JPS6055045B2 - patch - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a patch comprising a water-containing anti-inflammatory agent that stably maintains the drug contained therein over a long period of time.

In general, so-called poultices containing anti-inflammatory analgesics such as methyl salicylate, monoglycol salicylate, vanillylamide nonylate, tocopherol acetate, capsaicin, and indomethacin in a water-containing bone body contain ester bonds, acid amide bonds, etc. Due to hydrolysis, drugs are often broken down over a period of several months, and their medicinal properties are often halved.

In order to prevent drug loss due to hydrolysis, efforts have been made to stabilize the drug by adjusting the pH of water in the water-containing bone body and improving the main components of bone loss. The reality is that nothing satisfactory has yet been developed.

As a result of intensive studies in view of the state of the prior art, the present inventors found that by using higher fatty acid aluminum salt as a drug stabilizer, the medicinal ingredients can be maintained for a long period of time, and the present invention has been achieved. It is ivy. That is, the present invention
A patch using a drug-containing water-containing patch is characterized in that a higher fatty acid aluminum salt is used as a drug stabilizer.

The water-containing bone rest used in carrying out the present invention includes:
Using a conventionally known muddy skeleton or synthetic resin as a base component consisting of a viscous component such as glycerin, ganchi, gelatin, a solid component such as diatomaceous material and talc, and water, and using an emulsifier or an emulsifying aid, W. /0 or 0/W type emulsion and water-containing gel-like bone formed by gelling are used, and the water content is 3% by heel weight from the viewpoint of cooling sensation and stickiness.
The following shall apply.

In addition, as higher fatty acid aluminum salts, fatty acid c
Preferred are aluminum salts having a grade of 8-3 and having 1-3 fatty acids, such as aluminum monostearate, aluminum distearate, aluminum tristearate, aluminum monopalmitate, aluminum dipalmitate, trinonyl. Examples include acid aluminum and the like.

These higher fatty acid aluminum salts have a concentration of 0.0% in the bone body.
It is preferable to add it in an amount of 0.01 to 3% by weight.

In addition to anti-inflammatory drugs such as methyl salicylate, monoglycol salicylate, nonylic acid vanillylamide, tocopherol acetate, capsaicin, and indomethacin, the drugs used in the practice of the present invention include hydrolyzed by ester bond or acid amide bond. Also mentioned are the drugs that are used.

It is preferable that the drug is incorporated into the plaster in an amount of 2% or less. The fact that the patch of the present invention in which a higher fatty acid aluminum salt is blended into the drug-containing water-containing plaster has excellent drug stability over time is demonstrated by the following examples.

Example 1 5 parts of isoprene rubber (same parts below) and 35 parts of styrene-isoprene-styrene block copolymer rubber,
After masticating the two powders using a roll held at 15, 0.7 parts of aluminum distearate and 1.7 parts of aluminum trinonylate were added thereto and mixed uniformly.

Next, 13 parts of petroleum-based synthetic terpene resin and 7 parts of natural rosin were added and mixed, and after cooling the system to 95°C, 5 parts of polybutene, 14.18 parts of liquid paraffin, 3 parts of methyl salicylate, 3 parts of monoglycol salicylate, Add 0.5 parts of tocophenol acetate, 0.02 parts of vanillylamide nonylate, and 2 parts of sorbitan monooleate, mix the system uniformly,
Add 1 oz of purified water to this and mix it, then apply 0.8 Wr on the woven fabric.
! The adhesive is applied to a thickness of n and gelled to obtain a patch. Example 2 A patch was obtained in the same manner as in Example 1, except that aluminum trinonylate was not blended and only 2 parts of aluminum distearate was added.

Table 1 shows the test results of Examples 1 and 2.

The amount of decomposition in Table 1 is calculated by packaging each of the above patches in a moisture-impermeable base material made of laminated aluminum foil,
Calculations were made with the theoretical value after storage for 3 months in CfC set as 100%. Further, a comparative example is the same as in Example 1, except that aluminum trinonylate and aluminum distearate are not blended. As is clear from the above examples, when a higher fatty acid aluminum salt is used as a stabilizer in a water-containing paste, it is remarkable that the drug is less likely to be degraded by hydrolysis over time.

Claims (1)

[Claims] 1. In a patch using a drug-containing water-containing plaster,
A patch characterized by using higher fatty acid aluminum salt as a drug stabilizer.