JPS62129060A - Set for treating body fluids - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] (Industrial Application Field) The present invention is used for safely extracorporeally circulating body fluids from healthy body fluid donors (hereinafter simply referred to as "donors") and patients. This relates to a set for treating body fluids, and examples of body fluids include blood and ascites. Extracorporeal circulation treatments include hemodialysis, blood swab, plasma separation, plasma component fractionation, ascites concentration, ascites swab, adsorption, and the like.

(Prior art and its problems) Extracorporeal circulation processing circuits for collecting plasma from blood and for other body fluids have a complex structure combining various functional parts, so it is necessary to consolidate the functional parts as much as possible to create an integrated structure. Attempts to do so have been proposed so far.Representative known techniques include JP-A-54-113998;
There is Japanese Patent Application Laid-Open No. 60-500159.

The integral structure shown in these figures has a shape in which a relatively hard, non-flexible molded body with a curved surface is laminated with a substantially flat flexible film, and the space formed between the two can be used for various purposes. Functional parts, such as a pump function part, a blood conduit part, a part of a filter, a pressure-proof measuring part.

It consists of a positive pressure measuring section, a valve section, a part of a drip chamber, etc.

However, since these known integral structures alone do not have sufficient functionality, the inventors previously filed a patent application in 1207-1981.
In No. 07, we proposed an invention related to improvements to the pressure regulating section. However, subsequent research has revealed that it is difficult to maintain reliable function even in the valve section using the known integral structure method. In other words, when stress is applied to close the hole due to unavoidable causes such as distortion after molding the valve part, misalignment during film fusion, cracking, shrinkage deformation, etc., it is impossible to bring the two into perfect contact. It is extremely difficult to maintain liquid sealing properties. In addition, the flow of body fluids creates a pressure barrier on the downstream side of the valve, which often causes the film to stick to the non-flexible molded part, making it difficult to pass fluid through.

(Objective of the Invention) The present invention solves the above-mentioned problems with the valve part by disposing a rubber-like elastic body and a protrusion structure, or a rubber-like elastic body with protrusions in the space forming the valve part. This provides good adhesion, ensures reliable liquid sealing, and allows for good liquid passage under reduced pressure.

(Structure of the Invention) The present invention has an integrated structure by laminating a curved non-n-shape polymer molded body, which aggregates the upper part of a circuit for body fluid treatment, and a flexible polymer film. This body fluid treatment set is characterized by arranging a rubber-like elastic body and a protrusion structure, or a rubber-like elastic body with a protrusion structure, in the space forming the valve part, and the effect is reliable for liquid treatment. It maintains sealing performance and good liquid permeability under depressurization.

(Embodiment) Next, the present invention will be explained with drawings.
The body fluid of the present invention is characterized in that the T flexible polymer molded body (1) and the flexible film (2) are bonded together to form an integral structure, and the 671 portion of the circuit for body fluid treatment is formed in the space between the two. The treatment set and the known body fluid treatment set are basically the same.

FIG. 4 shows the structure of a known valve part, in which a flexible film (2) is pressed against a non-flexible restraining part (1) using an electric or air cylinder (3) to shut off body fluids. At this time, a pressure barrier is generated on the downstream side of the body fluid, that is, on the right side of the valve, and when the cylinder is opened, the film (1) is likely to be attracted to the holding part (2) and come into close contact with it. As a result, the flow of body fluids becomes unstable and the predetermined flow rate is not obtained. Figures 1 and 2 show a rubber-like elastic body (4) at the tip of the valve suppressor.
is installed, and a protrusion structure (5) for preventing pressure and suction is also placed at the same time. FIG. 1 shows an embodiment using a flat rubber-like elastic body, and FIG. 2 shows an example using a round-bar-shaped rubber-like elastic body. Further, the protruding structure is a thin prismatic or cylindrical structure having a size that does not obstruct the flow of fluid, and one or more protruding structures are installed before and after the tip of the valve suppressor. In addition, in the valve structure of the present invention, the elastic deformation of the film and the rubber-like elastic body is large, so it is easy to achieve complete contact, and the liquid-sealing property is improved. is reliably maintained. Furthermore, when the valve is opened, the projection prevents the film from coming into contact with the valve restraining portion, and the pressures before and after the valve immediately become equal, and liquid permeability is maintained.

Non-flexible polymer moldings that form curved surfaces include polyvinyl chloride resins, polyolefin resins, polystyrene resins, polyamide resins, polyacrylic resins, polyester resins, polyether resins, and cellulose resins. etc. can be used. On the other hand, as the polymer flexible film, the same material as the polymer molded product or a combination of different materials that can be bonded can be used, but in order to impart flexibility, l-0.01 mm, preferably A film having a thickness of 0.6 to 0.1 mm is preferable, and a film made flexible by adding a plasticizer can also be used.

In the space of the valve part formed by the polymer molded body (1) and the polymer film (2), as shown in Figs. Rubber-like elastic bodies include rubbers such as urethane rubber, silicone rubber, butadiene rubber, nitrile rubber, and imprene rubber, thermoelastomers represented by ethylene-propylene copolymers, and soft vinyl chloride. Any material that exhibits rubber-like elasticity, such as flexible thermoplastics such as resin, may be used.The shape is not particularly limited, such as plate, cylindrical, semi-cylindrical, triangular prism, etc., for suction prevention. The protrusion needs to be long enough to maintain a distance between the holding part (1) and the film (2) so that they do not normally come into contact with each other. Its length is in the flow path,
This should be determined depending on the flow rate and the strength of the pressure barrier depending on the flow rate, but it is appropriate that the restraining part and the film maintain a space of 0.5 to 3 mm.

If it is less than 0.5 mm, adhesion due to the interfacial tension of the liquid cannot be ignored, and if it exceeds 3 mm, the cylinder pressure will be excessive, which is wasteful.

[Brief explanation of drawings]

Figures 1 to 3 show embodiments of the present invention, and Figure 1 shows a plate-shaped elastic body and a valve in which one pressure-reducing suction prevention protrusion is disposed before and after the valve. The figure shows a cylindrical rubber-like elastic body and two protrusions arranged at the front and rear of the valve. FIG. 3 shows a valve structure in which the plate-shaped rubber elastic body itself has projections and depressions to provide both adhesion and suction prevention functions, and FIG. 4 shows a known valve structure. 1 /< Lube suppressing part (non-flexible polymer molded body) 2 Film (flexible) 3 Cylinder 4 Rubber-like elastic body 5 Projection structure

Claims (1)

[Claims] In a body fluid treatment set that has an integrated structure by laminating a non-flexible polymer molded body with a shape that consolidates the functional parts of the body fluid treatment circuit and a substantially flat flexible polymer film, the valve part 1. A set for body fluid treatment with improved liquid sealing properties and liquid permeability under negative pressure, characterized in that a rubber-like elastic body and a protrusion structure, or a rubber-like elastic body with protrusions are arranged in a space forming a body fluid.