JPS6229404B2 - - Google Patents
Info
- Publication number
- JPS6229404B2 JPS6229404B2 JP58220307A JP22030783A JPS6229404B2 JP S6229404 B2 JPS6229404 B2 JP S6229404B2 JP 58220307 A JP58220307 A JP 58220307A JP 22030783 A JP22030783 A JP 22030783A JP S6229404 B2 JPS6229404 B2 JP S6229404B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- parts
- aqueous solution
- fibroin
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 100
- 108010022355 Fibroins Proteins 0.000 claims description 90
- 239000007864 aqueous solution Substances 0.000 claims description 61
- 238000011282 treatment Methods 0.000 claims description 56
- 239000000203 mixture Substances 0.000 claims description 55
- 239000007788 liquid Substances 0.000 claims description 38
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 11
- 150000005846 sugar alcohols Polymers 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 44
- 230000014759 maintenance of location Effects 0.000 description 38
- 230000001680 brushing effect Effects 0.000 description 34
- 239000003795 chemical substances by application Substances 0.000 description 34
- 238000012360 testing method Methods 0.000 description 33
- 230000000052 comparative effect Effects 0.000 description 25
- 230000000694 effects Effects 0.000 description 25
- 239000006210 lotion Substances 0.000 description 20
- 230000006378 damage Effects 0.000 description 17
- 239000000118 hair dye Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 13
- 239000002453 shampoo Substances 0.000 description 13
- 230000003766 combability Effects 0.000 description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 10
- 102000008186 Collagen Human genes 0.000 description 10
- 108010035532 Collagen Proteins 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 229920001436 collagen Polymers 0.000 description 10
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- -1 propase Proteins 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 108010076876 Keratins Proteins 0.000 description 8
- 102000011782 Keratins Human genes 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 239000007844 bleaching agent Substances 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 229940058015 1,3-butylene glycol Drugs 0.000 description 5
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 238000002441 X-ray diffraction Methods 0.000 description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 239000004809 Teflon Substances 0.000 description 4
- 229920006362 Teflon® Polymers 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000004061 bleaching Methods 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 241001070941 Castanea Species 0.000 description 3
- 235000014036 Castanea Nutrition 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 238000007605 air drying Methods 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000003700 hair damage Effects 0.000 description 3
- 230000003699 hair surface Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- XUXNAKZDHHEHPC-UHFFFAOYSA-M sodium bromate Chemical compound [Na+].[O-]Br(=O)=O XUXNAKZDHHEHPC-UHFFFAOYSA-M 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 206010044625 Trichorrhexis Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000003051 hair bleaching agent Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000009991 scouring Methods 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 125000003944 tolyl group Chemical group 0.000 description 2
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- WYWJXYCHNSISPZ-UHFFFAOYSA-L N.[OH-].[OH-].[Cu++] Chemical compound N.[OH-].[OH-].[Cu++] WYWJXYCHNSISPZ-UHFFFAOYSA-L 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 238000000861 blow drying Methods 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 1
- BXKDSDJJOVIHMX-UHFFFAOYSA-N edrophonium chloride Chemical compound [Cl-].CC[N+](C)(C)C1=CC=CC(O)=C1 BXKDSDJJOVIHMX-UHFFFAOYSA-N 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 229940031957 lauric acid diethanolamide Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
- 229960001755 resorcinol Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Description
本発明は後記特定のフイブロインペプチド（フ
イブロイン加水分解物）を配合することによつて
改良された、毛髪処理用組成物（頭髪用化粧料）
に関する。更に詳しくは毛髪の損傷を防止し、化
学的、機械的な刺激から毛髪を保護し、毛髪に良
好な風合い、感触、光沢、櫛通り性、整髪効果、
セツト効果等を付与し得る毛髪処理用組成物に関
する。
一般に毛髪は、洗髪、ブローイング、ブラツシ
ング、あるいはコールドウエービシング、毛髪染
色等の美容処理が頻繁に施されるために、毛髪の
損傷と、劣化が著しく、その結果、乾燥してバサ
ついたり、枝毛、毛切れ、抜毛、等の増加、強度
低下や変色等を生起する等、種々の問題があるこ
とは、よく知られている。
上述の毛髪損傷に対しては、従来、如何にダメ
ージの少ない美容処理をあるいは積極的に、毛髪
の保護、修復を目的として、油剤やコラーゲンペ
プチド、ケラチンペブチド等を当該基剤に配合す
る方法がとられているが未だ満足し得る程度の効
果が得られていない。
本発明の目的は、毛髪の表面にフイブロインペ
プチドの皮膜を形成して、毛髪処理時の化学的、
機械的な刺激（作用）から毛髪を保護し、毛髪に
良好な風合い、感触、光沢、櫛通り性、整髪効
果、セツト効果を付与し得る毛髪処理用組成物を
提供することにある。
すなわち、本発明は、水性溶液を塗布して乾燥
するとα型に結晶化し得る平均分子料が300〜
3500のフイブロインペプチドが、水性基剤の中に
0.1〜10重量％（重量％は組成物の重量基準）溶
解している毛髪処理用組成物である。
本発明のフイブロインペプチドは、水に易溶
で、皮膜形成能を有し、その水溶液をガラス板、
合成樹脂シート、毛髪等の表面に塗布し、乾燥す
るとその形成皮膜はα型に結晶化し得る平均分子
量が300〜3500のフイブロインペプチドである。
フイブロインペプチドの平均分子量は、300〜
3500、好ましくは1000〜2500である。平均分子量
が300よりも小さいと、水性溶液の安定性や皮膜
形成能が低下し、乾燥しても結晶化しない他、毛
髪にべたつき感（毛髪がべたつくようなわるい感
触）を与えるので好ましくない。また平均分子量
が3500よりも大きいと、水に対する溶解性や水性
溶液の安定性が著しくわるくなり、かつ毛髪に付
着した場合、洗い落ちや感触がわるくなるので好
ましくない。
本発明のフイブロインペプチドは、それ自体、
非晶質であるため水溶液は透明であり、水溶液を
前記シート状物質に塗布、乾燥して得られる皮膜
は結晶化しており、その結晶は、Ｘ線回折像によ
りα型であることを確認している。
また、このフイブロインペプチドのアミノ酸組
成分折結果は、グリシン43〜54％、アラニン26〜
63％、セリン11〜15％、チロシン９〜12％、その
他のアミノ酸微量を与えている。
本発明のフイブロインペプチドは、人体に安全
で、皮膚刺激がなく、後記のDraizeの方法に準
じて行なつた結果、動物皮膚刺激スコアー、人体
皮膚刺激スコアーは何れも０（ゼロ）であり、何
れも無刺激性であることを、確認している。
〔Draize.J.H.，Association of Food and
Drug officials of the United States Appraisal
of the Safety of Chemicals in Foods Drug
and Cosmetics，46（1959），Texas State
Department of Health，Austin〕
本発明の前記フイブロインペプチドは、銅、エ
チレンジアミン水溶液、水酸化銅―アンモニア水
溶液、水酸化銅―アルカリ―グリセリン水溶液、
臭化リチウム水溶液、カルシウムあるいはマグネ
シウムまたは亜鉛の塩化物、あるいは硝酸塩また
はチオシアン酸塩の水溶液、チオシアン酸ナトリ
ウム水溶液よりなる群から選択された少なくとも
一種の溶媒に、精練絹原料を溶解後透析して得た
0.5〜20重量％の絹フイブロン水溶液を酵素ある
いは酸またはアルカリにより加水分解することに
よつて水溶液（フイブロインペプチド水溶液）の
かたちで得られ、粉末状のフイブロインペプチド
は、前記フイブロインペプチドの水溶液を噴霧乾
燥することによつて得られる。
酵素は通常の蛋白質分解酵素で例えばプロペア
ーゼ、パパイン、トリプシンが好ましい。蛋白質
分解酵素の使用量は0.1〜5.0重量％が好ましい。
加水分解に使用する酸としては塩酸、硫酸等の無
機酸や酒石酸、マロン酸、コハク酸、マレイン酸
等が好ましい。酵素による加水分解は、通常PH５
〜９、温度が20〜50℃で処理時間は１〜72時間で
行なわれる。
酸またはアルカリによる加水分解の条件は、通
常0.03〜3Nの濃度で20〜110℃で0.5〜50時間であ
る。
本発明における毛髪処理用組成物（頭髪用化粧
料）としては、シヤンプー、ヘヤーリンス、プレ
シヤンプー型毛髪処理剤、ヘアーコンデイシヨナ
ー、ブロートリートメントローシヨン、セツトロ
ーシヨン、ヘアーリキツド、ヘアークリーム、ヘ
アーブラツシング剤、プレパーマネントトリーメ
ント、パーマネートウエーブ剤（コールドウエー
ブ剤）の第１液および第２液、ヘアーダイ（染毛
剤）、ヘアーブリーチ剤等を包含される。
本発明のフイブロインペプチド（フイブロイン
加水分解物）は、上記の毛髪処理用組成物（頭髪
用化粧料）の水性基剤に配合される。
こゝで言う水性基剤とは水単独または水と水溶
性の当該化粧料用基剤、とからなる水溶液（水性
溶液）である。
フイブロインペプチドは、水溶液のかたちで配
合してもよく、また水性基剤の中に添加してもよ
い。
