JPS6040056A - Method and apparatus for producing deformable seamless soft capsule - Google Patents
Method and apparatus for producing deformable seamless soft capsuleInfo
- Publication number
- JPS6040056A JPS6040056A JP58147635A JP14763583A JPS6040056A JP S6040056 A JPS6040056 A JP S6040056A JP 58147635 A JP58147635 A JP 58147635A JP 14763583 A JP14763583 A JP 14763583A JP S6040056 A JPS6040056 A JP S6040056A
- Authority
- JP
- Japan
- Prior art keywords
- seamless soft
- mold
- soft capsule
- capsule
- soft capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Formation And Processing Of Food Products (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明はシームレス軟カプセル、就中、種々の形を有す
るシームレス軟カプセルの製造方法および製造装置に関
する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method and apparatus for manufacturing seamless soft capsules, particularly seamless soft capsules having various shapes.
従来、種々の形を有するカプレルが市販されているが、
これらは全てボディにキャップを嵌合する硬カプセル、
あるいは２枚のシートの継ぎ目を有する軟カプセルであ
り、シームレスの軟カプセルでは球形の−もののみしか
存在しない。これはシームレス軟カプセルが滴下法と呼
ばれる液滴がその表面張力によって球形になる性質を利
用して製造されるために、球形のカプセルだけが得られ
、他の形態のカブ［ルが得られないからである。Conventionally, caprels with various shapes have been commercially available, but
These all include a hard capsule that fits a cap onto the body.
Alternatively, it is a soft capsule that has a seam between two sheets, and among seamless soft capsules, only spherical capsules exist. This is because seamless soft capsules are manufactured using the dropping method, which utilizes the property of liquid droplets to become spherical due to their surface tension, so only spherical capsules can be obtained, and capsules of other shapes cannot be obtained. It is from.
本発明者等は球形だけではく、種々の形状、例えば、長
楕円形、卵形等を有する変形シームレス軟カプセルを得
るために鋭意研究の結果、本発明を成すに到った。The present inventors have completed the present invention as a result of intensive research to obtain deformed seamless soft capsules having not only a spherical shape but also various shapes, such as an oblong shape and an oval shape.
即ち、本発明は二ｍノズルの先端より、カブヒル充填物
質と皮膜物質とを一定速度で冷却液中に流出して凝固さ
せるシームレス軟カプセルを製造づる方法において、二
重ノズルから流出した液滴がゾル状態にある間に、成形
型中で冷却することを特徴とづる変形シームレス軟カプ
セルの製造方法を提供する。That is, the present invention provides a method for manufacturing seamless soft capsules in which a Cubhill filling material and a coating material are flowed into a cooling liquid at a constant rate from the tip of a two-meter nozzle and solidified. A method for producing modified seamless soft capsules is provided, which comprises cooling in a mold while in a sol state.
さらに本発明は、カプセル充填物質と皮膜物質とを流出
する二重ノズルと、流出した液滴を凝固づるための凝固
液を還流づる造粒部とを有づるシームレス軟カプセルの
製造装置において、該造粒部に成形冷却する成形型を備
えることを特徴とする変形シームレス軟カプセルの製造
装置を提供する。Furthermore, the present invention provides an apparatus for producing seamless soft capsules, which has a double nozzle for discharging a capsule filling material and a coating material, and a granulation section for refluxing a coagulating liquid for coagulating the discharged droplets. Provided is an apparatus for manufacturing modified seamless soft capsules, characterized in that a granulation section is equipped with a mold for molding and cooling.
本発明を図面により説明づる。The present invention will be explained with reference to the drawings.
第１図は、本発明装四の簡略化した全体図である。FIG. 1 is a simplified overall view of the device of the present invention.
第２図は、第１図の造粒部（Ａ）の模式的拡大断面図で
ある。FIG. 2 is a schematic enlarged sectional view of the granulation section (A) in FIG. 1.
