JPS6239132B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a method for producing a tablet confectionery containing a large number of living Bifidus bacteria, and more particularly, to a method for producing a tablet confectionery containing Bifidus bacteria that allows the bacteria to be stably preserved for a long period of time. The purpose of this invention is to provide a tablet confectionery containing a large number of Bifidus bacteria without killing the Bifidus bacteria during the production of the tablet confectionery, and also to prevent the number of Bifidus bacteria from decreasing significantly during the storage of the tablet confectionery. Another purpose of the present invention is to provide a tablet confectionery containing Bifidus bacteria that can be stored stably for a long period of time. Bifidus bacteria have beneficial effects on the human body, improving health and
It is known to have many beauty effects.
However, because it is an anaerobic bacterium, it is difficult to preserve it for a long period of time in the presence of air, and the decrease is particularly significant in the presence of moisture. In particular, when making a tablet confectionery, even if dry powder of Bifidus bacteria is used, from which moisture has been removed by freeze-drying, the number of bacteria is significantly reduced due to the addition of moisture and high pressure during the manufacturing process. Furthermore, even if there are surviving bacteria, the number of bacteria will further decrease during storage and distribution, probably due to contact with the trace amounts of moisture and air, and the bacteria will be almost ineffective when it reaches consumers. It became a thing. The inventors of this invention conducted research to develop a tablet confectionery that contains a large number of living Bifidus bacteria and does not significantly reduce the number of bacteria even after long-term storage. It was discovered that the decrease in the number of bacteria could be prevented by adding the mixture to other tablet confectionery raw materials, and this invention was completed. That is, this invention consists of mixing a bifidus bacteria-containing powder with oil and fat to form a bifidus mixture, and then forming the mixture into a tablet confectionery together with other tablet confectionery raw materials. Therefore, it is considered that the bifidus bacteria are coated with oil and fat and are protected from contact with air and moisture, making it difficult for the number of bacteria to decrease during production and storage. Furthermore, it was confirmed that even when the tablets were made by pressure molding, there was little death due to pressure. To carry out this invention, first, a bifidus bacteria-containing powder is mixed with an oil or fat to form a bifidus mixture. The bifidus bacteria-containing powder can be obtained by drying the cultured bifidus bacteria by freeze-drying or other known methods. At this time, sugars, sugar alcohols, proteins, amino acids, and other known bacterial cell protection substances are added if necessary. It is also possible to add sugars, sugar alcohols, proteins, dairy products, and other dry powdered edibles to the dry powder of Bifidus bacteria as a diluting and dispersing agent. In addition, the fats and oils used here are in order to prevent the fats and oils from melting and diffusing into the tissue of the tablets when they are made into tablets.
It is usually desirable to use solid vegetable fat that solidifies at room temperature. However, when manufacturing and storing at low temperatures, it is possible to use fats and oils that solidify at that temperature, even if they do not solidify at room temperature. Mixing the bifidus bacteria-containing powder and fat to form a bifidus mixture is carried out by mixing and stirring the two at a temperature higher than the melting point of the fat. However, if it is added to other tablet confectionery raw materials to make a tablet confectionery, if the particles of the bifidus mixture are too small, the durability during production and storage will be weakened. It is desirable to form the mixture into granules of a certain size, or to form a solidified product with a relatively large particle size, such as by granulating the mixture using a screen extrusion granulator or the like. This also improves workability during manufacturing. The oil and fat content in the Bifidus mixture must be sufficient to protect the Bifidus bacteria, and should be 20
% or more is desirable. However, if the oil and fat content is too high, the amount of oil and fat in the tablet confectionery will increase and the structure of the tablet confectionery will become brittle, or the taste will be poor, so it is desirable to keep it at 50% or less. Next, the bifidus mixture is added to other raw materials for tablet confectionery to form tablet confectionery. The production of tablet confectionery can be carried out by pressure molding powdered or/and granular tablet confectionery raw materials, or by pouring a solution tablet confectionery raw material into a mold and freeze-drying. That is, in the pressurized molding, powder raw materials such as sugar, sugar alcohol, protein, powdered milk, powdered yogurt, etc. are added with a lubricant, binder, etc. if necessary, or water is added to this powder and granulated. This is carried out by supplying the dried granules together with the bifidous mixture to the mortar of a pressure molding machine and applying pressure. In addition, in forming by freeze-drying, a bifidus mixture is added to a solution of sugar, sugar alcohol, protein, etc. or a liquid raw material such as condensed milk or yogurt, and the mixture is poured into a mold.After freezing, the mixture is left in the mold or removed from the mold. , by drying under reduced pressure while maintaining the frozen state. The bifidus mixture used at this time is granular or/
