JPS62115079A - Self-adhesive tape - Google Patents

Abstract

PURPOSE:To prevent the bonding between self-adhesive tapes themselves, by cutting the edge portion of a tape material comprised of a self-adhesive layer formed on a substrate diagonally with respect to the surface of the substrate and exposing the edge portion to irradiation. CONSTITUTION:A self-adhesive tape comprised of a self-adhesive layer formed on a substrate, wherein the edge portion of the self-adhesive tape material is diagonally cut at an angle of 10-80 deg. with respect to the surface of the substrate. The edge portion is directly exposed to irradiation, or is coated with a soln. contg. a peroxide and/or a vinyl polymer prior to irradiation. In a preferred embodiment of the tape, a percutaneously absorbable medicine is used. Any of topical or systemic medicine may be used as far as the medicine can be percutaneously absorbed into a living body and exhibits a pharmacological effect when the tape is applied on the skin. The self-adhesive agent may contain a proper amt. of an additive such as tackifier resin, liq. gum, and softener in order to modify the glass transition point of the polymer.

Description

Detailed Description of the Invention (a) Industrial Application Field The present invention relates to an adhesive tape that prevents adhesive from extruding from the side surfaces of the adhesive tape and prevents adhesive tapes from adhering to each other when multiple adhesive tapes are overlapped. It is something.

(b) Conventional technology Traditionally, adhesive tapes are made by applying an adhesive mainly composed of polyester, rubber, etc. onto a support such as polyvinyl chloride, polyethylene, rubber, paper, cellophane, polyester, or fluororesin. It is manufactured by drying to form an adhesive layer, pasting a separator treated with silicone or the like on the exposed surface of the adhesive layer, and then cutting it into appropriate dimensions.

When these adhesive tapes are stored, adhesive flows out from the cut surface, so-called "glue extrusion" occurs, and dust or the like adheres during storage and/or use, or when multiple adhesive tapes are overlapped, Inconveniences may arise during use, such as the adhesive tapes adhering to each other or the sides of the adhesive tape adhering to the packaging material, making it difficult to remove from the packaging material.

In order to solve these drawbacks, conventional methods have been to use the dry Ninono method, which uses a separator that is larger in size than adhesive tape, or to package individual items using packaging materials that have been treated with release treatment such as silicone. However, there were problems such as increased manufacturing costs.

For this reason, ultraviolet rays or electron beams (
Attempts have also been made to harden the adhesive by irradiating it with radiation (hereinafter referred to as irradiation radiation), thereby preventing "glue from extruding"; At least 2 from the side and the left side
This requires multiple irradiations, which is extremely uneconomical, and for this reason, the entire surface of the adhesive tape is usually irradiated with the irradiation rays.

(c) Problems to be solved by the invention However, in adhesive tapes obtained by irradiating the entire surface of the adhesive tape with radiation, the adhesive hardens, changes in quality, or decomposes due to the action of the radiation, resulting in a decrease in adhesive strength. Problems have arisen, such as deterioration or decomposition of the ingredients in the adhesive.

(d) Means for solving the problem The inventors of the present invention have found that the above problem can be solved by cutting the edge of the adhesive tape diagonally and removing the adhesive layer at the edge. The present invention was completed based on the discovery that irradiation can be applied directly to exposed areas or after coating a solution containing peroxide and V/vinyl polymer compound.

That is, the present invention is an adhesive tape material formed by forming an adhesive layer on a support, the edge of which is cut diagonally at an angle of 10 to 80 degrees with respect to the surface of the support,
and is characterized by being formed by directly applying a solution containing a peroxide and/or a vinyl polymer compound to the 1 & part and irradiating it with radiation.

The present invention will be explained in detail below.

Examples of the support used in the present invention include polyvinyl chloride, polyethylene, rubber, paper, cellophane, polyester, and fluorine at II.

Further, the adhesive layer used in the present invention is not particularly limited as long as it has pressure-sensitive adhesive properties at room temperature. and the glass transition point is -70 to -10
C1 is preferably selected from those in the range of -55 to -25°C, and examples include one type or a stack of two or more types thereof.

Specific examples of the synthetic trees include acrylic polymers, polyvinyl ethers, polyurethanes, polyesters, polyamides, ethylene-vinyl acetate copolymers, and the like.

Specific examples of rubber-based substances include rubbers such as styrene-isoprene-styrene block copolymer rubber, styrene-butane rubber, polybutene rubber, polyisoprene rubber, butyl rubber, silicone rubber, natural rubber, and synthetic imprene rubber. etc.

