JPS62268569A - Reservoir electrode for iontophoresis - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a reservoir electrode for iontophoresis which is used generally in iontophoresis and is particularly useful in shunt iontophoresis of polymeric substances.

Iontophoresis has recently been attracting more and more attention as an effective topical administration method that promotes transdermal absorption of ionic drugs, but conventional iontophoresis uses either a continuous flat generator or an intermittent flow generator. The output terminal is connected to a conductor such as a conductor such as a metal plate covered with an ionic drug-containing conductive layer or the like, and a similar conductor is connected. Implementation 1) It was complicated and its dissemination had to be limited.

Recently, various biological materials that have self-shape retention, skin adhesion, and electrical conductivity have been used for detection applications such as electrocardiograms and electroencephalogram measurements, and for grounding applications such as low-frequency therapy and iontophoresis (iontophoresis). electrodes have been proposed.

However, it is said that iontophoresis cannot exhibit sufficient ion permeability, especially for shunt iontophoresis made of polymeric substances, because the conductive layer containing ionic drugs has poor water discharging properties. It had drawbacks.

In view of the above, the present inventors have arrived at the present invention by providing a chemical reservoir in the electrode and sealing the opening with a water-permeable and skin-adhesive polymer layer or film or sheet.

As for the water-permeable and skin-adhesive film or sheet, it is desirable that the film or sheet be composed of a cohesive synthetic hydrophilic polymer that is safe to the skin, non-toxic; For example, the polymer of the reservoir electrode for iontophoresis of the present invention may be composed of a water-soluble monomer and a water-insoluble interpolymer containing usually about 15 mol % of the water-soluble monomer. Further, the above-mentioned polymer is usually plasticized with a polyhydric alcohol to form a film or sheet.

Hereinafter, the compositional elements, formulation and reaction conditions, mode of use, characteristics, etc. of the film or sheet of the electrode of the present invention will be explained in more detail.

water soluble monomer Possible water-soluble moamers include (1) to GO.

(1) Acrylic acids acrylic acid, methacrylic acid (2) Olefin polycarboxylic acids maleic acid,
Fumaric acid, itaconic acid, aconitic acid, citraconic acid (3) Acrylamides acrylamide, methacrylamide (4) N-alkylacrylamides N-methyl acrylamide, N-butylacrylamide, N-methylmethacrylamide (5) Vinyl 7 Rufurs (6) N-vinyllactams N-vinylpyrrolidone (7) Vinylpyridines 2-93- and 4-vinylpyrine (8) Aminoalkylacrylamides N-(2-
dimethylaminoethyl)acrylamide, N,N-bis(2-dimethylaminoethyl)acrylamide l',N-
(4-dimethylaminocyclohexyl)acrylamide (9) Aminoalkyl acrylates 2-tmethylamino/acrylate acrylate, 2-tmethylaminopropyl acrylate, 3-diethylaminopropyl methacrylate aO Vinyl ethers Vinyl methyl ether Non-ionic Water-insoluble Monomer (1) Acrylic acid esters methyl acrylate, methyl methacrylate, butyl acrylate, inoctyl acrylate, 2-ethylhexyl acrylate, dotecyl methacrylate, octadecyl methacrylate, cyclohexyl acrylate (2) Vinyl ethers 2-ethylhexyl acrylate Vinyl ether decyl vinyl ether, octadecyl vinyl ether (3) Vinyl acrylates Vinyl acetate, vinyl butyrate, vinyl dodecanoate (4) Olefins ethylene, flopylene, styrene, α-methylstyrene, 4-talolostyrene, iso-butylene, vinylcyclohexane (5) ) Olefinic polycarboxylic acid esters Dimethyl maleate, Dimethyl fumarate, Ethyl itaphonate (8) Vinyl halides Vinylidene dichloride formulation and reaction conditions The film or sheet of the reservoir electrode for iontophoresis of the present invention is water-soluble. and a water-insoluble monomer containing, for example, 15 mol % or more of a copolymerizable water-soluble moamer.

If surface polymers alone do not provide sufficient compatibility under the conditions of use, it is possible to plasticize them. Suitable plasticizers are listed here.

Plasticizers ethylene glycol, noethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, noprobylene glycol, tripropylene glycol, butanol, pentanool, hexylene glycol, octylene glycol, glycerin , trimethylolpropane, hexanetriol, polypropylene glufur, polyglycerin, polyvinyl alcohol, etc.

The material for the chemical reservoir may be, for example, a hard or flexible synthetic resin such as silicone-coated polypropylene or styrene resin with a recess for storing the chemical solution, but it can also be made of any suitable material with a storage structure. That's enough.