フイブロインペプチドの配合量は、前記の如く
0.1〜10重量％、好ましくは0.5〜５重量％であ
る。
本発明の該組成物は、フイブロインペプチドの
配合によつて、前述の如き種々の優れた毛髪処理
効果を与えるが、グリセリン、プロピレングリコ
ール、１，３―ブチレングリコール、ポリエチレ
ングリコール等の液状の多価アコールを更に添加
して併用する場合は、より優れた整髪効果、柔軟
性、セツト効果等を毛髪に付与することができ
る。
液状の多価アコールを併用する場合の配合量
は、該組成物の重量に対して高々10重量％、好ま
しくは１〜５重量％である。
本発明の該組成物には慣用される香料の他に、
可溶化剤、防腐剤、殺菌剤、油性物質、乳化剤等
を適宜配合することができる。
本発明の毛髪処理用組成物は、長期保存しても
極めて安定で、溶存しているフイブロインペプチ
ドが沈澱、凝固、析出等を生起することがなく、
油性物質が共存しない水系では均一透明な外観を
呈している。
毛髪処理用組成物を毛髪に塗布（施与）する
と、溶存している前記のフイブロインペプチドは
毛髪に対して高度の親和性を有しているので、選
択的に吸着し、乾燥の進行と共に毛髪の表面で皮
膜化すると共に結晶化が進行して、乾燥した皮膜
はａ型に結晶化している。毛髪の表面に形成した
フイブロインペプチドの皮膜は、α型に結晶化し
ているので適度の耐水性、耐アルカリ性、耐酸
性、耐酸化剤性等と共に、適度良好な強度と柔軟
性を有しているので、毛髪を水洗、シヤンプー処
理、ブラツシング、染色、脱色、コールドウエー
ビング等する時にも、安定で容易に脱落すること
がなく、毛髪を保護し、毛髪に良好な整髪効果、
セツト効果、櫛通り性、風合、感触を永く保持、
発現し得る。またフイブロインペプチドは、絹フ
イブロイン由来のペプチドであるから、毛髪に対
して、絹特有の良好な艶、光沢、しなやかな風
合、適度のこしを与え、かつ栄養となる当該アミ
ノ酸成分を付与して、毛髪の修復及び美粧効果を
より向上せしめることができる。
これらの有用顕著な作用効果は、コラーゲン由
来のコラーゲンペプチドやケラチン由来のケラチ
ンペプチドには見られないところであつて、本発
明の作用効果の特異性は著しい。
以下実施例について説明する。
なお、実施例に示した部とは重量部を、％とは
重量％を意味する。
実施例 １
(1) フイブロインペプチドの製造
塩化カルシウムの60％水溶液１に精練絹原
料140ｇを加熱溶解した後、この溶液を24時間
透析し、5.0％のフイブロイン水溶液2.8を得
た、次にこのフイブロイン水溶液１に濃塩酸
を加えて0.1N―塩酸溶液とし、85℃で８時
間、撹拌下で加熱してフイブロインの加水分解
を行なつた後、これを20％苛性ソーダ水溶液で
中和し、活性炭で脱色処理して微黄色透明のフ
イブロインペプチド水溶液を得た。次にこのフ
イブロインペプチド水溶液を、噴霧乾燥機を用
いて70〜120℃の雰囲気下で噴霧乾燥して、フ
イブロインペプチドの粉末を得た。このフイブ
ロインペプチドは、平均分子量が1000で、水に
易溶でその水溶液はテフロン板上に流延すると
皮膜を形成した。乾燥した皮膜はＸ線回折像に
よりα型に結晶化していることが確認された。
(2) 本発明のセツトローシヨンの調製
前記の(1)で得られたフイブロインペプチド３
部を水96.6部に溶解した後、この水溶液に香料
0.1部、ポリオキシエチレン硬化ヒマシ油（香
料の可溶化剤）0.2部とメチルパラベン0.1部を
添加溶解して本発明のセツトローシヨンを得
た。
(3) 本発明のセツトローシヨンの性能
実用テスト
専門検査員３人によつて実用テストを行な
つた。その結果艶のあるしなやかな仕上り
で、櫛通りが良く、ブラツシングによるフレ
ーキングが起らなかつた。またカール保持性
は高湿度の環境下においても良好であつた。
カール保持性のテスト
長さ20cm、２ｇの毛束を、支持台に吊し、
等速度でゆつくり回転させながら、本発明の
セツトローシヨンを均等に噴霧付着させ、こ
の液滴を均一に付着して直径約１cmのロツド
棒に巻き付け、60分間45℃にて風乾し試料と
する。これ等の試料を目盛板の上部に取り付
け、30℃、95％RHの高湿の条件下でカール
先端の降下位置を目盛板より読み取り、次式
より算出する。
カール保持率（％）＝Ｌ−Ｌｔ／Ｌ−Ｌｏ×100
Ｌ：試験用毛髪を充分に伸したときの長さ
Lo：調湿条件のもとにおく前のカール先端の
位置
Lt：調湿条件のもとに一定時間（ｔ）放置し
たときのカール先端の位置
上記の如く、測定した結果、本発明のセツ
トローシヨンのカール保持率は、毛束に付着
してから30分後で90.4％、60分後で89.7％、
120分後で89％であつて、カール保持性は極
めて良好であつた。
ブラツシングに対する損傷試験
で使用した毛束試料（本発明のセツトロ
ーシヨンを付着ずみ）に、ブラツシング500
回を行ない、ブラツシングによるスケールに
対する影響を顕微鏡観察し、ブラツシング前
後の摩擦係数をフリクシヨンメーターにて測
定した。
その結果、摩擦係数は、ブラツシング前で
0.13〜0.15、ブラツシング後で0.14〜0.17で、
摩擦係数の差は0.01〜0.02で非常に小さく、ま
た顕微鏡で毛髪表面を観察した結果、スケール
の損傷は殆んど見られなかつた。
比較例１ （セツトローシヨン）
フイブロインペプチドを使用せず、かつ水を
99.6部使用する他は、実施例１と同様に行なつて
調製した比較用のセツトローシヨンでは、感触、
櫛通り性が比較的わるかつた。またカール保持率
は毛束に付着して30分後で21.3％、60分後で14.9
％、120分後で10.6％であつて、カール保持性は
不良であつた。またブラツシングに対する損傷試
験においては、摩擦係数はブラツシング前で0.18
〜0.23で大きく、ブラツシング後で0.21〜0.30
で、摩擦係数の差は0.03〜0.07で可成り大きく、
また顕微鏡で毛髪表面を観察した結果、スケール
の損傷は大きかつた。
比較例２ （セツトローシヨン）
フイブロインペプチドの代りに、コラーゲンペ
プチド（平均分子量1000）を使用する他は、実施
例１の本発明と同様に行なつて、比較用のセツト
ローシヨンを調製した。このセツトローシヨンで
は、艶のないかつしなやかさのない仕上りで、櫛
通りおよびカール保持性も、本発明のセツトロー
シヨンのそれよりはわるく、ブラツシングよるフ
レーキングを防止することができなかつた。また
カール保持率は、毛束に付着してから30分後で
30.2、60分後で16.1、120分後で10.4でカール保持
性は比較的わるかつた。
比較例３ （セツトローシヨン）
フイブロインペプチドの代りに、ケラチンペプ
チド（平均分子量1000）を使用する他は、実施例
１の本発明と同様にして比較用のセツトローシヨ
ンを調製した。このセツトローシヨンでは艶のな
い、かつしなやかさのない仕上りで、櫛通りおよ
びカール保持性も比較的わるく、ブラツシングに
よるフレーキングを防止することができなかつ
た。またカール保持率は毛束に付着してから30分
後で26.8、60分後で22.0、120分後で17.9で、カー
ル保持性は比較的わるかつた。
実施例２ （セツトローシヨンにおけるフイブロ
インペプチドの配合量）
セツトローシヨンにおけるフイブロインペプチ
ドの配合量を第１表の如く変化する他は、実施例
１の本発明と同様に行なつて、各セツトローシヨ
ンを調製して、配合量の影響をしらべた。その結
果、フイブロインペプチドの配合量は、組成物
（処方成分の全量）に対して0.1〜10重量％、好ま
しくは0.5〜５重量％であることが判明した。
The present invention relates to a hair treatment composition (hair cosmetic) improved by incorporating a specific fibroin peptide (fibroin hydrolyzate) described below.
Regarding. More specifically, it prevents hair damage, protects hair from chemical and mechanical stimulation, provides good texture, feel, gloss, combability, hair styling effect,
The present invention relates to a hair treatment composition that can impart a setting effect and the like. In general, hair is frequently subjected to beauty treatments such as washing, blow-drying, brushing, cold waving, hair dyeing, etc., resulting in significant damage and deterioration of the hair, resulting in dryness, frizz, etc. It is well known that there are various problems such as an increase in split ends, hair breakage, hair loss, etc., and a decrease in strength and discoloration. Conventionally, in order to deal with the above-mentioned hair damage, there has been a method of blending oil agents, collagen peptides, keratin peptides, etc. into the base for the purpose of protecting and repairing the hair with cosmetic treatments that cause less damage or actively. However, satisfactory effects have not yet been obtained. The purpose of the present invention is to form a film of fibroin peptide on the surface of hair to prevent chemical damage during hair treatment.
To provide a hair treatment composition capable of protecting hair from mechanical stimulation (effect) and imparting good texture, feel, gloss, combability, hair styling effect, and setting effect to hair. That is, in the present invention, when an aqueous solution is applied and dried, the average molecular weight that can crystallize into the α form is 300 to 300.
3500 fibroin peptides in an aqueous base
0.1 to 10% by weight (% by weight is based on the weight of the composition) of the hair treatment composition. The fibroin peptide of the present invention is easily soluble in water and has film-forming ability, and its aqueous solution is spread on a glass plate.
When applied to the surface of a synthetic resin sheet, hair, etc. and dried, the formed film is a fibroin peptide with an average molecular weight of 300 to 3500 that can crystallize into the α form. The average molecular weight of fibroin peptide is 300~
3500, preferably 1000-2500. If the average molecular weight is less than 300, the stability of the aqueous solution and film-forming ability will be reduced, and it will not crystallize even when dried, and will give the hair a sticky feel (an unpleasant sticky feeling), which is undesirable. Moreover, if the average molecular weight is larger than 3500, the solubility in water and the stability of an aqueous solution will be significantly deteriorated, and if it adheres to hair, it will wash off easily and the texture will be poor, which is not preferable. The fibroin peptide of the present invention itself is
Since it is amorphous, the aqueous solution is transparent, and the film obtained by applying the aqueous solution to the sheet material and drying it is crystallized, and the crystal is confirmed to be α type by X-ray diffraction image. ing. In addition, the amino acid composition analysis results of this fibroin peptide are 43-54% glycine and 26-54% alanine.
