JPS60247616A - Contact lens cleaner - Google Patents

Abstract

PURPOSE:To provide a contact lens cleaner which is convenient to carry and can be cleaned while preventing contamination with microorganisms by impregnating an aq. soln. contg. a pharmaceutically permissible surface active agent and antiseptic as well as >=1 kind among a chelating agent, isotonizing agent and buffer agent to a water absorptive material and packaging and sealing such impregnated material with a moisture-proof film. CONSTITUTION:The water absorbent material maintains the solid form by holding the aq. soln. contg. the surface active agent, etc. and therefore said material facilitates packaging and handling in the stage of use. The water absorbent material which remains soft by absorbing the aq. soln. removes gently the stains of a lens and absorbs the removed stains when the lens is wiped clean by the cleaner. Thus the material helps prevent resticking of the stains to thelens. The surface active agent swells the stains of the lens by sticking and penetrating to and into said stains so that the stains can be stripped and diffused. The antiseptic prevents the rotatness during preservation, disinfects the hand and fingers during lens cleaning and prevents the lens from being contaminated by microorganisms. The chelating agent captures the polyvalent metals such as calcium ions and accelerates stain removal in the stage of cleaning the lens. The isotonizing agent helps prevent stimulating the eyes owing to the osmotic pressure of the hypertonicity or hypotonicity. The buffer agent helps prevent stimulating the eyes by adjusting the pH of the aq. soln.

Description

[Detailed description of the invention] (Industrial application field) The present invention relates to contact lens cleaners.

According to the present invention, dirt adhering to contact lenses can be easily and effectively removed at any time.

(Prior Art) Various contact lenses have been used in the past. The materials for these lenses can be broadly classified into water-containing materials and non-water-containing materials. Typical examples of non-water-containing contact lenses include lenses made of polymethyl methacrylate, cellulose acetate butyrate, and hard gas-permeable lenses containing siloxane.

When these contact lenses are worn on the eyes, eye secretions such as lipids and proteins and dust in the air adhere to the lenses, causing lens fogging and eye pain. To eliminate this problem, contact lenses must be removed from the eye and cleaned.

Traditionally, to clean contact lenses, you first wash your hands thoroughly with detergent, then remove the lens from your eyes, soak it in cleaning solution, rub the lens surface with your fingertips to remove dirt, and then rinse thoroughly with rinse agent. is being carried out.

(Problems to be Solved by the Invention) However, such operations are complicated, and there are many types of materials used, so it is inconvenient to make it portable, and there is a risk that it will not be completed in time if it is urgently needed.

(Means for Solving the Problems) As a result of repeated research to overcome these drawbacks, the present inventors have completed the present invention.

The present invention is capable of absorbing and retaining water, and when the surface of a contact lens is rubbed with the material that has absorbed the aqueous solution described below, the water absorption does not cause the adhesion of dust or damage to the lens, which would impede lens wearing. A pharmaceutically acceptable surfactant and preservative, preferably also a chelating agent,
This contact lens cleaner is made by impregnating the material with an aqueous solution containing at least one of a tonicity agent and a buffer, and wrapping and sealing the impregnated material with a moisture-proof film.

In the present invention, the material to be impregnated with the aqueous solution is one that is capable of absorbing and retaining moisture, and is free of dust that may interfere with lens wearing when the surface of a contact lens is rubbed with the aqueous solution absorbed. Water-absorbing materials are used that do not generate, adhere to, or damage the lens.

Examples of such materials include paper, cloth, polyhydroxyethyl methacrylate, water-containing gel films such as konnyaku gel, and open-cell hydrophilic synthetic resin foams made of hydrophilic fibers that are difficult to tear and are as long as possible. Can be mentioned.

Preferred examples include hydrophilic fibers such as rayon, cellulose acetate or triacetate, cotton, etc., so that the fibers do not separate from the material during use and become dust that adheres to the lens and interfere with the use of the lens. It is preferable to use fibers that are as long as possible, for example, about 10 fibers or more, preferably 3Qs+* or more.

The material may be a mass of entangled fibers, but in order to prevent the sown fibers from coming off, it is preferable to form the material into cloth, preferably gauze or coarse non-woven fabric.

Pharmaceutically acceptable surfactants can be selected from nonionic, anionic, cationic, and amphoteric types.

In consideration of low eye irritation, nonionic types are preferred, but other types can also be used by selecting the type and concentration.

