JPS6213016B2 - - Google Patents
Info
- Publication number
- JPS6213016B2 JPS6213016B2 JP58025995A JP2599583A JPS6213016B2 JP S6213016 B2 JPS6213016 B2 JP S6213016B2 JP 58025995 A JP58025995 A JP 58025995A JP 2599583 A JP2599583 A JP 2599583A JP S6213016 B2 JPS6213016 B2 JP S6213016B2
- Authority
- JP
- Japan
- Prior art keywords
- implant material
- collagen
- powder
- tissue
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000463 material Substances 0.000 claims description 28
- 239000007943 implant Substances 0.000 claims description 27
- 102000008186 Collagen Human genes 0.000 claims description 20
- 108010035532 Collagen Proteins 0.000 claims description 20
- 229920001436 collagen Polymers 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 7
- 230000003716 rejuvenation Effects 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 description 18
- 239000010410 layer Substances 0.000 description 6
- 230000007420 reactivation Effects 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 229910018487 Ni—Cr Inorganic materials 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- VNNRSPGTAMTISX-UHFFFAOYSA-N chromium nickel Chemical compound [Cr].[Ni] VNNRSPGTAMTISX-UHFFFAOYSA-N 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000004482 other powder Substances 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
Landscapes
- Dental Prosthetics (AREA)
Description
本発明は歯科用インプラント材などのインプラ
ント材にコラーゲンを付着させる方法に関する。
コラーゲンを付着させたインプラント材は、歯
周組織などの被植設骨の周辺組織と馴み易く、生
体コラーゲン繊維をインプラント材の植設部に誘
導生成させる作用を有しているため、前記被植設
骨に強固安定した状態で植設できるという長所を
有している。
本発明は前記インプラント材にコラーゲンを付
着させるに際し、コラーゲンが常に良好な状態に
あり、且つ歯科医等が簡単な手段でコラーゲン付
着作業を行うことができる方法を提供することを
目的とする。
以下本発明を図示する実施例に基き具体的に説
明する。
１は瓶（容器）２内に真空パツクされた組織賦
活用粉剤で、仔牛皮から得られ、コバルト照射な
どによる脱免疫処理を施された酸可溶性コラーゲ
ンの粉末、塩化ナトリウム、塩化カリウム、塩化
カルシウムなどからなるリンゲル液成分を粉末に
したものを含む。又この組織賦活用粉剤１は、前
記コラーゲンの粉末の溶解を促進するため、溶解
時の溶液をPH5.5程度の酸性とするリン酸塩、サ
ク酸塩などの溶解促進剤の粉末を微量含んでお
り、更にムコ多糖類などその他の粉末成分をも含
んでいる。
前記組織賦活用粉剤１は100ｇの蒸溜水に対
し、次のような成分を含むように構成できる。
The present invention relates to a method for attaching collagen to implant materials such as dental implant materials. The implant material to which collagen is attached is easily compatible with the tissues surrounding the implanted bone, such as the periodontal tissue, and has the effect of guiding and producing biological collagen fibers in the implanted part of the implant material. It has the advantage of being able to be firmly and stably implanted into the bone. An object of the present invention is to provide a method for attaching collagen to the implant material, in which the collagen is always in a good state, and a dentist or the like can perform the collagen attachment operation using simple means. The present invention will be specifically described below based on illustrated embodiments. 1 is a tissue retrieval powder vacuum-packed in a bottle (container) 2, which contains acid-soluble collagen powder obtained from calf skin and subjected to deimmunization treatment such as cobalt irradiation, sodium chloride, potassium chloride, and calcium chloride. Contains powdered Ringer's solution components. In addition, this tissue rejuvenation powder 1 contains a small amount of dissolution promoter powder such as phosphate or succinate, which makes the solution at the time of dissolution acidic to about PH 5.5, in order to promote the dissolution of the collagen powder. It also contains other powder components such as mucopolysaccharides. The tissue rejuvenating powder 1 can be configured to contain the following components per 100 g of distilled water.