63%, serine 11-15%, tyrosine 9-12%, and trace amounts of other amino acids. The fibroin peptide of the present invention is safe for the human body and does not cause skin irritation, and as a result of testing according to the Draize method described below, both the animal skin irritation score and the human skin irritation score were 0 (zero). It has been confirmed that both are non-irritating. [Draize.JH, Association of Food and
Drug officials of the United States Appraisal
of the Safety of Chemicals in Foods Drugs
and Cosmetics, 46 (1959), Texas State
Department of Health, Austin] The fibroin peptide of the present invention includes copper, ethylenediamine aqueous solution, copper hydroxide-ammonia aqueous solution, copper hydroxide-alkali-glycerin aqueous solution,
The scouring silk raw material is dissolved in at least one solvent selected from the group consisting of an aqueous solution of lithium bromide, a chloride of calcium, magnesium or zinc, an aqueous solution of nitrate or thiocyanate, and an aqueous solution of sodium thiocyanate, and then dialyzed. Ta
The powdered fibroin peptide is obtained in the form of an aqueous solution (fibroin peptide aqueous solution) by hydrolyzing a 0.5 to 20% by weight aqueous silk fibroin solution with an enzyme, an acid, or an alkali. Obtained by spray drying an aqueous solution of the peptide. The enzyme is a common proteolytic enzyme, such as propase, papain, or trypsin. The amount of protease used is preferably 0.1 to 5.0% by weight.
Preferred acids used for hydrolysis include inorganic acids such as hydrochloric acid and sulfuric acid, tartaric acid, malonic acid, succinic acid, and maleic acid. Enzymatic hydrolysis usually occurs at a pH of 5
~9. The temperature is 20-50°C and the treatment time is 1-72 hours. The conditions for acid or alkali hydrolysis are usually 0.03-3N concentration, 20-110°C, and 0.5-50 hours. Hair treatment compositions (hair cosmetics) in the present invention include shampoos, hair rinses, pre-shampoo type hair treatment agents, hair conditioners, blow treatment lotions, setting lotions, hair liquids, hair creams, and hair brushes. Shing agents, pre-permanent treatments, first and second liquids of permanent waving agents (cold waving agents), hair dyes, hair bleaching agents, and the like are included. The fibroin peptide (fibroin hydrolyzate) of the present invention is blended into the aqueous base of the above hair treatment composition (hair cosmetic). The aqueous base referred to herein is an aqueous solution (aqueous solution) consisting of water alone or water and a water-soluble cosmetic base. The fibroin peptide may be formulated in the form of an aqueous solution or added into an aqueous base. The amount of fibroin peptide is as described above.
0.1-10% by weight, preferably 0.5-5% by weight. The composition of the present invention provides various excellent hair treatment effects as described above by incorporating fibroin peptides, but it is also possible to use liquid peptides such as glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, etc. When polyhydric alcohol is further added and used in combination, better hair styling effects, flexibility, setting effects, etc. can be imparted to the hair. The amount of liquid polyhydric alcohol used in combination is at most 10% by weight, preferably 1 to 5% by weight, based on the weight of the composition. In addition to the perfumes commonly used in the composition of the invention,
Solubilizers, preservatives, bactericidal agents, oily substances, emulsifiers, and the like can be blended as appropriate. The hair treatment composition of the present invention is extremely stable even after long-term storage, and the dissolved fibroin peptide does not cause precipitation, coagulation, precipitation, etc.
In an aqueous system without oily substances, it has a uniform and transparent appearance. When the hair treatment composition is applied to the hair, the dissolved fibroin peptide has a high affinity for the hair, so it is selectively adsorbed and the drying progresses. At the same time, it forms a film on the surface of the hair and crystallization progresses, and the dried film is crystallized into type A. The fibroin peptide film formed on the surface of the hair is crystallized in the α-type, so it has moderate water resistance, alkali resistance, acid resistance, oxidation agent resistance, etc., as well as moderately good strength and flexibility. Therefore, even when washing, shampooing, brushing, dyeing, bleaching, cold waving, etc., the hair is stable and does not fall off easily, protects the hair, and has a good hair styling effect.
Maintains setting effect, combability, texture, and feel for a long time.
It can be expressed. Furthermore, since fibroin peptide is a peptide derived from silk fibroin, it gives the hair the good gloss, shine, supple texture, and moderate stiffness characteristic of silk, and also provides the amino acid component that is nutritious. As a result, hair repair and cosmetic effects can be further improved. These useful and remarkable effects are not found in collagen peptides derived from collagen or keratin peptides derived from keratin, and the specificity of the effects of the present invention is remarkable. Examples will be described below. In addition, the part shown in an Example means a weight part, and % means weight %. Example 1 (1) Production of fibroin peptide After heating and dissolving 140 g of scouring silk raw material in 60% aqueous solution 1 of calcium chloride, this solution was dialyzed for 24 hours to obtain 5.0% fibroin aqueous solution 2.8. Concentrated hydrochloric acid was added to this fibroin aqueous solution 1 to make a 0.1N-hydrochloric acid solution, which was heated at 85°C for 8 hours with stirring to hydrolyze the fibroin, and then neutralized with a 20% caustic soda aqueous solution, Decolorization was performed with activated carbon to obtain a slightly yellow and transparent fibroin peptide aqueous solution. Next, this fibroin peptide aqueous solution was spray-dried using a spray dryer in an atmosphere of 70 to 120°C to obtain a fibroin peptide powder. This fibroin peptide had an average molecular weight of 1000, was easily soluble in water, and formed a film when the aqueous solution was cast on a Teflon plate. It was confirmed by the X-ray diffraction image that the dried film was crystallized in the α type. (2) Preparation of settlement of the present invention Fibroin peptide 3 obtained in (1) above
After dissolving 1 part in 96.6 parts of water, add fragrance to this aqueous solution.
0.1 part of polyoxyethylene hydrogenated castor oil (fragrance solubilizer) and 0.1 part of methylparaben were added and dissolved to obtain the settling lotion of the present invention. (3) Performance of the settlement of the present invention Practical test A practical test was conducted by three specialized inspectors. The result was a glossy, supple finish that combed easily and did not cause flaking due to brushing. Further, curl retention was good even in a high humidity environment. Curl retention test A 20cm long, 2g hair bundle was hung on a support stand.
While slowly rotating at a constant speed, the settlement of the present invention is evenly sprayed and deposited, and the droplets are evenly deposited and wound around a rod with a diameter of approximately 1 cm, and air-dried at 45°C for 60 minutes to form a sample. do. Attach these samples to the top of the scale plate, read the descending position of the curl tip from the scale plate under high humidity conditions of 30°C and 95% RH, and calculate it using the following formula. Curl retention rate (%) = L-L t /L-Lo x 100 L: Length when the test hair is fully stretched Lo: Position of the curl tip before being placed under humidity conditioning conditions Lt: Conditioning The position of the tip of the curl when it is left for a certain period of time (t) under humid conditions. As a result of the measurement as described above, the curl retention rate of the settling lotion of the present invention is 30 minutes after it is attached to the hair bundle. 90.4%, 89.7% after 60 minutes,
The curl retention was 89% after 120 minutes, indicating extremely good curl retention. Brushing 500
The effect of brushing on the scale was observed under a microscope, and the coefficient of friction before and after brushing was measured using a friction meter. As a result, the coefficient of friction before brushing is
0.13-0.15, 0.14-0.17 after brushing,
The difference in friction coefficient was very small, 0.01 to 0.02, and when the hair surface was observed under a microscope, almost no scale damage was observed. Comparative Example 1 (Settling) No fibroin peptide and no water
A comparative settling lotion prepared in the same manner as in Example 1, except that 99.6 parts was used, had no
The combability was relatively poor. In addition, the curl retention rate is 21.3% after 30 minutes and 14.9% after 60 minutes.
%, 10.6% after 120 minutes, and curl retention was poor. In addition, in the damage test against brushing, the friction coefficient was 0.18 before brushing.
Large at ~0.23, 0.21-0.30 after brushing
The difference in friction coefficient is 0.03 to 0.07, which is quite large.
Furthermore, as a result of observing the hair surface under a microscope, it was found that the scale damage was large. Comparative Example 2 (Settling) A settling lotion for comparison was prepared in the same manner as in Example 1 of the present invention, except that collagen peptide (average molecular weight 1000) was used instead of fibroin peptide. did. This setting lotion gave a matte and non-flexible finish, and its combability and curl retention were worse than those of the setting lotion of the present invention, and flaking due to brushing could not be prevented. In addition, the curl retention rate is 30 minutes after it is attached to the hair bundle.
The curl retention was relatively poor with a score of 30.2, 16.1 after 60 minutes, and 10.4 after 120 minutes. Comparative Example 3 (Settling) A settling lotion for comparison was prepared in the same manner as in Example 1 of the present invention, except that keratin peptide (average molecular weight 1000) was used instead of fibroin peptide. This setting gave a matte and non-flexible finish, had relatively poor combability and curl retention, and was unable to prevent flaking due to brushing. In addition, the curl retention rate was 26.8 after 30 minutes, 22.0 after 60 minutes, and 17.9 after 120 minutes after being attached to the hair bundle, indicating that the curl retention was relatively poor. Example 2 (Amount of fibroin peptide blended in the settling lotion) The same procedure as in Example 1 of the present invention was carried out except that the blending amount of the fibroin peptide in the settling lotion was changed as shown in Table 1. We prepared various settlements and examined the effects of the amount of the mixture. As a result, it was found that the amount of fibroin peptide blended is 0.1 to 10% by weight, preferably 0.5 to 5% by weight, based on the composition (total amount of prescription components).
【表】【table】
【表】
実施例３ （フイブロインペプチドの平均分子量
の影響）
フイブロインペプチドの平均分子量を第２表の
如く変化する他は、実施例１と同様に行なつて、
各セツトローシヨンを調製して、各セツトローシ
ヨンの性能および、平均分子量の影響をしらべ
た。その結果、平均分子量は300〜3500、好まし
くは1000〜2500であることが判明した。[Table] Example 3 (Influence of average molecular weight of fibroin peptide) The same procedure as in Example 1 was carried out except that the average molecular weight of the fibroin peptide was changed as shown in Table 2.
Each settling lotion was prepared and the performance of each settling lotion and the influence of average molecular weight were examined. As a result, it was found that the average molecular weight was 300-3500, preferably 1000-2500.
