JPS605159A - Production of medical band - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention is mainly composed of a polymeric substance, and is used by being attached to an affected area in a body cavity such as the inside of the oral cavity or the inside of the cavity by the action of mucus in the body cavity. Regarding the manufacturing method of the Jru medical band, in more detail, it will stick to the affected area.
It sticks to the affected area for a long time, is flexible and easy to use, and provides strong stimulation to the affected area! This is a timeless method for manufacturing medical bands.

Conventionally, Zera 1-1 has been used as a medical substrate used as a base for drugs that adhere to affected areas within the oral cavity, the intracavity, etc. due to the action of mucus. Methyl cellulose
Some known tablets include water-soluble polymeric substances such as carboxymethylcellulose sodium chloride formed into a film on a sponge, and tablets formed from water-soluble polymeric substances such as polyacrylate and hydroxypropyl cellulose. ing. These medical materials are manufactured by freeze-drying a solution of a water-soluble polymer substance or compressing a powder into tablets, but conventional materials have various problems. . That is, the former sponge-like base material is flexible and quickly adheres to the affected area, so it is easy to use, but the adhesive strength is weak.
It has the disadvantage that the adhesion time is short, and the tablet-shaped base material on the back right has strong adhesion and a long adhesion time, but because it is a tablet, it is hard and may cause initial irritation to the affected area. ,
Moreover, it has disadvantages in terms of usability, such as the fact that it is impossible to change the size and shape depending on the area where it is used, and it is difficult to apply it to curved areas such as the gingival area. It could only be used by

In view of the above circumstances, the present inventors conducted various studies in order to obtain a band-shaped medical base material that has strong adhesion, long adhesion time, flexibility, and excellent usability, and found that hydroxypropyl cellulose , dissolve a film-forming polymeric substance such as polyvinylpyrrolidone in an organic solvent such as ethanol, and add to this solution a substance that is insoluble in the organic solvent and soluble in water, such as sodium to lithium polyacrylate, methylcellulose, sodium carboxymethylcellulose, etc. Alternatively, a powder of a water-soluble polymer substance that becomes sticky when gelled with water is dispersed and mixed, and a solution of a film-forming polymer substance in which the powder of the water-soluble polymer substance is dispersed is spread on a table to an appropriate thickness. By spreading and forming a film and drying it, the above objectives are effectively achieved, and the above-mentioned purpose is effectively achieved, and the drug base material for the oral cavity, the adhesive plaster for the oral cavity, the drug base material for the nasal cavity, the drug base material for the vaginal cavity, The inventors have discovered that it is possible to produce a medical band that can be suitably used as a hemostatic agent, etc., and have arrived at the present invention.

The present invention will be explained in detail below.

The method for manufacturing a medical band according to the present invention is as follows. A powder of a water-soluble polymer substance is dispersed and mixed, and then a solution of a film-forming polymer substance in which the powder of a water-soluble polymer substance is dispersed is formed into a film to a predetermined thickness, and this is dried to form a film-forming polymer substance. The present invention is characterized in that a medical band is obtained in which powder of a water-soluble polymer substance is dispersed in a sheet of a molecular substance.

In this case, the film-forming polymeric substance may be any polymeric substance that exhibits film-forming properties when dissolved in a solvent and dried; however, it is particularly hydrophilic. It is preferable to use a water-soluble material or a water-soluble material, which can further improve the adhesion of the band to the affected area.

Furthermore, as the water-soluble polymer substance powder, any polymer substance powder can be used as long as it dissolves in water or gels with water and exhibits stickiness, but particularly those with strong stickiness can be used. is preferred.

J3, the above-mentioned film-forming polymeric substances and water-soluble polymeric substances can be used regardless of whether they are natural polymeric substances, semi-synthetic polymeric substances, or synthetic polymeric substances; Examples of water-soluble polymer substances that can be used include semi-synthetic polymers such as gum arabic, gum tragacanth, locust bean gum, guar gum, agar, carrageenan, sodium alginate, dextrin, dextone, gelatin, and amylose. Substances include sodium carboxymethylcellulose, methylcellulose, hydroxylated alkylcellulose ethers, etc. Synthetic polymeric substances include hydrophilic polyvinyl compounds such as polyvinylvinylidene, esters of vinylpyrrolidone and acrylic acid, polyvinyl alcohol, partially hydrated Decomposed polyvinyl acetate or styrene, polymers copolymerizable with vinyl acetate, such as acrylic acid, methacrylic acid, crotonic acid, or esters thereof;
Allyl acetate, copolymer of methyl vinyl ether and maleic anhydride, polyvinyl sulfuric acid, polyitaconic acid, polyvinyl carboxamide such as polyacrylamide, copolymer of styrene and maleic anhydride, ethylene and 7-leic acid Copolymers with anhydrides, copolymers of acrylamide and acrylic acid, polyelectrolytes such as alginic acid, alginates, etc. may be used.

Among these, semi-synthetic polymeric substances and synthetic polymeric substances are preferable as the film-forming polymeric substance, and hydroxypropylcellulose and polyvinylpyrrolidone can be particularly preferably used. Further, as the powder of the water-soluble polymer substance, powders of strongly adhesive substances such as polyacrylic acid, salts of polyacrylic acid such as sodium polyacrylic acid, methyl cellulose, and sodium carboxymethyl cellulose can be suitably used. J'3, these polymeric substances may be used alone or in combination of two or more.