In order to adjust the glass transition temperature of the polymer, appropriate amounts of compounding agents such as tackifier resin, liquid rubber, and softener may be added to the above-mentioned pressure-sensitive adhesive.

Among the above-mentioned pressure-sensitive adhesives, one of the preferred adhesives is a homopolymer of an acrylic ester in which the alkyl group has 4 or more carbon atoms or an acrylic copolymer containing at least 50% by weight of an alkyl ester of methacrylic acid. be.

Examples of the acrylic copolymer include a copolymer of a (meth)acrylic acid alkyl ester and a functional monomer and/or vinyl nystermo/mer copolymerizable therewith.

The above functional monomer is desirably in a range of 0 to 20% by weight, preferably 0.5 to 10% by weight based on the entire copolymer, and the vinyl ester monomer is preferably in a range of 0 to 20% by weight based on the entire copolymer. ~40% by weight, preferably 5-30% by weight
It is desirable that the range be within the range of .

The above-mentioned functional monomer can improve the cohesiveness of the copolymer depending on the number of parts added, or change the hydrophilicity of the copolymer depending on the type of monomer. It causes intra- or intermolecular cross-linking.

On the other hand, the above-mentioned vinyl ester monomer contributes to adhesiveness.

Examples of the (meth)acrylic acid alkyl ester, functional monomer, and vinyl ester monomer include the following.

Examples of (meth)acrylic acid alkyl esters include n-butyl (meth)acrylate, hexyl (meth)acrylate, 2-ethylbutyl (meth)acrylate, inoctyl (meth)acrylate, and 2-ethyl (meth)acrylate. - Ethylhexyl, (meth)acrylic acid/nyl, decyl (meth)acrylate, dodecyl (meth)acrylate, tridecyl (meth)acrylate, and the like.

Examples of functional monomers include (meth)acrylic acid,
itaconic acid, maleic acid, maleic anhydride, hydroxyethyl acrylate, hydroxypropyl acrylate, (
Octyl meth)acrylate, ethoxyethyl (meth)acrylate, butoxyethyl acrylate, (meth)acrylamide, dimethylacrylamide, trimethylaminomethyl (meth)acrylate, monobutylaminoethyl (meth)acrylate, acrylonitrile , vinylpyrrolidone, vinylimiguzole and the like.

Furthermore, examples of vinyl ester monomers include vinyl acetate and vinyl propionate.

In addition, the transdermal absorbable drug used in a preferred embodiment of the present invention is one that is transdermally absorbed into the body when an adhesive tape is applied to the outer skin, and has the potential to exert a pharmacological effect. Either local or systemic drugs can be used.

Examples of such drugs include those listed below, and two or more of these drugs may be used in combination as necessary.

b) Flutifsteroids: For example, hydrocortiscin, prednisolone, beclomethasone propionate, flumethacin, triamcinolone, triamcinolone acetonide, fluocinolone acetonide, fluocinolone acetonide,
Fluocinolone acetonide acetate, clobetasol propionate, etc.) Analgesic anti-inflammatory agents: e.g. acetamino-7-ene, mefenamic acid, flufenamic acid, indomethacin, dichlo-7-enac, dichlo-7-enac sodium, alcro-7-enac, oxy-7-enbutazone, phenylbutazone. Syn, infuro-7ene, flurbipro-7ene, salicylic acid, methyl salicylate,! - Menthol, Kan7ar, Sulindac, Tolmetin Sodium, Naproxen, 7en, etc. c) Hypnotic Ii tranquilizers: For example, phenobarbital, amobarbital, cyfrobarbicur, triazolam, nitrazepam, lorazepam, halobe17)' 2) Tranquilizers: e.g. fluzenanone, teolitanone, diazepam, fludiazepam, flunitrazebam, haloperidol, chlorpromazine, etc. e) Antihypertensive agents: e.g. clonidine, clonidine hydrochloride, etc.
Pindolol, Propranolol, Probraf Hydrochloride 0-
g) Antihypertensive diuretics: e.g. hydrothiazide, bendroflumethiazide, cyclopenthiazide, etc. g) Antibiotics: e.g. penicillin, tetracycline,
Oxytetracycline, furanomycin sulfate, erythromycin, chloramphenicol, etc.; 1) Anesthetic agents, such as docaine, nobuirine hydrochloride, benzicaine, ethyl amylbenzoate, etc.; 4) Antibacterial substances, such as benzalcohydrochloride. g) Antifungal substances: e.g. pentamycin, amphotericin B, virolnidrine, tarotrimazole, etc. l) Vitamin preparations: e.g. vitamin A1 ergocalciferol, cholera Calciferolazine, riboflavin butyrate, etc., w) Anti-epileptic drugs: [If you ask, nitrazebam, mebrobamate, clonazepam, etc., w) Coronary vasodilator W11 + For example, nitroglycerin,
Nitroglycol, insorbide nonitrate, erythwatol tetranitrate, pentaerythritol tetranitrate, propyl nitrate, etc.) Antihistamines: e.g. noaenhydramine hydrochloride,
Chlorpheniramine, nophenylimiguzole, etc. ii) Antitussives: For example, dextromethorphan hydrobromide, terptasone sulfate, ephedrine, ephedrine hydrochloride, salbutamol sulfate, isoproterenol hydrochloride, isoprotelemer sulfate, etc. ri) Sex hormones: e.g. propsterone, estradiol, etc.; ii) Anti-inflammatory agents: e.g. doxepin) Cerebral circulation reforming agents: e.g. hydergine, iaenprodil, etc.; t) Anti-emetics, anti-ulcer agents: e.g. metoclopramide, clebopride, tonpelitone, sufboramine, bromide. sufpolamine hydroxide, etc.) Biomedicine: For example, polypeptide fi (TRH, LI
IRH transparent conductors), brostagranones, etc.
Others: Examples include 7-entanyl, digoxin, desmopressin, nohydroergotamine methanesulfonic acid, nohydroergotamine tartrate, 5-fluorouradil, mercaptopurine, and the like.