【表】
実施例４ （液状多価アルコールを併用した場合
の効果）
更に１，３―ブチレングリコール３部添加し、
かつ水を93.6部使用する他は、実施例１と同様に
行なつて、本発明のセツトローシヨンを調製し
て、更に１，３―ブチレングリコール（液状多価
アルコール）を配合して、フイブロインペプチド
と併用した場合の効果をしらべた。その結果、処
理した毛髪は良好な艶があり、かつ実施例１のセ
ツトローシヨン（本発明）に比較して、よりしな
やかな仕上りで、より櫛通りが良好で、ブラツシ
ングによるフレーキングが起らなかつた。またカ
ール保持性は高湿度の環境下においても極めて良
好であつた。またカール保持率は30分後で95.5
％、60分後で94％、120分後で93％で極めて良好
であつた。
またブラツシングにおける損傷試験では、摩擦
係数はブラツシング前で0.12〜0.14、ブラツシン
グ後で0.13〜0.16で、摩擦係数の差は0.01〜0.02
で非常に小さく、また顕微鏡で毛髪表面を観察し
た結果、スケールの損傷は見られなかつた。
実施例５ （ヘアーコンデイシヨナー）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド１部を水84部に溶解した水溶
液にプロピレングリコール２部とアミノ変性シリ
コーンオイル３部、エタノール10部を混合、溶解
して、本発明のヘアーコンデイシヨナーを調製し
た。このヘアーコーデイシヨナーの実用テストを
行なつた結果、コールドウエーブ処理やヘアーダ
イ処理で傷んだ毛髪に施した場合も、毛髪に張り
と腰を与えると同時に、滑りも、また以後の整髪
性も著しく向上した。
実施例６ （ヘアーリキツド）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド５部を水58部に溶解した水溶
液にエタノール25部、ポリオキシエチレン（E.O
＝20）ポリオキシプロピレン（P.O＝30）ブチル
エーテル10部、およびポリエーテル変性シリコー
ンオイル２部を混合、溶解して本発明のヘアーリ
キツドを調製した。
このヘアーリキツドの実用テストの結果は、べ
たつき感がなく、自然な風合で整髪ができ、かつ
整髪の保持性も優れていた。
実施例８ （ヘアーブラツシング剤）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド３部を水80部に溶解した水溶
解液に、１，３―ブチレングリコール５部、メチ
ルフエニルポリシロキサン２部およびエタノール
10部を混合、溶解して本発明のヘアーブラツシン
グ剤を調製した。このヘアーブラツシング剤の実
用テストを行なつた結果は、艶と滑らかさが改善
され、梳毛（櫛けずり）およびブラツシングによ
る抵抗を解消し、頻繁なブラツシングによつても
毛髪の傷み（スケールの剥離等）が見られなかつ
た。
実施例９ （シヤンプー）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド２部を水68部に溶解した水溶
液に、ラウリル硫酸トリエタノールアミン塩20
部、ラウリン酸ジエタノールアミド５部、ラウリ
ル硫酸ナトリウム塩３部およびエポキシ変性シリ
コーンオイル２部を添加し、均一に混合して本発
明のシヤンプーを調製した。のシヤンプーの実用
テストの結果は、シヤンプー後の濡れた状態での
毛髪のキシミ感および乾燥後の艶、櫛通り性が改
善され、乾燥後の毛髪の手触り（風合、触感）も
良好であつた。
実施例10 （ヘアーリンス）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド２部を水88部に溶解した水溶
液にエタノール５部、トリメチルステアリルアン
モニウムクロライド１部、セチルアルコール２部
およびメチルフエニルポリシロキサン２部を混
合、溶解して、本発明のヘアーリンスを調製し
た。このヘアーリンスの実用テストの結果は、優
れたリンスを効果を示し、毛髪に艶、張り、腰を
与え、しなやかな風合の仕上りになつた。
実施例11 （プレシヤンプー型毛髪処理剤）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド３部を水91部に溶解した水溶
液に、ポリエチレングリコール５部およびカチオ
ン化セルロース（ジエチルアミノエチル化セルロ
ース）１部を混合、溶解して、本発明のプレシヤ
ンプー型毛髪処理剤を調製した。このプレシヤン
プー型毛髪処理剤の実用テストを行なつた結果、
シヤンプー後の濡れた状態での毛髪のキシミ感お
よび乾燥後の艶、櫛通り性が改善され、乾燥後の
毛髪の手触りも良好であつた。
実施例12 （ブロートリートメントローシヨン）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド３部を水74部に溶解した水溶
液に、１，３―ブチレングリコール２部、エタノ
ール20部およびセチルトリメチルアンモニウムク
ロライド１部を混合、溶解して、本発明のブロー
トリートメントローシヨンを調製した。このブロ
ートリートメントローシヨンの実用テストを行な
つた結果、ドライヤーによる傷みを防止し、乾燥
による毛髪のパサつき、ゴワつきも起らず、艶の
ある自然でなめらかな風合を与えた。
実施例13 （プレパーマネントトリートメント）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド5.5部を水93.3部に溶解した
水溶液に、ポリオキシエチレン硬化ヒマシ油1.0
部、香料0.1部およびメチルパラベン0.1部を混
合、溶解して、本発明のプレパーマネントトリー
トメントを調製した。
次に、このプレパーマネントトリートメント
に、長さ20cm、２ｇの毛束を浸漬し、次いでチオ
グリコール酸6.5部、ポリオキシエチレン硬化ヒ
マシ油0.5部、香料0.2部、28％アンモニア水9.0部
および水83.8部からなるパーマネントウエーブ
（コールドウエーブ）剤の第１液に20分間浸漬
し、流水で５分間水洗した後、臭素酸ナトリウム
３部および水97部からなるパーマネントウエーブ
剤第２液に30分間浸漬し、更に流水で20分間水洗
し、風乾することによつてパーマネントウエーブ
処理した。
このパーマネントウエーブ処理した毛束の中か
ら同一太さの毛髪を１本抜き出し、これをテンシ
ロンに固定しその切断荷重を測定して強度とし
た。その結果、強度は142ｇで大きく、プレパー
マネントトリートメントによる、毛髪のパーマネ
ントウエーブ処理時における強度低下の防止効果
が高いことを認めた。
更に前記のパーマネントウエーブ処理を５回繰
返した後、毛髪の外観および毛髪のスケールの形
態を走査型電子顕微鏡で観察した。その結果、色
調に変化なく、かつスケールも変化がないことを
認めた。
〇 ウエーブ率の測定試験
長さ10cm、20本の毛束を、ウエーブ測定器具
（長さ２cm、直径３mmのピンを２列、７本配列
固定した板）に固定する。これを上記のパーマ
ネント処理を行ない、ウエーブ測定器具から取
りはずし、ウエーブ率を算出する。
ウエーブ率（％）
＝100−１００×（ｂ−ａ）／Ｃ−ａ（％）
ａ：ウエーブ測定器具の第１〜第５ピンまでの
距離
ｂ：カールした毛髪の５つのウエーブ山の長さ
ｃ：カールした毛髪を直線に延した時の長さ
ウエーブ率は95.8％で、高い値を示した。
〇 ウエーブ保持率の測定
パーマネントウエーブ処理した毛髪を１日放
置後、水中に20分間浸漬後のウエーブ率を、放
置前のウエーブ率と比較してこれをウエーブ保
持率とした。
ウエーブ保持率＝放置前のウエーブ率／放置後のウエー
ブ率×100
測定の結果、ウエーブ保持率99.6％で、高いこ
とを認めた。
比較例４ （プレパーマネントトリートメント）
フイブロインペプチドを使用せずかつ水を98.8
部使用する他は、実施例13と同様に行なつて比較
用のプレパーマネントトリートメントを調製し
た。次にこのプレパーマネントトリートメント
を、実施例13（本発明）のプレパーマネントトリ
ートメントの代りに使用する他は、実施例13と同
様に処理を行なつた。その結果、パーマネントウ
エーブ処理を施した毛髪の強度は104ｇで低く、
強度低下が大きいことを認めた。また処理毛髪の
外観における色調は赤く変色し、そしてスケール
の剥離が顕著であつた。また前記のウエーブ率は
92.8％でウエーブ保持率は96.6％で何れも低いこ
とを認めた。
比較例５ （プレパーマネントトリートメント）
フイブロインペプチドの代りに、ケラチンペプ
チド（平均分子量1000）を使用する他は、実施例
13と同様に行なつて比較用のプレパーマネントト
リートメントを調製した。
次にこのプレパーマネントトリートメントを実
施例13のプレパーマネントトリートメントの代り
に使用する他は、実施例13と同様に処理を行なつ
た。その結果、パーマネントウエーブ処理を施し
た毛髪の強度は124ｇで低く、強度低下が大きい
ことを認めた。また処理毛髪の外観における色調
は赤く変色し、そしてスケールの剥離が顕著であ
つた。またウエーブ率は76.3％、ウエーブ保持率
は92.2％で何れも低いことを認めた。
実施例14 （パーマネントウエーブ剤第１液組成
物）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド５部を水70.9部に溶解した水
溶液に、チオグリコール酸6.5部、ポリオキシエ
チレン硬化ヒマシ油0.5部、香料0.1部および28％
アンモニア水９部を混合、溶解して、本発明のパ
ーマネントウエーブ剤第１液組成物を調製した。
このパーマネントウエーブ剤第１液組成物に毛
束（長さ20cm）２ｇを20分間浸漬し、流水で５分
間水洗した後、臭素酸ナトリウム３部および水97
部からなる第２液に30分間浸漬し、流水で20分間
水洗し、風乾することによつてパーマネントウエ
ーブ処理した。
次にこのパーマネントウエーブ処理した毛髪を
実施例13と同じ方法で、緒物性を測定した。その
結果、処理毛髪の強度は138ｇで高く、その外観
の色調に何等変化がないこと、スケールにも何等
異状がないこと、ウエーブ率は93.4％、ウエーブ
保持率は98.6％で何れも高いこと、更にフイブロ
インペプチドの配合による効果が優れていること
等が判明した。
比較例６ （パーマネントウエーブ剤第１液組成
物）
フイブロインペプチドを使用せずかつ水を75.9
部使用する他は、実施例14と同様に行なつて比較
用のパーマネントウエーブ剤第１液組成物を調製
した。
次にこのパーマネントウエーブ剤第１液組成物
を実施例14のパーマネントウエーブ剤第１液組成
物の代りに使用する他は、実施例14と同様にして
パーマネントウエーブ処理を行なつた。その結
果、このパーマネントウエーブ処理した毛髪の強
度は103ｇで低いこと、外観の色調は赤く変色し
ていること、スケールの剥離が顕著であること、
ウエーブ率は90.4％、ウエーブ保持率が92.0％で
何れも低いことが判明した。
比較例７ （パーマネントウエーブ剤第１液組成
物）
フイブロインペプチドの代りに、コラーゲンペ
プチド（平均分子量1000）を使用する他は、実施
例14と同様に行なつて、比較用のパーマネントウ
エーブ剤第１液組成物を調製した。次に、このパ
