JPS6067448A - Aniline derivative and production thereof - Google Patents
Aniline derivative and production thereofInfo
- Publication number
- JPS6067448A JPS6067448A JP17557983A JP17557983A JPS6067448A JP S6067448 A JPS6067448 A JP S6067448A JP 17557983 A JP17557983 A JP 17557983A JP 17557983 A JP17557983 A JP 17557983A JP S6067448 A JPS6067448 A JP S6067448A
- Authority
- JP
- Japan
- Prior art keywords
- nitroaniline
- fluoro
- solvent
- tert
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は、２−クロロ−６−フルオロ−３−二トロアニ
リン（以下、本発明化合物と記す。）およびその製造法
に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to 2-chloro-6-fluoro-3-nitroaniline (hereinafter referred to as the compound of the present invention) and a method for producing the same.
本発明化合物は、例えばＥＰ７７９８８号に記載の除単
活性化合物をはじめ、その他医薬の合成中間体として有
用である。The compounds of the present invention are useful, for example, as monoactive compounds described in EP 77988, as well as other synthetic intermediates for pharmaceuticals.
本発明化合物は、標準的には２−フルオロ−５−ニトロ
アニリンと、これに対し１〜１．５当風の次亜塩素酸
ｔｅｒｔ−ブチル、塩素、塩化スルフリル等の塩素化剤
、好ましくは次亜塩素酸ｔｅｒｔ−ブチルとを溶媒中、
０°Ｃ−５０℃で、０．５時間〜ｌＯ時間反応させるこ
とによって得ることができる。The compounds of the present invention typically contain 2-fluoro-5-nitroaniline and 1 to 1.5 equivalents of hypochlorous acid.
tert-butyl, chlorine, chlorinating agent such as sulfuryl chloride, preferably tert-butyl hypochlorite in a solvent,
It can be obtained by reacting at 0°C to 50°C for 0.5 to 10 hours.
上記製造方法において使用できる溶媒としてはヘキサン
、ヘプタン、リグロイン、石油エーテル等の脂肪族炭化
水素、クロロホルム、四塩化炭素、ジクロロエタン、ク
ロロベンゼン、ジクロロベンゼン、トリクロルエチレン
、テトラクロルエチレン等のハロゲン化炭化水素、ジエ
チルエーテル、ジイソプロピルエーテル、ジオキサン、
テトラヒドロフラン、エチレングリコールジメチルエー
テル等のエーテル、ニトロベンセン等のニトロ化物等、
あるいはこれらの混合物が挙げられる。Solvents that can be used in the above production method include aliphatic hydrocarbons such as hexane, heptane, ligroin, and petroleum ether; halogenated hydrocarbons such as chloroform, carbon tetrachloride, dichloroethane, chlorobenzene, dichlorobenzene, trichlorethylene, and tetrachlorethylene; diethyl ether, diisopropyl ether, dioxane,
Ethers such as tetrahydrofuran and ethylene glycol dimethyl ether, nitrides such as nitrobenzene, etc.
Alternatively, a mixture thereof may be mentioned.
反応終了後の反応液は、有機溶媒による抽出および濃縮
など通常の後処理を行なうか、さらに必要に応じ、クロ
マトグラフィー、再結晶等の操作によって精製すること
により、目的の本発明化合物が得られる。After completion of the reaction, the reaction solution can be subjected to usual post-treatments such as extraction with an organic solvent and concentration, or if necessary, further purified by operations such as chromatography and recrystallization to obtain the desired compound of the present invention. .
次に本発明化合物の製造例を示す。Next, production examples of the compounds of the present invention will be shown.
製造例
２−Ｖｋオロー５−ニトロアニリン５ノをジクロルエタ
ン１００ｄ゛にとかした。次いで、これに次亜塩素酸
ｔｅｒｔ−ブチル８．５ノを水冷下８℃以下で加え、１
夜室温に放置した。Production Example 2 - Vk Olow 5-nitroaniline was dissolved in 100 d of dichloroethane. Next, add hypochlorous acid to this
Add 8.5 g of tert-butyl at below 8°C under water cooling, and add 1
It was left at room temperature overnight.
反応液を水で希釈後、塩化メチレンで抽出し゛、抽出液
を濃縮した後、得られた結晶を沖果し、５．２９の２−
クロロ−６−フルオロ−８−ニトロアニリンを得た。After diluting the reaction solution with water, it was extracted with methylene chloride, and the extract was concentrated.
Chloro-6-fluoro-8-nitroaniline was obtained.
ｍ、ｐ、１０１．０℃m, p, 101.0℃
Claims (2)
。(1) 2-chloro-6-fluoro-8-nitroaniline.
ることを特徴とする２−クロロ−６−フルオロ−３−ニ
トロアニリンの製造法。(2) A method for producing 2-chloro-6-fluoro-3-nitroaniline, which comprises chlorinating 2-fluoro-5-nitroaniline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17557983A JPS6067448A (en) | 1983-09-22 | 1983-09-22 | Aniline derivative and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17557983A JPS6067448A (en) | 1983-09-22 | 1983-09-22 | Aniline derivative and production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6067448A true JPS6067448A (en) | 1985-04-17 |
Family
ID=15998547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17557983A Pending JPS6067448A (en) | 1983-09-22 | 1983-09-22 | Aniline derivative and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6067448A (en) |
-
1983
- 1983-09-22 JP JP17557983A patent/JPS6067448A/en active Pending
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