JPS62210042A - Device for mixing liquid - Google Patents
Device for mixing liquidInfo
- Publication number
- JPS62210042A JPS62210042A JP61048361A JP4836186A JPS62210042A JP S62210042 A JPS62210042 A JP S62210042A JP 61048361 A JP61048361 A JP 61048361A JP 4836186 A JP4836186 A JP 4836186A JP S62210042 A JPS62210042 A JP S62210042A
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- mixer
- spiral
- fed
- mixing device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 239000012530 fluid Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 229910001220 stainless steel Inorganic materials 0.000 abstract description 3
- 239000010935 stainless steel Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract 2
- 239000011324 bead Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000004811 liquid chromatography Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/4314—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、液体混合装置に係り、特に、液体クロマトグ
ラフのグラジェント送液系に用いるのに好適な版体混合
装置に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a liquid mixing device, and particularly to a plate mixing device suitable for use in a gradient liquid feeding system of a liquid chromatograph.
液体クロマトグラフのグラジェント１＠Ｍ法では時１…
と共に送液系の組成比変えている。この組成比は機械的
にコントロールされており、スムーズに、ｉ化ζせる几
め、液体ン昆合装食（ミキシング装置ｆ）を柑いている
。この種の従来装置の混合器にはガラスピーズの光てん
されｔ容器中を通すもの、ミニスターラで攪拌するもの
、小さな容器中を（ｌ’１回か出入Ｖきせるものなどが
ある。In the gradient 1@M method of liquid chromatography, time 1...
At the same time, the composition ratio of the liquid delivery system was changed. This composition ratio is mechanically controlled to smoothly convert the mixture into liquids and mix them (mixing device f). Conventional mixers of this type include those in which glass beads are passed through a light-filled container, those in which they are stirred with a mini-stirrer, and those in which glass beads are stirred in and out of a small container (l' once or twice).
し発明が解決しよりとする問題点］
しかしながら、ガラスピーズ？光てんしたものでは、デ
ッドボリウムの問題があり、他のものでも、液の種類に
より効率が変化し４ｙｌ）、洗浄しにくいなどの欠点が
あった。まｔ、混合の究めに外部、電動系が必要なもの
もある。[Problems that the invention aims to solve] However, glass peas? The light-emitting type has a dead volume problem, and other types also have drawbacks such as efficiency varying depending on the type of liquid (4yl) and difficulty in cleaning. However, there are some that require an external, electric system to master mixing.
本発明の目的は、前記デッドポリウム、容器内洗浄、効
率の変化の問題がなく、しかも外ｓｍ動糸を必要としな
め混合器を備えｔグラジェント用液体混合装置ｉＩｔを
提供することである。An object of the present invention is to provide a liquid mixing device iIt for t-gradient, which is free from the problems of dead polyurethane, cleaning inside the container, and changes in efficiency, does not require an external SM moving thread, and is equipped with a swivel mixer.
本発明は、上記目的を達成するために、中空容器中にら
旋状の流体抵抗体を設けた混合器を提案するものである
。In order to achieve the above object, the present invention proposes a mixer in which a spiral fluid resistance element is provided in a hollow container.
従来装＠［あっては、器壁との流体抵抗ヤそれに伴う回
転作用で液体を混合したり、外部からの駆動力を用いて
スターテを回し混合することも行なわれていｔｏ
これに対して、本発明では、中空容器中にら旋状の物体
を入れて、４坏抵抗全増大させるとともに、外部動力な
しで回転を与え、元方に混合するものである。In conventional systems, liquids are mixed by the fluid resistance with the vessel wall and the resulting rotational action, or by rotating the starter using an external driving force. In the present invention, a spiral object is placed in a hollow container to increase the total resistance of the four members, and to rotate the object without external power to mix it in the original direction.
ら旋状の物体はすぐに取出せるから洗浄が容易であり、
１を薄い板状体を用いれば、デッドボリウムは少なくて
済む。Spiral-shaped objects are easy to clean because they can be taken out quickly.