ーマネントウエーブ剤第１液組成物を実施例14の
パーマネントウエーブ剤第１液組成物の代りに使
用する他は、同様に行なつてパーマネントウエー
ブ処理を行なつた。その結果このパーマネントウ
エーブ処理した毛髪の強度は118ｇで低いこと、
外観の色調は赤く変色していること、スケールの
剥離があること、ウエーブ率は91.3％、ウエーブ
保持率は88.1％で何れも低いことが判明した。
実施例15 （パーマネントウエーブ剤第２液組成
物）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド３部を91部の水に溶解した水
溶液に、臭素酸ナトリウム６部を溶解して、本発
明のパーマネントウエーブ剤第２液組成物を調製
した。
チオグリコール酸７部とアンモニア水93部から
なるパーマネントウエーブ剤第１液組成物を実施
例14のパーマネントウエーブ剤第１液組成物の代
りに使用し、かつ上記本発明のパーマネントウエ
ーブ剤第２液組成物を実施例14のパーマネントウ
エーブ第２液組成物の代りに使用する他は、実施
例14と同様にパーマネントウエーブ処理を行なつ
た。その結果、毛髪の損傷によるスケールの剥
離、外観の赤色変色、強度低下等を起さず、毛髪
に艶、滑らかさを与えた。またウエーブ保持性も
優れていた。
実施例16 （ヘアーブリーチ剤組成物）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド５部を水85.5部に溶解した水
溶液にチオグリコール酸0.5部とアンモニア水９
部を混合溶解して、第１液を調製した。
次にこの第１液に、35％過酸化水素20部と水80
部からなる第２液を１対１の割合で混合した後、
この混合液に毛束（長さ20cm）２ｇを20分間浸漬
し、次に流水で20分間水洗、風乾することにより
ブリーチ処理した。ブリーチ処理した毛髪の強度
は146ｇで強度低下は実質的になく、均一に脱色
されており、またスケールに何等異状が見られな
かつた。このように本発明のヘアーブリチ剤組成
物によれば、脱色にむらがなくブリーチでき、脱
色後の毛髪のスケールの剥離や強度低下もなく、
艶のある滑らかな風合を与えることができる。
比較例８ （ヘアーブリーチ剤組成物）
フイブロインペプチドを使用せずかつ水を90.5
部を使用する他は、実施例16と同様に行なつて比
較用のヘアーブリーチ剤第１液を調製し、実施例
16と同様にブリーチ処理を行なつた。その結果、
ブリーチ処理した毛髪の強度は113ｇで強度低下
が大きく、そのスケールは剥離していた。
比較例９ （ヘアーブリチ剤組成物）
フイブロインペプチドの代りに、コラーゲンペ
プチド（平均分子量1000）を使用する他は実施例
16と同様に行なつて、比較用のヘアーブリーチ剤
第１液を調製し、実施例16と同様にブリーチ処理
を行なつた。その結果ブリーチ処理した毛髪の強
度は124ｇで強度が低下しており、スケールは剥
離していて、わるい手触り（風合）を与えた。
実施例17 （ヘアーダイ第１液組成物）
実施例１の(1)に記載の水溶液を乾燥するとα型
に結晶化した皮膜を形成した平均分子量1000のフ
イブロインペプチド５部を水86.3部に溶解した水
溶液に、チオグリコール酸0.5部、アンモニア水
６部、パラフエニレンジアミン1.2部、オルソア
ミノフエノール0.5部およびレゾルシン0.5部を混
合、溶解して、本発明のヘアーダイ第１液組成物
を調製した。
次にこのヘアーダイ第１液組成物に、35％過酸
化水素水20部と水80部からなるヘアーダイ第２液
組成物を１対１の割合で混合し、実施例16と同様
の手順でヘアーダイ処理（毛髪染色）を行なつ
た。その結果、染色した毛髪の強度は144ｇで強
度低下はなく、毛髪は艶のある栗色に均一染色さ
れており、スケールの剥離なく、滑らかな風合を
与えた。
比較例10 （ヘアーダイ（染毛剤）第１液組成
物）
フイブロインペプチドを使用せずかつ水を91.3
部使用する他は、実施例17と同様に行なつて、比
較用のヘアーダイ第１液組成物を調製し、実施例
17と同様にヘアーダイ処理を行なつた。その結果
染色した毛髪は、強度が122ｇで強度が低下して
おり、艶のないわるい色調の栗色に染色されてい
て、スケールが剥離しており、わるい風合を与え
た。
比較例 11
フイブロインペプチドの代りにコラーゲンペプ
チド（平均分子量1000）を使用する他は実施例17
と同様に行なつて比較用のヘアーダイ第１液組成
物を調製し、実施例17と同様にヘアーダイ処理を
行なつた。その結果、染色した毛髪は、強力が
126ｇで強度が低下しており、色調のわるい栗色
に染色されていて、スケールが剥離しており、わ
るい風合を与えた。
実施例18 （プレシヤンプートリートメント剤）
(1) 下記第３表の処方にて、乳化物製造の常法に
よりプレシヤンプートリートメント剤を調製し
た。尚、フイブロインペプチド（実施例１の(1)
に記載のもの）、コラーゲンペプチドおよびケ
ラチンペプチドの平均分子量は1000である。[Table] Example 4 (Effect when using liquid polyhydric alcohol in combination) 3 parts of 1,3-butylene glycol was added,
A settling lotion of the present invention was prepared in the same manner as in Example 1, except that 93.6 parts of water was used, and 1,3-butylene glycol (liquid polyhydric alcohol) was further blended. We investigated the effect when used in combination with broin peptide. As a result, the treated hair had good shine, and compared to the setting procedure of Example 1 (invention), it had a more supple finish, was easier to comb, and did not cause flaking due to brushing. Nakatsuta. Further, curl retention was extremely good even in a high humidity environment. Also, the curl retention rate is 95.5 after 30 minutes.
%, 94% after 60 minutes and 93% after 120 minutes, which was extremely good. In addition, in the damage test during brushing, the friction coefficient was 0.12 to 0.14 before brushing and 0.13 to 0.16 after brushing, and the difference in friction coefficient was 0.01 to 0.02.
It was very small, and when the hair surface was observed under a microscope, no scale damage was observed. Example 5 (Hair conditioner) 1 part of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried, was dissolved in 84 parts of water. A hair conditioner of the present invention was prepared by mixing and dissolving 2 parts of propylene glycol, 3 parts of amino-modified silicone oil, and 10 parts of ethanol in an aqueous solution. As a result of a practical test of this hair conditioner, we found that when applied to hair that has been damaged by cold wave treatment or hair dye treatment, it gives firmness and elasticity to the hair, and at the same time prevents slippage, and significantly improves hair styling ability. Improved. Example 6 (Hair Liquid) When the aqueous solution described in (1) of Example 1 was dried, a film was formed which crystallized into the α form.An aqueous solution in which 5 parts of fibroin peptide with an average molecular weight of 1000 was dissolved in 58 parts of water was added with ethanol. 25 parts polyoxyethylene (EO
=20) A hair liquid of the present invention was prepared by mixing and dissolving 10 parts of polyoxypropylene (PO=30) butyl ether and 2 parts of polyether-modified silicone oil. The results of a practical test of this hair liquid showed that it did not have a sticky feel, could be styled with a natural texture, and had excellent hair retention properties. Example 8 (Hair brushing agent) 3 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried, was dissolved in 80 parts of water. 5 parts of 1,3-butylene glycol, 2 parts of methylphenyl polysiloxane and ethanol were added to the aqueous solution.
