JPS6253670A - Connection tube for infusion liquid adsorbing no drug - Google Patents
Connection tube for infusion liquid adsorbing no drugInfo
- Publication number
- JPS6253670A JPS6253670A JP60192954A JP19295485A JPS6253670A JP S6253670 A JPS6253670 A JP S6253670A JP 60192954 A JP60192954 A JP 60192954A JP 19295485 A JP19295485 A JP 19295485A JP S6253670 A JPS6253670 A JP S6253670A
- Authority
- JP
- Japan
- Prior art keywords
- tube
- infusion
- resin
- drug
- nitroglycerin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title claims description 8
- 239000003978 infusion fluid Substances 0.000 title 1
- 238000001802 infusion Methods 0.000 claims description 33
- 229920005672 polyolefin resin Polymers 0.000 claims description 15
- 229920005989 resin Polymers 0.000 claims description 15
- 239000011347 resin Substances 0.000 claims description 15
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 239000013078 crystal Substances 0.000 claims description 9
- 239000004711 α-olefin Substances 0.000 claims description 8
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 7
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 5
- 229920001169 thermoplastic Polymers 0.000 claims description 5
- 239000004416 thermosoftening plastic Substances 0.000 claims description 5
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 13
- 239000000006 Nitroglycerin Substances 0.000 description 12
- 229960003711 glyceryl trinitrate Drugs 0.000 description 12
- 229920001577 copolymer Polymers 0.000 description 10
- -1 polyethylene Polymers 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 229920001684 low density polyethylene Polymers 0.000 description 4
- 239000004702 low-density polyethylene Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 3
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 3
- 239000005038 ethylene vinyl acetate Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002747 voluntary effect Effects 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- NTXGQCSETZTARF-UHFFFAOYSA-N buta-1,3-diene;prop-2-enenitrile Chemical compound C=CC=C.C=CC#N NTXGQCSETZTARF-UHFFFAOYSA-N 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- WSSSPWUEQFSQQG-UHFFFAOYSA-N dimethylbutene Natural products CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Landscapes
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
産業上の利用分野
本発明は、輸液投与回路における連結チューブに関する
。DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a connecting tube in an infusion administration circuit.
従来の技術とその問題点
輸液セットに代表される輸液投与回路の連結チューブは
、柔軟性を要求されるので、軟質塩化ビニル樹脂製のも
のが主として使用されている。しかしながら、塩化ビニ
ル樹脂は、ニトログリセリン、硝酸イソソルバイト、ジ
アゼパム等の脂溶性薬剤成分を吸着するので、実際の投
薬時に問題点となっている。ニトログリセリンについて
は、ポリエチレン、ポリプロピレン、アクリロニトリル
−ブタジェン樹脂、ポリエステル、ポリアミド、フッ素
樹脂等が非吸着性の樹脂として知られているが、これ等
の樹脂はいずれも硬質材料であって可撓性に欠ける為、
単独では輸液用連結チューブとして使用することは出来
ない。この為、ニトログリセリンを吸着しない低密度ポ
リエチレン（ＬＤＰＥ）を内層とし、ニトログリセリン
を吸着するが、柔軟で且つＬＤＰＥとの接着性の良いエ
チレン−酢酸ビニル共重合体（ＥＶＡ）を外層とする二
層チューブが、ニトログリセリン用輸液セットの連結デ
ユープとして実用化されている。しかしながら、この二
層チューブにおいては、内層の強度維持と耐ピンホール
特性向上のために、ＬＤＰＥの肉厚を一定以上とする必
要があり、また外層と内層との接着性向上のために、外
層ＥＶＡ中のエチレンの配合比率を高める必要もあるの
で、結果的にチューブの柔軟性は満足すべきものとはい
えない。従つＣ１この様な二層デユープを輸液セットの
輸液ポンプに接続する場合には、輸液ポンプフィンガー
の抑圧によってはチューブが充分に閉塞せず、輸液投与
速度の制御を行なうことは出来ない。このため、連結チ
ューブの一部として柔軟なシリコンチューブを併用した
り、ポリュメトリック型のポンプカセットを接続しなけ
ればならないので、コスト高や作業の繁雑化等は避けら
