JPS60215092A - Powdery aerosol composition to be applied to the human body - Google Patents

Abstract

PURPOSE:To provide the titled compsn. which has excellent re-dispersibility and dryness in its use and is not sticky, consisting of active components, a powder component having a specified particle size, n-pentane and/or iso-pentane and a propellant. CONSTITUTION:0.5-20wt% active components such as antiperspirant, vermin repellent, germicide, etc., 1-30wt% powder component having an average particle size of 5-45mu such as kaolin, 1-80wt% n-pentane and/or iso-pentane, 10- 95wt% propellant such as dichlorodifluoromethane and optionally additives such as oil, alcohol, surfactant, emollient, etc. are blended together.

Description

[Detailed description of the invention] The present invention relates to a powdered aerosol composition for application to the human body.

Conventionally, aerosol products applied to the human body have been blended with powder components, and it has been considered desirable to incorporate powder components in order to improve the effectiveness of the active ingredients contained in the base ingredient and to improve the feeling of use.

For example, aerosol products used as antiperspirants include
Powder ingredients are considered essential ingredients, and aerosol products used as insect repellents and foot-seals should preferably contain various rice powder ingredients in order to retain the active ingredients on the skin or improve the feel of use. It is rare. In addition, various aerosol products such as anti-inflammatory agents, disinfectants, and athlete's foot medicines have been developed by blending powder components into aerosols for application to the human body. The average particle diameter of these powder components is mainly used for reasons such as achieving uniform sprayability, good redispersibility of the powder, and less clogging of the injection hole of the aerosol container. Fine powder with a diameter of about 1 μm is used.

However, it has been pointed out that when an aerosol composition containing all powder components having such small particle diameters is applied to the human skin surface, there is a risk of inhaling the powder dispersed with exhalation.

Paul Fi, Pa1m, Tbeodore Hat
According to Cb et al. (1956), the particle size that is most likely to deposit in the lungs is about 1 μm in diameter, and Murayama (1968) reported that particles with a diameter of about 3 μm after injection.
It is pointed out that after 10 minutes, mist with an average particle size of 3 to 5 microns will remain suspended and there is a high possibility of inhalation.

The human lungs communicate with the mouth and nose through the trachea, which further branches into the bronchi and tubes inside the lungs and reaches the alveoli. In general, the trachea and bronchi have a larger cross-sectional diameter than the tubes, and these epithelial cells are equipped with cilia that trap inhaled powder and expel it from the body, preventing foreign matter from being inhaled into the lung cannon. . In particular, it has been reported that particles of 10μ or larger do not enter the lungs because they are 100% absorbed by hair and deposits in the nasal cavity.

Cambridge (1973)).

Furthermore, when a powder aerosol for human body application is applied to the human skin surface, regardless of the internal pressure of the spray, the type of groperant, the shape of the injection nozzle, etc., there should be almost no particles larger than 5μ above the injection position. is also known [
Murayama et al. (1968)].

Therefore, taking all of this knowledge into consideration, the powder component of a powder aerosol for application to the human body should be 5μ or more, preferably 10μ.
It is thought that a powder with an average particle size of 100% or more should be blended, but if the particles of the powder used become large, the settling speed after redispersion will be slow, the jetting property will be uneven, and the jetting It is difficult and rare to manufacture all aerosol products successfully for reasons such as the tendency to cause mouth clogging.

In order to overcome these difficulties, the inventors of the present invention, as a result of intensive research, have found that an active ingredient and a powder component with an average particle size of 5 to 45 μm are mixed with n-pentane and/or 1θ0--Q-ntane and a propellant. When dispersed to form an aerosol composition, the powder component is uniformly dispersed in the composition despite its large average particle size, and has excellent redispersibility during use; When filled in an air-sol container and applied to the skin, it can be applied evenly, has good drying properties, is less sticky, and has an excellent feeling of use.Also, the active ingredients are retained on the skin for a long time, making it effective and smooth. The present invention was completed based on the discovery that a powdered aerosol composition for application to the human body can be obtained without fear of inhalation into the lungs because the average particle size of the sprayed mist is over 5 μm.

That is, the present invention has an active ingredient of 0.5-201L, an average particle size of 5-45μ, and a powder component of 1-30% by weight.
pentane and/or is.

A powder aerosol composition for application to the human body containing -1 to 80% by weight of pentane and 10 to 95% by weight of a propellant (hereinafter referred to as -) is provided.

The powder components used in the powder aerosol composition for application to the human body of the present invention may be those conventionally used for this type of application, as long as they have an average particle size of between 5 and 45 μm.
Specific examples include aluminum oxide, kaolin, talc, aluminum chlorohydroxide, titanium oxide, magnesium carbonate, magnesium silicate, fish scale foil, titanium mica, mica, starch, and synthetic polymer substances (nylon, ?
Examples include powders such as magnesium salt, calcium salt, or aluminum salt of stearic acid, iron oxide such as red iron oxide, bentonite, etc.), and these may be used alone or in combination of two or more kinds.

Considering inhalation toxicity, these powder components have an average particle size of 5.
It is necessary that it is more than 45μ, and if it exceeds 45μ, roughness will appear on the applied skin surface and the feeling of use will be poor. This powder component accounts for 1 to 30% of the total composition, preferably 3 to 13%.
% is added.