In the case of a powder, it can be made into a tablet confectionery with the bifidus mixture dispersed throughout, and in the case of a granule, it is also possible to make a tablet confectionery with a core. If desired, fruits, dried fruits, vegetables, juices, powdered juices, coffee and other flavor substances, colorants, flavorings, acids, sweeteners, nutritional ingredients, and pharmaceutical ingredients may be added to the bifidus mixture and/or other tablet confectionery raw materials. It is also possible to add emulsifiers, stabilizers, etc. as necessary. In addition, it is desirable to mix bifidus growth factors into the bifidus mixture and/or other raw materials in order to help the bifidus bacteria colonize and multiply in the intestines when the tablets of the present invention are eaten. Bifidus growth factors used for this purpose include β-ethyl-N-acetylglucosamine (bifidus factor 1), a protease hydrolyzate of proteins such as casein (bifidus factor 2), and a lactose hydrolyzate obtained by alkaline decomposition of whey or crude lactose (bifidus factor 2). GLL), lactulose, carrot juice, lysozyme, etc. can be used. Furthermore, if the outer circumferential surface of each particle of a bifidus mixture, especially a granulated bifidus mixture, is coated with silica, it not only prevents moisture absorption but also protects the bifidus bacteria from stomach acid and becomes active after reaching the intestines. The internal fixation property becomes even more excellent. Coating of the bifidus mixture with Sierrak is carried out by placing the granules in a rotary kettle and spraying with an alcoholic solution of Sierrak while rotating. Next, the present invention will be explained by examples. Example 1 4 parts of dry powder obtained by adding cultured Bifidus bacteria to skim milk and freeze-drying them and 64 parts of β-lactose were heated at 40 to 50°C.
The mixture was added to 32 parts of vegetable solid fat that had been heated and melted and mixed, and then granulated using a screen extrusion granulator to obtain a granular bifidus mixture with a diameter of approximately 1 mm. Separately, 40 parts of sugar and 60 parts of glucose were mixed, a lubricant and a binder were mixed, water was added, and the mixture was granulated using a screen extrusion granulator and dried at 55°C. A granular confectionery raw material with a diameter of approximately 1 mm was obtained. Next, 15 parts of the bifidus mixture and 85 parts of the tablet confectionery raw material were mixed and pressure molded using a pressure molding machine to obtain a tablet confectionery containing bifidus bacteria. Further, this tablet confectionery was placed in an aluminum foil-laminated flat bag, sealed on all sides, and stored at 30°C. Comparative Example 1 Bifidus freeze-dried powder 4 used in Example 1
15 parts of powder mixed with 96 parts of β-lactose and 96 parts of β-lactose, 85 parts of powder mixed with 40 parts of sugar, 60 parts of glucose, a lubricant and a binder, and after adding water, the mixture was granulated by screen extrusion. The mixture was granulated using a machine and dried at 60°C to form granules with a diameter of approximately 1 mm. Next, the granules were pressure molded using a pressure molding machine to obtain a tablet confectionery containing Bifidus bacteria. In addition, this tablet confectionery was placed in an aluminum foil-laminated flat bag, sealed on all sides, and stored at 30°C. Test Example 1 The granule mixture of Example 1 before pressure molding, the tablet confectionery immediately after pressure molding, and the tablet confectionery after 6 months storage, the powder mixture before granulation of Comparative Example 1, the tablet confectionery immediately after pressure molding, and Table 1 shows the results of measuring the number of Bifidus bacteria in each of the tablet confections after 6 months of storage.

[Table] Example 2 35 parts of dry powder obtained by adding cultured Bifidus bacteria to skim milk and freeze-drying and 30 parts of lactose were added to 35 parts of vegetable solid fat heated and melted at 40 to 50°C, mixed, and then screened. The mixture was granulated using an extrusion granulator to obtain a granular bifidus mixture with a diameter of 1 mm. Next, add skim milk to a mixed solution of 90 parts of fermented yogurt and 5 parts of sugar.
Add 5 parts of the bifidus mixture obtained above and pour into a plastic mold having a number of tablet-shaped depressions,
The mixture was frozen as it was and dried under reduced pressure to obtain a tablet confectionery containing Bifidus bacteria. Without removing this product from the mold, the opening of the mold was sealed with moisture-proof seal paper, and the product was stored in an aluminum foil bag, sealed and sealed. Comparative Example 2 A mixed solution of 5 parts of the mixed powder of 35 parts of Bifidus dry powder and 65 parts of lactose used in Example 2, and a mixed solution of 90 parts of yogurt and 5 parts of sugar was added to plastic in the same manner as in Example 2. The mixture was poured into a mold and freeze-dried to obtain a tablet confectionery containing Bifidus bacteria. In addition, this product was sealed with a sticker paper in the same manner as in Example 2, placed in an aluminum foil bag, sealed, and stored. Test Example 2 Mixed solution to which the bifidus mixture of Example 2 was added, tablet confectionery immediately after freeze-drying, tablet confectionery after storage at room temperature for 6 months, mixed solution immediately after mixing of Test Example 2, tablet confectionery immediately after freeze-drying, and 6 Table 2 shows the number of Bifidus bacteria in each of the tablet confections after storage at room temperature for several months. However, the number of bacteria in the mixed solution is calculated per 1 g of solid content.

