JPS61206459A - Catheter - Google Patents
CatheterInfo
- Publication number
- JPS61206459A JPS61206459A JP60046516A JP4651685A JPS61206459A JP S61206459 A JPS61206459 A JP S61206459A JP 60046516 A JP60046516 A JP 60046516A JP 4651685 A JP4651685 A JP 4651685A JP S61206459 A JPS61206459 A JP S61206459A
- Authority
- JP
- Japan
- Prior art keywords
- catheter
- polymer membrane
- substances
- blood
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
〔発明の利用分野〕
本発明は内部を二分割され、周辺部にガス、イオン、有
機物、金属などを透過する高分子膜を張り、内部をキャ
リヤー液が循環できるカテーテルに係り、特にクロマト
グラフ、質量分析計などに好適なカテーテルに関する。[Detailed Description of the Invention] [Field of Application of the Invention] The present invention relates to a catheter whose interior is divided into two parts, a polymer membrane permeable to gases, ions, organic substances, metals, etc. is lined around the periphery, and a carrier liquid can circulate inside the catheter. In particular, the present invention relates to a catheter suitable for use in chromatographs, mass spectrometers, and the like.
質量分析計で血液や組織のガス分圧を測定することが可
能であり、幾つかの専用カテーテルが知られている〔ク
リティカル・ケアー・メデイスン（Ｃｒｉｔ、 Ｃａｒ
ａ Ｍａｄ、） 、 ４．２３９−２４４．１９７６）
、これらは、孔を持つ中空状あるいは螺旋溝を持つ棒
状の支持体にガス透過性高分子膜をコーティングした。It is possible to measure gas partial pressures in blood and tissues with a mass spectrometer, and several specialized catheters are known [Critical Care Medicine (Crit, Car)].
a Mad, ), 4.239-244.1976)
These are hollow or rod-shaped supports with spiral grooves coated with a gas-permeable polymer membrane.
血液・組織のガスのみを測定するカテーテルであり、挿
入部位のイオン、有機物、金属などは測定できなかった
。This catheter measures only blood and tissue gas, and cannot measure ions, organic matter, metals, etc. at the insertion site.
一方、山村らは雑誌′医用電子と生体工学′の第２１巻
特別号、 ｐ ５３７ （１９８３）で、体外循環系内
にホローファイバ膜を置き、その内外でガス濃度ＴＰＨ
が平衝する性質を用いて、血中にセンサを挿入しないで
長期に互り安定に血中ガス濃度。On the other hand, in the journal 'Medical Electronics and Bioengineering', Volume 21 Special Issue, p 537 (1983), Yamamura et al. placed a hollow fiber membrane in the extracorporeal circulation system, and the gas concentration TPH was
Using the property of balancing, the blood gas concentration can be stabilized over a long period of time without inserting the sensor into the blood.
ｐＨを測定することを試みている。しかし、本法は体外
循環系内にホローファイバ系インターフェイスを挿入し
ており、これを生体内に血管や組織に挿入することは形
状が大きくて不可能である。I'm trying to measure pH. However, this method involves inserting a hollow fiber interface into the extracorporeal circulation system, and it is impossible to insert this into blood vessels or tissues in vivo due to its large size.
また、ガス濃度とＰＨのみを対象としており、高分子膜
が不充分なので他のイオン、有機物、金属などの測定用
インターフェイスとはならない。In addition, it only measures gas concentration and pH, and because the polymer membrane is insufficient, it cannot serve as an interface for measuring other ions, organic substances, metals, etc.
本発明の目的はガスのみでなく、イオン、有機物、金属
などの血液や組織の濃度を測定するためのカテーテルを
提供することにある。An object of the present invention is to provide a catheter for measuring the concentration of not only gases but also ions, organic substances, metals, etc. in blood and tissues.
人工腎臓では高分子膜を介して、血液と透析液の間で、
イオン、有機物などの交換が拡散現象により行われる。In an artificial kidney, blood and dialysate are passed through a polymer membrane.
Exchange of ions, organic substances, etc. takes place through diffusion phenomena.
透析液の濃度を調節することにより老廃物が血液から除
去され、必要な物質は供給されるようになっている。こ
れと同原理であるが、人工腎臓は透析部であるダイアラ
イザーで大型であるため１体外循環系が必要である。By adjusting the concentration of the dialysate, waste products are removed from the blood and necessary substances are supplied. Although it is based on the same principle, an artificial kidney requires an extracorporeal circulation system because the dialyzer, which is the dialysis unit, is large.