In the present invention, a solution is prepared by dissolving the film-forming polymeric substance in an organic solvent, but in this case, a film-forming polymeric substance that dissolves in the organic solvent used may be appropriately selected and used. be. Incidentally, as the organic solvent, an appropriate one such as ethanol, acetylene, etc. can be used. In addition, in the above solution, the film-forming polymer substance is 1 to 30% of the organic solvent.
% (weight %, hereinafter the same) is preferable from the viewpoint of workability and the like.

In J3-C of the present invention, a powder of a water-soluble polymer substance that does not dissolve in the organic solvent is appropriately selected, the powder of the water-soluble polymer substance is dispersed and mixed in the above solution, and the dispersion is placed on a bench or the like. A film is formed by spreading it to a predetermined thickness on an appropriate base, and this film is dried to form a medical product in which powder of a water-soluble polymeric substance is dispersed in a sheet of film-forming polymeric substance. This is what you get for your band. In this case, the thickness to be formed varies depending on the purpose of the medical band and is not particularly limited, but it is usually spread so that the thickness of the band when dried is 0.5 to 3 m + n4'1 degree. preferable. Further, as a drying method, an appropriate method such as natural drying, low temperature drying, reduced pressure drying, etc. can be adopted.

a3. In the present invention, other ingredients such as active ingredients and surfactants are blended as necessary in the solution of the J-described film-forming convex molecular substance or in the rice of the water-soluble polymer substance described above. I don't mind if you do that.

Accordingly, the method for manufacturing a medical band according to the present invention involves adding a film-forming polymer substance to a solution obtained by dissolving a film-forming polymer substance in an organic solvent, which is insoluble in the organic solvent, and dissolved in water or gelled with water to make it sticky. A powder of a water-soluble polymer substance exhibiting the above is dispersed and mixed, and then a solution of a film-forming polymer substance in which the powder of the water-soluble polymer substance is dispersed is formed into a film to a predetermined thickness, and this is dried to form a film. By constructing a medical band in which powder of a water-soluble polymeric substance is dispersed in a sheet of a water-soluble polymeric substance, the manufacturing method of the present invention has strong adhesion, a long adhesion time, and is flexible enough to easily adhere to the affected area. It does not cause any irritation to the skin, can be formed into any size and shape when used, and can be applied to any part of the body cavity, making it suitable for a variety of applications. It is possible to manufacture medical bands.

EXAMPLES The present invention will be specifically explained below with reference to Examples.

Note that all percentages do not indicate weight percent.

[Example 1] Total 100.0% Among the above materials, A was mixed and dissolved in ethanol so that hydroxypropyl cellulose (film-forming polymeric substance) was 20% of the ethanol to obtain film-forming property. A solution was obtained.

Next, a powder of a water-soluble polymer substance mixed with B) was added to this film-forming solution, stirred to disperse the powder, and the dispersion was spread to a thickness of 1 inch on a table. to form a film and dry it for medical treatment.

I got a band for it.

Next, the following experiment was conducted using the medical band of Example 1 above.

Back side--1 One side of the medical band prepared in Example 1 was spray coated with a 1delcellulose solution to form an ethyl cellulose film. Next, using five panelists, the side of the medical band on which the ethyl cellulose coating was not formed was adhered to each panel at the intraoral placement site shown in the table below, and the adhesion time until the band was peeled off was measured. The results are shown in the table. Note that each band used had a size of 1010×10T. Furthermore, the subjects were asked to eat a meal between 3 and 4 hours after each panel was pasted.

From the results shown in the table, it was confirmed that the medical band obtained by the method of the present invention has a long attachment time of 3 to 6.5 hours.

(Example 2) Total ioo, o% The back A of the above materials was mixed, and this was dissolved in ethanol so that hydroxypropyl cellulose (film-forming polymeric substance) was 5% of the ethanol to determine film-forming property. A solution was obtained. Next, a mixture of 8 (powder of a water-soluble polymer substance) is added to this film-forming solution, stirred to disperse the powder, and the dispersion is spread on a table to a thickness of 0.7 mm. A film was formed, and this was dried to obtain a medical band.

[Example 3] ←(PEG-400) Total ioo, o% Among the above materials, A was mixed, and polyvinylpyrrolidone (film-forming polymeric substance) was mixed with ethanol in an amount of 1% of the ethanol.
A film-forming solution was obtained by dissolving the solution to a concentration of 0%. Next, 88% of mixed Chinoku water-soluble polymer material powder was added to this film-forming solution, stirred to disperse the powder, and the dispersion was spread to a thickness of 1 inch on table F. This was dried under reduced pressure to obtain a medical band.

When the same experiment as in Example 1 was conducted using the medical band of Example 2.3, it was found that the band also had a long attachment time.

Applicant: Laion Co., Ltd. Agent: Patent Attorney Takashi Kojima

Claims (1)

[Scope of Claims] 1. A water-soluble polymer V which is insoluble in the organic solvent and exhibits stickiness when dissolved in water or gelled with water in a solution prepared by dissolving a film-forming polymeric substance in an organic solvent. The powder of the water-soluble polymer substance is dispersed and mixed, and then a solution of the film-forming polymer substance in which the water-soluble polymer substance powder is dispersed is formed to a predetermined thickness, and this is dried to form a film-forming polymer substance. A method for manufacturing a medical band, characterized by obtaining a medical band in which a powder of a water-soluble polymer substance is dispersed in a sheet. 2. Film-forming polymer substance 1 is selected from hydroxypropylcellulose and polyvinylpyrrolidone. 3. The water-soluble polymer substance that exhibits adhesive properties when dissolved or gelled in water is a salt of polyacrylic acid or polyacrylic acid. ,
'! according to claim 1 or 2, which is selected from methylcellulose and sodium carboxymethylcellulose. <j jjff method.