These drugs can be used in a mixed system with a compounding agent such as a solubilizing agent, if desired. Examples of the dissolved M include benol alcohol, butyl benzoate, isopropyl myristate, octyl, 1,3-butanediol, propylene glycol, crotamiton, polypropylene glycol, ethylene glycol, glycerin, and the like.

The mixing ratio of the above-mentioned adhesive and drug varies depending on the adhesive used, the type of drug, and the amount, but usually the ratio of the drug in the mixture of both is in the range of 0.1 to 30% by weight. It is preferable to adjust it to 111.

In order to produce the adhesive tape of the present invention, an adhesive layer is formed on a support by a known method, or an adhesive layer is formed on a release sheet by a known method, and the adhesive layer is It is formed into an adhesive tape material by various methods such as transferring onto a support, and the adhesive tape material is cut into a desired size.

In this case, the adhesive tape piece is cut so that the edges are diagonal.

The cutting angle of the cut surface of the thus obtained adhesive tape piece is preferably set so that θ shown in FIG. Preferably θ is 10 degrees to 60 degrees.

The irradiation may be either ultraviolet rays or electron beams, and the irradiation may be applied directly or by applying a peroxide such as benzoyl peroxide and/or an organic solvent solution of a vinyl polymer compound to improve the crosslinking rate. After that, radiation may be irradiated. The output of the electron beam is preferably in the range of 100 to 500 kcV, and the irradiation amount of the electron beam is 0.1 to 20 Mrad.
Let's do it! ! The larger the N firing rate, the greater the bridging effect.
It is effective in preventing "glue oozing out".

However, in the present invention, the edge of the sheet-like adhesive tape piece is cut diagonally and the exposed adhesive surface is effectively irradiated with the electron beam, so even a small output can be seen to be sufficiently effective, and in actual use. 0.1 at an output of 100 to 200 keV
If irradiation is carried out at -5 Mrad, it is possible to prevent "glue extrusion".

In addition, when electron beam irradiation is performed at a low power, the cured layer becomes only a very rough part from the side surface, and the inside of the adhesive layer is not affected, and the adhesive properties are maintained as they are.

Furthermore, as for the above-mentioned ultraviolet rays, those with shorter wavelengths have more energy.
(This is preferable because it has a large effect.)

The above-mentioned peroxide is not particularly limited as long as it generates free radicals when irradiated with radiation and hardens the adhesive by the action of the Ha group, and benzoyl peroxide is a typical example thereof. .

Crosslinking occurs between the vinyl polymer compound and the adhesive. A: Improving speed of drying, curing 1111] Useful for increasing surface strength, examples include vinyl acetate-ethylene copolymer, styrene-butadiene copolymer, and tetraethylene glycol diacrylate copolymer.

Since the adhesive tape thus obtained has a shape in which the edges are cut diagonally, fingers can easily get caught in the separator, making it easy to peel off and easy to handle during use.

On the other hand, during adhesion, the angle between the adhesion surface and the side surface of the support is gentle, making it less susceptible to external stress (and has a shape that is difficult to peel off) compared to a typical sheet-shaped adhesive tape cut at 90 degrees. be.

