JPS62205102A - Production of ion exchanger - Google Patents
Production of ion exchangerInfo
- Publication number
- JPS62205102A JPS62205102A JP61047077A JP4707786A JPS62205102A JP S62205102 A JPS62205102 A JP S62205102A JP 61047077 A JP61047077 A JP 61047077A JP 4707786 A JP4707786 A JP 4707786A JP S62205102 A JPS62205102 A JP S62205102A
- Authority
- JP
- Japan
- Prior art keywords
- carrier
- ion exchanger
- porous spherical
- paraffin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 238000005342 ion exchange Methods 0.000 claims abstract description 19
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 claims abstract description 16
- 239000012188 paraffin wax Substances 0.000 claims abstract description 8
- 239000000126 substance Substances 0.000 claims abstract description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 6
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 5
- 239000012052 hydrophilic carrier Substances 0.000 claims abstract description 4
- 239000000178 monomer Substances 0.000 claims abstract description 4
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
- 239000002904 solvent Substances 0.000 claims abstract description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000003054 catalyst Substances 0.000 claims abstract 3
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims abstract 2
- -1 alkylene diglycidyl ether Chemical compound 0.000 claims abstract 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 3
- 239000012670 alkaline solution Substances 0.000 claims description 2
- UPTHZKIDNHJFKQ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;propane-1,2,3-triol Chemical compound CC(=C)C(O)=O.CC(=C)C(O)=O.OCC(O)CO UPTHZKIDNHJFKQ-UHFFFAOYSA-N 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 150000002500 ions Chemical class 0.000 abstract description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 235000010288 sodium nitrite Nutrition 0.000 abstract 1
- 238000000926 separation method Methods 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 4
- 239000003456 ion exchange resin Substances 0.000 description 4
- 229920003303 ion-exchange polymer Polymers 0.000 description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
- 238000004255 ion exchange chromatography Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 235000010265 sodium sulphite Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 1
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 1
- 229910015900 BF3 Inorganic materials 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- UKMBKKFLJMFCSA-UHFFFAOYSA-N [3-hydroxy-2-(2-methylprop-2-enoyloxy)propyl] 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(CO)OC(=O)C(C)=C UKMBKKFLJMFCSA-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000011882 ultra-fine particle Substances 0.000 description 1
Landscapes
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Description
【発明の詳細な説明】
〈産業上の利用分デｆ〉
本発明は、親水性担体の表面にのみ微量のイオン交換括
が導入これイオンクロマトグラフ用充填剤等で使用され
るイオン交換体を製造する方法に関する。[Detailed Description of the Invention] <Industrial Application Def> The present invention introduces a trace amount of ion exchanger only on the surface of a hydrophilic carrier. Relating to a method of manufacturing.
く従来の技術〉
上述のようなイオン交換体は、イオンクロマトグラフ用
充填剤として使用される場合、低交換当量で且つ表面に
のみイオン交換基が導入されているものであることが望
ましい。このため、例えば外径０．０１〜０．０５μｍ
の超微細粒子でなるラテックス状イオン交＠樹脂を担体
の表面に付着させたものがイオン交換体として利用され
ている。このようなラテックス型のイオン交換体は、担
体の表面にラテックス状イオン交換樹脂を安定的に保持
させることが困難であるという欠点があった。また、イ
オン交換体を充」ハしてなる分離カラムの分離性能がラ
テックス状イオン交換樹脂によって支配されるため、分
離カラムの分離性能の多手工化を図るにはラテックス状
イオン交換イＳ（脂も多種類必要となる欠点があった。BACKGROUND ART When the above-mentioned ion exchanger is used as a packing material for ion chromatography, it is desirable that the ion exchanger has a low exchange equivalent and has ion exchange groups introduced only on the surface. For this reason, for example, an outer diameter of 0.01 to 0.05 μm
A latex-like ion exchange resin made of ultrafine particles is attached to the surface of a carrier and is used as an ion exchanger. Such latex-type ion exchangers have a drawback in that it is difficult to stably retain the latex-like ion exchange resin on the surface of the carrier. In addition, since the separation performance of a separation column filled with an ion exchanger is controlled by the latex ion exchange resin, it is necessary to use latex ion exchange resin (S) to increase the separation performance of the separation column. There was also a drawback that many types were required.