If a thin plate-like body is used for 1, the dead volume can be reduced.
以下１本発明の一実施例を、第１図および第２図で説明
する。第１図はグラジェントの形態を示す原理図で、高
圧式の人と低圧式のＢの二方法がある。第１図人は３台
のポンプ４〜６で溶離液１〜３を別々に送液し、液組成
はコノトローラ８でポンプの送液ｔｋ調節して決める。An embodiment of the present invention will be described below with reference to FIGS. 1 and 2. Figure 1 is a principle diagram showing the form of a gradient, and there are two methods: high-pressure method B and low-pressure method B. In FIG. 1, three pumps 4 to 6 are used to separately feed eluents 1 to 3, and the liquid composition is determined by adjusting the liquid feed tk of the pumps using a controller 8.
四方ジョイノド９で合流し、混合器７で均一化される。They are combined at a four-way joint 9 and homogenized at a mixer 7.
第一図Ｂは三液とバルブコントローラの組み合わせであ
り１時間分割で浴ｅ、を選択し１台のポンプ４送徹する
もので、混合時は常圧のｔめ低圧方式と呼ばれる。ポン
プ４を出ｔあとの液は、同様に混合器７で均一化され液
流１１として送出−ｇｔする。Figure 1B shows a combination of three liquids and a valve controller, which selects bath e in 1-hour divisions and sends it through one pump 4, which is called a low-pressure system where the pressure is normal during mixing. The liquid after leaving the pump 4 is similarly homogenized in the mixer 7 and sent out as a liquid stream 11.
本発明はこれらニア式のグラジェントシステムで用いら
れる混合器７に関するもので、その構成を、第２図人に
示す。外筒１２は１円径４鵡、長さ１５０圏のステンレ
ス裂カラムを使用し、この内部に巾４鳩のステンレス板
を、図のように捻じりピッチ数１６にしたものを挿入し
である。ポンプから送液されてきｔ液は、下方人口１４
から流入し、ら旋にしたがって流れる過程で自然に攪拌
均一比ざｎｌ、上方出口１５より吐出される。第２図Ｂ
は、内挿の攪拌板？１３．１３’の二つに分け、ら旋の
方向を逆向きにすることにより、混合効率をζらに向上
させｔものである。これらの実施例で内挿のら腕板は、
特に、外筒に対して固定せず、取出して洗浄できるよう
にしている。The present invention relates to a mixer 7 used in these near-type gradient systems, the configuration of which is shown in FIG. For the outer cylinder 12, a stainless steel column with a diameter of 4 mm and a length of 150 mm is used, and a stainless steel plate with a width of 4 mm and twisted with a pitch of 16 as shown in the figure is inserted inside this column. . The liquid sent from the pump has a lower population of 14
In the process of flowing in a spiral manner, the liquid is naturally stirred at a uniform ratio nl, and is discharged from the upper outlet 15. Figure 2B
Is the interpolation stirring plate? By dividing it into two parts 13 and 13' and reversing the direction of the spiral, the mixing efficiency can be improved to ζ et al. In these examples, the interpolated arm plate is
In particular, it is designed so that it can be taken out and washed without being fixed to the outer cylinder.
第３図は、従来のガラスピーズを密閉容器に入ｆ１−ｙ
ｔミ牛テと本実施例とのクロマトグラムのベースライン
における対比を示している。人はビーズミキサによるも
ので、一定のノイズの他に、ふらつき現象を伴う。Ｂは
、本実施例を示しており、大きなふらつき現象は現われ
ない。このときの測定は、二液混合の低圧グラジェント
を用い、カラムは円径４糊Ｘ長ざ１５０聰のＯＤＳ形全
接続し、ボ／ブ流耐１ｍｔ、溶液ｌは水３０幅、溶液２
はメタノ−／ｌ／ ７０ ％ 、検出器ＵＶ２５０ｎｍ
、 ０．０１ＡＵＪ’Ｓの感度で行なっている。Figure 3 shows conventional glass beads placed in an airtight container f1-y.
