JPS608209A - Stabilized solid agricultural chemical composition - Google Patents

Abstract

PURPOSE:To suppress decomposition of carbosulfan, by blending a solid preparation of carbosulfan with calcium oxide, calcium hydroxide, or calcium carbonate. CONSTITUTION:In supporting carbosulfan: 2,3-dihydro-2,2-dimethyl-7-benzofuranyl- N-dibutylaminothio-N-methyl carbamate shown by the formula, well-known as an improved insecticide having excellent effect on various kinds of insect pests in paddy rice plants and crops in plowed fields, showing wide insecticidal spectrum on a powdery or granular mineral carrier (e.g., bentonite, or clay), the insecticide is blended with >=5wt% calcium oxide, calcium hydroxide, or calcium carbonate. Addition of another stabilizer such as epoxydized soybean oil, etc. further raises stabilizing effect.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to 2,3-dihydro-2,2-dimethyl-7-benzofuranyl-N-dibutylaminothio-N-methylcarhame-1- (hereinafter simply referred to as carbosulfan).
The present invention relates to a stabilized solid agrochemical composition characterized in that one or more of calcium oxides, hydroxides, or carbonates are blended into a solid pharmaceutical preparation.

Carbosulfan is one of the most commercially available insecticides.
It is a component compound and is known as an excellent insecticide with a wide range of insecticidal spectra and is extremely effective against various pests in paddy rice and field crops. However, carbosulfan is extremely unstable and commonly used mineral carriers (e.g. hennite).

clay, zeolite, diatomaceous, etc.) or polyitocarbon (e.g. Carplex #1120, #80.
15) of Geotsugi Pharmaceutical (manufactured by θ Kiku) or when formulated by being supported on granules, Cal7sawa sulfan was significantly decomposed and the decomposition rate was 100% after 1 month at 50°C.
In some cases, highly toxic carbofuran is also produced during the decomposition process, and there is a strong desire to suppress this decomposition as much as possible from a safety standpoint.

0=C-N-3-N = (n=Bu)z H O= C-N-CH3 (carbofuran) The present inventors have repeatedly conducted various studies on suppressing the decomposition of carbosulfan made into a solid agricultural chemical formulation. The result.

It has been discovered that by incorporating one or more calcium oxides, hydroxides, or carbonates into a solid preparation of carbosulfan, the stability of carbosulfan can be significantly increased, that is, decomposition can be significantly inhibited. The invention has been completed.

In the present invention, the solid agricultural chemical formulation refers to one powder.

This refers to formulations such as fine granules and wettable powders, and the mineral carrier or white carbon used as the carrier is in the form of two crushed powder particles.

It may be in the form of fine particles or blocks, or it may be granulated from a powder using a binder, a surfactant, water, etc.

Calcium oxide Cab is an oxide of calcium.

Calcium peroxide is Ca%, and calcium hydroxide includes Ca(Oll)2. Moreover, CaC01 is mentioned as a carbonate. Although the amount added is not particularly limited, it is effective to add 5% or more. Furthermore, even higher effects may be obtained by adding other stabilizers 9, such as epoxidized soybean oil.

The method and effects of the present invention will be described below with reference to Examples, but the content of the present invention is not limited thereto. : ``1 case'' - Powder carbosulfan drug substance (iF containing 4% epoxidized soybean oil)
Mc), 10 parts of additives, and 87 parts of powdered tare (produced in Saitama Prefecture) were mixed in advance and mixed and pulverized in a hammer mill (manufactured by Fuji Baudal) to obtain a 3% powder. This powder was placed in a glass bottle, sealed tightly, and stored in a 40°C incubator for one month.The content of carbosulfan was analyzed to determine the decomposition rate relative to the initial content. The results are shown in Table 1.

Table 1 with blank space below Additives Decomposition rate of rufosulfan 1 No additive (control) 34% 2 Ca0z 10% 3 Ca0 13% 4 Ca(OH)2, 15% 5 CaCO3 17% 6 CaO1/CaC03 (1: 1) 12% 7Na
OH (control) 100% As shown in Table 1, it is clear that the stability of carbosulfan in the powder formulation according to the present invention is suppressed to 1/2 or less compared to the control. Also, caustic soda has no stabilizing effect (on the contrary, it promotes decomposition).

A sharp dish (0 to 50% powdered calcium peroxide, 97 to 47 parts of powdered mineral carrier or white carbon mixed together to form carbosulfan raw material (containing 4% epoxidized soybean oil, manufactured by FMC)
After spray-mixing 3 parts, the mixture was crushed in a hammer mill (manufactured by Fuji Baudal) to obtain a 3% powder. This powder was placed in a glass container, sealed tightly, and stored in a 40° C. incubator for one month, and then the carbosulfan content was analyzed to determine the decomposition rate relative to the initial content. The results are shown in Table 2.