一方、多孔質な担体は透過性がよく究極的に上記分列カ
ラムの分離性能も高くなるため、イオンクロマトグラフ
用充填剤（０１１ち、イオン交換体）の担体として広く
使用されている。On the other hand, porous carriers have good permeability and ultimately improve the separation performance of the separation column, so they are widely used as carriers for ion chromatography packing materials (011, ion exchangers).
このようなタイプのイオン交換体は、化学結合によって
イオン交換基が担体に導入されていて安定であるため、
ＪＨ体に種々のイオン交換基を容易に導入できる利点が
ある。This type of ion exchanger is stable because the ion exchange group is introduced into the carrier through chemical bonding.
There is an advantage that various ion exchange groups can be easily introduced into the JH form.
然し乍ら、上記多孔質担体であっても表面にのみイオン
交換基を導入するのは困叉「であり、該担体の細孔内部
までイオン交換基が導入されてしまうという欠点があっ
た。このため、イオン交換体のイオン交換容量の調節が
回圧となるうえ、担体の細孔内へ試料が拡ｎｔしたりす
る現象も生じ、こうしたイオン交換体を充填した分離カ
ラムの分離性能向上は殆んど期待できなくなっていた。However, even with the above-mentioned porous carrier, it is difficult to introduce ion exchange groups only to the surface, and there is a drawback that the ion exchange groups are introduced into the pores of the carrier. In addition, adjustment of the ion exchange capacity of the ion exchanger becomes a rounding pressure, and a phenomenon such as the sample expanding into the pores of the carrier also occurs, so that the separation performance of a separation column packed with such an ion exchanger is hardly improved. I had lost all hope.
〈発明が解決しようとする問題点〉
本発明はかかる状況に比みてなされたものであり、その
目的は、イオンクロマトグラフ用充填剤として使用した
場合、分離カラムの性能が向上すると共に分離特性も容
易に変化させられるようなイオン交換体の製造方法を提
供することにある。<Problems to be Solved by the Invention> The present invention has been made in consideration of such a situation, and its purpose is to improve the performance of a separation column and improve the separation characteristics when used as a packing material for ion chromatography. The object of the present invention is to provide a method for producing an ion exchanger that can be easily changed.
く問題点を解決するための手段〉
上述のような問題点を解決する本発明の特徴は、イオン
交換体の製造方法において、親水性の多孔性球状担体に
導入されるグリシシン基と直接的に反応してイオン交換
基となる物質とグリシシン基を反応させ、親水性１ｕ体
の表面にのみ微量のイオン交換基が導入されるようにし
たことにある。Means for Solving the Problems> The feature of the present invention that solves the problems described above is that in the method for producing an ion exchanger, the glycicin groups introduced into the hydrophilic porous spherical carrier and The reason is that a substance that reacts to become an ion exchange group is reacted with a glycicin group, so that a trace amount of an ion exchange group is introduced only onto the surface of the hydrophilic 1U body.
〈実施例〉
以下、本発明について図を用いて詳しく説明する。図は
本発明実施例を説明するフローチャートである。図にお
いて、最初、モノマーを架橋剤と一緒に重合させて１’
Ｊられる多孔性球状担体にパラフィンを含浸させること
が行なわれる。即ち、例えばグリセリンジメタクリレー
トでなる架橋剤と、例えば３−ヒドロキシプロピルメタ
クリレートのような千ツマ−と、例えばα、α°−７ゾ
ビスイソブチルニトリルのような重合触媒と、例えばク
ロルベンゼンおよびジエチルフタレートからなる混合物
を、一定の溶液（例えば、ｍ合度５００のポリビニアル
コールと塩化カリウＪ＼を脱イオン水に溶解した溶液）
に加え、高速攪拌しながら例えば６５°Ｃに加温して懸
濁１合を行なわせる。このようにして生成した重合体粒
子を、濾別し温水浄洗してのちインプロパツールで洗浄
し、例えば粒径８〜１２μｍの上記多孔性球状担体を得
る。該担体をメタノール洗浄してのち、例えば８０°Ｃ
で４時間乾燥し、その後、炭素数８〜２０程度のパラフ
ィン（例えば、ｎ−デカン）の中に入れ、例えば超音波
をかけて攪拌する。このようにして、上記多孔性球状担
体にパラフィンが含浸される。次に、上記多孔性球状担
体にグリシジル基を導入することが行なわれる。即ち、
グリシジル基を有し且つ水酸基と反応しろる試薬（例え
ば、１．４−ブタンジオールジグリシジルエーテル）と
水素化ホウ素ナトリウムを含むアルカリ性溶液（例えば
ＩＮのカセイソーダ）に、上記多孔性球状担体を加え、
例えば室温で５峙間攪拌しながら反１．ｉＳさせる。そ
の後、メタノール、クロロホルム、およびメタノールの
順で洗浄することにより、未反応物と上記パラフィンを
洗い流して、グリシジル基が導入された多孔性球状担体
を？ソる。最後に、１を亥ｊ１体のグリシジル基と直目
的に反１５ してイオン交換４Ｂとなる物質（ｆ＋ｌＩ
えば、亜硫酸ナトリウム）を上記多孔性球状１［！体と
を反応させ、多孔性球状担体の表面に微量のイオン交換
基を導入する。即ち、グリシジル基が４人された多孔性
球状担体を、例えば亜硫酸ナトリウムが溶解された水溶
液中に分ｉ！ＩＬ、、１促ｊ′Ｆシながら例えば７０°
Ｃで５１１７ ｔ？ｊｆ反応させ、その後、脱イオン水
で洗浄して希塩酸中にｌ提清させて、表面に微量のイオ
ン交換基が導入された多孔性球状担体を生成・保存する
。因みに、このようにして得られた多孔性球状担体をイ
オンクロマトグラフ用分離カラ１、に充１（１シ、Ｌｉ
’、Ｎａ’、ＮＩ１％、に’を含む試料を分析したとこ
ろ、これら全てのイオンが分析周期わずか５分で良好に
分離する結果が得られた。<Example> Hereinafter, the present invention will be explained in detail using the drawings. The figure is a flowchart illustrating an embodiment of the present invention. In the figure, monomers are first polymerized together with a crosslinking agent to form 1'
The porous spherical carrier to be prepared is impregnated with paraffin. a crosslinking agent such as glycerol dimethacrylate, a polymer such as 3-hydroxypropyl methacrylate, a polymerization catalyst such as α,α°-7 bisisobutyl nitrile, and a combination of e.g. chlorobenzene and diethyl phthalate. A mixture consisting of a certain solution (for example, a solution of polyvinyl alcohol with a m content of 500 and potassium chloride
In addition, suspension is carried out by heating to, for example, 65°C while stirring at high speed. The polymer particles thus produced are separated by filtration, washed with hot water, and then washed with an impropat tool to obtain the porous spherical carrier having a particle size of, for example, 8 to 12 μm. After washing the carrier with methanol, for example, at 80°C
The sample is dried for 4 hours, and then placed in paraffin having about 8 to 20 carbon atoms (for example, n-decane) and stirred, for example, by applying ultrasonic waves. In this way, the porous spherical carrier is impregnated with paraffin. Next, glycidyl groups are introduced into the porous spherical carrier. That is,
Adding the porous spherical carrier to an alkaline solution (e.g. IN caustic soda) containing a reagent having a glycidyl group and reacting with a hydroxyl group (e.g. 1,4-butanediol diglycidyl ether) and sodium borohydride,
For example, while stirring for 5 minutes at room temperature, add 1. Let it be iS. Thereafter, by washing with methanol, chloroform, and methanol in this order, unreacted substances and the above paraffin are washed away, and the porous spherical carrier into which the glycidyl group has been introduced is removed. Soru. Finally, a substance (f + lI
For example, sodium sulfite) into the porous spherical 1 [! A minute amount of ion exchange group is introduced onto the surface of the porous spherical carrier. That is, a porous spherical carrier having four glycidyl groups is separated into an aqueous solution in which, for example, sodium sulfite is dissolved. IL,, for example, 70° while pressing 1
5117 t in C? jf reaction, and then washed with deionized water and dissolved in dilute hydrochloric acid to produce and preserve a porous spherical carrier having a trace amount of ion exchange group introduced onto its surface. Incidentally, the porous spherical carrier thus obtained was filled into 1 ion chromatographic separation column (1 column, Li
When a sample containing ', Na', 1% NI, and Ni' was analyzed, all of these ions were successfully separated in an analysis cycle of only 5 minutes.
尚、本発明は上述の実施例に限定されることなく種−？
の変形が可能であり、例えば、多孔（イＬ球状担体の表
面に微量のイオン交換基を導入する工程を次のように変
更してもよいものとする。即ち、ヒドロキシプロパンス
ルホン酸と３−フッ化ホウ４；ニーＦルエ−テ］しをｒ
ｌむ１１−シーオー什ン溶イｒｔＱ ｌ、二、上記テノ
リシシル括か導入Ｊ′Σれた多孔１′Ｆ球状世体？（加
え、例えば１０°Ｃで６時間反ｊ、シ、させろｌ：稈に
変り１したり、グリコール酸と水酪化ホウ素ナトリウム
を含む水溶Ｍｉ中に、Ｊ−１記グリシジルＪλが導入さ
れた多孔性球状担体を加え、（！／１えば５０゛Ｃで５
時間反応させる工程に変更してもよい。また、多孔性球
状担体にグリシジル基を導入する上述の工程も、市販の
相当試薬（例えば、口本石油株式会社製ｒ （１号ソル
ベント１■」）の中に上記多孔性球状担体を分散、させ
、更に、エピクロルヒドリンを含む希カセイソーダ溶溶
を加え、例えば４ （１’Ｃで２時間だけ、１１１７、
１’ｌ！ ｌ、ながら反応させる工程に変更してもよい
ものとする。It should be noted that the present invention is not limited to the above-mentioned embodiments, but can be applied to other species.
For example, the step of introducing a small amount of ion exchange groups onto the surface of the porous spherical carrier may be changed as follows. Boron fluoride 4;
lm11-ShiOten melting rtQ l, 2, the above-mentioned tenorishicil bracket introduced J'Σ porous 1'F spherical world? (In addition, for example, let it incubate for 6 hours at 10°C. It turns into a culm, or the glycidyl Jλ described in J-1 is introduced into the aqueous Mi containing glycolic acid and sodium boroborohydride. Add a porous spherical carrier, (!/1 for example 5 at 50°C)
The process may be changed to a step of reacting for a period of time. The above-mentioned step of introducing glycidyl groups into the porous spherical carrier can also be carried out by dispersing the porous spherical carrier in a commercially available equivalent reagent (for example, R (No. 1 Solvent 1■) manufactured by Kuchimoto Sekiyu Co., Ltd.). Then add dilute caustic soda solution containing epichlorohydrin, for example 4 (1117 for 2 hours at 1'C,
1'l! However, the process may be changed to a step in which the reaction is carried out while reacting.
〈発明の効果〉
以上詳しく説明したような本発明によれば、親水性の多
孔性球状１目体の表面にのみｉ、？！！鑓のイオン交換
基が導入されるようなも一１成であるため、試オ）（被
測定体）は親水性担体の表面でだけイオン交換反応を起
こすようになる。従って、本発明によれば、前記従来例
のように担体の細孔内へ試本］が拡１１々する現象が回
避でき、イオン交換体を充填した分離カラムの分離性能
が向上する利点がある。<Effects of the Invention> According to the present invention as described in detail above, i, ? ! ! Since the ion-exchange group is introduced, the sample (analyte) undergoes an ion-exchange reaction only on the surface of the hydrophilic carrier. Therefore, according to the present invention, it is possible to avoid the phenomenon of the sample expanding into the pores of the carrier as in the conventional example, and there is an advantage that the separation performance of the separation column packed with the ion exchanger is improved. .
また、上記多孔性球状担体の表面に微量のイオン交換基
を導入する工程で反応試薬を変えるだけで、分列特性の
異なるイオン交換体を容易に製造できる利点もある。更
に、上記多孔性球状担体が親水性であるため、試料［１
コの疎水性物質によるイオン交換体（ひいては分蹟カラ
ム）の汚染が防止できる利点もある。Another advantage is that ion exchangers with different sorting characteristics can be easily produced by simply changing the reaction reagent in the step of introducing a small amount of ion exchange groups onto the surface of the porous spherical carrier. Furthermore, since the porous spherical carrier is hydrophilic, sample [1
Another advantage is that contamination of the ion exchanger (and thus the fractionation column) by hydrophobic substances can be prevented.
図は本発明実ＪＩ８ｉ例のイオン交換体製造方法を説明
するフローチャートである。The figure is a flowchart illustrating a method for producing an ion exchanger according to the JI8i example of the present invention.
Claims (5)
の表面にのみ微量のイオン交換基を導入することを特徴
とするイオン交換体製造方法。 （ａ）モノマーを架橋剤と一緒に重合させて得られる親
水性の多孔性球状担体にパラフィンを含浸させる工程。 （ｂ）前記パラフィンを含浸する多孔性球状担体をアル
カリ性溶液に分散させ、グリシジル基を有し水酸基と反
応しうる試薬と触媒存在下で反応させ、前記担体にグリ
シジル基を導入する工程。 （ｃ）前記パラフィンを含浸する多孔性球状担体を溶媒
で洗浄して、前記パラフィンを洗い出す工程。 （ｄ）前記グリシジル基と直接的に反応してイオン交換
基となる物質を前記多孔性球状担体に加えて反応させ、
該担体の表面に微量のイオン交換基を導入する工程。(1) A method for producing an ion exchanger, which comprises introducing a trace amount of ion exchange groups only onto the surface of a hydrophilic carrier by the following steps (a) to (d). (a) A step of impregnating paraffin into a hydrophilic porous spherical carrier obtained by polymerizing a monomer together with a crosslinking agent. (b) A step of dispersing the paraffin-impregnated porous spherical carrier in an alkaline solution and reacting it with a reagent having a glycidyl group and capable of reacting with a hydroxyl group in the presence of a catalyst to introduce glycidyl groups into the carrier. (c) washing the paraffin-impregnated porous spherical carrier with a solvent to wash out the paraffin; (d) adding a substance that directly reacts with the glycidyl group to become an ion exchange group to the porous spherical carrier and causing the reaction;
A step of introducing a trace amount of ion exchange groups onto the surface of the carrier.
ル、グリシジル、ポリエチレングリコール、メタクリル
酸メチル、およびビニルエーテルのいずれかでなる特許
請求範囲第（１）項記載のイオン交換体製造方法。(2) The method for producing an ion exchanger according to claim (1), wherein the monomer is any one of hydroxyalkyl, glyceryl, glycidyl, polyethylene glycol, methyl methacrylate, and vinyl ether.
コールジメタクリレート、およびグリセリンジメタクリ
レートのいずれかでなる特許請求範囲（１）項記載のイ
オン交換体製造方法。(3) The method for producing an ion exchanger according to claim (1), wherein the crosslinking agent is one of divinylbenzene, ethylene glycol dimethacrylate, and glycerin dimethacrylate.
レンジグリシジルエーテルでなる特許請求範囲第（１）
項記載のイオン交換体製造方法。(4) The reagent is epichlorohydrin or an alkylene diglycidyl ether according to claim (1).
The method for producing an ion exchanger described in Section 1.
リルでなる特許請求範囲第（１）〜第（４）項のいずれ
かに記載のイオン交換体製造方法。(5) The method for producing an ion exchanger according to any one of claims (1) to (4), wherein the catalyst is α,α'-azobisisobutylnitrile.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61047077A JPS62205102A (en) | 1986-03-04 | 1986-03-04 | Production of ion exchanger |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61047077A JPS62205102A (en) | 1986-03-04 | 1986-03-04 | Production of ion exchanger |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62205102A true JPS62205102A (en) | 1987-09-09 |
| JPH0518321B2 JPH0518321B2 (en) | 1993-03-11 |
Family
ID=12765106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61047077A Granted JPS62205102A (en) | 1986-03-04 | 1986-03-04 | Production of ion exchanger |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62205102A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007057526A (en) * | 2005-07-26 | 2007-03-08 | Showa Denko Kk | Method for analyzing low-molecular-weight compound in sample containing water-soluble polymer and low-molecular-weight compound |
-
1986
- 1986-03-04 JP JP61047077A patent/JPS62205102A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007057526A (en) * | 2005-07-26 | 2007-03-08 | Showa Denko Kk | Method for analyzing low-molecular-weight compound in sample containing water-soluble polymer and low-molecular-weight compound |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0518321B2 (en) | 1993-03-11 |
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