れない。Prior art and its problems Connecting tubes for infusion administration circuits, typified by infusion sets, are required to be flexible, so those made of soft vinyl chloride resin are mainly used. However, vinyl chloride resin adsorbs fat-soluble drug components such as nitroglycerin, isosorbite nitrate, and diazepam, which poses a problem during actual administration. Regarding nitroglycerin, polyethylene, polypropylene, acrylonitrile-butadiene resin, polyester, polyamide, fluororesin, etc. are known as non-adsorptive resins, but all of these resins are hard materials and are not flexible. Because it is missing,
It cannot be used alone as a connecting tube for infusion. For this reason, the inner layer is low-density polyethylene (LDPE), which does not adsorb nitroglycerin, and the outer layer is ethylene-vinyl acetate copolymer (EVA), which adsorbs nitroglycerin but is flexible and has good adhesion to LDPE. Layered tubes have been put into practical use as connecting duplexes for nitroglycerin infusion sets. However, in this double-layer tube, in order to maintain the strength of the inner layer and improve pinhole resistance, the thickness of the LDPE must be greater than a certain level, and in order to improve the adhesion between the outer layer and the inner layer, the outer layer must be Since it is also necessary to increase the blending ratio of ethylene in EVA, the flexibility of the tube cannot be said to be satisfactory as a result. Therefore, C1, when such a two-layer duplex is connected to an infusion pump of an infusion set, the tube is not sufficiently occluded by the depression of the infusion pump finger, and the rate of infusion administration cannot be controlled. For this reason, it is necessary to use a flexible silicone tube as part of the connecting tube or to connect a polymetric pump cassette, which inevitably increases costs and complicates the work.
問題点を解決するための一段
本発明者は、上記の如き技術の現状に鑑みて鋭意研究を
重ねた結果、直鎖型低密度ポリエチレン（以下ＬＬＤＰ
Ｅという）と熱可塑性低結晶α−オレフィン系樹脂（以
下低結晶オレフィン樹脂という）とを特定割合で配合し
たブレンド樹脂が、輸液中の薬剤成分を実質的に吸着せ
ず、しかも柔軟性、可撓性、強度、耐ピンホール性等に
も優れていることを見出した。即ち、本発明は、Ｌ Ｌ
、 ＤＰＥと低結晶オレフィン樹脂のブレンド樹脂から
なり、低結晶オレフィン樹脂の配合比が５〜５５重量％
であることを特徴とする薬剤吸着のない輸液用連結チュ
ーブに係る。As a result of intensive research in view of the current state of the technology as described above, the present inventor took a step toward solving the problem, and as a result, developed a linear low-density polyethylene (hereinafter referred to as LLDP).
A blended resin containing a specific ratio of thermoplastic low-crystalline α-olefin resin (hereinafter referred to as E) and thermoplastic low-crystalline α-olefin resin (hereinafter referred to as low-crystalline olefin resin) does not substantially adsorb drug components in infusions, and is flexible and flexible. It was also found that it has excellent flexibility, strength, pinhole resistance, etc. That is, the present invention provides L L
, Consisting of a blend resin of DPE and low crystal olefin resin, the blending ratio of low crystal olefin resin is 5 to 55% by weight.
The present invention relates to a connecting tube for infusion without drug adsorption, which is characterized by:
本発明で使用する直鎖型低密度ポリエチレンは、エチレ
ン−α−オレフィンの共重合体であり、構造的にはポリ
エチレンの直鎖にα−オレフィンの短側鎖を有する密度
０．９２〜０．９４ｇ／ｃｍ３程度（ＡＳＴＭ １５
０５による）の直鎖型ポリエチレンである。α−オレフ
ィンとしては、ブテン−１、ヘキセン−１、メチルペン
テン−１、オクテン−１等が例示される。特に好ましい
ものとして、密度０．９２ｇ／Ｃ１１３のエチレン−ブ
テン−１共重合直鎖型低Ｚ度ポリエチレンが例示される
。The linear low-density polyethylene used in the present invention is an ethylene-α-olefin copolymer, and structurally has a linear polyethylene chain and a short side chain of α-olefin, and has a density of 0.92-0. Approximately 94g/cm3 (ASTM 15
05) is a linear polyethylene. Examples of α-olefins include butene-1, hexene-1, methylpentene-1, octene-1, and the like. Particularly preferred is ethylene-butene-1 copolymerized linear low Z degree polyethylene having a density of 0.92 g/C113.