A hair brushing agent of the present invention was prepared by mixing and dissolving 10 parts. Practical tests of this hair brushing agent have shown that it improves shine and smoothness, eliminates resistance caused by combing and brushing, and reduces hair damage (scaling) caused by frequent brushing. No peeling, etc.) was observed. Example 9 (Shampoo) When the aqueous solution described in Example 1 (1) was dried, a fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form, was dissolved in an aqueous solution of 2 parts in 68 parts of water. Lauryl sulfate triethanolamine salt 20
1 part, 5 parts of lauric acid diethanolamide, 3 parts of sodium lauryl sulfate salt, and 2 parts of epoxy-modified silicone oil were added and mixed uniformly to prepare the shampoo of the present invention. The results of a practical test of the shampoo showed that the squeaky feeling of the wet hair after shampooing, the shine and combability after drying were improved, and the feel (texture, feel) of the hair after drying was also good. Ta. Example 10 (Hair Rinse) When the aqueous solution described in Example 1 (1) was dried, it formed a film crystallized in the α form. 2 parts of fibroin peptide with an average molecular weight of 1000 was dissolved in 88 parts of water. A hair rinse of the present invention was prepared by mixing and dissolving 5 parts of ethanol, 1 part of trimethylstearylammonium chloride, 2 parts of cetyl alcohol, and 2 parts of methylphenyl polysiloxane. The results of a practical test of this hair rinse showed that it had excellent rinsing effects, giving the hair shine, tension, and elasticity, and a finish with a supple texture. Example 11 (Pre-shampoo type hair treatment agent) 3 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried, was added to 91 parts of water. A pre-shampoo type hair treatment agent of the present invention was prepared by mixing and dissolving 5 parts of polyethylene glycol and 1 part of cationized cellulose (diethylaminoethylated cellulose) in the dissolved aqueous solution. As a result of practical tests of this pre-shampoo type hair treatment agent,
The squeaky feeling of the wet hair after shampooing, the shine and combability after drying were improved, and the feel of the hair after drying was also good. Example 12 (Blow treatment lotion) 3 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried, was dissolved in 74 parts of water. A blow treatment lotion of the present invention was prepared by mixing and dissolving 2 parts of 1,3-butylene glycol, 20 parts of ethanol, and 1 part of cetyltrimethylammonium chloride in an aqueous solution. Practical tests of this blow treatment lotion revealed that it prevents damage caused by hair dryers, does not cause hair to become dry or stiff, and gives a glossy, natural, smooth texture. Example 13 (Pre-permanent treatment) An aqueous solution in which 5.5 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in (1) of Example 1 was dried, was dissolved in 93.3 parts of water. to polyoxyethylene hydrogenated castor oil 1.0
A pre-permanent treatment of the present invention was prepared by mixing and dissolving 0.1 part of perfume, 0.1 part of fragrance, and 0.1 part of methylparaben. Next, a 20 cm long, 2 g hair bundle is soaked in this pre-permanent treatment, followed by 6.5 parts of thioglycolic acid, 0.5 parts of polyoxyethylene hydrogenated castor oil, 0.2 parts of fragrance, 9.0 parts of 28% aqueous ammonia, and 83.8 parts of water. 1 part of permanent wave (cold wave) agent for 20 minutes, rinsed with running water for 5 minutes, and then immersed for 30 minutes in the second part of permanent wave agent consisting of 3 parts of sodium bromate and 97 parts of water. Then, a permanent wave treatment was performed by rinsing with running water for 20 minutes and air drying. One hair of the same thickness was extracted from the permanently waved hair bundle, fixed on Tensilon, and the cutting load was measured to determine the strength. As a result, the strength was high at 142 g, and it was confirmed that the pre-permanent treatment has a high effect of preventing strength loss during permanent wave processing of hair. After repeating the above permanent wave treatment five times, the appearance of the hair and the morphology of the hair scale were observed using a scanning electron microscope. As a result, it was found that there was no change in color tone and no change in scale. 〇 Wave ratio measurement test 20 hair strands with a length of 10 cm are fixed to a wave measurement device (a plate fixed with 2 rows of 7 pins each having a length of 2 cm and a diameter of 3 mm). This is subjected to the above permanent treatment, removed from the wave measuring instrument, and the wave rate is calculated. Wave rate (%) = 100-100 x (ba-a)/C-a (%) a: Distance from the 1st to 5th pins of the wave measuring device b: Length of the 5 wave peaks of curled hair c: Length when curled hair is stretched in a straight line The wave rate was 95.8%, which was a high value. 〇 Measurement of wave retention rate After leaving the permanently waved hair for one day, the wave rate after immersing it in water for 20 minutes was compared with the wave rate before leaving it, and this was taken as the wave retention rate. Wave retention rate = Wave rate before being left / Wave rate after being left × 100 As a result of the measurement, the wave retention rate was 99.6%, which was recognized to be high. Comparative Example 4 (Pre-permanent treatment) No fibroin peptide and 98.8% water
A pre-permanent treatment for comparison was prepared in the same manner as in Example 13, except that the same procedure was used as in Example 13. Next, the same treatment as in Example 13 was carried out, except that this pre-permanent treatment was used in place of the pre-permanent treatment of Example 13 (invention). As a result, the strength of permanently waved hair was 104g, which was low.
It was observed that there was a large decrease in strength. In addition, the appearance of the treated hair was discolored to red, and peeling of scale was noticeable. Also, the wave rate mentioned above is
The wave retention rate was 92.8% and 96.6%, both of which were admittedly low. Comparative Example 5 (Pre-permanent treatment) Same as Example except that keratin peptide (average molecular weight 1000) was used instead of fibroin peptide.
Pre-permanent treatment for comparison was prepared in the same manner as in Example 13. Next, the treatment was carried out in the same manner as in Example 13, except that this pre-permanent treatment was used in place of the pre-permanent treatment of Example 13. As a result, the strength of the hair subjected to the permanent wave treatment was low at 124 g, and it was recognized that the strength reduction was large. In addition, the appearance of the treated hair was discolored to red, and peeling of scale was noticeable. He also admitted that his wave rate was 76.3% and his wave retention rate was 92.2%, both of which were low. Example 14 (Permanent waving agent first liquid composition) When the aqueous solution described in Example 1 (1) was dried, 5 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form, was mixed with 70.9 parts of water. 6.5 parts of thioglycolic acid, 0.5 parts of polyoxyethylene hydrogenated castor oil, 0.1 part of fragrance and 28%
A first liquid composition of a permanent wave agent of the present invention was prepared by mixing and dissolving 9 parts of aqueous ammonia. 2 g of hair bundles (length 20 cm) were immersed in this permanent wave agent first liquid composition for 20 minutes, washed with running water for 5 minutes, and then mixed with 3 parts of sodium bromate and 97% water.
Permanent wave treatment was carried out by immersing the sample in a second solution consisting of 50% water for 30 minutes, rinsing with running water for 20 minutes, and air drying. Next, the physical properties of the permanently waved hair were measured in the same manner as in Example 13. As a result, the strength of the treated hair was high at 138 g, there was no change in the external color tone, there was no abnormality in the scale, the wave rate was 93.4%, and the wave retention rate was 98.6%, both of which were high. Furthermore, it was found that the effect of incorporating fibroin peptide was excellent. Comparative Example 6 (Permanent wave agent first liquid composition) No fibroin peptide and 75.9% water
A comparative permanent waving agent first liquid composition was prepared in the same manner as in Example 14, except that the same amount was used. Next, permanent wave treatment was carried out in the same manner as in Example 14, except that this permanent wave agent first liquid composition was used in place of the permanent wave agent first liquid composition of Example 14. As a result, the strength of this permanent wave-treated hair was low at 103g, the appearance was discolored to red, and the peeling of scale was noticeable.
It was found that the wave rate was 90.4% and the wave retention rate was 92.0%, both of which were low. Comparative Example 7 (Permanent waving agent first liquid composition) A comparative permanent waving agent was prepared in the same manner as in Example 14, except that collagen peptide (average molecular weight 1000) was used instead of fibroin peptide. A first liquid composition was prepared. Next, permanent wave treatment was carried out in the same manner except that this permanent wave first liquid composition was used in place of the permanent wave first liquid composition of Example 14. As a result, the strength of this permanent wave treated hair was low at 118g.
It was found that the external color tone was discolored to red, that there was peeling of scale, and that the wave rate was 91.3% and the wave retention rate was 88.1%, all of which were low. Example 15 (Permanent wave agent second liquid composition) 91 parts of 3 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried. A permanent waving agent second liquid composition of the present invention was prepared by dissolving 6 parts of sodium bromate in an aqueous solution of . A permanent wave agent first liquid composition consisting of 7 parts of thioglycolic acid and 93 parts of aqueous ammonia was used in place of the permanent wave agent first liquid composition of Example 14, and the permanent wave agent second liquid composition of the present invention was used in place of the permanent wave agent first liquid composition of Example 14. Permanent wave treatment was carried out in the same manner as in Example 14, except that the composition was used in place of the permanent wave second liquid composition of Example 14. As a result, the hair was given shine and smoothness without causing scale peeling, red discoloration, or decrease in strength due to damage to the hair. Moreover, the wave retention property was also excellent. Example 16 (Hair bleach composition) 5 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried, was dissolved in 85.5 parts of water. Add 0.5 part of thioglycolic acid and 9 parts of ammonia water to the aqueous solution.
A first liquid was prepared by mixing and dissolving the following parts. Next, add 20 parts of 35% hydrogen peroxide and 80 parts of water to this first solution.
After mixing the second liquid consisting of parts in a 1:1 ratio,
2 g of hair bundles (length: 20 cm) were immersed in this mixture for 20 minutes, then washed with running water for 20 minutes, and air-dried for bleaching. The strength of the bleached hair was 146 g, with virtually no decrease in strength, the hair was uniformly bleached, and no abnormality was observed in the scale. As described above, according to the hair bleaching agent composition of the present invention, bleaching can be performed evenly, and there is no peeling of hair scale or loss of strength after bleaching.
It can give a shiny and smooth texture. Comparative Example 8 (Hair bleach composition) No fibroin peptide and 90.5% water
A hair bleach first solution for comparison was prepared in the same manner as in Example 16, except for using the same method as in Example 16.
Bleach treatment was performed in the same manner as in 16. the result,
The strength of the bleached hair was 113 g, which was a significant decrease in strength, and the scale had peeled off. Comparative Example 9 (Hair bleach composition) Same as Example except that collagen peptide (average molecular weight 1000) was used instead of fibroin peptide.
A first liquid bleaching agent for comparison was prepared in the same manner as in Example 16, and bleached in the same manner as in Example 16. As a result, the strength of the bleached hair was 124 g, which was a decrease in strength, and the scale had peeled off, giving it an unpleasant texture. Example 17 (Hair dye first liquid composition) 5 parts of fibroin peptide with an average molecular weight of 1000, which formed a film crystallized in the α form when the aqueous solution described in Example 1 (1) was dried, was added to 86.3 parts of water. A hair dye first liquid composition of the present invention is prepared by mixing and dissolving 0.5 parts of thioglycolic acid, 6 parts of aqueous ammonia, 1.2 parts of paraphenylene diamine, 0.5 parts of orthoaminophenol, and 0.5 parts of resorcin into the dissolved aqueous solution. did. Next, a hair dye second liquid composition consisting of 20 parts of 35% hydrogen peroxide solution and 80 parts of water was mixed with this hair dye first liquid composition in a 1:1 ratio, and hair dye was applied in the same manner as in Example 16. Treatment (hair dyeing) was performed. As a result, the strength of the dyed hair was 144 g, with no decrease in strength, and the hair was uniformly dyed to a glossy chestnut color, with no peeling of scale and a smooth texture. Comparative Example 10 (Hair dye (hair dye) first liquid composition) No fibroin peptide and 91.3% water
A comparative hair dye first liquid composition was prepared in the same manner as in Example 17, except that
Hair dye treatment was performed in the same manner as in 17. As a result, the dyed hair had a reduced strength of 122 g, was dyed to a matte, dull chestnut color, had peeled scales, and had an unpleasant texture. Comparative Example 11 Example 17 except that collagen peptide (average molecular weight 1000) was used instead of fibroin peptide.
A comparative hair dye first liquid composition was prepared in the same manner as in Example 17, and hair dye treatment was performed in the same manner as in Example 17. As a result, dyed hair has a strong
At 126 g, the strength was decreased, the color was dyed a bad chestnut color, and the scale was peeling off, giving it a bad texture. Example 18 (Pre-sympoo treatment agent) (1) A pre-sympoo treatment agent was prepared according to the formulation shown in Table 3 below using a conventional emulsion manufacturing method. In addition, fibroin peptide ((1) of Example 1)
), the average molecular weight of collagen peptides and keratin peptides is 1000.
