JPS6027535B2 - wound covering agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a covering agent that promotes the repair and healing of a wound in Guangjo, and more specifically to a covering agent that promotes the growth of tissue cells in a wound and drains body fluids from the wound. The object of the present invention is to provide a novel wound lifting bar agent that can be removed from the wound surface while preventing infection of the wound surface due to bacterial invasion from the outside.

Wounds are caused by burns, skin abrasion (for skin grafts), physical injuries, etc., and these can be treated using ointment bases containing silver nitrate or cartilage bases containing topical antibiotics. Covering therapy is commonly used. This therapy attempts to heal the wound by applying the ointment to the wound to absorb body fluids and prevent bacterial infection.

However, this therapy has the disadvantage that it takes a long time for complete recovery because no means have been found to actively promote the growth of tissue cells.

Recently, in place of such therapy, a homograft method using human skin and a heterograft method using pig skin have been studied and adopted.

However, since the homograft method uses human skin, its range of application is naturally limited, and the heterograft method also requires complicated operations such as washing and sterilizing fresh pig skin with boiling water. There is a problem that it is difficult to obtain products of uniform quality.

On the other hand, attempts have been made to use freeze-dried pig skin, and some have even undergone clinical tests, but this requires a complicated operation of aseptically soaking it in physiological saline and softening it before use. If water or the like adheres to the posterior pig skin, there are problems such as water infiltration and delayed healing.

Furthermore, as covering agents, polymethyl glutamate, polybenzyl glutamate, silicone rubber, flock-like materials made of fibers such as polyamide or polyester, and polyvinyl formal sponges have recently been proposed; At present, no material has yet been developed that is satisfactory in terms of performance, moisture permeability, etc.

Therefore, a first object of the present invention is to provide a wound covering agent that has good adhesion to wound tissue and promotes the growth of tissue cells.

A second object of the present invention is to provide a wound covering agent that is capable of removing body fluids from a wound and also prevents the invasion of water or bacteria from the outside.

This object of the present invention is achieved by forming a biocompatible polymer film layer on the surface of a porous fluororesin film. The wound covering agent of the present invention has the characteristics that it has good adhesion to the wound site and promotes the growth of tissue cells, so that the wound site heals quickly and is also prevented from being infected by bacteria.

The porous fluororesin film used in carrying out the present invention has pores that do not allow water or bacteria to enter from the outside, and have pores that are large enough to allow bodily fluids coming out of the wound to evaporate through the pores. It has a countless number of pores, has particularly high twill water properties, and can form uniform pores.

The pore diameter of the pores in the porous fluororesin film is 10
The range of the kite is from 0A to 100A, preferably from 1000A to loAm.If it is less than 100A, it is undesirable because it inhibits the evaporation of body fluids, and if it is more than 100A, it is not preferred because water etc. will enter. In addition, the biocompatible polymer film layer used in carrying out the present invention is made of proteins such as collagen, keratin, and chitin, and has a thickness of 2,000 mm or less, preferably in the range of 10 to 500 mm. Among these, films made of collagen are particularly preferred because they greatly contribute to the growth of tissue cells. These biocompatible polymer films contain polyhydric alcohols such as glycerin and polyethylene glycol with a molecular weight of 400 to 5,000 in an amount of 5 to increase their flexibility and eliminate irritation to the skin. It can be blended in an amount of % by weight or less.

In addition, if the biocompatible polymer film itself is made porous, the pores (0
．． This is preferable because it is reliably evaporated from the porous fluororesin film through the pore-forming fluororesin film.

Furthermore, in order to prevent the biocompatible polymer film from being melted by body fluids, it is preferable to appropriately crosslink it using light irradiation such as ultraviolet irradiation or a compound such as an aldehyde.

In this way, the wound lifting force bar made of a composite of a porous fluororesin film and a biocompatible polymer film layer may optionally contain sulfated mucopolysaccharides such as chondroitin sulfate and hyaluronic sulfate, which have the effect of promoting wound healing. or the like is mixed into the film layer, which is cut into a desired shape and fixed to the wound site with surgical adhesive tape, or a biocompatible adhesive is formed in advance in the shape of a frame around the covering material piece. It is used by keeping it in place and fixing it. Since the lifting force bar of the present invention is constructed as described above, body fluids are evaporated by the porous fluororesin film and water is prevented from entering, so that the biocompatible polymer film layer is melted. Moreover, since the film layer promotes the growth of tissue cells, it has the effect of reliably and quickly healing the wound area. Examples of the present invention will be shown below.

Example 1 Adhesive was partially applied to one side of a fluororesin film with a thickness of 50 cm, which has countless pores with pore diameters of 1000A to 1R, and this coated surface was cross-linked with aldehyde. A collagen film (glycerin: 3% by weight) of 80 mm was laminated to obtain a lift bar agent.

Example 2 An adhesive was partially applied to one side of the porous fluororesin film obtained in Example 1, and a collagen film with a thickness of 80 mm cross-linked with glutaraldehyde (glycerin and chondroitin sulfate were respectively added to the coated surface) was applied. (containing 30% by weight) to obtain a wound covering agent.

Example 3 A wound covering agent was obtained in the same manner as in Example 1, except that a collagen film having pore size of 5 mm and skin-like pores was used.

Table 1 shows the characteristic results of Examples 1 to 3.

In the comparative example in Table 1, commercially available freeze-dried pig skin was aseptically soaked in sterilized physiological saline, taken out after 20 minutes, and used for treatment. The tests in Table 1 were conducted as follows.

The hair on the backs of Wistar rats was shaved, washed with a neutral soap solution, and further disinfected with alcohol. Four skin abrasion wounds with a size of 2 x 3 angles were created, and 10 animals were grouped into one group.

The samples of Examples 1 to 3 sterilized with ethylene oxide gas and the pigskin as a comparative example were pasted on the wound, the surrounding area was fixed with a biological adhesive, and gauze was placed on the sample. and fixed with surgical adhesive tape. Wounds were observed every two days after treatment. The samples of Examples 1 to 3 in Table 1 were easier to treat and showed comparable adhesion to the wound area compared to the pig skin of the comparative example.

Furthermore, regarding the degree of healing, the samples of Examples 1 and 2 had less melting and were superior to pigskin, and the samples of Example 3 were at the same level as the comparative example. As is clear from the above examples, the wound covering agent of the present invention is superior to the conventional pig skin in terms of handling and healing effects, and is notable for the fact that it is less prone to melting due to infection.

Claims (1)

[Scope of Claims] 1. A wound covering agent comprising a biocompatible polymer film layer formed on the surface of a microporous fluororesin film. 2 Microporous fluororesin film average pore diameter of 100 Å to 1
The wound covering agent according to claim 1, which has a particle diameter of 00 μm. 3. The wound covering agent according to claim 1, wherein the biocompatible polymer film is a collagen film. 4. The wound covering agent according to claim 3, wherein the collagen film contains a polyhydric alcohol.