Aspects of Structure The film or sheet of the reservoir electrode for iontophoresis of the present invention prepared as described above is substantially water-insoluble or non-water-disintegrable, but has appropriate water permeability. , which exhibits good stability even during long-term adhesive use, can reliably electrically connect the conductive element, the drug solution, and the skin, and can sufficiently contain water in the drug solution. Therefore, it must have low impedance characteristics, or it must be able to hold a polymer ionic drug at a desired concentration without containing impurity ions, which are particularly undesirable as an iontophoresis electrode. It also has advantages such as facilitating shunt iontophoresis of polymeric substances.

A further understanding of the invention will also be facilitated by reference to the accompanying drawings. FIG. 1 is a top perspective view of a typical iontophoresis reservoir electrode according to the present invention, and FIG. 2 is an enlarged cross-sectional view of the electrode taken along line A--A in FIG. be.

In FIG. 2, an electrode film 1 and a conductive element 2 such as metal
The chemical solution 3 exists in the space sandwiched between them. By connecting a lead wire to the conductive element 2, it can be electrically connected to the main body of the 8i device and used as a server electrode for the iontophoresis of the present invention.

Also, 4 is an adhesive tape, which helps to secure the electrode to the patient's skin.

Furthermore, FIG. 3 shows a perspective view of the upper part of a reservoir electrode for iontophoresis, which is another embodiment according to the present invention. FIG. 4 is an enlarged cross-sectional view of the electrode taken along line A'-A' in FIG.

In FIG. 4, 9 is a conductive film made of metal foil or carbon. Also, like the electrodes described above, the conductive element 8, the film 7, the chemical liquid reservoir 11 made of a flexible synthetic resin film, etc., and the chemical liquid 10 are used for the iontophoresis of the present invention 4, - etc. Refund? 5m 1 minute Pe 11
- Ha Suga I silkworm! ＋ zl＞ Gaku Ko Nami It is possible to effectively supply the skin over a wide area, and it can be manufactured to be thin and flexible as a whole, so it can be applied to areas of the body that are inflamed. Moreover, the advantages include being able to maintain a large effective area and being extremely easy to handle.

Examples The mixtures of Formulation Examples 1 to 8 below were heated at about 50°C for 24 hours and reacted to prepare a film or sheet, and the film or sheet obtained from the above electrode was all substantially water-insoluble and It was water permeable and also had suitable skin adhesion and low impedance properties.

Formulation Example 1, Inoctyl acrylate Niacrylic acid (61:
39) 2. Inoctyl acrylate: acrylic acid (48: 5
2) 3. Butyl acrylate: itaconic acid (67: 33) 4
．． Furyl methacrylate: methacrylic acid (34: 66
) 5.1[Nil: Vinyl alcohol (Uo:3o)6
, vinyl mide: vinyl alcohol (60: 40)
7. Ethylene: Vinyl alcohol (60: 40) 8
, butyl acrylate: 3-dimethylaminopropylacrylamide 1' (60: 40) Although typical examples of the film or sheet have been described in detail above, the present invention is not limited thereto, and may be applied to biological electrodes. The materials disclosed in the prior art below, which are known as base materials, are also included. Namely, JP-A No. 95895 of 1972, JP-A No. 77489 of 1974,
No. 52742 of 1955, No. 81635 of 1955, No. 129035 of 1955, No. 15728 of 1956, No. 15728 of 1956,
1956 No. 36939, 1956 No. 36940, 1956 No. 5
No. 60534 of 1996, No. 89270 of 1956, No. 56 of 1996
No. 143141, No. 28505, No. 49431, No. 57, No. 52463, No. 5, 1957.
No. 5132, No. 131428 of 1957, No. 1 of 1957
No. 60439, No. 164064 of 1957, No. 1 of 1957
No. 66142, No. 168675 of 1957, No. 4 of 1957
No. 569, No. 10066 of 1958, 31 of 1961
No. 169, No. 80689 of 1972, No. 135706 of 1972, No. 138603 of 1972, No. 93305 of 1972,
No. 179413 of 1957, No. 185309 of 1957,
and so on.

[Brief explanation of the drawing]

1 and 3 are perspective views showing the upper part of a typical reservoir electrode for iontophoresis in one embodiment of the present invention, and FIGS. FIG. 4 is an enlarged cross-sectional view of the electrode taken along lines AA and A′-A′ in FIG. 3; 1.7... Electrode film or sheet, 2.8... Conductive element, 3.10... Chemical solution, 4... Adhesive tape, 5... Supporting member, 6.11... Chemical solution reservoir . Patent applicant: Advance Development Institute Co., Ltd. Figure 1 Figure 2

Claims (1)

[Claims] (1) A reservoir electrode for iontophoresis, comprising a chemical liquid reservoir and a water-permeable and skin-adhesive polymer film or sheet that seals the opening of the chemical liquid reservoir.