JPS6163692A - Novel 2'-5' oligoadenylic acid compound, preparation thereof and antigen for 125i-labeling composed of same used for 2'5' oligoadenylic acid measurement by radioimmunoassay - Google Patents

Novel 2'-5' oligoadenylic acid compound, preparation thereof and antigen for 125i-labeling composed of same used for 2'5' oligoadenylic acid measurement by radioimmunoassay

Info

Publication number
JPS6163692A
JPS6163692A JP18287184A JP18287184A JPS6163692A JP S6163692 A JPS6163692 A JP S6163692A JP 18287184 A JP18287184 A JP 18287184A JP 18287184 A JP18287184 A JP 18287184A JP S6163692 A JPS6163692 A JP S6163692A
Authority
JP
Japan
Prior art keywords
labeling
radioimmunoassay
antigen
oligoadenylic acid
alanyltyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP18287184A
Other languages
Japanese (ja)
Other versions
JPH0631309B2 (en
Inventor
Kaichiro Ishibashi
Masao Ito
Hiroaki Sawai
Original Assignee
Hiroaki Sawai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hiroaki Sawai filed Critical Hiroaki Sawai
Priority to JP18287184A priority Critical patent/JPH0631309B2/en
Publication of JPS6163692A publication Critical patent/JPS6163692A/en
Publication of JPH0631309B2 publication Critical patent/JPH0631309B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NEW MATERIAL:Methyl ester of 5'-triphospho (adenylyl 2'-5')2 adenosine-β- alanyltyrosine, expressed by formula I.
USE: An antigen for labeling with 125I, used to measure 2'-5' adenylic acid with RIA (radioimmunoassay).
PREPARATION: 5'-Monophospho (adenylyl 2'-5')2 adenosine expressed by formula II is oxidized with an oxidizing agent (example; periodic acid, etc.) and further reacted with methyl ester of β-alanyltyrosine in DMF (dimethyl formamide) solvent in the presence of sodium hydroxide to obtain methyl ester of 5'- monophospho (adenylyl 2'-5')2 adenosine-β-alanyltyrosine. The resultant compound is then reacted with N,N'-carbonyldiimidazole in a solvent such as DMF in the presence of triethylamine and tri-n-octylamine, and further reacted with pyrophosphoric acid. Labeling is carried out in 0.05M phosphoric acid buffer solution (7.5pH) using the 125I by chloramine T method.
COPYRIGHT: (C)1986,JPO&Japio
JP18287184A 1984-09-03 1984-09-03 Novel 2'-5 'oligoadenylic acid compound and method for producing the same Expired - Lifetime JPH0631309B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18287184A JPH0631309B2 (en) 1984-09-03 1984-09-03 Novel 2'-5 'oligoadenylic acid compound and method for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18287184A JPH0631309B2 (en) 1984-09-03 1984-09-03 Novel 2'-5 'oligoadenylic acid compound and method for producing the same

Publications (2)

Publication Number Publication Date
JPS6163692A true JPS6163692A (en) 1986-04-01
JPH0631309B2 JPH0631309B2 (en) 1994-04-27

Family

ID=16125886

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18287184A Expired - Lifetime JPH0631309B2 (en) 1984-09-03 1984-09-03 Novel 2'-5 'oligoadenylic acid compound and method for producing the same

Country Status (1)

Country Link
JP (1) JPH0631309B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908610A (en) * 1987-09-28 1990-03-13 Mitsubishi Denki Kabushiki Kaisha Color image display apparatus with color palette before frame memory
JP2007303707A (en) * 2006-05-10 2007-11-22 Tokyo Rika Kikai Kk Dryer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908610A (en) * 1987-09-28 1990-03-13 Mitsubishi Denki Kabushiki Kaisha Color image display apparatus with color palette before frame memory
JP2007303707A (en) * 2006-05-10 2007-11-22 Tokyo Rika Kikai Kk Dryer

Also Published As

Publication number Publication date
JPH0631309B2 (en) 1994-04-27

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