【表】【table】
【表】
(2) 損傷試験
長さ20cm、重さ２ｇの毛束を水で濡らし、第
３表記載のプレシヤンプートリートメント剤１
ｇを塗布し、５分間放置する。これを後記のシ
ヤンプーにて洗浄した後、35℃の湯で１分間毛
束をすすぎ、濡れた状態でブラツシングを200
回行う。この操作を５回繰り返した後風乾し毛
髪の感触、櫛通り易さの官能評価、走査型電子
顕微鏡によるスケールの観察及び抜毛発生率の
計測を行つた。官能評価は20人のパネルにより
比較１を基準として一対比較を行い、下記評価
点を付してその平均値を採つた。
評価点 評 価
＋２ …… 比較１より、良い
＋１ …… 〃 やや良い
０ …… 〃 と同等
−１ …… 〃 やや悪い
−２ …… 〃 悪い
以上の結果を第４表に示す。[Table] (2) Damage test Wet a hair strand with a length of 20 cm and a weight of 2 g with water, and apply pre-shampoo treatment agent 1 listed in Table 3.
Apply g and leave it for 5 minutes. After washing this with the shampoo described below, rinse the hair strands with hot water at 35℃ for 1 minute, and brush the hair 200 times in a wet state.
Do it twice. After repeating this operation 5 times, the hair was air-dried and sensory evaluation of the feel of the hair, ease of combing, observation of the scale using a scanning electron microscope, and measurement of the incidence of hair pulling were performed. The sensory evaluation was performed by a panel of 20 people, and paired comparisons were made using Comparison 1 as a standard, and the following evaluation scores were given and the average value was taken. Evaluation Point Evaluation +2 ... Better than Comparison 1 +1 ... Somewhat good 0 ... Same as -1 ... Somewhat bad -2 ... Bad The above results are shown in Table 4.
【表】【table】
【表】
実施例19 （シヤンプー組成物）
(1) 下記第３表の処方にて常法によりシヤンプー
を調製した。
尚、フイブロインペプチド（実施例１の(1)に
記載のもの）、コラーゲンペプチドおよびケラ
チンペプチドの平均分子量は1000である。[Table] Example 19 (Shampoo Composition) (1) Shampoo was prepared according to the formulation shown in Table 3 below in a conventional manner. The average molecular weight of the fibroin peptide (described in Example 1 (1)), collagen peptide, and keratin peptide is 1000.
【表】
(2) 損傷試験
長さ20cm、重さ２ｇの毛束を第３表記載のシ
ヤンプー１ｇを使用して洗浄し35℃の湯で１分
間すすいだ後、濡れた状態でブラツシング200
回行う。この操作を５回繰返した後風乾し、実
施例18と同様の方法で官能評価及びスケールの
観察を行つた。この結果を第６表に示す。[Table] (2) Damage test A bundle of hair with a length of 20 cm and a weight of 2 g was washed using 1 g of the shampoo listed in Table 3, rinsed with hot water at 35°C for 1 minute, and then brushed while wet for 200 minutes.
Do it twice. After repeating this operation five times, it was air-dried, and sensory evaluation and scale observation were performed in the same manner as in Example 18. The results are shown in Table 6.
【表】
実施例20 （ヘアーリンス組成物）
(1) 下記第７表の処方にて常法により、ヘヤーリ
ンスを調製した。
尚、フイブロインペプチド（実施例１の(1)に
記載のもの）、コラーゲンペプチドおよびケラ
チンペプチドの平均分子量は1000である。[Table] Example 20 (Hair rinse composition) (1) A hair rinse was prepared according to the formulation shown in Table 7 below in a conventional manner. The average molecular weight of the fibroin peptide (described in Example 1 (1)), collagen peptide, and keratin peptide is 1000.
【表】
(2) 損傷毛の調製
長さ20cm、重さ２ｇの毛束をパーマネントウ
エーブ剤第１液に20分間浸漬し、流水で10分水
洗する。次いでパーマネントウエーブ剤第２液
に20分間のヘアーリンスにて処理し、更に35℃
の湯で10秒間すすいで風乾した後、実施例18と
同様の方法で官能評価を行つた。但し基準毛髪
としては損傷処理のみを行つた毛髪を用いた。
この結果を第８表に示す。[Table] (2) Preparation of damaged hair A hair bundle with a length of 20 cm and a weight of 2 g is immersed in the first solution of the permanent wave agent for 20 minutes, and then rinsed with running water for 10 minutes. Next, the hair was rinsed with the second part of the permanent wave agent for 20 minutes, and further heated at 35°C.
After rinsing with hot water for 10 seconds and air drying, sensory evaluation was performed in the same manner as in Example 18. However, as the reference hair, hair that had only been subjected to damage treatment was used.
The results are shown in Table 8.
【表】
比較例 12
(1) フイブロインペプチドの製造
塩化カルシウムの60％水溶液１に精錬絹原
料の140ｇを加熱溶解した後、この溶液に酸性
亜硫酸ソーダを0.02モル量撹拌下に溶解してか
ら１時間後に24時間透析し、4.96％のフイブロ
イン水溶液2.75を得た。次にこのフイブロイ
ン水溶液１に濃塩酸を加えて0.1N―塩酸溶
液とし、85℃で８時間、撹拌下で加熱してフイ
ブロインの加水分解を行つた後、これを20％苛
性ソーダで中和し、活性炭で脱色処理して微黄
色透明のフイブロインペプチド水溶液を、得
た。次にこのフイブロインペプチド水溶液を噴
霧乾燥機を用いて70〜120℃の雰囲気下で噴霧
乾燥して、フイブロインペプチドの粉末を得
た。このフイブロインペプチドは、平均分子量
が1000で、水に易溶でその水溶液をテフロン板
上に流延（塗布）すると皮膜を形成した。乾燥
した皮膜はＸ線回折像により結晶化していない
こと（無定形）が確認された。
(2) 比較のセツトローシヨンの調製
前記実施例１の(1)で得られたフイブロインペ
プチド（平均分子量1000）の代わりに、前記の
(1)で得られたフイブロインペプチド（平均分子
量1000）を使用する他は、前記実施例１の(2)と
同様に行つて比較のセツトローシヨン（毛髪セ
ツトローシヨン）を得た。
(3) 比較のセツトローシヨンの性能
実用テスト
前記実施例１の(3)のと同様に実用テスト
を行つた。その結果、櫛通りもカール保持性
も実施例１の本発明よりはわるく、ブラツシ
ングによるフレーキングを防止することがで
きなかつた。
カール保持性のテスト
前記実施例１の(3)のと同様に行つた。そ
の結果、カール保持性は毛束に付着してから
30分後で45.5％、60分後で40.5％、120分後
で38.1％でカール保持性は比較的わるかつ
た。
ブラツシングに対する損傷試験
前記実施例１の(3)のと同様に行つた。そ
の結果、摩擦係数はブラツシング前で0.15〜
0.18、ブラツシング後で0.17〜0.24で摩擦係
数の差は0.02〜0.06で可成り大きく、また顕
微鏡でもうはく表面を観察した結果、スケー
ルはやや損傷していた。
以上の結果と実施例１（本発明）の結果を比較
して明らかなように、平均分子量1000（本発明の
300〜3500の範囲内）であつても、水性溶液を塗
布し乾燥すると結晶化していない（非晶質の）皮
膜を形成するようなフイブロインペクチドでは、
良好な櫛通り性、セツト効果、毛髪保護効果を毛
髪に付与することができない。
実施例 21
(1) フイブロインペプチドの製造
フイブロインペプチド水溶液の加水分解を85
℃で12時間行う他は実施例１の(1)と同様に行つ
て、フイブロインペプチドの粉末を得た。この
フイブロインペプチドは、平均分子量が390で
水に易溶でその水溶液はテフロン板上に流延す
ると皮膜を形成した。乾燥した皮膜はＸ線回析
像によりα型に結晶化していることが確認され
た。
(2) 本発明のセツトローシヨンの調製
実施例１の(1)で得られたフイブロインペプチ
ドの代わりに、前記の(1)で得られたフイブロイ
ンペプチド（平均分子量390）を使用する他
は、実施例１の(2)と同様に行なつて、本発明の
セツトローシヨンを得た。
(3) 本発明のセツトローシヨンの性能
実用テスト
実施例１の(3)のと同様にして実用テスト
を行つた。その結果、良好な艶のあるしなや
かな仕上りで、櫛通りが良く、ブラツシング
によるフレーキングが起こらなかつた。また
カール保持性は高湿度の環境下においても良
好であつた。
カール保持性のテスト
実施例１の(3)のと同様に行なつた結果、
本発明のセツトローシヨンのカール保持率は
良好であつた。
(4) ブラツシングに対する損傷試験
実施例１の(3)のと同様に行つた結果、摩擦
係数は、ブラツシング前で0.14〜0.17、ブラツ
シング後で0.16〜0.21、摩擦係数の差は0.02〜
0.04で非常に小さく、また顕微鏡で表面を観察
した結果、スケールの損傷は殆んど見られなか
つた。
比較例 13
(1) フイブロインペプチドの製造
フイブロインペプチド水溶液の加水分解を85
℃で12時間行う他は比較例12の(1)と同様に行な
つて、フイブロインペプチドの粉末を得た。こ
のフイブロインペプチドは、平均分子量が390
で水に易溶で、その水溶液はテフロン板上に流
延すると皮膜を形成した。乾燥した皮膜はＸ線
回析像により結晶化していないこと（無定形）
が確認された。
(2) 比較のセツトローシヨンの調製
前記実施例１の(1)で得られたフイブロインペ
プチドの代わりに前記(1)で得られたフイブロイ
ンペプチド（平均分子量390）を使用する他
は、実施例１の(3)と同様に行つて比較のセツト
ローシヨンを得た。
(3) 比較のセツトローシヨンの性能
実用テスト
前記実施例１の(3)のと同様に実用テスト
を行つた。その結果、櫛通りもカール保持性
も実施例21の本発明よりはわるく、ブラツシ
ングによるフレーキングを防止することがで
きなかつた。
カール保持性のテスト
前記実施例１の(3)のと同様に行つた。そ
の結果、カール保持率は毛束に付着してから
30分後で32.1％、60分後で21.5％、120分後
で19.1％で比較的カール保持性はわるかつ
た。
ブラツシングに対する損傷試験
実施例１の(3)のと同様に行つた結果、摩
擦係数は、ブラツシング前で0.16〜0.22、ブ
ラツシング後で0.19〜0.28、摩擦係数の差は
0.03〜0.06で大きく、また顕微鏡で表面を観
察した結果、スケールは損傷していた。
以上の結果と実施例21（本発明）の結果を比較
して明らかなように、平均分子量が390（本発明
の300〜3500の範囲内）であつても、水性溶液を
塗布し乾燥すると結晶化していない（非晶質の）
皮膜形成するようなフイブロインペプチドでは、
良好な櫛通り性、セツト効果、毛髪保護効果を毛
髪に付与することができない。[Table] Comparative Example 12 (1) Production of fibroin peptide After heating and dissolving 140 g of the refined silk raw material in a 60% aqueous solution of calcium chloride 1, 0.02 molar amount of acidic sodium sulfite was dissolved in this solution while stirring. One hour later, the mixture was dialyzed for 24 hours to obtain 2.75% of a 4.96% fibroin aqueous solution. Next, concentrated hydrochloric acid was added to this fibroin aqueous solution 1 to make a 0.1N-hydrochloric acid solution, which was heated at 85°C for 8 hours with stirring to hydrolyze the fibroin, and then neutralized with 20% caustic soda. By decolorizing with activated carbon, a slightly yellow and transparent fibroin peptide aqueous solution was obtained. Next, this fibroin peptide aqueous solution was spray-dried using a spray dryer in an atmosphere of 70 to 120°C to obtain a fibroin peptide powder. This fibroin peptide had an average molecular weight of 1000, was easily soluble in water, and formed a film when the aqueous solution was cast (coated) on a Teflon plate. It was confirmed by the X-ray diffraction image that the dried film was not crystallized (amorphous). (2) Preparation of comparative settlement In place of the fibroin peptide (average molecular weight 1000) obtained in (1) of Example 1, the
A comparative setting lotion (hair setting lotion) was obtained in the same manner as in (2) of Example 1, except that the fibroin peptide obtained in (1) (average molecular weight 1000) was used. (3) Comparative Settling Performance Practical Test A practical test was conducted in the same manner as in (3) of Example 1 above. As a result, combability and curl retention were worse than those of Example 1 of the present invention, and flaking due to brushing could not be prevented. Curl retention test The test was conducted in the same manner as in (3) of Example 1 above. As a result, curl retention is improved after it is attached to the hair bundle.
