JPS61104780A - Cultivator - Google Patents

Cultivator

Info

Publication number
JPS61104780A
JPS61104780A JP22574884A JP22574884A JPS61104780A JP S61104780 A JPS61104780 A JP S61104780A JP 22574884 A JP22574884 A JP 22574884A JP 22574884 A JP22574884 A JP 22574884A JP S61104780 A JPS61104780 A JP S61104780A
Authority
JP
Japan
Prior art keywords
tank
magnets
stirring
shaft
driving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP22574884A
Other languages
Japanese (ja)
Inventor
Masakatsu Fujimoto
藤本 正勝
Seiji Nomura
野村 聖次
Kenji Kato
加藤 健児
Kunihiko Too
東尾 邦彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Ltd
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Priority to JP22574884A priority Critical patent/JPS61104780A/en
Publication of JPS61104780A publication Critical patent/JPS61104780A/en
Pending legal-status Critical Current

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  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

PURPOSE:In a cultivation tank, a specific stirring shaft is allowed ton rotate at a prescribed rotation with sufficient driving torque which is given through walls by magnets to keep the tank completely free from germs and effect animal cell cultivation in the tank. CONSTITUTION:A stirring shaft 2 which is provided with stirring blades 12, driving elements 3, 4 bearing magnets on both top and tail end is supported with two bearings, the one 10 which is supported with arm 11 fixed to the inner wall of the reactor and the other 19 which is projected on the mount at the bottom and inserted into the depression at the center of the shaft end. In the meantime, driving magnets 5, 7 and motors 6, 8 are rotatably set in cylindrical depressions at the top and the bottom of the tank. Then, 3-phase alternate power is applied from the source 13 through power converter 9 consisting of converter 14 and inverter 15 to drive motors 6, 8 at a desired rotation and rotation torque is given from the magnets 5, 7 through walls 17, 18 to the driving elements 3, 4 to rotate the shaft whereby the culture mixture in the tank is stirred.

Description

【発明の詳細な説明】 〔発明の利用分野〕 本発明は、培養装置に係り、特にマグネ咋ト駆動の攪拌
槽を用いた培養装置に関するものである。
DETAILED DESCRIPTION OF THE INVENTION [Field of Application of the Invention] The present invention relates to a culture device, and particularly to a culture device using a stirring tank driven by a magnet.

〔発明の背景〕[Background of the invention]

マグネット駆動の攪拌槽を用いた培養装置は、例えば、
特開昭53−66486号公報、特開昭57−8778
号公報、特開昭58−116675号公報、特開昭59
−48071号公報等暑こ開示されている。従来公知の
この種装置は、攪拌軸の上部あるいは下部にのみマグネ
ットで構成される被駆動体を設け、攪拌槽の隔壁を介し
て外部より駆動用マグネットをモータにより回転させ、
この回転によって内部の被駆動体を回転させて攪拌軸お
よびこの軸に取付けた攪拌翼を回転させるものであ−だ
。このように、駆動マグネットの磁力を外部から与える
ものの場合、内部の被駆動体に伝達される回転トルクは
小さく、攪拌が十分に行なえないという問題を残してい
る。特に、大容屋の攪拌槽にマグネット駆動を適用しよ
うとすると、不十分なものとなってしまう。
A culture device using a magnetically driven stirring tank is, for example,
JP-A-53-66486, JP-A-57-8778
No. 58-116675, Japanese Patent Application Laid-Open No. 1983
Publications such as No. 48071 have been disclosed. This type of device is conventionally known, in which a driven body consisting of a magnet is provided only at the upper or lower part of the stirring shaft, and the driving magnet is rotated by a motor from the outside through the partition wall of the stirring tank.
This rotation causes the internal driven body to rotate, thereby rotating the stirring shaft and the stirring blades attached to this shaft. In this way, when the magnetic force of the driving magnet is applied from the outside, the rotational torque transmitted to the internal driven body is small, leaving the problem that sufficient stirring cannot be achieved. In particular, if a magnetic drive is applied to a stirring tank in a large container store, it will be insufficient.

