JPS61183203A - Composition for etching - Google Patents

Abstract

PURPOSE:To obtain an etching agent free from adverse effect to the dental pulp and having comparable adhesive strength, by combining ethy lenediaminetetraacetic acid or its alkali metal salt with its metal complex salt and using the mixture as the etching agent suitable for the etching of dentine. CONSTITUTION:The objective etching agent for especially dentine is produced by compounding (A) ethylenediaminetetraacetic acid or its alkali metal salt (preferably an aqueous solution of 0.1-0.5mol % concentration) and (B) a metal complex salt of ethylenediaminetetraacetic acid (preferably an aqueous solution of 0.1-0.5mol % concentration) at a molar ratio of preferably 1:0.2-20. The etching agent is suitable for the etching of dental enamel. EFFECT:The rate of decalcification is low, and the damage to teeth can be minimized.

Description

[Detailed description of the invention] (a) Industrial application field This invention is applicable to surface treatment of teeth performed when performing treatment for the purpose of preventing dental caries, or to teeth that are damaged due to caries or other reasons. An object of the present invention is to provide a pretreatment agent composition suitable for tooth surface treatment performed during tooth restoration. obey,
and is used in the dental medical field.

(b) Conventional technology When restoring a defective tooth in the moist oral cavity, in order to firmly attach the tooth and adhesive composition by adhesion, the adhesion surface is pretreated. things are being done. Through this pretreatment, it is possible to create a fine uneven structure on the tooth surface, expand the bonding area, and obtain mechanical fitting and anchoring effects.

The pretreatment method employed here is an acid etching method. Examples of what can be used include inorganic acids such as phosphoric acid and hydrochloric acid, and organic acids such as formic acid, citric acid and lactic acid.

All of these are thought to be involved in demineralization of the tooth surface. Phosphoric acid has the best demineralization ability and adhesion properties, and is widely used.

However, acid etching methods, typically using phosphoric acid,
Although it has contributed to significantly increasing the strength of adhesion to enamel, its adhesion to dentin is still in the exploration stage and requires further research.

(C) Problems to be Solved by the Invention As stated in 11 above, when repairing teeth by adhesive means or preventing cavities, regardless of whether the tooth is enamel or dentin, In order to increase the adhesive strength ((pre-treatment called etching), applying the etching agent used for etching the enamel part to the dentin for a period of one month is important because the dentin is rich in organic matter. This causes various problems because it is a layer, and because the layer is close to the dental pulp, it has been pointed out that it may have an effect on the pulp.

However, in order to strengthen the adhesion to dentin,
It is considered necessary to remove the smear layer, and pre-treatment preparations for dentin are already commercially available. These commercially available products include those whose main component is citric acid and those whose main component is ethylenediaminetetratoic acid (ED'I''A).However, citric acid is not suitable for pre-treatment of enamel. Since it is the second strongest etching agent after the commonly used phosphoric acid, there are concerns about pulp reactions.It is safe for the pulp and is said to be effective in removing the smear layer by 1/'c.
Cleaning agents containing D.T. as a main ingredient are said to be somewhat weak in effectiveness, so the inventors of the present invention have thought about the development of this thread, and while writing poems about its favorable functions, we have also tried to overcome its weak points. The present invention was developed as a result of extensive research into improving the effectiveness of the technology.

That is, it has been found that by combining EDTA or its alkali metal salt with its metal complex salt, it becomes an etching agent suitable for rB of dentin. The etching agent provided by the present invention is a 10% citric salt-3% ferric chloride (I O-
Compared to 8), there is no need to worry about the effect on the dental pulp, and the adhesive strength is comparable. In addition, it can be used as an etching agent not only for dentin but also for the enamel layer.
It was found to be as effective as the commonly used etching agent.

Therefore, the etching agent suitable for etching tooth dentin provided by the present invention has a composition comprising E I) T A or an alkali metal salt thereof, and an EDTA metal complex salt. It is a thing.

EDTASEDTA-alkali metal salt used in the present invention is usually used in the form of an aqueous solution. The concentration is not particularly specified, but from the viewpoint of ease of use, it is 0.1 to 0.5.
Mol% is better. When EDTA is used, it is difficult to dissolve in water, so it is best to neutralize it with sodium hydroxide, potassium hydroxide, etc.

Next, EDTA-metal complex salts are also usually used in the form of aqueous solutions. The concentration is preferably 0.1 to 0.5 mol%.

