JPS62215520A - Adhesive gel composition - Google Patents

Abstract

PURPOSE:The titled composition, consisting essentially of polyvinyl alcohol, consisting of completely saponified polyvinyl alcohol and partially saponified polyvinyl alcohol together and having improved tackiness to the skin and water. CONSTITUTION:An adhesive gel composition, consisting essentially of polyvinyl alcohol (PVA) and water and containing (A) 7-30wt% completely saponified PVA with >=95mol% saponification degree and >=500 average polymerization degree and (B) 5-30wt% partially saponified PVA with >=85mol% saponification degree and >=200 average polymerization degree and useful as a base of an anti-inflammatory hydrous application agents, e.g. anti-inflammatory and analgesic agents, cooling tools, etc. The above-mentioned composition has tough skeleton of gel and improved shape retaining property and water holding property. Since the tackiness thereof is excellent, handling is readily carried out without requiring the use of adhesive tapes, etc. Thereby the composition can be widely applied to local cold insulants, cataplasm plaster, gel for bioelectrodes, etc.

Description

[Detailed Description of the Invention] [Industrial Application Field] This invention relates to a gel composition with excellent adhesiveness that is used as a base for water-containing patches for anti-inflammatory and analgesic poultices, cooling devices, etc. .

[Conventional technology]

Currently, water-containing gel compositions are made using water-soluble polymers such as polyvinyl alcohol, polyacrylic acid, or polyacrylates, and their characteristics are that they feel good on the skin and are less irritating to living organisms ( Hiroshi Sakurada, “Polymers” 24. 590 (1975), Hiroshi Tanzawa, “Medical Polymers” P2O, PO2 (1978) Imori Publishing), hydrophilicity and resemblance to biological tissue (Hiroshi Tanzawa, “Medical Polymers” P2O, PO2 (1978) Imori Publishing); molecule"
It is expected to be used as a medical material or a drug sustained release material because of its excellent P2O (1978) or selective permeability.

Among these, various hydrogel compositions using polyvinyl alcohol (hereinafter abbreviated as "PvA") have been reported for a long time, and in recent years, PVA-based hydrogel compositions with excellent strength have been reported.

[Problem that the invention seeks to solve]

However, all conventional PVA-based hydrogel compositions have adhesiveness to the skin. Because it is not possible to
It must be fixed to the skin surface using adhesive tape or the like, making it inconvenient to use.

The present invention was made in view of the above circumstances, and provides a gel composition that is rich in shape retention, has excellent water retention and adhesive properties, and has adhesive properties that can be directly fixed to the skin surface. The purpose is to

[Means to achieve the purpose]

In order to achieve the above object, the adhesive gel composition of the present invention is an adhesive gel composition containing polyvinyl alcohol and water as main components, in which the polyvinyl alcohol completely binds, the north wall polyvinyl alcohol partially binds, The north wall is made of polyvinyl alcohol.

That is, as a result of intensive research to obtain an adhesive gel composition suitable for application to the skin, the present inventors discovered that PV
They discovered that the desired objective could be achieved by using fully saponified PVA and partially saponified PVA in combination as A, and arrived at this invention.

The adhesive gel composition of the present invention has PVA and water as its main components, and in particular, as PVA, fully saponified PVA and partially saponified PVA are used in combination.

Here, the term "main component" is intended to include cases where the entire component consists only of the main component.

The above-mentioned PVA is a water-soluble polymer compound obtained by a known method, for example, by saponifying polyvinyl acetate with an alkali, etc. It forms the skeleton of the composition in a gel state, has good biocompatibility, and can be applied to the skin. suitable for. Above PVA
The mechanical strength of the composition can be easily changed by changing the degree of saponification, the average degree of polymerization, or the blending ratio in the composition. Both PVA.

Generally, PVA with a saponification degree of 96.0 mol% is called a completely saponified type, and PVA with a saponification degree of 80 to 93.5 mol% is called a partially saponified type.
"Saponification degree is 95 mol% or more."

This completely saponified PVA forms the skeleton of the gel composition of the present invention, and has good biocompatibility and properties suitable for application to the skin. From this point of view, the degree of saponification was set to be 95 mol% or more, and this invention can be achieved with this degree of saponification. More preferred is 99 mol% or more. If the degree of saponification is less than 95 mol%, sufficient gelation cannot be obtained and a gel skeleton cannot be formed.