また、熱可塑性低結晶α−オレフィン系樹脂は、エチレ
ンとα−オレフィンとの共重合体で、結晶化度が５０％
以下の低結晶性のものであり、密度が０．８７〜０．８
９程度である。低結晶オレフィン樹脂としては、エチレ
ン−ブテン−１共重合体、エチレン−ペンテン−１共重
合体、４−メチル−１−ペンテン共重合体、エチレン−
ヘキセン−１共重合体、エチレン−オクテン−１共重合
体等が例示される。特に好ましいものとして、密度０、
ＢＢＱ／ｃｍ３のエチレン−ブテン−１共重合直鎖型低
密度ポリエチレンが例示される。In addition, thermoplastic low-crystal α-olefin resin is a copolymer of ethylene and α-olefin, and has a crystallinity of 50%.
It has the following low crystallinity and has a density of 0.87 to 0.8
It is about 9. Examples of the low-crystalline olefin resin include ethylene-butene-1 copolymer, ethylene-pentene-1 copolymer, 4-methyl-1-pentene copolymer, and ethylene-1-pentene copolymer.
Examples include hexene-1 copolymer and ethylene-octene-1 copolymer. Particularly preferred are density 0,
An example is ethylene-butene-1 copolymerized linear low density polyethylene of BBQ/cm3.
ＬＬＤＰＥと低結晶オレフィン樹脂との配合割合は、ブ
レンド樹脂１００重量部中通常前者９５〜４５重世部に
対し後者５〜５５重量部程度であり、より好ましくは前
者８０〜６０重良部に対し後者２０〜４０重量部程度で
ある。低結晶オレフィン樹脂の配合割合が、ブレンド樹
脂重量の５％未満である場合には、連結チューブとして
の柔軟性が充分でなく、ベリスタティックフィンガ一式
輸液ポンプに装着した場合にフィンガ一部の押圧により
チューブが完全に閉塞せず、またポンプ駆動時のチュー
ブの復元性が弱い。一方、低結晶オレフィン樹脂の配合
割合が、ブレンド樹脂重量の５５％を上回る場合には、
輸液ポンプに装着した際に輸液ポンプ排出液中に約１０
μｍ以上の樹脂異物が発生する危険性がある。The blending ratio of LLDPE and low crystal olefin resin is usually about 95 to 45 parts by weight of the former to 5 to 55 parts by weight of the latter, more preferably 80 to 60 parts by weight of the former to 100 parts by weight of the blend resin. It is about 20 to 40 parts by weight. If the proportion of low-crystalline olefin resin is less than 5% of the weight of the blended resin, it will not have sufficient flexibility as a connecting tube, and when attached to a veristatic finger infusion pump, the fingers may be partially pressed. The tube is not completely occluded, and the tube does not recover easily when the pump is driven. On the other hand, when the blending ratio of low crystal olefin resin exceeds 55% of the blend resin weight,
When attached to an infusion pump, about 10
There is a risk of resin foreign matter of μm or larger being generated.
本発明の輸液用連結チューブは、公知の輸液投与回路に
おいて既存の連結チューブに代えてそのまま使用可能で
ある。The infusion connecting tube of the present invention can be used as is in a known infusion administration circuit in place of an existing connecting tube.
発明の効果 本発明によれば、以下の如き顕著な効果が奏される。Effect of the invention According to the present invention, the following remarkable effects are achieved.
（＋＞輸液中の脂溶性薬剤成分を実質上吸着しない。(+> Does not substantially adsorb fat-soluble drug components in the infusion.