(e) Effect The adhesive tape of the present invention has its edges cut diagonally, and only the exposed areas of the adhesive layer at the edges are irradiated with radiation to harden the exposed areas of the adhesive layer. This has the effect of preventing glue from oozing out from the edges.

In addition, since the irradiation beam is irradiated to the sloped area at the edge of the adhesive tape from a direction perpendicular to the adhesive tape, the output of the irradiation beam may be small. Since the radiation is only applied to the adhesive tape and not the entire surface of the adhesive tape, the adhesive strength of the adhesive tape may decrease or the compound in the adhesive layer may decompose or change in quality. It has the effect of preventing problems from occurring.

(f) Examples Hereinafter, the present invention will be explained in detail based on Examples, but the present invention is not limited thereto.

In the examples, parts or % mean parts by weight or % by weight.

Adhesive cheese 7 1) of the present invention was obtained by the method described below.

Example 1 A polyethylene terephthalate sheet with a thickness of 20 IJa+ was used as the support (2), and acrylic 1! Adhesive consisting of 95 g of a2-ethylhexyl and 5 parts of acrylic acid (
Tg = -40°C), and the adhesive was applied to the support (2).
) onto the support (2) to a thickness of 80 μm.
) was formed on the adhesive Wl/H (3) to obtain an adhesive tape material.

Note that (4) is a release sheet that protects the exposed surface of the adhesive layer (3).

The adhesive tape material obtained in this way was 5CI11 x 5cm.
Cut into corners. In this case, the edge (1'
) is cut so that θ is 30 degrees as shown in FIG. 1, and the edge (1') is irradiated with an electron beam from the side of the support (2) using IMrad to prepare the adhesive tape of the present invention. (1) was obtained.

Example 2 The 5 cm x 5 cm square piece of adhesive tape obtained in Example 1 was used. In this case, the edge (1') of the adhesive tape piece is cut so that θ is 50 degrees in the same way as in Example 1, and the edge (1') is Line 0.3
The adhesive tape (1) of the present invention was obtained by irradiating with Mrad.

Example 3 A polyethylene sheet with a thickness of 40 μm was used as the support (2), and 40 parts of styrene-isoprene-styrene block copolymer (isoprene content 40%), 40 parts of terpene resin, 10 parts of olive oil, and Using an adhesive (Tg = -40°C) consisting of 10 parts of dimethyl sulfoxide, the adhesive was applied to the support (2) to a thickness of 100 μm.
A pressure-sensitive adhesive layer (3) was formed on the support (2), thereby obtaining a pressure-sensitive adhesive tape material.

The adhesive tape material was cut into 5cI11×50IL1 square.

In this case, the edge (1') of the adhesive tape piece in Example 1
Similarly, cut so that θ is 45 degrees, and cut this edge ff
After applying tetraethylene glycol diacrylate to the cut surface of 1s (1'), an electron beam of 2 Mrad was irradiated from the supporting water (2) side to obtain the adhesive tape (1) of the present invention.

In this case, as in Example 1, the exposed surface of the adhesive layer (3) was covered with a release sheet (4).

Example 4 A polyethylene sheet with a thickness of 10μ[n was used as the support (2), and 70 parts of acrylic l'122-ethylhexyl, 5 parts of acrylic acid, and 25 parts of isobutyl acrylate were used as the support (2).
Using a t/i product'I (Tg = 35°C) consisting of 300 ml of adhesive, apply one coat of adhesive on the support (2) to a thickness of 50 μm. ) Adhesive layer (3) on top
After forming, it was covered with a release sheet (4), thereby obtaining an adhesive tape material.

The adhesive tape material was cut into 5 cm x 5 cm squares.

In this case, the edge (1') of the adhesive tape piece in Example 1
Similarly, cut so that θ is 45 degrees, and cut this edge (1
After applying a 5% solution of benzoyl peroxide in ethyl acetate to the cut surface of the support (2), an electron beam was applied from the side of the support (2).
The adhesive tape (1) of the present invention was obtained by irradiating with rad.

Example 5 Polyethylene terephthalate with a thickness of 20 μm was used as the support (2), and 2-ethylhexyl acrylate 9
5 parts of acrylic acid (Tg=-40
After mixing 10% by weight of isosorbidinyl F-rate at a temperature of 10°C, the drug-containing adhesive was applied to the support (2).
Coat the support (2) to a thickness of 50 μm on top.
After forming an adhesive layer (3) thereon, it was covered with a release sheet (4), thereby obtaining an adhesive tape material.