3 shows a baseline comparison of the chromatograms of the chromatograms of the T-milk cowte and the present example. Humans are caused by bead mixers, and in addition to constant noise, there is also a wobbling phenomenon. B shows this example, and no large fluctuation phenomenon appears. In this measurement, a low-pressure gradient of two-liquid mixture was used, and the column was an ODS type with a diameter of 4 and a length of 150.
is methanol/l/70%, detector UV250nm
, with a sensitivity of 0.01 AUJ'S.
本発明によれば、駆動系が不要であり装置が簡略化てれ
消耗部分もなく、シかもスターラ？用いる方式と同様な
ミキシング効果が傅らｎ、る混合器全備えｔ液体混合装
置が得られる。According to the present invention, there is no need for a drive system, the device is simplified, there are no consumable parts, and there is no need for a stirrer. A liquid mixing device equipped with all mixers is obtained, which has a mixing effect similar to that of the system used.
８ｇ１図は液体クロマトグラフのグラジェント溶離液作
成に用いる液体混合装置の原理的系統を示す図、第２図
は本発明による混合器の構成を示す模式図、第３図は従
来方式と本発明の混合器の安定性を比較して示す測定例
である。Figure 8g1 is a diagram showing the principle system of a liquid mixing device used to create a gradient eluent for liquid chromatography, Figure 2 is a schematic diagram showing the configuration of the mixer according to the present invention, and Figure 3 is a diagram showing the conventional system and the present invention. This is a measurement example to compare and show the stability of the mixers.
Claims (1)
対応した複数台のポンプと各ポンプに指令を送る流量コ
ントロールユニットからなり、または前記複数台の容器
に対応した液体選択用バルブコントロールユニットと１
台の送液用ポンプとからなり各液の比率を変える液組成
変更部と、液組成変更部から送られた液を混合し次段に
送出する混合器とにより構成された液体混合装置におい
て、混合器が、中空容器とその中に挿入したら旋状の流
体抵抗体とからなることを特徴とする液体混合装置。1. Consisting of a holding container each containing a plurality of liquids, a plurality of corresponding pumps, and a flow rate control unit that sends commands to each pump, or a liquid selection valve control unit corresponding to the plurality of containers;
In a liquid mixing device, the liquid mixing device is composed of a liquid composition changing section that changes the ratio of each liquid, and a mixer that mixes the liquid sent from the liquid composition changing section and sends it to the next stage. A liquid mixing device characterized in that the mixer comprises a hollow container and a spiral fluid resistance element inserted into the hollow container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61048361A JPS62210042A (en) | 1986-03-07 | 1986-03-07 | Device for mixing liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61048361A JPS62210042A (en) | 1986-03-07 | 1986-03-07 | Device for mixing liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62210042A true JPS62210042A (en) | 1987-09-16 |
Family
ID=12801212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61048361A Pending JPS62210042A (en) | 1986-03-07 | 1986-03-07 | Device for mixing liquid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62210042A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007132873A (en) * | 2005-11-11 | 2007-05-31 | Nippon Soda Co Ltd | Analytical method, separation method, mixer, and analyzer |
| US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
| US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
| US11898999B2 (en) | 2020-07-07 | 2024-02-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
-
1986
- 1986-03-07 JP JP61048361A patent/JPS62210042A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007132873A (en) * | 2005-11-11 | 2007-05-31 | Nippon Soda Co Ltd | Analytical method, separation method, mixer, and analyzer |
| JP4690864B2 (en) * | 2005-11-11 | 2011-06-01 | 日本曹達株式会社 | Analysis method, separation method, mixer, and analyzer |
| US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
| US11898999B2 (en) | 2020-07-07 | 2024-02-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
| US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
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