[Table] Example 3 Containing 5% glycerin in cultured Bifidus bacteria
Dry powder lyophilized with 1/15M phosphate buffer
Mix 25 parts and 46 parts of sorbitol powder, add to 29 parts of melted vegetable solid fat (including 1 part of lecithin), and after mixing, use a screw extrusion granulator to form a granular bifidus mixture with a diameter of about 2 mm. And so.
10 parts of this bifidus mixture and 1 part of lactulose
90 parts of sorbitol powder containing % of sorbitol were mixed, an appropriate amount of menthol and a lubricant were added, and the mixture was press-molded to obtain a tablet confectionery containing bifidus bacteria. Example 4 7 parts of a dry powder obtained by dispersing cultured Bifidus bacteria in a 20% sugar solution and freeze-drying the mixture, 42 parts of sugar, and 9 parts of lactose.
Add 41 parts of solid vegetable fat, 1 part of lecithin, and a red pigment to the mixture, heat (45°C), and mix. The resulting slurry is then molded into a template having many disc-shaped recesses with a diameter of 10 mm. After the mixture was injected into a cold mold and solidified, it was removed from the mold plate to obtain a bifidus mixture. Separately, 59 parts of peach nectar, 23 parts of sugar, 13 parts of skim milk powder, 4 parts of water, and 1 part of pectin were mixed to prepare a solution raw material. Next, the solution raw material is poured into a square mold with sides of 20 mm, the bifidus mixture is inserted into the center of the mold, and after freezing,
It was removed from the mold and dried under reduced pressure while maintaining the frozen state, to obtain a bifidus-containing tablet confectionery in which a bifidus mixture was present in the center of the square tablet confectionery in the shape of a Japanese flag. Example 5 5 parts of a dry powder obtained by mixing cultured Bifidus bacteria in a 10% solution of skim milk powder and dissolving 1% monosodium glutamate and 5% sugar and freeze-drying the mixture.
Mix 17 parts of skim milk powder and 48 parts of sugar, mix with 30 parts of vegetable solid fat colored with carotene, make granules with a diameter of about 0.8 mm using a screen extrusion granulator, and then put the granules in a rotary kettle and add Sierra Tsuk alcohol. The solution was sprayed on and the surface of the granules was coated with Sierrak to form a bifidus mixture. Meanwhile, apart from this, 32 parts of yogurt, 20 parts of strawberries cut into chips,
20 parts of sugar, 9 parts of carrot juice, 6 parts of water, 2 parts of lactose decomposition product, and 1 part of pectin are mixed to obtain a solution raw material, and 10 parts of the bifidus mixture is added to this to form a plastic mold having a disc-shaped recessed part. inject into
After freezing, the frozen product was taken out from the mold and dried under reduced pressure while maintaining the frozen state to obtain a tablet confectionery containing Bifidus bacteria. Example 6 40 parts of the dry powder of Bifida bacteria described in Example 4, 24 parts of glucose, 4 parts of lactulose powder (lactulose content 40%), 32 parts of vegetable solid fat, and a pigment were mixed, and the mixture was mixed with a screen extrusion granulator. Granulation diameter
A granular bifidus mixture of 1.5 mm was prepared. In addition,
Pigments of yellow, green, orange, red, and blue were granulated separately to obtain bifidous mixtures of each color. On the other hand, 30 parts of sugar and 70 parts of glucose were mixed with a lubricant and a binder, granulated by wet granulation, and dried to obtain a granular raw material. Next, 20 parts of a mixture of bifidus mixtures of each color, 80 parts of granular raw materials, and powdered flavoring were mixed and molded using a pressure molding machine, so that the granular bifidus mixtures of various colors were dispersed in white tablets. A very beautiful tablet confectionery containing Bifidus bacteria was obtained.

Claims (1)

[Scope of Claims] 1. A method for producing a tablet confectionery containing a bifidus bacterium, which comprises mixing a bifidus bacterium-containing powder with an oil or fat to form a bifidus mixture, which is then added to other tablet confectionery raw materials and formed into a tablet confectionery. 2. A method for producing a tablet confectionery containing Bifidus bacteria according to claim 1, which comprises molding a powdered raw material into a tablet confectionery by pressure molding. 3. A method for producing a tablet confectionery containing bifidus bacteria according to claim 1, which comprises forming a tablet confectionery by putting a solution-like raw material into a mold and freeze-drying it. 4. The method for producing a tablet confectionery containing Bifidus bacteria according to claim 1, wherein the Bifidus mixture and/or other tablet confectionery raw materials contain a Bifidus growth factor.