JPS61243016A - Tablet having columnar part containing active constituent - Google Patents

Abstract

PURPOSE:A tablet, having a columnar part containing an active constituent perpendicular to the flat surface of the tablet in the inside of the peripheral part thereof, and constituted to release the active constituent at a constant rate after the administration. CONSTITUTION:A tablet obtained by forming a peripheral part 1 thereof in the ring form from a material disintegrating slowly in the digestive tract, and a part 2 containing a columnar part containing the active constituent perpendicular to the flat surface of the tablet from a mixture of the material slowly disintegrating similarly in the digestive tract with the active constituent perpendicular to the flat surface of the table,t and integrating both parts. The length (B) of the column in the part 2 containing the active constituent is >= twice based on the width (A) of the ring in the peripheral part. The above-mentioned tablet disintegrates at the same rate of the upper and lower cut end of the part 2 containing the active constituent as the surface of the peripheral part 1, and the exposed surface area of the part 2 containing the active constituent does not change even if the tablet becomes small. Therefore, the release rate of the active constituent is kept at a constant value.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to tablets designed to release active ingredients at a constant rate after the tablet is taken.

When taking pharmaceutical drugs orally, sustained-release tablets are used that release the active ingredient over a long period of time in order to reduce the number of times the drug is taken and to maintain its efficacy even during sleep.

However, after taking conventional sustained-release drugs, the surface area gradually decreases in the gastrointestinal tract, so the active ingredient released also decreases.
As a result, the amount gradually decreases, resulting in a drawback that sufficient medicinal efficacy cannot be expected.

The object of the present invention is to provide a tablet that releases active ingredients at a constant rate over a long period of time after taking the tablet.

To explain this invention based on the drawings, in FIGS. 1 and 2, a peripheral portion 1 of the tablet is formed in an annular shape with a material that gradually disintegrates in the digestive tract, and inside thereof, a material that gradually disintegrates in the digestive tract is formed. It is made by adding active ingredients to the ingredients used in
2. a column-shaped active ingredient-containing part' perpendicular to the flat surface of the tablet; The tablet is formed by integrating the image part into a tablet.

The dimensional ratio of this tablet is the width A of the ring of the peripheral portion '1 in Fig. 2.
In contrast, the length B of the pillar of the part 2゛ containing the active ingredient is 2
Do it within twice as much.

Because this tablet is constructed in this way, the upper and lower ends of the part 2 containing the active ingredient and the surface of the surrounding part 1 disintegrate at the same speed in the digestive tract, so that even if the tablet becomes small, the active ingredient can be absorbed. Since the exposed area of the containing portion, 2. does not change, the release rate of the active ingredient remains constant until the tablet is exhausted.

Therefore, when taking drugs that need to maintain a constant blood concentration, such as anticancer drugs, antibiotics, and treatments for diseases that cause seizures, this tablet will increase the therapeutic effect and increase the number of times the drug is taken. can be reduced. Furthermore, this tablet can be applied not only to internally administered drugs, but also to disinfectants for environmental hygiene, chemical reaction agents for industrial use, etc., which require gradual release of active ingredients over a long period of time.

[Brief explanation of drawings]

FIG. 1 is a perspective view of the tablet, and FIG. 2 is a longitudinal sectional view of the tablet.

Claims (1)

[Claims] A tablet characterized by having a columnar active ingredient-containing part (2) perpendicular to the flat surface of the tablet inside the peripheral part (1) of the tablet.