JPS62229071A - Analysis of continuous plural items - Google Patents

Abstract

PURPOSE:To prevent suspension of flow-distribution of specimen and increase analysis of specimen provided with analysis item by the No.2 quantitatives analysis method, by detecting that a proceeding specimen is not existing in an analysis position of the analysis item by the No.2 quantitative analysis method and performing the analysis giving priority to this. CONSTITUTION:Detection is made to confirm that no preceding specimen is existing in an analysis position of analysis item by the No.2 quantitative analysis method, and flow-distribution of specimen for the analysis item by the No.2 quantitative analysis method is conducted following this detecting signal in such a way that the priority is given to the specimen flow-distribution for the analysis item by the No.1 quantitative analysis method, and consequently, time for frequency of specimen flow-distributions for analysis item by the No.1 quantitative analysis method can be saved. When a specimen subject to analysis with respect to the analysis item according to the No.2 quantitative analysis method continues, for a specimen located in the succeeding position, specimen flow-distribution for analysis item by the No.2 quantitative analysis method can be performed by giving priority to the specimen flow-distribution for the specimen item according to the remaining No.1 quantitative analysis method at the time when the preceding specimen no more exists in the analysis position of the analysis item according to the No.2 quantitative analysis method.

Description

Detailed Description of the Invention (a) Industrial Application Field The present invention relates to analysis using a plurality of analysis items by a first quantitative analysis method and a second quantitative analysis method using different measurement means from the first quantitative analysis method. Concerning continuous multiple-item analysis methods that perform continuous analysis of items, especially for samples such as blood, serum, plasma, urine, other body fluids, and secretions, for example, for biochemical analysis items and other analysis items by spectrophotometry, For example, the present invention relates to a continuous multiple-item analysis method that uses spectrophotometry, such as electrolyte analysis and blood gas analysis, and allows one analysis item to be performed in parallel. The present invention also relates to a sample dispensing method for a single-line, multi-channel type automatic biochemical analyzer that can perform electrolyte analysis in parallel.

(B) Prior art Analysis of samples such as blood, plasma, serum, urine, other body fluids and secretions is used for diagnosis, treatment guidelines, etc., for example. Many of these analysis items are analyzed, for example, by spectrophotometry, but -power, for example, electrolyte items are analyzed by ion electrode method, and are not based on absorption photometry. Therefore, when analyzing these analysis items for a sample using an automatic analyzer, for example, biochemical items and electrolyte items may be measured in separate measurements.
This is done by using IltW1 and forming separate lines for each.

(c) Problems to be solved by the invention When these analysis items are performed on a specimen, especially with a single-line, multi-channel type automatic analyzer, the analysis items using the ion electrode method are better for one sample. Since the time required for analysis is longer than the total dispensing time for the analysis item using the spectrophotometry method, it is not possible to move on to dispensing the next sample unless the analysis item using the ion electrode method is completed. This, in turn, results in a reduction in the processing power of the automatic biochemical analyzer, which is a problem. However, if multiple ion electrode devices are provided for electrolyte items, and one ion electrode device is measuring while the other ion electrode device is measuring, for example, the electrolyte M'l! Item 1 is rather not a general inspection item 1], so it is not always used frequently and becomes idle, which is a problem. Moreover, since the dimensions and characteristics of multiple ion electrode devices are not the same, it takes a lot of effort to calibrate the measured values between each ion electrode device, and the maintenance effort for each one also increases, which is a problem. be. In addition, by separating electrolyte items from biochemical items,
There is a method of analyzing each sample using its own line, but since the analysis results are recorded separately, it is necessary to compile the analysis results for each sample, which is a problem because it takes a lot of time.

The present invention provides a sample solution for both analysis items per sample, such as an analysis item by a first quantitative analysis method, for example, an absorption photometry method, and an analysis item by a second quantitative analysis method, for example, an ion electrode method. Note: The time required for analysis is longer than the analysis time, and the number of samples to be analyzed is smaller than that of the first quantitative analysis method. The aim is to resolve problems in analytical methods that are carried out in parallel.

(d) Means for Solving the Problems The present invention provides analysis items based on the first quantitative analysis method, for example, spectrophotometry, and the analysis items on the second quantitative analysis method, such as the ion electrode method. , the time required for analysis is longer than the sample dispensing time per sample, and the number of samples to be analyzed is smaller than the analysis items of the first quantitative analysis method. The purpose of this invention is to provide a continuous analysis method for multiple items that can be performed in parallel with the quantitative analysis method for each sample, and that can minimize the time required for dispensing the sample 11.