〔発明の目的〕[Purpose of the invention]

本発明の目的は、十分な回転トルクを与えることのでき
るマグネット駆動の攪拌槽を用いた培養装置を提供する
ことである。
An object of the present invention is to provide a culture apparatus using a magnetically driven stirring tank that can provide sufficient rotational torque.

〔発明の概要〕[Summary of the invention]

本発明は、攪拌翼を取付けた攪拌軸を攪拌槽内に設け、
該攪拌軸の上端部および下端部にマグネットによって駆
動力が与えられる被駆動体を取付け、そして、該攪拌軸
を支持する軸受を該攪拌槽内に取付け、該攪拌槽の上部
および下部には該被駆動体に駆動力を与えるマグネット
を軸に取付けたモータをそれぞれ配置し、該両モータに
共通の・電力を供給する電力変換装置を設けたことを特
徴とする。
The present invention provides a stirring shaft equipped with stirring blades in a stirring tank,
A driven body to which a driving force is applied by a magnet is attached to the upper and lower ends of the stirring shaft, and a bearing that supports the stirring shaft is installed in the stirring tank, and the upper and lower parts of the stirring tank are provided with a driven body. The present invention is characterized in that motors each having a magnet attached to a shaft that provides a driving force to a driven body are arranged, and a power conversion device is provided that supplies common electric power to both motors.

〔発明の実施例〕[Embodiments of the invention]

以下、本発明を図面を用いて詳細に説明する。 Hereinafter, the present invention will be explained in detail using the drawings.

第1図は本発明の一実施例を示す図であり、ここでは動
物細胞培養装置に本発明を実施した例を示す。攪拌槽l
内には、攪拌IIt12を取付けた攪拌軸2が設けられ
ている。この攪拌軸2の上端部および下端部には、マグ
ネットを取付けた被駆動体3および4が取付けられてい
る。そして、攪拌軸2は、軸受10および19により支
持されている。軸受lOは、攪拌槽1の内面側壁に取付
けた軸受サポート11に取付けられる。下部の軸受19
は、攪拌槽1の底部凸部面に突起状に設けられており、
軸2の中心部の凹部と嵌合される。攪拌槽1の上部およ
下部は円筒状の凹部を形成しており、この凹部にそれぞ
れの駆動用マグネット5および7が挿入されるように、
各モータ6および8が取付けられる。
FIG. 1 is a diagram showing an embodiment of the present invention, and here, an example in which the present invention is implemented in an animal cell culture apparatus is shown. Stirring tank l
A stirring shaft 2 to which a stirring IIt 12 is attached is provided inside. Driven bodies 3 and 4 to which magnets are attached are attached to the upper and lower ends of the stirring shaft 2. As shown in FIG. The stirring shaft 2 is supported by bearings 10 and 19. The bearing lO is attached to a bearing support 11 attached to the inner side wall of the stirring tank 1. Lower bearing 19
is provided in a protrusion shape on the convex bottom surface of the stirring tank 1,
It is fitted into a recess in the center of the shaft 2. The upper and lower parts of the stirring tank 1 form cylindrical recesses, and the driving magnets 5 and 7 are inserted into the recesses.
Each motor 6 and 8 is attached.

マグネット5および7は、それぞれモータ6および8の
軸Iこ取付けられ回転自在となっている。この結果、被
駆動体3および4の回転トルクは、円筒状凹部の隔壁1
7および18を介してそれぞれの被駆動体3および4に
伝達される。モータ6および8は、同一仕様のモータで
あり、ここでは3相誘導電動m(IM)を用いている。
Magnets 5 and 7 are attached to the shafts of motors 6 and 8, respectively, and are rotatable. As a result, the rotation torque of the driven bodies 3 and 4 is reduced to the partition wall 1 of the cylindrical recess.
7 and 18 to the respective driven bodies 3 and 4. The motors 6 and 8 have the same specifications, and here a three-phase induction motor m (IM) is used.