The average degree of polymerization of the completely saponified PVA is 500 or more, preferably 1000 or more, more preferably 1500-2
It is desirable to set it to 000. That is, if the average degree of polymerization is less than 500, sufficient gelation cannot be obtained.

In addition, the above partially saponified PVA has a saponification degree of 85 mol%.
This refers to 93.5 mol% or less of the above, and this substance imparts tackiness to the gel composition so that it can be applied to the skin. Particularly preferred is a degree of saponification of 88 mol% or more, 93.
It is 5 mol% or less. That is, if less than 85 mol% is used, the resulting gel composition will have increased stickiness, making it unsuitable for skin application; on the other hand, if more than 93.5 mol% is used, the resulting gel composition will become sticky. This is because it will no longer be recognized.

The above-mentioned partial north wall PVA has an average degree of polymerization of 200 or more,
It is desirable to set it preferably between 1000 and 3000. That is, if a material having an average degree of polymerization of less than 200 is used, adhesiveness suitable for application to the skin cannot be obtained.

The water used together with the above two types of PVA is not particularly limited, and water that is normally used for producing hydrogels can be used.

In addition, polyhydric alcohol can be used in the adhesive gel composition of the present invention in addition to the above-mentioned raw materials, if necessary, and antibacterial agents can be used to prevent bacterial infection of the wound skin or to treat suppuration. It can also be used. In some cases, physiologically active substances that can be applied transdermally can also be used.

Examples of the polyhydric alcohol include glycerin, polyglycerin, ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, and ethylene-propylene glycol copolymer. These polyhydric alcohols may be used alone or in combination of two or more without any problem.

Antibiotics include sulfadiazine, sulfadiazine, and benzalkonium chloride.

Cetalkonium chloride, methylbenzethonium, neomycin sulfate, hexachlorophene, eosin, penicillin G, cephalocin, cephaloridine, tetracycline, lincomycin, nyscutin, kanamycin,
Examples include penicillinase-resistant penicillin, fradiomycin sulfate, silver lactate, and the like, which are used alone or in combination.

Examples of the physiologically active substances include salicylic acid ester, menthol, camphor, and peppermint.

Capsicum Chekis. Poultice agents such as cabsaicin,
prezonisolone, dexamethacin, hydrocortisone,
Steroids such as dexamethacin acetate and hydrocortisone acetate, anginal drugs such as nitroglycerin and isosorbide dinitrate, local anesthetics such as pensicaine, protylene, and xylocaine, antihistamines such as diphenhydramine, and β-stimulants such as alprenolol, propranolol, and pindolol. - Blockers, antihypertensive drugs such as clonidine and nifedipine, bronchodilators such as methylephedrine, chlorbrenalin, salbutamol, and terbutaline, asthma drugs such as cromoglycic acid, drugs such as prostaglandins and hormones, water-soluble collagen, and aloe extract. , female hormones, beautifying ingredients such as loofah extract, allantoin, lecithin, vitamins E, A, D, B, vitamins such as pantothenic acid, cam azulene, guaya azulene, γ-oryzanol, urea, sulfur, salicylic acid, yellow oak, western horse chestnut Examples include extracts of herbal medicines such as , Toki, Shikon, etc., and fragrances. These may be used alone or in combination without any problem.

The adhesive gel composition of the present invention can be produced, for example, as follows. That is, an aqueous solution containing completely embossed north wall PVA and partially embossed north wall PVA is frozen at a temperature below -5°C for 5 hours or more, and then left at a relatively low temperature of 0 to 10°C for 10 hours or more to form a gel. It can be manufactured by

The blending amount of the above-mentioned completely broken north wall PVA is preferably 7 to 30% by weight (hereinafter abbreviated as "%"), more preferably 10 to 20%. That is, if it is less than 7%, gelation will not be good, and if it exceeds 30%, the elasticity of the gel will decrease and skin adhesion will be poor.

In addition, the blending amount of PVA on the north wall of the above part is 5 to 50% of the total amount.
It is preferably 30%, more preferably 7 to 20%.

This is also for the same reason as above.

Note that the polyhydric alcohol and physiologically active substance can be added to the aqueous solution in which the two types of PVA are dissolved, if necessary.