Preferred examples of nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polystyrene phenyl ether, and polyoxyethylene-polyoxypropylene glycol (including block polymers and random polymers). ), polyoxyethylene-polyoxypropylene alkyl ether (including random polymers), polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyoxyethylene fatty acid ester, polyoxyethylated castor oil, These include fatty acid jetanolamide and triethanolamine fatty acid partial ester.

Preferred examples of other types include 7-methyl sulfate salt, polyoxyethylene alkyl ether sulfate salt, N-acylmethyl taurine salt, etc. in the anion type, and benzalkonium chloride, benzethonium chloride, etc. in the cation type. In the amphoteric type, alkylimidacillin, alkyl acetic acid betaine, etc. are recommended.

The concentration of surfactant in aqueous solution is generally 0.05-30%
The concentration of the cationic type is preferably as low as about 1%.

Preferred examples of preservatives include benzalkonium chloride,
Examples include benzethonium chloride, chlorhexidine salt, sorbic acid and its sodium salt, chlorobutanol, benzyl alcohol, phenethylalconopeparabens, and the like. If a cationic type is used as the surfactant or sexing agent, it can act as a preservative as well as a surfactant.

In addition to a surfactant and a preservative, the aqueous solution may desirably contain one or more of a chelating agent, an isotonizing agent, and a buffering agent.

Examples of the chelating agent include sodium edetate, sodium citrate, and condensed sodium phosphate.

Isotonic agents usually include sodium chloride, potassium chloride,
Sugars etc. are used.

Examples of buffering agents include combinations of boric acid and its salts, citric acid and its salts, tartaric acid and its salts, gluconic acid and its salts, acetic acid and its salts, various amino acids and their salts, and phosphoric acid and its salts. It will be done.

In addition, if desired, thickeners such as sodium carboxymethylcellulose, glycerin, hydroxyethylcellulose, and methylcellulose may be added to increase the viscosity of the solution, and thickeners such as alumina, calcium carbonate, magnesium carbonate, and silica may be added to increase the viscosity of the solution. Fine powder may be added as an abrasive.

The aqueous solution containing the above surfactant and preservative and optionally other additives is impregnated into a water-absorbing material and packaged and sealed with a moisture-proof film. The pre-impregnated material may be packaged in a film, or the water-absorbing material may be placed in a film bag, an aqueous solution may be poured into the film bag to impregnate the bag, and the bag may then be sealed. Considering convenience in use, it is desirable that the size of the impregnated material is suitable for one use. For example, the size of rayon gauze is about 200 cJ, which can be folded and used.

The moisture-proof film is preferably one that can be thermally bonded, such as heat sealing, impulse sea-nope high frequency bonding, or ultrasonic bonding. You can choose.

The film is preferably laminated with an aluminum film to provide complete moisture proofing and to avoid deterioration of the packaged contents by transmitted light as much as possible.

Sealing can be accomplished by heat sealing or by using an adhesive, depending on the nature of the film.

(Function) In the present invention, the water-absorbing material retains an aqueous solution containing a surfactant and the like to maintain its solid state, making it convenient to package and handle during use, and to wipe it clean by rubbing it with the cleaner of the present invention. The water-absorbent material, which becomes flexible by absorbing an aqueous solution, gently peels off dirt from the lens, absorbs the removed dirt, and helps prevent it from re-adhering to the lens. At that time, there is no risk that dust will be generated from the same material and adhere to the lens, or that the lens will be spoiled, so it will not interfere with subsequent wearing of the lens.

gL Memetic Pregnancy + l + - Addition to the prayer of the lens - Penetrates and swells, and combined with the friction of the water-absorbing material, it can peel off and disperse dirt that is difficult to remove just by rubbing with your fingers. can.

The preservative not only prevents the cleaner of the present invention from deteriorating during storage, but also disinfects the hands and fingers when cleaning the lens, and also protects the lens from contamination with microorganisms9. Captures polyvalent metals and facilitates stain removal.

Isotonic agents help prevent hypertonic or hypotonic osmotic pressure from irritating the eye even if the aqueous cleaner solution is attached to the lens when the lens is put on the eye after cleaning, and also provides a buffering agent. The agent helps to adjust the pH of the aqueous solution to about 5-8 to prevent eye irritation.

(Effects of the Invention) The cleaner of the present invention is convenient to carry, and when used, remove the impregnated material from the packaging, wipe your hands and fingers with it as needed, and then wipe the lens with it after removing it from your eyes. can be washed. therefore,
It is important to clean your lenses at all times and everywhere while preventing microbial contamination. Furthermore, since the impregnated material has a preservative effect, it is also possible to store removed lenses by inserting them into this material. Even if the aqueous solution absorbed by the impregnated material leaks out due to pressure during lens cleaning, it will be reabsorbed by the water-absorbing material when the pressure is stopped, so the lens can be worn as is after cleaning. can.