モータ6および8に対する電力の供給は、電力変換装置
9から共通の電力が供給されている。この側における電
力変換!J9は、3相交流源13から供給される交流電
力を直流電力に変換するコンバータ14と、コンバータ
14で変換された直流電力から可変の周波数を有する交
流電力を発生するインバータ15とで構成されている。
Common power is supplied to the motors 6 and 8 from a power conversion device 9. Power conversion on this side! J9 is composed of a converter 14 that converts AC power supplied from a three-phase AC source 13 into DC power, and an inverter 15 that generates AC power having a variable frequency from the DC power converted by the converter 14. There is.

インバータ15が発生する交流電力の周波数は、図示し
ない回転速度制御部からの制御指令によって任意に変更
できる。この結果、モータ6および8は、その周波数に
応じた回転速度で回転する。なお、上述のモータ6.8
は他の交流モータを用いても良く、あるいは直流モータ
を用いても良い。この場合には、電力変換装置9は使用
するモータξ二適したものを用いることは当然である。
The frequency of the AC power generated by the inverter 15 can be arbitrarily changed by a control command from a rotation speed control section (not shown). As a result, motors 6 and 8 rotate at rotational speeds that correspond to their frequencies. In addition, the above-mentioned motor 6.8
Alternatively, another AC motor may be used, or a DC motor may be used. In this case, it goes without saying that the power converter 9 should be one that is suitable for the motor ξ used.

さて、モータ6および8は、上述したように同一仕様の
ものを用いており、しかも共通の電力が供給される構成
なので、はぼ同一トルクで同一速度で回転する。したが
って、被駆動体3および4に伝達される伝達トルクもほ
ぼ同一となlハ上下でのトルク差がなくなり、攪拌軸2
は大きな伝達トルクが得られる。また、この実施例では
、攪拌槽lの上部と下部に円筒状の凹部を設け、この凹
部の隔壁を介して、駆動マグネットと被駆動体とのトル
ク伝達を行なうようにしているので、両者が向き合って
いる面積を大きくとることができ、この間のトルク伝達
は従来に比し、かなり大きなものとなる。
Now, as mentioned above, the motors 6 and 8 have the same specifications and are configured to be supplied with common electric power, so that they rotate at the same speed with approximately the same torque. Therefore, the transmission torque transmitted to the driven bodies 3 and 4 is almost the same, and there is no torque difference between the upper and lower parts, and the stirring shaft 2
A large transmission torque can be obtained. Furthermore, in this embodiment, cylindrical recesses are provided at the upper and lower parts of the stirring tank l, and torque is transmitted between the driving magnet and the driven body through the partition walls of the recesses, so that both The area facing each other can be increased, and the torque transmission during this area is considerably larger than that of the conventional method.

このように、攪拌軸2は、大きなトルクで回転すること
になり、外乱等があっても攪拌翼認の最適な回転を維持
することができ、また停止9回転数変更も短時間で確実
に行なうことができる。特に、動物細胞の培養において
は、動物細胞を担体(例えば、マイクロキャリヤ)に付
着させる場合の最適な回転、細胞が付着した担体を浮遊
培養する場合の最適な回転、担体から細胞をはq離させ
る場合の強い回転というように、広範囲かつ正確な速度
調整が要求されるが、このような用途において本実施例
はそ、れに十分対処できる。
In this way, the stirring shaft 2 rotates with a large torque, and can maintain the optimum rotation of the stirring blade even if there is a disturbance, and can also change the rotation speed quickly and reliably. can be done. In particular, in the culture of animal cells, the optimal rotation when attaching animal cells to a carrier (e.g., microcarrier), the optimal rotation when suspending culture of a carrier with attached cells, and the separation of cells from the carrier are important. A wide range and accurate speed adjustment is required, such as strong rotation when rotating the motor, but this embodiment can sufficiently cope with this in such applications.