これに対し、本法は人工腎臓に使用す′る高分子膜のう
ち、分子量１０４程度の物質を透過する材料をカテーテ
ル状にし、カテーテル内部をキャリヤー液が循環し、血
液のガス、イオン、有機物、・金属などを洗い出す構造
とした。このカテーテルの構造を第２図に示す。Ｆは軸
方向、Ｇ、Ｈは軸の垂直方向での断面図である。該カテ
ーテルは高分子膜１と、キャリヤー液の流入口と流出口
を隔離する支持体２から成る。カテーテルの流出口側に
はガス、イオン、有機物、金属などの測定装置が接続さ
れ、連続測定が可能である。カテーテルの流出口と流入
口を閉ループにすれば、血液からの有用物質の損失を少
なくできるが、ループ内の容積をできるだけ少なくしな
ければ応答が遅くなる。カテーテルの流出口と流入口を
開ループにすれば、応答は早くできるが、微量分析とな
り高感度の分析装置が必要である。また、長時間に互れ
ば血液内の有用物質の損失も問題となろう。In contrast, in this method, a material that is permeable to substances with a molecular weight of about 104 among the polymer membranes used in artificial kidneys is made into a catheter shape, and a carrier liquid is circulated inside the catheter to remove blood gases, ions, and organic substances.・It has a structure that washes out metals, etc. The structure of this catheter is shown in FIG. F is an axial direction, and G and H are cross-sectional views in a direction perpendicular to the axis. The catheter consists of a polymeric membrane 1 and a support 2 separating the inlet and outlet of the carrier liquid. Measuring devices for gases, ions, organic substances, metals, etc. are connected to the outlet side of the catheter, allowing continuous measurement. A closed loop between the inlet and outlet of the catheter reduces the loss of useful substances from the blood, but the volume in the loop must be minimized or the response will be slow. If the catheter's outflow and inflow ports are made into an open loop, a faster response can be achieved, but this requires a highly sensitive analyzer to analyze trace amounts. In addition, if the treatment lasts for a long time, the loss of useful substances in the blood may also become a problem.
以下、本発明の一実施例を第１図により説明する。第１
図のＡは本発明のカテーテルの軸方向の断面図、Ｂ、Ｃ
，Ｄ、Ｅは軸に垂直方向での断面図である。本カテーテ
ルはポリメチルメタクリレート（ＰＭＭＡ） 、 ｘチ
レンビニ）ＬＩア）Ｌｉ’：１−）Ｌｔ （ＥＶＡ）。An embodiment of the present invention will be described below with reference to FIG. 1st
In the figure, A is an axial cross-sectional view of the catheter of the present invention, B, C
, D, and E are cross-sectional views taken in a direction perpendicular to the axis. This catheter is made of polymethyl methacrylate (PMMA), x tyrene (EVA).
ポリアクリロニトリル（ＰＡＮ）、セルローストルアセ
テート、セルロースアセテート、ポリスルフォン、ポリ
カーボネートなどのように分子量１０４程度の物質が透
過でき、生体適合性のある高分子膜２と、該高分子膜を
透過した物質を運び去るキャリヤー液の通路を持ち、ス
テンレス線のような耐食性・不透過性・柔軟性を持つ、
前記高分子膜の支持体から成る。高分子膜の膜厚は５〜
３０μｍが好ましく、ガス、イオン、有機物、金属など
を透過する。透過したこれらの物質は、キャリヤー液に
より分析装置に導かれ、連続測定が可能である。A biocompatible polymer membrane 2 that allows substances with a molecular weight of about 104 to permeate, such as polyacrylonitrile (PAN), cellulose toluacetate, cellulose acetate, polysulfone, and polycarbonate, and substances that have permeated through the polymer membrane. It has a passageway for carrier liquid to be carried away, and has corrosion resistance, impermeability, and flexibility like stainless steel wire.
It consists of a support for the polymer membrane. The thickness of the polymer membrane is 5~
The thickness is preferably 30 μm, and allows gases, ions, organic substances, metals, etc. to pass through. These substances that have permeated are guided to an analyzer by a carrier liquid and can be continuously measured.
本発明によれば、血液や組織の諸成分を連続的に採集で
きるので、ガスのみでなく、イオン、有機物、金属など
の血液や組織の濃度を測定できる効果がある。According to the present invention, since various components of blood and tissues can be continuously collected, the concentration of not only gases but also ions, organic substances, metals, etc. in blood and tissues can be measured.
第１図は本発明によるカテーテルの一実施例で、Ａは軸
方向の断面図、Ｂ、Ｃ，Ｄ、Ｅは軸に垂直方向での断面
図であり、第２図は本発明の基本的構造図で、Ｆは軸方
向の断面図、Ｇ、Ｈは軸に垂直方向での断面図である。FIG. 1 shows an embodiment of the catheter according to the present invention, where A is an axial cross-sectional view, B, C, D, and E are cross-sectional views perpendicular to the axis, and FIG. 2 shows the basic structure of the present invention. In the structural diagram, F is a cross-sectional view in the axial direction, and G and H are cross-sectional views in the direction perpendicular to the axis.
Claims (1)
組織の挿入部分のガス、イオン、有機物、金属などを透
過させる高分子膜と、該高分子膜を透過した前記物質を
運び去るキャリヤー液の通路を持つ前記高分子膜の支持
体を設けたことを特徴とするカテーテル。 ２、特許請求の範囲第１項に記載のカテーテルにおいて
、高分子膜の材質がポリメチルメタアクリレート（ｐｏ
ｌｙｍｅｔｈｙｌｍｅｔｈａｃｒｙｌａｔｅ、ＰＭＭＡ
）、エチレンビニルアルコール（ｅｔｈｙｌｅｎｅｖｉ
ｎｙｌ−ａｌｃｏｈｏｌ、ＥＶＡ）、ポリアクリロニト
リル（ｐｏｌｙａｃｒｙｌｏｎｉｔｒｉｌｅ、ＰＡＮ）
、セルローストリアセテート（ｃｅｌｌｕｌｏｓｅｔｒ
ｉａｃｅｔａｔｅ）、セルロースアセテート（ｃｅｌｌ
ｕｌｏｓｅａｃｅｔａｔｅ）、ポリスルフォン（ｐｏｌ
ｙｓｕｌｒｏｎ）、ポリカーボネート（ｐｏｌｙｃａｒ
ｂｏｎａｔｅ）などのように分子量１０＾４程度の物質
が透過でき、生体適合性のあることを特徴とするカテー
テル。 ３、特許請求の範囲第２項に記載のカテーテルにおいて
、高分子膜の膜厚が５〜３０μｍであることを特徴とす
るカテーテル。[Claims] 1. In a catheter to be injected into a living body, a polymer membrane that allows gases, ions, organic substances, metals, etc. to pass through the insertion portion of blood or tissue, and carries away the substances that have passed through the polymer membrane. A catheter characterized in that it is provided with a support for the polymeric membrane having a passageway for a carrier liquid. 2. In the catheter according to claim 1, the material of the polymer membrane is polymethyl methacrylate (polymethyl methacrylate).
lymethylmethacrylate, PMMA
), ethylene vinyl alcohol
nyl-alcohol, EVA), polyacrylonitrile (PAN)
, cellulose triacetate
iacetate), cellulose acetate (cell
uloseacetate), polysulfone (pol
ysulron), polycarbonate (polycar
A catheter characterized by being biocompatible and capable of permeating substances with a molecular weight of about 10^4, such as 10^4 molecular weight. 3. The catheter according to claim 2, wherein the polymer membrane has a thickness of 5 to 30 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60046516A JPS61206459A (en) | 1985-03-11 | 1985-03-11 | Catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60046516A JPS61206459A (en) | 1985-03-11 | 1985-03-11 | Catheter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61206459A true JPS61206459A (en) | 1986-09-12 |
Family
ID=12749434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60046516A Pending JPS61206459A (en) | 1985-03-11 | 1985-03-11 | Catheter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61206459A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999045982A3 (en) * | 1998-03-11 | 1999-11-25 | Jan Liska | A catheter to be inserted into a blood vessel, and a method for detection of substances |
| WO2008038015A3 (en) * | 2006-09-28 | 2008-07-03 | Probe Scient Ltd | Molecular exchange device |
| US8961791B2 (en) | 2008-02-13 | 2015-02-24 | Probe Scientific Limited | Molecular exchange device |
-
1985
- 1985-03-11 JP JP60046516A patent/JPS61206459A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999045982A3 (en) * | 1998-03-11 | 1999-11-25 | Jan Liska | A catheter to be inserted into a blood vessel, and a method for detection of substances |
| WO2008038015A3 (en) * | 2006-09-28 | 2008-07-03 | Probe Scient Ltd | Molecular exchange device |
| JP2010504787A (en) * | 2006-09-28 | 2010-02-18 | プローブ サイエンティフィック リミテッド | Molecular exchange equipment |
| RU2470590C2 (en) * | 2006-09-28 | 2012-12-27 | Проуб Сайентифик Лимитид | Device for molecular exchange |
| US8790586B2 (en) | 2006-09-28 | 2014-07-29 | Probe Scientific Limited | Molecular exchange device |
| CN105997100A (en) * | 2006-09-28 | 2016-10-12 | 探测器科学有限公司 | Molecular exchange device |
| US8961791B2 (en) | 2008-02-13 | 2015-02-24 | Probe Scientific Limited | Molecular exchange device |
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