JPS6142729B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION Iodine complexes produced by mixing polyvinylpyrrolidone and iodine are described in U.S. Pat. This was proposed as an advantageous method using This product is preferred for surgical applications where it is applied to the skin prior to incision.

Polyvinylpyrrolidone (hereinafter abbreviated as PVP)
is a water-soluble polymer, and PVP-iodine complex is also water-soluble. This solubility in water may be undesirable in some cases. For example, when used as a water-soluble disinfectant, it lasts only a short time because it is not only easily washed away by water but also washed away by sweat. The water-insoluble complex with iodine is highly persistent as is the modified iodine property.

The object of the present invention is to provide a water-insoluble, long-lasting iodine complex that has pharmacological effects similar to water-soluble PVP-iodine complexes.

Another object of the present invention is to add iodine element in small amounts to
Another object of the present invention is to provide a water-insoluble iodine complex that releases iodine slowly and effectively over a long period of time, reduces the side effects of stimulation, and maintains its bactericidal action for a long time.

Another object of the present invention is to provide a buttress or bandage suture material that has bactericidal and antifungal properties.

Another object of the present invention is to provide a water-insoluble, long-lasting antiseptic ointment for external use.

Other purposes will become apparent from the description below.

Polypyrrolidone has the general formula A polymer (also referred to as nylon-4) having units of the structure shown in FIG. - The difference is that polyprolidone iodine complexes are water insoluble while iodine complexes are water soluble.

It was unexpected that polypyrrolidone forms a complex with iodine. This was unexpected because polypyrrolidone has a polyamide structure and the pyrrolidone ring exists in PVP but not in polypyrrolidone. However, a complex is formed between polypyrrolidone and iodine, and PVP-iodine has no properties other than its solubility in water.
It has properties strikingly similar to complex.

The polypyrrolidone used to form the iodine complex can be used in various forms such as powdered resin, pulp (fibrils), extruded rods, fibers, fabrics from fibers, films, or other molded bodies. sell. In order to produce ointment, a finely divided powdered resin may be used, and the molecular weight is not important. In order to produce sutures, bandages, bandages, and knitted fabrics, melt spinning is necessary to produce filaments or fibers. For this purpose, a polymer with good thermal stability is required, and molecular weight is an important factor.

in hexafluoroisopropanol at 25 °C.
Molecular weights that give an intrinsic viscosity of at least 2.0 d/g as a 0.5 g/d solution are desirable. For melt spinning, the intrinsic viscosity is 3.0 to 4.0 or
Those higher than this are particularly preferred. A method for making polymers of 2-pyrrolidone with properties of this type is described in US Pat. No. 3,721,652. A method for measuring intrinsic viscosity is also described in that patent.

Polypyrrolidone-iodine complex is
The polypyrrolidone product may be prepared by soaking it in an aqueous iodine-potassium iodide solution.

A preferred composition is 3.3 g of potassium iodide, 100 ml of water and 2.0 g of iodine.

When a white polypyrrolidone product is immersed in this solution, it almost instantly changes color to a dark tyokolate brown and then to black.

When dry, the color becomes lighter. An immersion time of several seconds to a few minutes is sufficient. A short soaking time will give the dried product a golden color, whereas a long soaking time will give the dried product a dark brown color. The color of the dried complex indicates the degree of iodine content.
Excessive iodine content degrades the polypyrrolidone polymer and should be avoided where non-degradation is important, such as in textile fibers.

Polypyrrolidone products can also be prepared by other methods such as exposing to iodine vapor or grinding iodine crystals with powdered resin to form polypyrrolidone-iodine complexes.

On the other hand, after mixing the iodine crystals, the polypyrrolidone resin may be processed in a ball mill to form a powdered complex, used as a dry powder, or incorporated into an ointment. Anti-caking agents or other compounds that provide a medicinal effect may also be included in the mixture. In the formulation of the ointment, desired bases such as lanolin, mineral oil, potassium stearate, and others may be used.

The iodine is held fairly tightly in the complex. For example, if absorbent cotton (or other hydrophilic fibers) is soaked in the iodine solution obtained according to the above formulation, it will turn dark brown as well. but,
The iodine is only physically retained and is washed out within 1 minute by washing with water. However, in the case of the dark brown complexes formed in polypyrrolidone, the iodine is not easily washed out with water. A small amount of iodine is released, but the rate of release is temperature dependent. At room temperature, the release rate is significantly slower, but at about 100°C it is significantly faster. Therefore, if the complex is placed in boiling water, the iodine can be completely released within a few minutes. Similarly, if placed in a 100°C warmer, iodine sublimes from the complex to form colorless polypyrrolidone in a short time.
Samples can be stored for several months at room temperature without losing much of the iodine content. If it is 40℃,
During 24 hours, very little iodine will be lost. The complex is almost unaffected by changes in pH, and the iodine component content (iodine ions) does not drop significantly in the pH range of 5 to 10.

In order to be effective, iodine must be released slowly. At body temperature, this iodine release occurs at a reasonable rate. For a variety of reasons, the hotpot or bandage is replaced every 24 hours, and the complex must remain effective during this time. PVP-Iodine
An important aspect of polypyrrolidone-iodine complexes, in contrast to polypyrrolidone-iodine complexes, is that the disinfectant does not run off when the hotpot or bandage or other product becomes wet, such as with perspiration.

Another aspect of the invention is to provide a sterile suture. In this type of use,
The polypyrrolidone resin is melt spun at about 290° C. under the pressure of an extruder screw. Before melt extrusion, approx.
Melt extrusion must be carried out by sending dry nitrogen gas into the feeder that feeds the extruder to dry it to less than 0.03% moisture and to prevent moisture from being taken in.

The molten resin is spun through a spinneret with a single spinning hole to form a monofilament or through a spinneret with multiple spinning holes to form textile fibers. The hole size and degree of elongation are
Determined by the diameter and tensile strength of the filament or multifilament.

In some applications, a multifilament structure is desired. In either case, the suture is passed through an iodine solution of the composition described above. The residence time in the bath is from a few seconds to a few minutes, depending on the desired iodine content of the complex. The resulting material is briefly washed with water and air dried.

For headband or bandage applications, polypyrrolidone fibers are used to make suitable knitted fabrics and treated in a similar manner through an iodine solution.

Polypyrrolidone-iodine complex is
It can also be used for various other purposes. For example, it may be used as an inner layer of a package to provide a sterile barrier, thereby rendering the packaged contents sterile, or as a low concentration source of iodine vapor to create a sterile atmosphere.

It should be understood that there are various other embodiments of the invention and the invention is not limited to the examples described herein.

Claims (1)

[Claims] 1. Polypyrrolidone-iodine complex. 2 Ointment containing polypyrrolidone iodine complex. 3. A sterilizing powder containing polypyrrolidone iodine complex.