皮膜物質（１）とカプセル充填物質（２）が１０〜９０
℃に保たれた恒温タンク（１６，１７）から、定量ポン
プ（１１，１４）を介して二重ノズル（３）に連結され
、二重ノズル（３）の外側に皮膜物質（１）が供給され
、内側にカプセル充填物質（２）が供給される。The coating material (1) and the capsule filling material (2) are 10 to 90
A constant temperature tank (16, 17) kept at ℃ is connected to the double nozzle (3) via a metering pump (11, 14), and the coating material (1) is supplied to the outside of the double nozzle (3). and the inside is filled with capsule filling material (2).
皮膜物質（１）はゼラチンＪ５よび水溶性多価アルコー
ルまたはその水溶性誘導体から成り、常套のカプセルの
製造に用いられるいがなるものを用いてもよい。水溶性
多価アルコールまたはその水溶性誘導体の例としては、
グリセリン、ポリグリセリン、ソルビット、エチレング
リコール、ポリエチレングリコール、プロピレングリコ
ール、ポリプロピレングリコール、酸化エチレン−酸化
プロピレン共重合体、オリゴサツカライド、シュガーエ
ステル、グリヒリト、ソルビタンエステル類が挙げられ
る。The coating material (1) consists of gelatin J5 and a water-soluble polyhydric alcohol or a water-soluble derivative thereof, and any material used in conventional capsule production may be used. Examples of water-soluble polyhydric alcohols or their water-soluble derivatives include:
Examples include glycerin, polyglycerin, sorbitol, ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, ethylene oxide-propylene oxide copolymer, oligosaccharide, sugar ester, glyhirite, and sorbitan esters.
カプセル充填物質（２）の例としては、通常、軟カプセ
ルに充填されるいかなるものを用いてもよい。例えば、
痔疾治療剤、非麻薬性鎮咳桑、非ステロイドまたは非ピ
リン系消炎鎮痛・解熱剤、抗生物質、抗パーキンソン氏
病治療剤または脳・末梢血流改善剤等が挙げられる。As an example of the capsule filling material (2), any material that is normally filled into soft capsules may be used. for example,
Examples include anti-hemorrhoids, non-narcotic antitussive mulberry, non-steroidal or non-pyrine anti-inflammatory and analgesic/antipyretic agents, antibiotics, anti-Parkinson's disease therapeutic agents, and cerebral/peripheral blood flow improving agents.
二重ノズル（３）に供給された物質はノズル口から凝固
液（４）中に流出覆る。凝固液（４）の温度は、一般に
９〜１０℃であることが好ましい。The substance supplied to the double nozzle (3) flows out from the nozzle opening into the coagulating liquid (4). The temperature of the coagulating liquid (4) is generally preferably 9 to 10°C.
凝固液（４）はゼラチン溶液と混じらない溶媒であって
、例えば、流動パラフィン、鉱物油、植物油等があげら
れる。The coagulating liquid (4) is a solvent that does not mix with the gelatin solution, and includes, for example, liquid paraffin, mineral oil, vegetable oil, and the like.
凝固液（４）中に放出された物質は、その表面缶力によ
り液滴（５）を形成°ツる。形成された液滴（５）は、
液滴（５）がゾル状態にある間に種々のキャビディを有
する成形型（８）に送られ、成形冷却される。液滴（５
）がゾル状態である時間は、液滴の大きさ、凝固液（４
）の温度等に左右され限定的ではないが、通常３秒以内
である。The substance released into the coagulation liquid (4) forms droplets (5) due to its surface forces. The formed droplet (5) is
While the droplets (5) are in a sol state, they are sent to a mold (8) having various cavities, where they are molded and cooled. Droplet (5
) is in the sol state depending on the size of the droplet, the coagulation liquid (4
Although it depends on the temperature, etc., and is not limited, it is usually within 3 seconds.
従って、流出から３秒以内に成形型（８）に送られるの
が適当である。冷却温度は特に限定的ではないが、６〜
７℃が好ましい。Therefore, it is appropriate to send it to the mold (8) within 3 seconds from the time it flows out. The cooling temperature is not particularly limited, but is 6~
7°C is preferred.
