95 parts of the sodium polyacrylate powder obtained in Example 1 was uniformly mixed with 5 parts of talc, and the mixture was filled into a sealed bottle. Example 3 2 parts of fradiomycin sulfate were uniformly mixed with 98 parts of the sodium polyacrylate powder obtained in Example 1, and the mixture was filled into a sealed bottle. Example 4 While rapidly stirring aqueous solution 1 in which 50 g of sodium polyacrylate having an average molecular weight of about 7.1 million and 58.5 g of sodium chloride are dissolved, 200 ml of an 8.6% calcium chloride aqueous solution is gradually added. Then, 70% of the carboxyl groups generated are Na salts, 30
% of a calcium salt is precipitated by adding anhydrous methanol, dried by heating at 140°C for 5 hours, crushed to a particle size of 200 mesh or less, and filled into a sealed bottle. Example 5 40 parts of powder of 200 mesh or less of sodium polyacrylate with an average molecular weight of about 8 million, 10 parts of sodium alginate, 40 parts of beeswax, and 10 parts of ODO (glycerin fatty acid ester) are thoroughly and uniformly kneaded to make an ointment. . Example 6 A homogeneous mixed aqueous solution of 1.8% sodium polyacrylate and 0.2% sodium alginate with an average molecular weight of about 5 million was prepared, and after evaporating to dryness, it was heated at 120°C 4
Dry for a sufficient amount of time, crush into a powder of 200 mesh or less, and fill in a sealed bottle. Example 7 70 parts of powder of 200 mesh or less of sodium polyacrylate with an average molecular weight of about 8 million, 15 parts of horse starch thoroughly dried at 80°C for 10 hours, and 15 parts of anhydrous calcium phosphate thoroughly dried at 180°C for 6 hours. Mix the parts evenly and fill into a sealed bottle.

[Brief explanation of the drawing]

FIG. 1 shows an apparatus for measuring the adhesive force of a denture fixing adhesive, and FIGS. 2 and 3 show an apparatus for measuring the viscoelastic force Px ₂ of a wet gel of the denture fixing adhesive. A...Cow bedding skin piece (3 x ^3cm2 ), B...Denture fixing adhesive, C...Stainless steel spindle with a disc ( ^2cm2 ) attached to the tip, D...Thermostatic cell capable of circulating running water at 37°C (capacity 100ml), E...Connection support part to Fudo Kogyo rheometer, F...Stainless steel needle spindle, G...rod-shaped spindle with a disc-shaped current terminal (H) at the tip, H...disc terminal, I... Surface of wet gel of denture fixing adhesive.

Claims (1)

[Claims] 1. A denture fixing adhesive characterized by containing powder of polyacrylic acid metal salt.