（ｉｉ ）柔軟性に優れているので、輸液ポンプフィン
ガーの押圧によってチューブが容易に閉塞し、もって輸
液投与速度の制御を正確に行ない得る。(ii) Since the tube is highly flexible, the tube can be easily occluded by pressing the infusion pump finger, thereby making it possible to precisely control the rate of infusion administration.
（ｉｉｉ ）可撓性、強度、耐ピンホール性等にも優れ
ている。(iii) Excellent flexibility, strength, pinhole resistance, etc.
実 施 例
以下実施例を示し、本発明の特徴とするところをより一
層明らかにする。EXAMPLES Examples will be shown below to further clarify the characteristics of the present invention.
実施例１
第１図に示す輸液セットの連結チューブとしてＬＬＤＰ
Ｅ （Ｌと略記）と低結晶オレフィン樹脂（下と略記）
とを第１表に示す種々の割合で配合したブレンド樹脂か
らチューブを作成した。尚、ＬＬＤＰＥとしては、エチ
レン−ブテン−１共重合体（密度０．９２０／ｃｎ＋３
＞を、また低結晶オレフィン樹脂としては、エチレン−
ブテン−１共重合体（密度０．８８０／ＣＩｌ＋３、結
晶化度５０％以下）を使用した。Example 1 LLDP was used as a connecting tube for the infusion set shown in Figure 1.
E (abbreviated as L) and low crystal olefin resin (abbreviated as below)
Tubes were made from blended resins containing the following in various proportions as shown in Table 1. In addition, as LLDPE, ethylene-butene-1 copolymer (density 0.920/cn+3
>, and as a low crystal olefin resin, ethylene-
A butene-1 copolymer (density 0.880/CI1+3, crystallinity 50% or less) was used.
第１図に示す輸液セットにおいて、（１）は薬液導入針
、（２）は上部チューブ、（３）は上部クランプ、（４
）は定量筒、（５）は点滴筒、（６）は下部クランプ、
（７）は下部チューブ、（８）はルアーチップを夫々示
す。第１表に示す組成のチューブは、上部チューブ（２
）及び下部チューブ（７）として使用した。In the infusion set shown in Figure 1, (1) is a drug solution introduction needle, (2) is an upper tube, (3) is an upper clamp, and (4) is an upper tube.
) is the metering tube, (5) is the drip tube, (6) is the lower clamp,
(7) shows the lower tube, and (8) shows the lure tip. The tube with the composition shown in Table 1 has an upper tube (2
) and the lower tube (7).
ニトログリセリン注射液を生理食塩水で希釈して濃度１
００μｇ／−とし、試験溶液とした後、該試験溶液１０
０１１１Ｑを定量筒（４）に注入した。Dilute nitroglycerin injection solution with physiological saline to a concentration of 1.
00 μg/-, and after making it into a test solution, the test solution 10
0111Q was injected into the metering cylinder (4).
次いで、輸液セットの回路内の空気抜きを行なった後、
輸液ポンプ（米国ＩＶＡＣ社１！Ｊ５３０型）に装着し
、１０ＩＩＩ２／ｈｒの流速で試験溶液を連続滴下した
。ニトログリセリンの吸着性及び輸液ポンプとの適合性
を調べた結果を第１表に併せて示す。Next, after venting the air in the infusion set circuit,
It was attached to an infusion pump (model 1!J530, manufactured by IVAC, USA), and the test solution was continuously dropped at a flow rate of 10III2/hr. Table 1 also shows the results of examining the adsorption properties of nitroglycerin and compatibility with infusion pumps.
尚、ニトログリセリンの吸着は、ルアーチップ（８）か
らの流出液を経時的にサンプリングし、高速液体クロマ
トグラフィーにより以下の容領で定量し、流出液中の二
；・ログリセリン濃度が１度でも当初濃度の９５％以下
となった場合に吸着ありとした。In addition, the adsorption of nitroglycerin was determined by sampling the effluent from the Luer chip (8) over time and quantifying it by high performance liquid chromatography in the following volume. However, if the concentration was 95% or less of the initial concentration, adsorption was determined.