成形型（８）はカプセル回収管（６）の内部にあって、
落下りる液滴（５）をレンザー（図示されていない）等
により確認し挟示づる。成形型の材質はガラス、アクリ
ル、シリコン、テフロン等が例示されるが、シリコン、
テフロンが好ましい。The mold (8) is inside the capsule collection tube (6),
The falling droplet (5) is confirmed and pinched using a lens (not shown) or the like. Examples of mold materials include glass, acrylic, silicone, and Teflon, but silicone,
Teflon is preferred.
冷却された液滴（５）は、カプセル回収管（６）を通っ
て分離板（９）により分離し乾燥され、種々の形を有す
る変形シームレス軟カプセルが得られる。回収された凝
固液（４）は、セパレーター（１０）から定ｍポンプ（
１３）を介して貯蔵タンク（１５）に送られる。凝固液
く４）は、再び定１ポンプ（１４）を介して造粒部（Ａ
）に供給される。The cooled droplets (5) pass through the capsule collection tube (6), are separated by the separator plate (9), and are dried, yielding modified seamless soft capsules with various shapes. The collected coagulating liquid (4) is passed from the separator (10) to a constant m pump (
13) to the storage tank (15). The coagulating liquid 4) is sent to the granulation section (A) again via the constant pump (14).
).
本発明によれば、成形型（８）の形状を変えると種々の
形態を有する変形シームレス軟カプセルが製造できる。According to the present invention, modified seamless soft capsules having various shapes can be manufactured by changing the shape of the mold (8).
例えば、第３図に示される形態を有する変形シームレス
軟カプセルが製造できる。For example, a modified seamless soft capsule having the configuration shown in FIG. 3 can be manufactured.
本発明により得られた変形シームレス軟カプセルは、楕
円等の形状を有し服用し易くなる。皮膜処方に自由度を
有し、易溶性カプセルを４ｑることもできる。また、内
容液と皮膜の精度が従来品の５〜１０％に比べて３％に
向上する。さらに、比較的小さな径のものを得ることも
でき、医薬品以外の用途（例えば、食品、菓子等）への
応用も可能である。The modified seamless soft capsule obtained by the present invention has a shape such as an ellipse, making it easy to take. There is a degree of freedom in coating formulation, and easily soluble capsules can be made into 4q. In addition, the accuracy of the liquid content and coating is improved to 3% compared to 5-10% for conventional products. Furthermore, it is possible to obtain products with relatively small diameters, and applications other than pharmaceuticals (eg, foods, confectionery, etc.) are also possible.
第１図は、本発明装置の簡略化した全体図である。
第２図は、第１図の造粒部（Ａ）の模式的拡大断面図で
ある。
第３図は、本発明により得られた種々の形のカプセルを
表わづ。
図中の記号は以下の通りである：
（１）・・・皮膜物質、（２）・・・カプセル充填物質
、（３）・・・二重ノズル、（４）・・・凝固液、（５
）・・・液滴、（６） ノＪプセル回収管、（９〉分離
板、（１０）・・・セパレーター、（１１，１２，１３
゜１４）・・・定量ポンプ、く１５）・・・貯蔵タンク
、（１６，１７）恒温タンク
第２図
第３図FIG. 1 is a simplified overall view of the device of the invention. FIG. 2 is a schematic enlarged sectional view of the granulation section (A) in FIG. 1. FIG. 3 represents capsules of various shapes obtained according to the invention. The symbols in the figure are as follows: (1)...Coating material, (2)...Capsule filling material, (3)...Double nozzle, (4)...Coagulation liquid, ( 5
)...Droplet, (6) NoJ Pcell collection tube, (9> Separation plate, (10)... Separator, (11, 12, 13)
゜14)...metering pump, 15)...storage tank, (16,17) constant temperature tank Fig. 2 Fig. 3
Claims (1)
物質とを一定速度で冷却液中に流出して凝固させるシー
ムレス軟カプセルを製造づる方法において、二重ノズル
から流出した液滴がゾル状態にある間に、成形型中で成
形冷却することを特徴とＪる変形シームレス軟カプセル
のｌｉｔ造方法。 ２、 液滴が成形型に３秒以内に達する第１項記載の方
法。 ３、 カブヒル充填物質と皮膜物質とを流出する二重ノ
ズルと、流出した液滴を凝固するための凝固液を還流す
る造粒部とを有するシームレス軟カプセルの製造装置に
おいて、該造粒部に成形冷却する成形型を備えることを
特徴とする変形シームレス軟カプセルの製造装置。 ４、 液滴が成形型に３秒以内に達する第３項記載の装