The adhesive tape material was cut into a 5 cm x 5 c+a square.

In this case, the edge (1') of the adhesive tape piece in Example 1
Similarly, cut so that θ is 45 degrees, and cut the above support (
2) IMrad electron beam was irradiated from the surface side to obtain the adhesive tape (1) of the present invention.

Comparative Example 1 The adhesive tape material obtained in Example 1 was cut into a 5cm+a×5cm square so that θ was 90 degrees, that is, the edges were not cut diagonally.

Comparative Example 2 A cut piece of the adhesive tape of Comparative Example 1 was irradiated with IMrad electron beam from the support (2) side.

Comparative Example 3 The pressure-sensitive adhesive sheet material obtained in Example 3 was cut into 5 cm x 5 cm squares so that θ was 90 degrees, that is, the edges were not cut diagonally.

Comparative Example 4 After applying tetraethylene glycol diacrylate to the cut surface of the cut piece of the adhesive tape of Comparative Example 3, the cut piece was irradiated with 2 Mracl of electron beams from the support (2) side.

Comparative Example 5 The pressure-sensitive adhesive sheet material obtained in Example 5 was cut into 5 cm x 5 cm squares so that θ was 90 degrees, that is, the edges were not cut diagonally.

Experimental Example 1 Mutual a″4 property during storage After stacking and sealing each 10 samples, the temperature was 50’C.
Each sample was left in a thermostatic chamber at a temperature of 70° C. for one month, and the mutual adhesion between the samples was evaluated using the method described below.

Evaluation score 5... 80% of the edge cut surface is bonded 4... 60-79% of the edge cut surface is bonded 3... the edge cut surface is bonded 4
0 to 59% adhesive 2... 20 to 39% of the cut edge surface is bonded 1... 19% or less of the edge cut surface is bonded ○: Average evaluation score is 1.0 to 2.0 Δ : The average of lW value points was 2.1-4.0'y, Experimental Example 2 Each sample was applied to the backs of 10 skin-adhesive pollantia for 24 hours.
Adhesive strength was evaluated.

Evaluation score 5: 80% or more of the adhesive surface peels off 4...P
j: 50% or more of the bonded surface is peeled 3...20% or more of the bonded surface is peeled 2...10% or more of the bonded surface is peeled 1...Less than 10% of the bonded surface is peeled ○: Evaluation Average score is 1.0 to 2.0 Δ: Average score is 2.1 to 4.0 ×: Average score is 4.1 to 5.0 Experiment 3 'Residual rate of drug 5 cmX 5 cm The samples of Example 5 and Comparative Example 5 (n = 10) cut into corners were extracted three times with 15 mN methanol, and after adding ethylparaben as an internal standard, the total volume of the extract was adjusted to 50 mfl, and the liquid It was determined by chromatography. In addition, the residual rate was calculated using the following formula.

(Left below) Table 1 From Table 1, it is clear that the adhesive tape of the present invention can be stored at high temperatures.
There was almost no problem of ``glue extrusion,'' and the skin adhesion was good, with almost no decrease in adhesion to the skin or decomposition of the drug in the adhesive.

(g) Effects of the Invention As a result of the adhesive tape of the present invention having the above-mentioned structure, "glue extrusion" hardly occurs, and therefore, there is no possibility that dust may adhere to the side surface of the adhesive tape during storage or use. When two adhesive tapes are stacked, there are almost no problems such as the adhesive tapes adhering to each other or the sides of the adhesive tapes adhering to the packaging material, making it difficult to remove them.

In addition, the adhesive tape of the present invention is formed by irradiating only the edges with radiation to harden the exposed portion of the adhesive layer at the edges, and since the entire adhesive tape is irradiated with radiation, Because there is no adhesive, problems such as the adhesive hardening, deterioration, or decomposition resulting in a decrease in adhesive strength, or the deterioration or decomposition of compounds such as drugs in the adhesive can be achieved.

[Brief explanation of drawings]

FIG. 1 is an enlarged sectional view of the adhesive tape of the present invention. 1...adhesive tape, 1'...edge, 2...Support, 3... Adhesive layer.

Claims (2)

[Claims] (1) An adhesive tape material comprising an adhesive layer formed on a support, the edge of the adhesive tape material being cut diagonally at an angle of 10 to 80 degrees with respect to the surface of the support, and An adhesive tape formed by directly applying a solution containing a peroxide and/or a vinyl polymer compound to the edge and irradiating it with radiation. (2) The adhesive tape according to claim 1, wherein the adhesive layer contains a transdermally absorbable drug.