Table 2 with blank space below Carrier (parts) Amount of CaO1 added Carbosulfan decomposition rate Hentonite (97 parts) 0 parts 100% Hentonite I- (87 parts) 10 parts 33% Clay (97 parts) 0
93 34% Clay (96 parts) 1 part 15% Clay (92 parts) 5 parts 8% Clay (87 parts) 10 parts 10% Clay (62 parts) 35 parts 12% Clay (47 parts) 50 parts 11% Carplex (97 parts) 0 parts 100% #1120 Carplex (87 parts) 10 parts 6% #1120 Calcium carbonate (97 parts) 0 parts 6% Hentonite (produced in Gunma), Clay (produced in Saitama), Carplex #1120 ( Uses white carbon (manufactured by Geotsugi Pharmaceutical) and calcium carbonate (produced in Yamaguchi).

Table 2 shows that the present invention suppresses the decomposition of carbosulfan regardless of the carrier.

Sharp plate main powder A 3% powder having the following composition was prepared in the same manner as in Example 2.

This powder was placed in a glass jar, sealed tightly, and stored in a 40"C thermostat for one month. The content of carbosulfan was analyzed to determine the decomposition rate relative to the initial content.

The results are shown in Table 3.

Table 3 Composition Carbosulfan decomposition rate Ben1-Nite 97 parts 100% Bentonite 95 parts, 8502 parts 50% CaCO58
5 parts, 10 parts of Ca0, 2 parts of ESO 2% ESO indicates epoxidized soybean oil (manufactured by Takemoto Yushi).

Hentonite zeolite (Miyagi Co., Ltd.), diatomaceous earth (Okayama Co., Ltd.), and calcium carbonate (Yamaguchi Co., Ltd.), which were crushed and sieved to have a particle size of 14 to 42 mm, were used as granular carriers, each granular carrier 95 In the part, carbosulfan drug substance (epoxidized large Ij
iFMC containing 4% oil! ! 5 parts of the mixture were mixed and stirred slowly with a pipette to prepare 5% granules. Put this granule in a glass), seal it tightly, and place it in a 40℃ thermostat.
After storage for one month, the carbosulfan content was analyzed and the decomposition rate relative to the initial content was determined. The results are shown in Table 4.

Table 4 Support Carbosulfan decomposition rate Hentonite 98% Clay 30% Zeolite 100% Diatomite 38% Calcium carbonate 3% Example 1 Granulated mineral support and calcium peroxide were mixed in the proportions shown in Table 5, To 97 parts of this mixture, 1 part of calcium lignin sulfonate, 1 part of Gohsenol 05S (polyvinyl alcohol manufactured by Nippon Gosei@), 1 part of Tsurupol 5060 (surfactant manufactured by Toho Chemical) and 15 parts of water were added and kneaded.
Pelletization was carried out using an Esoku pelleter (manufactured by Fuji Paudal Co., Ltd.) equipped with a screen of 0.0 and 8 mmφ. The above operation was quickly carried out, and the resulting water-containing granules were quickly dried in a fluidized dryer (manufactured by Fuji Paudal Co., Ltd.) to obtain a granular carrier. 95 parts of the resulting granulated empty spheres were spray-mixed with 5 parts of carbosulfan raw material (i FMC Co., Ltd. 111 containing 4% epoxidized soybean oil) to obtain 5% granules. Glass llH of this granule
After storing it in a thermostat at 40℃ for 1 month, the content of carbosulfan was analyzed, and the amount of 11 minutes relative to the initial content was analyzed.
Achieved +T rate. The results are shown in Table 5.

Table 5 with blank space below Carrier (parts) Addition amount of CaO□ Carbosulfan decomposition rate Hentoni I-100 parts 0 parts 95% hentonite clay 100 parts 0 parts 32% Clay 80 parts 20 parts 11% Calcium carbonate 100 parts 0 parts 6 % Calcium carbonate 80 parts 20 parts 7% Practical erect wettable powder Carbosulfan raw material (contains 4% epoxidized soybean oil;
1? (manufactured by MC) 10 parts, powdered mineral carrier, 1 part lignin sulfonic acid 1 part 1 shim, 3 parts Tsurupol 5080
(Toho Chemical surfactant) 5 parts, Carplex #11
20 5 parts of White Carbon (manufactured by Geotsugi Pharmaceutical Co., Ltd.) and calcium peroxide were mixed in the proportions shown in Table 6, and then finely ground with a Jet-O-Miser (manufactured by Seishin Enterprises) to obtain a 10% hydrating powder. . This hydrating powder was placed in a glass bottle, sealed and stored in a 40°C thermostat for one month, and then the carbosulfan content was analyzed to determine the decomposition rate relative to the initial content.

The results are shown in Table 6.

Table 6 Support (parts) Ca% addition amount Carbosulfan decomposition rate Zicraite PPP 77 parts 0 parts 35% Ziecrite PPP 72 parts 5 parts 11% Neocarrier 0277
Part 0 part 31% Neocarrier 0272 part 5 part 12
% heavy calcium carbonate 77 parts 0 parts 11% heavy calcium carbonate 72 parts 5 parts 9% Patent applicant Nissan Chemical Industries, Ltd.

Claims (1)

[Claims] 2. One or more calcium oxides, hydroxides, or carbonates are added to the solid pesticide formulation of 2.3-dihydro-2,2-dimethyl-7-benzofuranyl-N-dibutylaminothio-N=methylcarbamate. A stabilized solid agricultural chemical composition characterized by containing