また、本実施例では、攪拌槽lの上部および下部の凹部
が、内側に凸となっているので、デッドスペースがなく
、この種用途で不可欠の滅菌(例えば蒸気滅菌)を完全
に行なえる。また、攪拌槽lに貫通部がなく、蒸気滅菌
後の無菌保持が容易である。もちろん、大容量の培養装
置とする場合にも好適である。
Furthermore, in this embodiment, since the recessed portions at the upper and lower portions of the stirring tank l are inwardly convex, there is no dead space, and sterilization (for example, steam sterilization) essential for this type of use can be completely performed. Furthermore, the stirring tank 1 does not have any penetrating parts, making it easy to maintain sterility after steam sterilization. Of course, it is also suitable for a large-capacity culture device.

〔発明の効果〕〔Effect of the invention〕

以上説明したように本発明によれば、十分な回転トルク
を攪拌軸に伝達することができる。
As explained above, according to the present invention, sufficient rotational torque can be transmitted to the stirring shaft.

【図面の簡単な説明】[Brief explanation of the drawing]

第1図は本発明の一実施例を示す図である。 FIG. 1 is a diagram showing an embodiment of the present invention.

Claims (1)

【特許請求の範囲】[Claims] 1、攪拌翼を取付けた攪拌軸を攪拌槽内に設け、該攪拌
軸の上端部および下端部に取付けられマグネットによっ
て駆動される被駆動体と、該攪拌軸を支持する軸受とを
該攪拌槽内に備えており、該攪拌槽の上部および下部に
は該被駆動体を駆動するマグネットを軸に取付けたモー
タをそれぞれ設け、該両モータに共通の電力を供給する
電力変換装置を設けたことを特徴とする培養装置。
1. A stirring shaft with stirring blades attached is provided in the stirring tank, and driven bodies attached to the upper and lower ends of the stirring shaft and driven by magnets, and bearings that support the stirring shaft are installed in the stirring tank. A motor with a magnet attached to the shaft for driving the driven body is installed at the upper and lower part of the stirring tank, and a power converter is installed to supply common power to both motors. A culture device characterized by.
JP22574884A 1984-10-29 1984-10-29 Cultivator Pending JPS61104780A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22574884A JPS61104780A (en) 1984-10-29 1984-10-29 Cultivator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22574884A JPS61104780A (en) 1984-10-29 1984-10-29 Cultivator

Publications (1)

Publication Number Publication Date
JPS61104780A true JPS61104780A (en) 1986-05-23

Family

ID=16834211

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22574884A Pending JPS61104780A (en) 1984-10-29 1984-10-29 Cultivator

Country Status (1)

Country Link
JP (1) JPS61104780A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016529918A (en) * 2013-09-16 2016-09-29 ジェネンテック, インコーポレイテッド Bioreactor with multiple or positionable agitator design

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU411122A1 (en) * 1972-02-09 1974-01-15
SU810804A1 (en) * 1979-07-27 1981-03-07 Всесоюзный Научно-Исследовательскийинститут Биосинтеза Белковыхвеществ Главного Управлениямикробиологической Промышленностипри Cobete Министров Cccp Apparatus for culturing microorganisms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU411122A1 (en) * 1972-02-09 1974-01-15
SU810804A1 (en) * 1979-07-27 1981-03-07 Всесоюзный Научно-Исследовательскийинститут Биосинтеза Белковыхвеществ Главного Управлениямикробиологической Промышленностипри Cobete Министров Cccp Apparatus for culturing microorganisms

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016529918A (en) * 2013-09-16 2016-09-29 ジェネンテック, インコーポレイテッド Bioreactor with multiple or positionable agitator design
JP2019146575A (en) * 2013-09-16 2019-09-05 ジェネンテック, インコーポレイテッド Bioreactor of plurality of or position-adjustable agitators design
US10563161B2 (en) 2013-09-16 2020-02-18 Genentech, Inc. Bioreactors with multiple or adjustable-position agitator designs
US11155777B2 (en) 2013-09-16 2021-10-26 Genentech, Inc. Bioreactors with multiple or adjustable-position agitator designs

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