That is, following the analysis of a sample in which multiple analysis items are analyzed using the first quantitative analysis method, the first quantitative analysis method, which requires longer analysis time than the total dispensing time for each analysis item per sample, is applied. In a continuous multiple-item analysis method in which a sample is analyzed for an analysis item by a second quantitative analysis method with a different measurement method, there is no preceding sample at the analysis position of the analysis item by the second quantitative analysis method. is detected, and based on this detection signal, the sample dispensing for the analysis item by the second quantitative analysis method is performed with priority over the sample dispensing for the analysis item by the first quantitative analysis method. There is a multiterm IJ analysis method.

In the present invention, the quantitative analysis method refers to all instrumental quantitative analyzes by optical measurement, electrical measurement, magnetic measurement, etc.In the present invention, the plurality of analysis items by the quantitative analysis method include, for example, Examples include biochemical analysis items of the specimen, but are not limited thereto, and are not limited by the measuring means.

However, the number of samples to be analyzed in the first quantitative analysis method needs to be larger than the number of samples to be analyzed in the analysis items in the second quantitative analysis method. In addition, taking the spectrophotometric method as an example of one of the quantitative analysis methods, analysis items that are not based on the spectrophotometric method are, for example, analytical items that are analyzed using the ion electrode method, e.g.
Examples include, but are not limited to, electrolyte items of the specimen.

In the present invention, when the analysis item by the second quantitative analysis method is, for example, an analysis item by an electrical measurement method, particularly an ion electrode method, the analysis position is a cell and a part communicating therewith, preferably, An example is the part that communicates with the cell entrance. Therefore, if there is no previous sample in any of these storage areas, the sample for analysis by the ion electrode method is dispensed, for example, before the sample for biochemical item analysis is dispensed. However, when a prior sample is present at any of these locations, the first quantitative analysis method, e.g.
It is preferable to pipet the sample with priority given to the analysis items by spectrophotometry. In the case of the second quantitative analysis method, for example, the ion electrode method, the detection of these preliminary samples is based on the measurement current flowing through the ion electrode. Mention may be made of well-known optical and electrical means capable of detecting the presence or absence of liquid flowing in a cell or in a conduit.

Therefore, the detection signal is an electrical signal, an optical signal, etc.
Based on these signals, the sample dispenser determines which measuring means to give priority to and performs sample dispensing, that is, sample dispensing.

(E) Effect The present invention detects the absence of a preceding sample at the analysis position of the analysis item by the second quantitative analysis method, and uses this detection signal to dispense the sample for the analysis item by the second quantitative analysis method. Since this is performed with priority over the sample dispensing for the analysis item by the first quantitative analysis method, time for the sample dispensing position for the analysis item by the first quantitative analysis method is gained. Therefore, if there are consecutive samples to be analyzed for the analysis item by the second quantitative analysis method, the subsequent samples will be analyzed at the point when the preceding sample no longer exists at the analysis position of the analysis item by the second quantitative analysis method. , it is possible to perform sample dispensing for the analysis items according to the second quantitative analysis method, giving priority to the sample dispensing for the analysis items according to the remaining first quantitative analysis method. Even if the time required to analyze an analysis item using the second quantitative analysis method is longer than the sample dispensing time for all items in one sample, the number of sample dispensing times for the analysis item using the first quantitative analysis method will be reduced. This will save you time. Therefore, in the present invention, even if the analysis of the analysis item by the first quantitative analysis method is performed in parallel with the analysis of the analysis item by the second quantitative analysis method, the sample dispensing for the analysis item by the first quantitative analysis method is not performed. It never stops for a long time.

(F) Examples Hereinafter, examples of embodiments of the continuous multiple-item analysis method of the present invention will be described with reference to the accompanying drawings, but the present invention is not limited by this explanation and exemplification.

The PtSi diagram is a schematic explanatory diagram mainly showing the sample dispensing section of an automatic analyzer according to an embodiment of the present invention. FIG. 2 is a process diagram illustrating the temporal flow of the sample dispensing process in one embodiment of the present invention, with the upper stage showing the sample dispensing process and the lower stage showing the electrolyte measuring process.

