JPS6052707B2 - Method for producing dibenzazepine derivatives - Google Patents
Method for producing dibenzazepine derivativesInfo
- Publication number
- JPS6052707B2 JPS6052707B2 JP12987676A JP12987676A JPS6052707B2 JP S6052707 B2 JPS6052707 B2 JP S6052707B2 JP 12987676 A JP12987676 A JP 12987676A JP 12987676 A JP12987676 A JP 12987676A JP S6052707 B2 JPS6052707 B2 JP S6052707B2
- Authority
- JP
- Japan
- Prior art keywords
- producing
- formula
- dibenzazepine derivatives
- compound represented
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Description
【発明の詳細な説明】
本発明は抗精神病薬として有用な、一般式〔式中ＸはＨ
またはＣｌを示す。DETAILED DESCRIPTION OF THE INVENTION The present invention provides a compound of the general formula [wherein X is H
Or indicates Cl.
〕で表わされる化合物の新規な製造法に関する。] This invention relates to a novel method for producing a compound represented by:
とを１０−般式（Ｉ）の化合物は、本発明に従つて、一
般式〔式中Ｘは前記と同義である。and 10- Compounds of general formula (I) according to the present invention can be prepared by the general formula [wherein X is as defined above].
〕２０で表わされる化合物を水素添加することにより製
造される。] It is produced by hydrogenating the compound represented by 20.
この反応は、通常の接触還元、たとえば次の反応条件下
に実施されうるが、原料化合物などに応じて適宜変更さ
れうることは勿論のことである。This reaction can be carried out under the usual catalytic reduction, for example, under the following reaction conditions, which may of course be changed as appropriate depending on the raw material compounds and the like.
２５触媒：ニツケル（ラネーニツケルなど）、白金（酸
化白金など）、パラジウム（（パラジウム−炭素など）
など溶媒：エタノール、ジオキサン、氷酢酸など反応温
度：室温〜１００℃反応圧力ニ常圧〜１叩気圧
反応時間：１〜８時間
上記方法で製造された一般式（１）の化合物は、たとえ
ば塩酸塩、マレイン酸塩の形で医薬品として用いられる
。25 Catalyst: Nickel (Raney nickel, etc.), platinum (platinum oxide, etc.), palladium ((palladium-carbon, etc.)
Solvent: ethanol, dioxane, glacial acetic acid, etc. Reaction temperature: room temperature to 100°C Reaction pressure: normal pressure to 1 pounding pressure Reaction time: 1 to 8 hours The compound of general formula (1) produced by the above method can be It is used as a medicine in the form of salt and maleate.
以下実施例により本発明を具体的に説明する。The present invention will be specifically explained below using Examples.
実施例１５−〔３−（４−カルバモイルー４−ピペリジ
ノピペリジノ）プロピル〕一駈ージベンズ〔ｂ−ｆ〕ア
ゼピン８．８ｙを、ジオキサン１００ｍ１中、ラネーニ
ツケル（ニッケルとして０．５ｙ）の存在下、８幌圧、
５０℃で３時間、ついで室温で２時間水素添加する。Example 15 - 8.8y of [3-(4-carbamoyl-4-piperidinopiperidino)propyl]dibenz[b-f] azepine in the presence of Raney nickel (0.5y as nickel) in 100ml of dioxane Lower, 8 hood pressure,
Hydrogenate at 50° C. for 3 hours and then at room temperature for 2 hours.
反応後、触媒をＰ去し、溶媒を減圧下に留去する。淡褐
色結晶性残査をトルエン８０ｍ１に溶かし、５％塩酸水
５０ｍ１を加え、析出した結晶を戸取し、メタノールか
ら再結晶すると、融点２６０℃（分解）の５−〔３−（
４−カルバモイルー４−ピペリジノピペリジノ）プロピ
ル〕−１０，１１ージヒトロー胆ージベンズ〔Ｂ，ｆ〕
アゼピン・２塩酸塩・１水和物が得られる。実施例２実
施例１と同様にして、３−クロロー５−〔３−（４−カ
ルバモイルー４−ピペリジノピペリジノ）プロピル〕一
駈ージベンズ〔Ｂ，ｆ〕アゼピンから、融点２５９ジＣ
（分解）の３−クロロー５一〔３−（４−カルバモイル
ー４−ピペリジノピペリジノ）プロピル〕−１０，１１
ージヒトロー胆ージベンズ〔Ｂ，ｆ〕アゼピン・２塩酸
塩・１水和物が得られる。After the reaction, the catalyst is removed and the solvent is distilled off under reduced pressure. The light brown crystalline residue was dissolved in 80 ml of toluene, 50 ml of 5% hydrochloric acid was added, and the precipitated crystals were collected and recrystallized from methanol to give 5-[3-(
4-carbamoyl-4-piperidinopiperidino)propyl]-10,11-dihydro-dibenz[B,f]
Azepine dihydrochloride monohydrate is obtained. Example 2 In the same manner as in Example 1, 3-chloro-5-[3-(4-carbamoyl-4-piperidinopiperidino)propyl]-dibenz[B,f]azepine was prepared with a melting point of 259 diC.
(Decomposition) of 3-chloro5-[3-(4-carbamoyl-4-piperidinopiperidino)propyl]-10,11
-Dihydro-dibenz[B,f]azepine dihydrochloride monohydrate is obtained.
Claims (1)
る、一般式▲数式、化学式、表等があります▼ 〔式中Ｘは同義である。 〕で表わされる化合物の製造法。[Claims] 1 General formula ▲ Numerical formula, chemical formula, table, etc. ▼ [In the formula, X represents H or Cl. ] There are general formulas ▲ mathematical formulas, chemical formulas, tables, etc. that are characterized by subjecting the compound represented by ] to a hydrogenation reaction ▼ [In the formula, X has the same meaning. ] A method for producing a compound represented by
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12987676A JPS6052707B2 (en) | 1976-10-27 | 1976-10-27 | Method for producing dibenzazepine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12987676A JPS6052707B2 (en) | 1976-10-27 | 1976-10-27 | Method for producing dibenzazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5353684A JPS5353684A (en) | 1978-05-16 |
| JPS6052707B2 true JPS6052707B2 (en) | 1985-11-20 |
Family
ID=15020486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12987676A Expired JPS6052707B2 (en) | 1976-10-27 | 1976-10-27 | Method for producing dibenzazepine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6052707B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5885882A (en) * | 1981-11-16 | 1983-05-23 | Yoshitomi Pharmaceut Ind Ltd | Novel dibenzazepin derivative |
-
1976
- 1976-10-27 JP JP12987676A patent/JPS6052707B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5353684A (en) | 1978-05-16 |
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