置。[Claims] 1. In a method for manufacturing seamless soft capsules in which a capsule filling material and a coating material flow out from the tip of a double nozzle into a cooling liquid at a constant rate and solidify, A method for making a modified seamless soft capsule by molding and cooling in a mold while the droplets are in a sol state. 2. The method according to item 1, wherein the droplet reaches the mold within 3 seconds. 3. In a seamless soft capsule manufacturing apparatus having a double nozzle for discharging the Kabuhil filler material and a coating material, and a granulating section for refluxing a coagulating liquid for coagulating the discharged droplets, the granulating section A manufacturing device for deformed seamless soft capsules, characterized in that it is equipped with a mold for molding and cooling. 4. The device according to item 3, wherein the droplet reaches the mold within 3 seconds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58147635A JPS6046981B2 (en) | 1983-08-11 | 1983-08-11 | Manufacturing method and device for deformed seamless soft capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58147635A JPS6046981B2 (en) | 1983-08-11 | 1983-08-11 | Manufacturing method and device for deformed seamless soft capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6040056A true JPS6040056A (en) | 1985-03-02 |
| JPS6046981B2 JPS6046981B2 (en) | 1985-10-18 |
Family
ID=15434788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58147635A Expired JPS6046981B2 (en) | 1983-08-11 | 1983-08-11 | Manufacturing method and device for deformed seamless soft capsules |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6046981B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6215531U (en) * | 1985-07-10 | 1987-01-30 | ||
| US5209978A (en) * | 1985-12-26 | 1993-05-11 | Taisho Pharmaceutical Co., Ltd. | Seamless soft capsule and production thereof |
| EP1690518A1 (en) * | 2003-11-07 | 2006-08-16 | Freund Corporation | Seamless capsule manufacturing method, seamless capsule manufacturing device, and seamless capsule |
| KR101250087B1 (en) * | 2002-06-24 | 2013-04-02 | 추가이 세이야쿠 가부시키가이샤 | Process for producing aspheric seamless capsule and apparatus therefor |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6052085U (en) * | 1983-09-19 | 1985-04-12 | キタムラ機械株式会社 | Automatic workpiece discharge device for laser processing machine |
-
1983
- 1983-08-11 JP JP58147635A patent/JPS6046981B2/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6215531U (en) * | 1985-07-10 | 1987-01-30 | ||
| US5209978A (en) * | 1985-12-26 | 1993-05-11 | Taisho Pharmaceutical Co., Ltd. | Seamless soft capsule and production thereof |
| KR101250087B1 (en) * | 2002-06-24 | 2013-04-02 | 추가이 세이야쿠 가부시키가이샤 | Process for producing aspheric seamless capsule and apparatus therefor |
| EP1690518A1 (en) * | 2003-11-07 | 2006-08-16 | Freund Corporation | Seamless capsule manufacturing method, seamless capsule manufacturing device, and seamless capsule |
| EP1690518A4 (en) * | 2003-11-07 | 2008-12-31 | Freund Corp | Seamless capsule manufacturing method, seamless capsule manufacturing device, and seamless capsule |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6046981B2 (en) | 1985-10-18 |
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