機 器：■日立製作新製 ６３８型
カラム：米国ＥＲＭＡ ０ＰＴＩＣＡＬＷＯＲＫＳ社
製
ＥＲＣ−ＯＤＳ １１６１
移動相ニアセトニトリル：テトラヒドロ７ラン：水＝２
６０： １００ ： ６４０
流 速＝２．０鵬／分
検出器： ＵＶ Ｄｅｔｅｃｔｏｒ （２１８ｎｍ）
又、輸液ポンプへの適合性については、（イ）輸液ポン
プフィンガーによるチューブ押圧により゛チューブが完
全に閉塞し且つ所定流速での液の排出をコントロールし
得るとともに、（ロ）輸液ポンプによりチューブを通し
て排出した純水５００噌を０．４５μｍメンブレンフィ
ルターでｔ濾過して捕集し、更に０．４５μｍメンブレ
ンフィルターで再度濾過した後、１００倍の顕微鏡下で
フィルター上に１０μｍ以上の樹脂異物を認めない場合
を適とした。Equipment: New model 638 column manufactured by Hitachi: ERC-ODS 1161 manufactured by ERMA 0PTICAL WORKS, USA Mobile phase: Niacetonitrile: Tetrahydro7ran: Water = 2
60: 100: 640 Flow rate = 2.0 hours/min Detector: UV Detector (218nm)
In addition, regarding compatibility with infusion pumps, (a) the tube can be completely occluded by pressing the tube with the infusion pump finger, and the discharge of fluid at a predetermined flow rate can be controlled, and (b) the tube can be passed through the tube by the infusion pump. After filtering and collecting 500 tablespoons of discharged pure water with a 0.45 μm membrane filter and filtering it again with a 0.45 μm membrane filter, no resin foreign matter of 10 μm or more is observed on the filter under a 100x microscope. suitable for the case.
第 １ 表
実施例２
実施例１と同様のＬＬＤＰＥ７０重団％及び実施例１と
同様の低結晶オレフィン樹脂３０重世％からなるブレン
ド樹脂からチューブを作成し、これを使用して実施例１
と同様にしてニトログリセリンの吸着を測定した。Table 1 Example 2 A tube was made from a blended resin consisting of 70% LLDPE as in Example 1 and 30% as low crystalline olefin resin as in Example 1, and was used to prepare a tube for Example 1.
Adsorption of nitroglycerin was measured in the same manner as above.
輸液ポンプ駆動開始時点から流出液を経時的にサンプリ
ングした結果を第２図に曲線Ａとして示す。The results of sampling the effluent over time from the start of driving the infusion pump are shown as curve A in FIG.
ニトログリセリンの吸着がほとんど認められないことが
明らかである。It is clear that almost no adsorption of nitroglycerin is observed.
比較例１
軟質塩化ビニル樹脂製連結チューブを使用する市販輸液
セットにつき実施例２と同様にしてニトログリセリンの
吸着を測定した。結果は、第２図に曲線Ｂとして示す通
りである。Comparative Example 1 The adsorption of nitroglycerin was measured in the same manner as in Example 2 for a commercially available infusion set using a flexible vinyl chloride resin connecting tube. The results are shown as curve B in FIG.
ニトログリセリンの吸着が著るしく大であることが明ら
かである。It is clear that the adsorption of nitroglycerin is significantly greater.