Example: Non-woven gauze made from rouyon (fiber length: approximately 30 mm)
．． 69 (approximately 200 c+#) and put it in a bag made of laminate film of polyethylene terephthalate and unstretched polypropylene, and prepare the following formulation: Chlorhexidine gluconate 0.029 Disodium edetate 0.1 g Polyoxyethylene octylphenyl ether 0.59 Boric acid 1 ．． Of/Borax Add an appropriate amount of purified water to make it 100- (pH about 7.0) An aqueous solution of 2.0- was uniformly injected, impregnated, and heat-sealed.

Example 2 The same procedure as Example 1 was carried out except that the aqueous solution was formulated as follows.

Benzalkonium chloride 0.02 fl Disodium edetate 0.19 Boric acid 1.0 g Borax Appropriate amount Sodium chloride 0.3 f Add purified water to adjust to 100- (pH approximately 7.5) Example 3 Prescription of aqueous solution The procedure was the same as in Example 1, except that the sample was packaged, sealed, and then sterilized using high-pressure steam.

Chlorhexidine gluconate 0.019 Polysorbate) 80 0.3f Disodium edetate 0.1F Boric acid 1.0g Borax Add appropriate amount of purified water to adjust to 100- (pH approximately 7.5) Example 4 Prescription of aqueous solution The same procedure as Example 3 was carried out except as follows.

Polyoxyethylene octylphenyl ether 0.5g Disodium edetate 0.1g Boric acid 1.0g Borax Appropriate amount Sodium chloride 0.3g Add purified water to make 100- (p)I approx. 7.5) Reference Example 1 Safety test (1) Irritation to eye tissue The packaging of the cleaners obtained in Examples 1 to 4 was opened, the impregnated cloth was taken out, and the squeezed liquid was instilled into each eye of two white rabbits. , one untreated eye served as a control.

Thirty minutes after instillation, the degree of eye damage was determined by the modified Draize method and corneal fluorescein staining spots were examined. As a result, no abnormality was found in any of the rabbits, and no particular safety problems occurred.

(2) Safety for lenses Two siloxane-containing Muhard lenses, two polymethyl methacrylate lenses, and two cellulose self-acetate/butyrate lenses were scrubbed and cleaned with the impregnated cloths of Examples 1 to 4 for 10 minutes, but the lenses were No scratches or other particular problems occurred.

Reference Example 2 Cleaning Power Test The cleaning power was tested using the impregnated cloths of Examples 1 to 4 using siloxane-containing hard lenses, polymethyl methacrylate lenses, and cellulose acetate butyrate lenses coated with artificial dirt (Note). .

The lenses were rubbed with fingers through the impregnated cloth and then observed with the naked eye. As a result, I was able to clean the lens in a short amount of time without having to attach any lenses.

(Note) Apply the following artificial stain composition to various lenses and
The lens was left to stand at ℃ for one day to allow the dirt to completely adhere to the lens.

(Part) Myristic acid 4.15 Oleic acid 4.15 Tristearin 4.15 Triolein 4.15 Cholesterol stearate), 0.55 Cholesterol 2.2 Squalene 2.75 Carbon black 0.25 Patent applicant Senju Pharmaceutical Co., Ltd. Company agent Patent attorney Kuruma Takeuchi

Claims (1)

[Claims] lj When the surface of a contact lens is rubbed with a material that can absorb and retain moisture and has absorbed the following aqueous solution,
A water-absorbing material that does not attract dirt or damage the lens that would interfere with lens wear, plus pharmaceutically acceptable surfactants and preservatives, preferably in addition to chelating agents, tonicity agents, and buffering agents. A contact lens cleaner made by impregnating an aqueous solution containing one or more of the following, and packaging and sealing this impregnated material with a moisture-proof film. 2. The cleaner according to claim 1, wherein the water-absorbing material impregnated with the aqueous solution is composed of long hydrophilic fibers. 3. Claim 1 or 2, wherein the water-absorbing material impregnated with the aqueous solution is a cloth made from hydrophilic long fibers.
Cleaner listed in section. 4. The cleaner according to claim 1 or 2, wherein the water-absorbing material impregnated with the aqueous solution is a nonwoven fabric. 5. The cleaner according to claim 1, wherein the surfactant is a nonionic surfactant.