In the PtSi diagram, when the sample cup 1 arrives at the sample dispensing position 2, the data processing station J! ! The setup RA3 is based on whether or not there is an electrolyte analysis item ELI among the analysis items of the sample manually entered in advance, and whether there is a preceding sample in the cell (not shown) of the ion electrode device. , issues an operation signal to the sample dispenser 4.

When there is no preceding sample in the cell of the ion electrode device, the sample dispenser 4 performs a sample dispensing operation A of dispensing the sample to the electrolyte dispensing position 5, as shown in FIG. This is carried out at the beginning of dispensing, and then the sample dispenser 4 performs a sample dispensing operation B in which the sample is sent to the reaction line 6 and dispensed into the reaction tube 7, and the biochemical analysis items CH1, CH2 are dispensed in order.

In this example, sample (2) following sample (2) also has electrolyte analysis item EL2 among its analysis items. However, at the time of dispensing sample ■, the analysis of electrolyte analysis item EL2 for sample I has not been completed, so the cell of the ion electrode device has
Preliminary samples exist. Therefore, the data processing device 3 issues an operation signal to the sample dispensing device 4 to perform the sample dispensing operation B even though the electrolyte analysis item EL2 is present in the sample (2). Based on this signal, the sample dispenser 4 selects the reaction sample ■ to be sent to the reaction line 6. ? CH3 to 7
, CH4. After dispensing CH4,
Since the analysis of electrolyte analysis item ELI of sample I is completed,
The analyte I is discharged and no longer exists in the cell of the ion 'Kim device.

The data processing device 3 issues an operation signal for the sample dispensing operation A to the sample dispenser. In response to this signal, the sample dispenser 4 performs sample dispensing of the electrolyte analysis item EL2 for the sample ■. Since the subsequent sample 1■ does not have an electrolyte analysis item, the data processing device performs sample dispensing C115 for the biochemical analysis item.

CH6 is sent to the reaction line 6 and then transferred to the reaction tube 7.

In this example, for convenience of explanation, the number of biochemical analysis items for the sample is set to 2, but this number depends on the analysis items required for the sample for diagnosis, for example, and cannot be increased or decreased. It goes without saying that the number of analysis items does not need to be uniform for each sample, and can vary.

(g) Effect of the invention The present invention detects the absence of a preceding sample at the analysis position of the analysis item by the second quantitative analysis method, and uses this detection signal to prepare the sample for the analysis item by the second quantitative analysis method. Since dispensing is given priority to sample dispensing for analysis items by the first quantitative analysis method, the number of analysis items per sample is small, and the laboratory time for analysis items by the second quantitative analysis method is shorter. Even if the groove is longer than the sample dispensing position per sample, the sample dispensing operation does not have to be stopped as in the conventional case, and the analysis of samples that have analysis items using the second quantitative analysis method has been increased. can do. Therefore, according to the present invention, in case of emergency, analysis can be performed without burning special equipment and without having to stop the analysis of other samples.In addition, data can be displayed. This will be done at the same time, eliminating the hassle of compiling data for each specimen for diagnosis, etc.

[Brief explanation of drawings]

Figure t51 is a schematic explanatory diagram mainly showing the sample dispensing section of the automatic analyzer in one embodiment of the present invention. FIG. 2 is a process diagram illustrating the temporal flow of the sample dispensing process in one embodiment of the present invention. Regarding the explanation of the symbols, 1 is the sample cup, 2 is the sample dispensing position, 3 is the data processing device, 4 is the sample dispenser, 5 is the electrolyte dispensing position, 6 is the reaction line, 7 is the reaction tube, ELI and EL2 is an electrolyte analysis item, A and B are sample dispensing operations, I
, II and 1■ are specimens.

Claims (1)

[Claims] Following the analysis of a sample in which multiple analysis items are analyzed using the first quantitative analysis method, the analysis is performed using the first quantitative analysis method, which requires longer analysis time than the total dispensing time for each analysis item per sample. In a continuous multiple-item analysis method in which a sample is analyzed for an analysis item by a second quantitative analysis method with a different method, it is detected that there is no preceding sample at the analysis position of an analysis item by the second quantitative analysis method. and, based on this detection signal, sample dispensing for the analysis item by the second quantitative analysis method is performed with priority over sample dispensing for the analysis item by the first quantitative analysis method. Analysis method.