第１図は、本発明連結チューブを使用する輸液セットの
１例を示す図面、第２図は、本願実施例及び比較例にお
けるニトログリセリンの吸着度合を示すグラフである。
（１）・・・薬液導入針、
（２）・・・上部チューブ、
（３）・・・上部クランプ、
（４）・・・定量筒、
（５）・・・点滴筒、
（６）・・・下部クランプ、
（７）・・・下部チューブ、
（８）・・・ルアーチップ。
（以 上）
手 続 補 正 ＩＩ（自発）昭和６０年１１
月１日
１ 事件の表示
昭和６０年特許願第１９２９５４号
２ 発明の名称
薬剤吸着のない輸液用連結チューブ
３ 補正をする者
事件との関係 特許出願人
株式会社大塚製薬工場
４ 代 理 人
大阪市東区平野町２の１０ 沢の鶴ビル自 発
６ 補正の対象
明細書中「発明の詳細な説明」の項
７ 補正の内容
別紙添付の通り
補 正 の 内 容
１ 明細書第３頁第３〜４行に「チューブを・・・・・
・ポンプに」とあるを「チューブの輸液セットを輸液ポ
ンプに」と訂正する。
２ 明細書第５頁第３行にｒＯ，８９程度」とあるをｒ
ｏ、８９ｇ／ｃｍ３程度」と訂正する。
３ 明細書第５頁９〜１０行に「共重合・・・・・・ポ
リエチレン」とあるを「共重合体」と訂正する。
４ 明ＩＩ！第８頁第１５行に「容領」とあるを「要領
」と訂正する。
５ 明細書第９頁第１３〜１５行に［純水・・・・・・
捕集し、］とあるを［濾過純水５００ｍ１ｌ！（０，４
５μｍメンブランフィルタ−で濾過したもの）を、」と
訂正する。
（以 上）FIG. 1 is a diagram showing an example of an infusion set using the connecting tube of the present invention, and FIG. 2 is a graph showing the degree of adsorption of nitroglycerin in Examples and Comparative Examples of the present invention. (1)...Medical solution introduction needle, (2)...Upper tube, (3)...Upper clamp, (4)...Metering tube, (5)...Drip tube, (6)... ...lower clamp, (7) ...lower tube, (8) ...luer tip. (Above) Procedural Amendment II (Voluntary) November 1985
Month 1st 1 Display of the case 1985 Patent Application No. 192954 2 Name of the invention Infusion connecting tube without drug adsorption 3 Person making the amendment Relationship to the case Patent applicant Otsuka Pharmaceutical Factory Co., Ltd. 4th representative Mr. Higashi, Osaka City 2-10, Hirano-cho, Ward, Sawanotsuru Building, Voluntary 6 Section 7 of “Detailed Description of the Invention” in the specification to be amended Contents of the amendment As attached in the attached sheet Contents of the amendment 1 Page 3 of the specification, Sections 3 to 3 Line 4 says “Tube...”
・Correct the phrase "to the pump" to "the tube infusion set to the infusion pump." 2. On page 5, line 3 of the specification, it says "rO, 89 approx."
o, about 89g/cm3.'' 3. On page 5, lines 9-10 of the specification, the phrase "copolymerization...polyethylene" is corrected to "copolymer." 4 Ming II! On page 8, line 15, the word ``property'' is corrected to ``principle''. 5. On page 9 of the specification, lines 13-15, [pure water...
[500ml of filtered pure water! (0,4
(filtered with a 5 μm membrane filter),” is corrected. (that's all)
Claims (1)
オレフィン系樹脂とのブレンド樹脂からなり、熱可塑性
低結晶α−オレフィン系樹脂の配合比が５〜５５重量％
であることを特徴とする薬剤吸着のない輸液用連結チュ
ーブ。(1) Linear low density polyethylene and thermoplastic low crystal α-
Consisting of a blended resin with an olefin resin, the blending ratio of thermoplastic low crystal α-olefin resin is 5 to 55% by weight.
A connecting tube for infusion without drug adsorption, characterized by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60192954A JPS6253670A (en) | 1985-08-30 | 1985-08-30 | Connection tube for infusion liquid adsorbing no drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60192954A JPS6253670A (en) | 1985-08-30 | 1985-08-30 | Connection tube for infusion liquid adsorbing no drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6253670A true JPS6253670A (en) | 1987-03-09 |
| JPH0231989B2 JPH0231989B2 (en) | 1990-07-17 |
Family
ID=16299785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60192954A Granted JPS6253670A (en) | 1985-08-30 | 1985-08-30 | Connection tube for infusion liquid adsorbing no drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6253670A (en) |
-
1985
- 1985-08-30 JP JP60192954A patent/JPS6253670A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0231989B2 (en) | 1990-07-17 |
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| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |