JPS62185026A - Remedy for itching dermatopathy - Google Patents

Abstract

PURPOSE:A remedy composition, containing decoctions of Macleaya cordata and Isodon trichocarpus Kudo and useful for treating senile pruritus, atopic dermatitis, etc. CONSTITUTION:A remedy for itching dermatopathy containing decoctions of Maleaya cordata and Isodon trichocarpus Kudo. The individual above-mentioned decoctions are not respectively ineffective and the sole decoction of the Maleaya cordata may cause rather contact dermatitis in reverse in some cases. The composition consisting of the decoctions of both plants is very effective for treating itching dermatopathy, e.g. senile pruritus, cold urticaria, keratosis, contact dermatitis, atopic dermatitis, etc. Any parts of the plants may be used. Although both plants grow wild, cultivation thereof is readily carried out. After drying and cutting the collected plant bodies, 1pt.wt. Macleaya cordata is charged into about 4pts.wt. water and boiled. The Isodon trichocarpus Kudo of the same weight as the Coleaya cordata used is charged into the water in the end of boiling and the decoctions is allowed to cool while mixing and stirring. The cooled decoctions are filtered to afford the aimed composition.

Description

[Detailed Description of the Invention] [Industrial Application IP1] The present invention provides a composition for external treatment of pruritic skin diseases such as senile pruritus, cold measles, keratosis, xeroderma, and atopic dermatitis. relating to things.

[Prior art] Pruritic skin diseases affect many people, especially young people with pathological conditions, due to unknown causes for which accurate investigation results have not been obtained, such as the inability to psychologically adapt to the social life that has become more complicated in recent years. It is a disease that is fairly universally seen in elderly people and is increasing in number, but it is caused by diabetes, liver damage, gout, kidney damage, endocrine disorders, and rash due to external factors. It is said to be associated with cancer, digestive system disorders, vitamin deficiencies, hormonal imbalances, aging, metabolic abnormalities, calcium deficiency, etc., and at present the mechanism is unknown and there is no effective treatment.

Most empirically, the application of vitamin A-D ointment, vitamin E ointment, adrenal corticosteroid ointment, etc., oral administration of antihistamines or external use of the same ointment, treatment of the above-mentioned related diseases, etc. have been used, but of course there is no definitive cure. No therapeutic agent has yet been obtained.

[Means for Solving the Problems] The present inventors have been researching the effects of various physiologically active natural products, and found that a decoction of bamboo rush and black-and-white broom has been found to be effective against senile pruritus and cold measles, for example. , keratosis,
The present invention was completed based on the discovery that the present invention is extremely effective in treating pruritic skin diseases such as xeroderma, rash, and atopic dermatitis.

The therapeutic agent of the present invention is derived from Bamboo rush and Bamboo shoots!
? (Although it consists of exudate, it is not effective when used as a liquid alone. (In particular, a decoction of bamboo rush alone may even cause rashes depending on the case.) However, the therapeutic agent of the present invention (It was completely unexpected that a composition consisting of a liquid would show remarkable effects for the first time.

It is usual to add an appropriate amount of alcohol or glycerin to the composition of the present invention in order to increase its skin permeability, but it is generally convenient to add alcohol in order to obtain antibacterial and antiseptic effects. be. It is also possible to use cellulose derivatives such as carboxymethyl cellulose, synthetic polymers such as carboxyvinyl polymers, natural products such as alginic acid, and other appropriate thickeners to create cream-like or plaster-like forms. Of course.

The scientific name of bamboo rush is Maeleya eordata
, is a large perennial plant that grows naturally in the Koyo area, and since ancient times, the dried whole plant has been shown to have anti-inflammatory, anti-tumor, detoxifying, and insecticidal effects, and has been used externally to treat bad marks, membranes, ulcers, otitis media, etc. It was medicine. The scientific name of Rabdosi is Rabdosi.
A trichoearpa is a perennial perennial plant that grows naturally in the mountains and fields. It is also called Enmeiso, and is known to be a health medicine. Recently, however, a group of chemical components collectively known as trichorhabdal have been identified, and this has been shown to have antitumor properties. It has been found to be effective. Furthermore, a composition consisting of the pre-liquids of these two plants is also highly effective as a curative agent for skin diseases caused by M. albicans, and the present inventors have proposed its use in Japanese Patent Application No. 231787-1983.
He has completed the invention of No.

For the purposes of the present invention, the thin parts of both plants may be used, but economically it is preferable to use the whole plant, that is, without any waste. Although both plants are wild, they are easy to cultivate, and the plants can be regenerated from the remaining roots, and propagated using mochi seeds.

Even if you use the whole plant, it is wise to leave the roots for next year.

Foreign matter is removed from the collected plants as usual, and the plants are dried and cut to the extent that they are easy to handle. First, Takenib 91
Pour the weight into about 4 weight of water and boil. Generally, 30 minutes to 1 hour is sufficient, but there is no problem in extending the time further. At the end of boiling, approximately the same weight of the bamboo rush used as the bamboo rush is added. Remove the heat source and, if possible, leave to cool while stirring with an atomizer or juicer. Cool to approximately room temperature and filter. For example, 10% of its volume of alcohol is added to the filtrate, although the addition of alcohol is not essential. In this way, the therapeutic composition of the present invention is obtained.

[Effect of the invention] The therapeutic agent of the present invention may be applied to the itchy area several times a day.

The present invention will bring about effective results in treating symptoms for which conventional drugs have not been able to achieve the goal of treatment, and will greatly contribute to this field.

[Example] Examples and test examples are shown below, but the present invention is not limited to these examples.

Example 1 A plant body dried in the shade for several days and cut into small pieces was used. Add 100g of bamboo rush to 400g of water, heat and boil for 30 minutes. At the same time as 100 g of Black Banana Cucumber was added, the heat source was removed, and when the mixture was hot, the aqueous mixture was transferred to a mixer and stirred vigorously. Filter in a place that has cooled to near room temperature using a large filter paper for chemical experiments. A dark reddish-brown clear filtrate is obtained.

Example 2: Take 100 ml of the filtrate from Example 1 and add 1 ml of alcohol to it.
0o+lt- mix. A dark reddish-brown, clear and aromatic solution is obtained.

Example 3: 5 g of powder of cross-linked polyacrylic acid (commercial product name: Yaipiswako-104; manufactured by Wako Pure Chemical Industries, Ltd.) was mixed with 100 ml of the filtrate of Example 1, and while stirring, the number of triethanolamines was increased. Give drops to neutralize. You can get a dark reddish-brown color with no turbidity. The same holds true when the solution of Example 2 is used.

Test Example 11 A patient who showed no signs of improvement while using existing external medicines such as antihistamine ointment, corticosteroid ointment, vitamin A-D ointment, vitamin E ointment, etc. alone or in combination for a long period of time. The therapeutic agent composition of the present invention alone was applied to each of the selected mice. The effect of the treatment appears and the itching disappears on the 2nd to 3rd day, the rash mostly disappears on the 3rd to 5th day, and after 1 to 2 weeks, a fresh rash appears on the keratinized area. I have come to recognize that my skin has a unique appearance. During this time, there were no side effects such as pain. The situation is summarized in the table below.

Patent applicant: Nitendo Pharmacy Co., Ltd. Patent applicant: Hong Moto Sato Procedural amendment June 6th, 1986

Claims (1)

[Claims] A therapeutic agent for pruritic skin diseases consisting of a decoction of bamboo rush and black-and-white bamboo shoots.