Thus, an aqueous solution of EDTA or an alkali metal salt thereof;
By combining it with the EDTA-metal complex salt aqueous solution, an etching composition suitable for etching dentin, which is the object of the present invention, is provided. Here EDTA
Alternatively, the ratio of the alkali metal salt thereof and the EDTA-metal complex salt is preferably blended such that the EDTA-metal complex salt is 05 to 20 moles per mole of E I) TA or its alkali metal salt. Here, the EDTA used
- the metal complex is EDTA alkali metal salt or EJ)T
A: It consists of ammonium salt or EDTA and metal complex salt ions.

Effects of the Invention The composition provided by the present invention is neutral, and when used for etching dentin, the adhesive strength is equal to or higher than that of the adhesive composition obtained when etching at 10-3. In addition to obtaining the results of ``2'', there is no need to worry about the effect on the pulp that is a concern with 0-3, and on top of that, 10-3
It can be said that the present invention has an advantage over the prior art in that the amount of demineralization is small compared to phosphoric acid and phosphoric acid, and damage to teeth can be reduced.

Even when the composition provided by the present invention is used as an etching agent for enamel, sufficient adhesive strength for therapeutic purposes can be obtained. Also, E l) T A or an alkali metal salt thereof,
As can be seen from the comparative example, when the DTA-metal complex salt was used alone, strong adhesive strength was never obtained.

Examples will be described below to specifically explain the present invention.

Example 1゜0, 3 mo/L' 1℃DA, T-2N a and 02
Moles of E D T A -F e Na and water 101
00O to obtain a homogeneous aqueous solution. Using the resulting solution, treat the dentin of a fresh tooth ground with Emery Paper ≠ 600 for 60 seconds! After washing, the surface was thoroughly washed with distilled water, and the moisture adhering to the surface was removed using a sieve, and the surface was used as a surface to be adhered.

4-M TII'T'A as added monomer
%-containing methyl methacrylate 1- K TB B -O
was added and placed on the surface to be adhered together with polymethyl methacrylate powder using the car load method, and an acryl rod with a diameter of 5.0 mm was placed perpendicularly to the surface to be adhered, and immersed in water at 37C for 30 minutes. After being immersed for one day, the adhesive strength was measured.

Example 2~? .

The adhesive strength was measured in the same manner as in Example 1 except that the additives were changed.

Example 8 Same as Example 1 except that the etching agent was changed.
Adhesive strength was measured.

-7= Example 9 The adhesive strength was measured in the same manner as in Example 1 except that dentin was replaced with enamel.

In Examples 10-12 and Example 9, adhesive strength was measured in the same manner as in Example 9 except that the added monomer was used instead.

Example 13 The adhesive strength was measured in the same manner as in Example 9 except that the etching agent was changed.

Comparative Example In the example, the adhesive strength was measured in the same manner as in the example except that the etching agent was replaced with another etching agent.

The results are listed in Table 1.

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Shiba afu in * Ya 1-2 1 1121. +1 dimension Dimension country dimension Dimension 8 "Humidity temperature [Yes] @ Me @ @ Police Yushu ゎ... ゎ Riρ■'s *1) The abbreviation for additives represents the following compounds.

4-MET'A: 4-methacrylogyethyl trimegutic anhydride JPPM: 2-hydroxy-3-phenoxyprobyl notacrylate HNI) M: 2-hydroxy-3-β-naftogycyprovir Methacryla-1/3P: 2-hydroquine-3-(p-phenoxyphenoxy)propyl methacrylate 5F: 2-hydroxy-3-(pentafluorophenoquine)propyl methacrylate 4-MBTA: 4-methacryloxybutyl 1-Limelic acid anhydride *2) The symbol for etching agent is the following ingredients in 100Q ml of water.
Represents a solution dissolved in water (excluding L-1i) r:o
, 3 moles of E D '1. ' A -2N a and 0.2
-E#(7) EDTA-B"e Na f : EDTA-2N of 0,8-r-nyl
a and 0.2 Morno TEID 'r A -M g 2
N JiI: 10% citric acid 3% ferric chloride aqueous solution W: 0.5 mozlz(7)'El)TA-2Na
V: Q, 5-r=)v EDTA-FeN
a■: Phosphoric acid

Claims (1)

[Claims] An etching composition comprising ethylenediaminetetraacetic acid or an alkali metal salt thereof and a metal complex salt of ethylenediaminetetraacetic acid.