【表】
前記組織賦活用粉剤１は、滅菌状態下で真空パ
ツクされ、長期保存に耐えるようにされている。
前記組織賦活用粉剤１は、インプラント材３を
植設する直前において使用される。すなわち、第
２図に示す如く、注射器４を用いて、蒸溜水を前
記容器２内に注入し、前記組織賦活用粉剤１を溶
解させ、組織賦活用溶液１ａを作る。次いで滅菌
処理された多孔層を有するインプラント材３を前
記容器２内に投入し、これを組織賦活用溶液１ａ
に浸漬させ、再び容器２を密封状態とする（第３
図）。その後前記注射器４を用いて、容器２内の
空気を吸引して、容器２内を滅圧状態とする（第
４図）。
かくしてインプラント材３の多孔層には組織賦
活用溶液１ａが侵入し、インプラント材３の表面
は組織賦活用溶液１ａが覆うことになる。
このようにしてコラーゲンを付着させたインプ
ラント材３は所望の箇所に植設される。前記イン
プラント材３としては、少なくとも表面層に多孔
層（ボーラス層）を有するものを採用するとよい
が、例えばセラミツク製インプラント材３におい
ては、その焼結時に適度の気孔率を有する多孔層
を全体にわたつて形成することは容易である。又
チタン系インプラント材、ニツケルクロム系イン
プラント材などの金属製インプラント材３におい
ては、溶射膜被覆により、その溶射膜を多孔質構
造とすることができる。
本発明方法は、上記実施例に１例が示されるよ
うに、脱免疫処理を施した酸可溶性コラーゲンの
粉末、リンゲル液成分を粉末にしたものを含む組
織賦活用粉剤１を容器２内に真空パツクして保存
し、所望時にこれを溶解した後インプラント材３
に付着させることを特徴とするものであるが、上
記実施例に示す外、種々の態様に構成することが
できる。
例えば、前記組織賦活用粉剤１に粉状アパタイ
トを混合し、インプラント材３にコラーゲンの付
着と同時に、アパタイトの付着を行えるようにす
ることができる。
又インプラント材３を多孔層を有しない構成と
し、組織賦活用溶液１ａを塗布などによつてイン
プラント材３に付着させてもよい。
又インプラント材３としては、バイオセラミツ
クにモリブデン、チタンなどの金属、又はセラミ
ツクをコーテイングしたものを採用することがで
きる。
更にコラーゲンを付着したインプラント材３を
即時使用する外、これを冷凍保存して任意の時に
使用してもよい。
本発明方法は、上記構成を有するので、コラー
ゲンを粉末状態且つ真空状態で長期保存でき、そ
の変質を防ぐことができるので、インプラント材
に付着されたコラーゲンを最良の状態とすること
ができる。従来の如く液状にして、コラーゲンを
保存しておくと、変質し易く、特に高温において
変質し易く、インプラント材に付着されたコラー
ゲンの品質に十分な信頼を置くことができない
が、本発明によれば、真空状態での保存と相俟つ
て、上記問題点を解消することができるのであ
る。
又本発明方法によれば、組織賦活用粉剤に酸可
溶性コラーゲンの粉末に加えて、リンゲル液成分
を粉末にしたものを含ませているので、所望時に
容器内の組織賦活用粉剤を蒸溜水によつて溶解す
るだけで、これをインプラント材に付着させるこ
とができ、歯科医等が簡単な手段でコラーゲン付
着作業を行うことができる。[Table] The tissue retrieval powder 1 is vacuum packed under sterile conditions to withstand long-term storage. The tissue retrieval powder 1 is used immediately before implanting the implant material 3. That is, as shown in FIG. 2, distilled water is injected into the container 2 using a syringe 4 to dissolve the tissue reactivation powder 1, thereby producing a tissue reactivation solution 1a. Next, a sterilized implant material 3 having a porous layer is put into the container 2, and the tissue reactivation solution 1a is added to the implant material 3.
and seal the container 2 again (third step).