In this way, the adhesive gel composition of this invention is obtained. This composition has excellent mechanical strength and adhesiveness 1 and is suitable for application to the skin, so it can be used as it is as a topical ice pack, poultice plaster, or bioelectrode gel. In addition, this composition can be molded into any shape, and especially when used as a patch such as a poultice applied to the skin, -
It is preferable to form it into a sheet using a shaft or twin-screw extruder.

The adhesive gel composition of the present invention can be commercialized as a poultice or the like by laminating it with a support. Examples of the support include plastic films such as polyethylene, ethylene-vinyl acetate copolymer, vinyl chloride, polyurethane, and polyester, nylon, and rayon.

Examples include nonwoven fabrics such as urethane, polyester, and absorbent cotton, cloth, elastic fabrics, paper, cellophane, and the like, and can be appropriately selected depending on the intended use.

In addition, the base using the adhesive gel composition of this invention includes:
Furthermore, other water-soluble polymers and water-absorbing resins.

Inorganic fillers, tackifiers, pH regulators, surfactants, chelating agents, various crosslinking agents, transdermal absorption enhancers.

Other additives such as preservatives can be added as appropriate depending on the purpose.

〔Effect of the invention〕

As described above, since the adhesive gel composition of the present invention contains fully saponified PVA, partially saponified PVA, and water, the gel skeleton is strong and has excellent shape retention and water retention. Moreover, since it has extremely good adhesive properties, it does not need to be fixed to the skin using adhesive tape or the like as in conventional products, making it an excellent patch that is extremely easy to handle. This is the greatest feature of this invention. Therefore, the adhesive gel composition of the present invention can be widely applied as a local cold pack, a poultice, a bioelectrode gel, etc.

Next, examples will be described together with comparative examples.

[Examples 1 to 16. Comparative Examples 1 to 4] A mixed solution of fully saponified PVA, partially saponified PVA, and water was prepared with the formulation shown in Table 1 below, and the solution was
3 (J. I got something.

In addition, as a comparative product, a gel composition containing only either fully saponified PVA or partially saponified PVA was obtained in the same manner as the above-mentioned experimental product.

Regarding the actual product and comparative product obtained in this way,
The thickness of the back of the hand of the 10 panelists is lyu X3C11X3cIm.
A sample was applied to the skin, and the adhesion area ratio between the sample and the skin was examined after 8 hours. The results are also shown in Table 1.

(Left below) As is clear from the table above, in all of the comparative examples, either the gel could not be obtained, or even if it gelled, the sample did not adhere to the skin and fell off, whereas the example was excellent. It can be seen that it has good skin adhesion.

[Example 17] 15% fully saponified PVA with a saponification degree of 99.5 mol% and an average degree of polymerization of 1700, 0% partially saponified PVAl with a saponification degree of 88 mol% and an average degree of polymerization of 1900, and 74.55% water.
(7) A gel composition of the present invention was obtained by adding 0.45% borax to a PVA aqueous solution and gelling it. When this composition was also subjected to the same skin adhesion test as described above, the bond between the sample and the skin was The adhesion area ratio was approximately 70%, indicating that it had excellent skin adhesion.

Claims (1)

[Scope of Claims] 1) An adhesive gel composition containing polyvinyl alcohol and water as main components, wherein the polyvinyl alcohol is composed of fully saponified polyvinyl alcohol and partially saponified polyvinyl alcohol. Gel composition. (2) The content of fully saponified polyvinyl alcohol is
The adhesive gel composition according to claim 1, wherein the content of partially saponified polyvinyl alcohol is set to 7 to 30% by weight, and the content of partially saponified polyvinyl alcohol is set to 5 to 30% by weight. (3) The adhesive gel composition according to claim 1 or 2, wherein the completely saponified polyvinyl alcohol has a saponification degree of 95 mol% or more. (4) The fully saponified polyvinyl alcohol has an average degree of polymerization of 500 or more.
The adhesive gel composition according to any one of Item 3. (5) The adhesive gel composition according to any one of claims 1 to 4, wherein the partially saponified polyvinyl alcohol has a saponification degree of 85 mol% or more. (6) Partially saponified polyvinyl alcohol has an average degree of polymerization of 200 or more.
The adhesive gel composition according to any one of Item 5.