D-pentane and/or aiso-pentane are blended in an amount of 1 to 80%, preferably 5 to 30%, based on the total composition.

As propellants, those commonly used in such cases can be used, including dichlorodifluoromethane (
70-12), trichloromonofluoromethane (Freon 11), cyclotidrafluoroethane (70-114)
), liquefied petroleum gas, dimethyl ether, etc. These are single or 21! ! It can be used as a mixture of the above, and is blended in an amount of 10 to 95%, preferably 70 to 90% of the total composition.

The powdered aerosol composition for application to the human body of the present invention can be used for various purposes such as an antiperspirant, an insect repellent, a bactericidal agent, etc. by appropriately selecting one active ingredient to be incorporated as a main ingredient.

As an active ingredient, for example, aluminum hydroxychloride is used as an antiperspirant, and N, N- as an insect repellent.
As a fungicide , isozolobylmethylfluor, penzalkoniwam chloride, trichlorohydroxydiphenyl ether, etc. These can be used alone or in combination of two or more, and the blending amount varies depending on the type of active ingredient, but is preferably 0.5 to 20% of the total composition.

In addition to the above-mentioned essential ingredients, the powder aerosol for application to the human body of the present invention contains isozolovir myristate, 9) isozolovir rumitate, which increases the adhesion of the powder to the skin surface to which it is applied.
Isozolobyl stearate, butyl stearate, Zometel? Oil agents such as resiloxane: Alcohols such as ethyl alcohol and isozorobyl alcohol to enhance the cooling sensation: Next sorbitan monolawalate, which improves the dispersibility of powder components in solvents and propellants. Surfactants such as lyoxyethylene sorbitan monolawoleate and oxyethylene sorbitan trioleate: avocado oil lanolin alcohol, white oil, liquid 9-loughin,
Emollients such as squalane; or fragrances, etc.
Food or two or more types can be added.

The powder aerosol composition for application to the human body of the present invention can be filled into an aerosol container and applied to the skin or the like. When the powder aerosol composition for human body application filled in an aerosol container is specially used, the active ingredient and the powder component are well redispersed in n-pentane and/or 1so-pentane and the propellant, and the dispersion is Since it is retained for a long time, it can be applied uniformly to the skin without clogging the injection holes, and can exhibit excellent effects. Further, by using a powder component having an average particle size of 5 to 45 μm, problems such as inhalation toxicity of the powder component occur, and there is less discomfort. Furthermore, due to the action of the highly volatile solvent, it has good drying properties, and there are no particles that can contaminate sticky clothes, clothing, etc.
It has various advantages.

Next, an example will be given and explained.

Example 1 An antiperspirant, pest repellent, and fungicide 'ftp having the composition shown in Table 1 below was prepared, and its redispersibility, occurrence of clogging of injection holes, and feeling of use were examined. The results are shown in the second page.

(Redispersibility test) After each aerosol composition was left at a temperature of 45° C. for 6 months, the dispersion state of the powder was evaluated according to the following criteria.

Uniformly dispersed O Slight tendency to agglomerate 6 Partially strong aggregates formed Injection was performed every day, and the presence or absence of clogging and the feeling of use were examined.

Table 2 Example 2 A powder aerosol composition for application to the human body was prepared using talc powder with an average particle size of 1 μm or 10 μm, and the particle size after spraying was measured by the following measuring method. The results are shown in Table 3 and Figure 2.

(Composition) N,N-diethyltoluamide 3(thi)η-pentane
15 Zomethylborisiloxane 2 Talc 10.0 Fragrance Trace propellant 70.0 (Measurement method) After assembling the under-seven sansoler device shown in Figure 1 and setting the flow rate to 29.34/min, The above aerosol composition was injected at about 5V and sampling was performed for about 30 minutes.

After sampling, the collection grate and the backup filter were stored in a desiccator containing a desiccant for about 24 hours, and their weight was measured to examine the distribution of particles collected on each collection grate.

Table 3 Example 3 Invention product in Example 1 1. Button item 2. The aerosol composition of Comparative Product 1 was filled into an aerosol container and applied 151 times to the upper arm of a healthy adult male, and the amount of pest repellent was 0.2.
After applying the product by spraying it, the mosquitoes were inserted into the Guzo for 2 minutes, into which about 50 adult female Aedes albopictus mosquitoes that had not sucked blood were released every 2 hours, and the number of mosquitoes that sucked blood was observed.

The results are shown in Table 4.

Insert for 1 minute

[Brief explanation of drawings]

Figure 1 is a diagram showing the structure of Andersensan f2-, and Figure 2 is a diagram showing the particle size distribution of particles being sprayed.
---) and when using 10μ powder (=). ~: Andersen Zolar F, M: Float type area flowmeter (70-meter) ■ = Pulp for flow rate adjustment F: Filter R: Rotary compressor 8r: Silencer E: Spray inlet Sushi: Simple Chenno station - diameter 151M, Height 30ctn or more Figure 1 F, M

Claims (1)

[Claims] 1. Active ingredient 0.5-20% by weight, average particle size 5-4
5μ powder component 1 to 30% by weight - 1n-pentane and/or 1so-4% 1 to 80% by weight - and propellant 10 to 80% by weight
A powder aerosol composition for human body application containing 95% by weight.