figure). Thereafter, the air inside the container 2 is sucked using the syringe 4 to bring the inside of the container 2 into a depressurized state (FIG. 4). Thus, the tissue reactivation solution 1a penetrates into the porous layer of the implant material 3, and the surface of the implant material 3 is covered with the tissue reactivation solution 1a. The implant material 3 to which collagen has been attached in this manner is implanted at a desired location. As the implant material 3, it is preferable to adopt one having a porous layer (bolus layer) at least on the surface layer. For example, in the case of the ceramic implant material 3, a porous layer having an appropriate porosity is formed over the entire surface during sintering. It is easy to form across. Further, in the case of a metal implant material 3 such as a titanium-based implant material or a nickel-chromium implant material, the sprayed film can be made into a porous structure by coating with a sprayed film. As an example of the method of the present invention is shown in the above embodiment, a tissue rejuvenation powder 1 containing powdered acid-soluble collagen that has been subjected to deimmunization treatment and a powdered Ringer's solution component is vacuum packed in a container 2. Implant material 3
However, it can be configured in various ways other than those shown in the above embodiments. For example, it is possible to mix powdered apatite into the tissue rejuvenation powder 1 so that apatite can be attached to the implant material 3 at the same time as collagen is attached. Alternatively, the implant material 3 may have a structure without a porous layer, and the tissue activating solution 1a may be attached to the implant material 3 by coating or the like. Further, as the implant material 3, bioceramic coated with a metal such as molybdenum or titanium, or ceramic can be used. Furthermore, in addition to using the implant material 3 to which collagen is attached immediately, it may be stored frozen and used at any time. Since the method of the present invention has the above configuration, collagen can be stored for a long period of time in a powdered state and in a vacuum state, and its deterioration can be prevented, so that the collagen attached to the implant material can be kept in the best condition. If collagen is stored in a liquid state as in the past, it tends to deteriorate, especially at high temperatures, and the quality of the collagen attached to the implant material cannot be fully trusted. For example, in combination with storage in a vacuum state, the above problems can be solved. Furthermore, according to the method of the present invention, in addition to the acid-soluble collagen powder, the tissue retrieval powder contains powdered Ringer's solution components, so the tissue retrieval powder in the container can be added to distilled water when desired. It can be attached to an implant material simply by applying it and dissolving it, allowing dentists and the like to carry out collagen attachment work by simple means.
図面は本発明の実施例を示し、第１図乃至第４
図は夫々本発明方法の説明図である。
１……組織賦活用粉剤、２……容器、３……イ
ンプラント材。
The drawings show embodiments of the present invention, and include FIGS. 1 to 4.
Each figure is an explanatory diagram of the method of the present invention. 1... Tissue retrieval powder, 2... Container, 3... Implant material.
Claims (1)
末、リンゲル液成分を粉末にしたものを含む組織
賦活用粉剤を容器内に真空パツクして保存し、所
望時にこれを溶解した後インプラント材に付着さ
せることを特徴とするインプラント材にコラーゲ
ンを付着させる方法。1. Vacuum-pack and store a tissue rejuvenation powder containing deimmunized acid-soluble collagen powder and powdered Ringer's solution components in a container, dissolve it at desired time, and then attach it to the implant material. A method for attaching collagen to an implant material characterized by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58025995A JPS59151951A (en) | 1983-02-17 | 1983-02-17 | Adhesion of collagen to implant material and tissue activating powder agent used therein |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58025995A JPS59151951A (en) | 1983-02-17 | 1983-02-17 | Adhesion of collagen to implant material and tissue activating powder agent used therein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59151951A JPS59151951A (en) | 1984-08-30 |
| JPS6213016B2 true JPS6213016B2 (en) | 1987-03-23 |
Family
ID=12181295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58025995A Granted JPS59151951A (en) | 1983-02-17 | 1983-02-17 | Adhesion of collagen to implant material and tissue activating powder agent used therein |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59151951A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0366218U (en) * | 1989-10-24 | 1991-06-27 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5344457A (en) * | 1986-05-19 | 1994-09-06 | The University Of Toronto Innovations Foundation | Porous surfaced implant |
| US5051091A (en) * | 1990-10-17 | 1991-09-24 | Rosenfeld Philip J | Simplified dental implant operation |
| ES2352635B1 (en) * | 2010-09-16 | 2011-12-29 | Biotechnology Institute, I Mas D, S.L. | IMPLANT WITH CALCIUM IN ITS SURFACE, AND METHOD OF MODIFICATION OF THE SURFACE OF AN IMPLANT TO PROVIDE SUCH CALCIUM SURFACE. |
| WO2016068228A1 (en) * | 2014-10-29 | 2016-05-06 | 株式会社高研 | Carrier for sustained drug release and method for sustained drug release |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57125745A (en) * | 1981-01-27 | 1982-08-05 | Yoshizumi Asakura | Implant material |
-
1983
- 1983-02-17 JP JP58025995A patent/JPS59151951A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57125745A (en) * | 1981-01-27 | 1982-08-05 | Yoshizumi Asakura | Implant material |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0366218U (en) * | 1989-10-24 | 1991-06-27 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59151951A (en) | 1984-08-30 |
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