Curl retention was relatively poor at 45.5% after 30 minutes, 40.5% after 60 minutes, and 38.1% after 120 minutes. Damage test against brushing The test was carried out in the same manner as in (3) of Example 1 above. As a result, the friction coefficient is 0.15~0.15 before brushing.
0.18, and 0.17 to 0.24 after brushing, the difference in friction coefficient was quite large at 0.02 to 0.06, and observation of the surface of the flake under a microscope revealed that the scale was slightly damaged. As is clear from comparing the above results with the results of Example 1 (the present invention), the average molecular weight was 1000 (the present invention).
300 to 3500), fibroinpectide forms a non-crystalline (amorphous) film when an aqueous solution is applied and dried.
It is not possible to impart good combability, setting effect, and hair protection effect to the hair. Example 21 (1) Production of fibroin peptide Hydrolysis of fibroin peptide aqueous solution at 85%
Fibroin peptide powder was obtained in the same manner as in Example 1 (1), except that the reaction was carried out at ℃ for 12 hours. This fibroin peptide had an average molecular weight of 390 and was easily soluble in water, and when the aqueous solution was cast on a Teflon plate, it formed a film. It was confirmed by the X-ray diffraction image that the dried film was crystallized in the α type. (2) Preparation of settlement of the present invention Instead of the fibroin peptide obtained in (1) of Example 1, the fibroin peptide obtained in (1) above (average molecular weight 390) was used. Except for the above steps, the same procedure as in Example 1 (2) was carried out to obtain a settlement according to the present invention. (3) Performance of the settlement of the present invention Practical test A practical test was conducted in the same manner as in (3) of Example 1. As a result, it had a smooth finish with good gloss, was easy to comb, and did not cause flaking due to brushing. Further, curl retention was good even in a high humidity environment. Curl retention test The results were conducted in the same manner as in (3) of Example 1.
The curl retention rate of the settling lotion of the present invention was good. (4) Damage test for brushing The same procedure as in (3) of Example 1 was conducted, and the friction coefficient was 0.14 to 0.17 before brushing, 0.16 to 0.21 after brushing, and the difference in friction coefficient was 0.02 to 0.17.
0.04, which is extremely small, and when the surface was observed under a microscope, almost no scale damage was observed. Comparative Example 13 (1) Production of fibroin peptide Hydrolysis of fibroin peptide aqueous solution at 85%
Fibroin peptide powder was obtained in the same manner as in Comparative Example 12 (1) except that the reaction was carried out at ℃ for 12 hours. This fibroin peptide has an average molecular weight of 390
It was easily soluble in water, and when the aqueous solution was cast on a Teflon plate, a film was formed. The dried film is not crystallized according to the X-ray diffraction image (amorphous)
was confirmed. (2) Preparation of comparative settlement In addition to using the fibroin peptide obtained in (1) above in place of the fibroin peptide obtained in (1) of Example 1 above. A comparative settlement was obtained in the same manner as in Example 1 (3). (3) Comparative Settling Performance Practical Test A practical test was conducted in the same manner as in (3) of Example 1 above. As a result, combability and curl retention were worse than those of Example 21 of the present invention, and flaking due to brushing could not be prevented. Curl retention test The test was conducted in the same manner as in (3) of Example 1 above. As a result, the curl retention rate increases after it is attached to the hair bundle.
Curl retention was relatively poor at 32.1% after 30 minutes, 21.5% after 60 minutes, and 19.1% after 120 minutes. Damage test for brushing A test was conducted in the same manner as in (3) of Example 1. As a result, the friction coefficient was 0.16 to 0.22 before brushing, and 0.19 to 0.28 after brushing, and the difference in friction coefficient was
The scale was large (0.03 to 0.06), and observation of the surface under a microscope revealed that the scale was damaged. As is clear from comparing the above results with the results of Example 21 (the present invention), even if the average molecular weight is 390 (within the range of 300 to 3,500 according to the present invention), crystals crystallize when an aqueous solution is applied and dried. Not amorphous (amorphous)
For film-forming fibroin peptides,
It is not possible to impart good combability, setting effect, and hair protection effect to the hair.
Claims (1)
した皮膜を形成し得る平均分子量が300〜3500の
フイブロインペプチドが水性基剤の中に0.1〜10
重量％（重量％は組成物の重量基準）溶解してい
る毛髪処理用組成物。 ２ 更に、液状の多価アルコールを含有してい
る、特許請求の範囲第１項記載の毛髪処理用組成
物。[Claims] 1. Fibroin peptide with an average molecular weight of 300 to 3,500, which can form a film crystallized in the α form when an aqueous solution is applied and dried, is contained in an aqueous base containing 0.1 to 10 fibroin peptides having an average molecular weight of 300 to 3,500.
% by weight (% by weight is based on the weight of the composition) of a hair treatment composition dissolved. 2. The hair treatment composition according to claim 1, further comprising a liquid polyhydric alcohol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22030783A JPS60112710A (en) | 1983-11-21 | 1983-11-21 | Hair treatment composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22030783A JPS60112710A (en) | 1983-11-21 | 1983-11-21 | Hair treatment composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60112710A JPS60112710A (en) | 1985-06-19 |
| JPS6229404B2 true JPS6229404B2 (en) | 1987-06-25 |
Family
ID=16749090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22030783A Granted JPS60112710A (en) | 1983-11-21 | 1983-11-21 | Hair treatment composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60112710A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0517323A (en) * | 1991-07-11 | 1993-01-26 | Etouwaale:Kk | Hair treating agent |
| JP4612250B2 (en) * | 2001-08-10 | 2011-01-12 | ホーユー株式会社 | Permanent wave second agent composition and permanent wave agent |
| CN108498369A (en) * | 2018-05-08 | 2018-09-07 | 江苏澳特丝生物科技有限公司 | A kind of application of fibroin albumen in shampoo |
| MX2021004303A (en) | 2018-10-23 | 2021-05-27 | Unilever Ip Holdings B V | Cosmetic compositions comprising low molecular weight silk fibroin. |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138132A (en) * | 1978-04-19 | 1979-10-26 | Ichimaru Boeki | Production of powder for improved skin cosmetics made by treating silk fiber |
| JPS55124793A (en) * | 1979-03-22 | 1980-09-26 | Kanebo Ltd | Preparation of aqueous solution of silk fibroin peptide |
| JPS573827A (en) * | 1980-06-11 | 1982-01-09 | Ichimaru Boeki Kk | Production of solubilized silk peptide and skin cosmetics containing the same |
| JPS574910A (en) * | 1980-06-11 | 1982-01-11 | Ichimaru Boeki Kk | Cosmetic for skin containing solubilized silk peptide |
| JPS5740495A (en) * | 1980-08-25 | 1982-03-06 | Ichimaru Boeki Kk | Fat-soluble silk peptide and cosmetic containing the same |
-
1983
- 1983-11-21 JP JP22030783A patent/JPS60112710A/en active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138132A (en) * | 1978-04-19 | 1979-10-26 | Ichimaru Boeki | Production of powder for improved skin cosmetics made by treating silk fiber |
| JPS55124793A (en) * | 1979-03-22 | 1980-09-26 | Kanebo Ltd | Preparation of aqueous solution of silk fibroin peptide |
| JPS573827A (en) * | 1980-06-11 | 1982-01-09 | Ichimaru Boeki Kk | Production of solubilized silk peptide and skin cosmetics containing the same |
| JPS574910A (en) * | 1980-06-11 | 1982-01-11 | Ichimaru Boeki Kk | Cosmetic for skin containing solubilized silk peptide |
| JPS5740495A (en) * | 1980-08-25 | 1982-03-06 | Ichimaru Boeki Kk | Fat-soluble silk peptide and cosmetic containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60112710A (en) | 1985-06-19 |
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| LAPS | Cancellation because of no payment of annual fees |