JPS60199818A - Anemia preventing agent - Google Patents

Abstract

PURPOSE:A safe anemia preventing agent, obtained by incorporating l-tryptophan or a derivative thereof as an active constituent in an animal tissue extract, etc., and capable of very remarkably preventing iron deficiency anemia. CONSTITUTION:An anemia preventing agent, obtained by incorporating l-tryptophan or a derivative thereof, e.g. n-acetyl-l-tryptophan or 5-hydroxytryptophan, in a substance selected from an animal tissue extract, pulverized animal tissue or enzymic decomposition product. A mammal, e.g. cattle or pig, bird, fish or shellfish, etc. may be used as the animal, and the liver or blood is preferably used in the case of particularly a large animal. A pharmaceutical containing the tissue extract, etc. and l-tryptophan at 1:0.1-20 compounding ratio has particularly good anemia preventing effect.

Description

[Detailed description of the invention] The present invention relates to an anemia preventive agent.

In recent years, iron-deficiency anemia has been increasing and has become a social problem. For example, people with rapidly growing bodies, such as pre-school children and adolescent girls, who eat an unbalanced diet, and among the latter, especially those who are at the beginning of their menstrual period, may be at risk of iron deficiency. I often fall into it. In addition, during pregnancy, delivery, and the puerperium, pregnant women can develop severe iron deficiency +rM'x due to iron supplementation of the fetus/＼, bleeding during childbirth, and iron supplementation of the baby's body through breast milk. This is often the case.

Once a person falls into a state of iron deficiency, he or she must initially rely on administration of oral iron preparations to improve the anemia. However, even after the anemia has improved, iron supplementation through daily diet or nutritional supplements is necessary to maintain the improved state. It was desired.

As a result of intensive research into the actual situation, the present invention '4 has developed a mixture of one or more strains selected from the group consisting of animal tissue extracts, pulverized products, and enzymatic decomposition products, and L to tryptophan or The present invention has been completed based on the discovery that iron deficiency anemia can be significantly prevented by the combined use of all of the derivatives.

That is, the present invention effectively utilizes a substance selected from the group consisting of animal tissue extracts, pulverized products, and enzymatically decomposed products (hereinafter referred to as "animal tissue extracts, etc."), as well as t-tryptophan or its derivatives. It is recommended as an anemia preventive agent as a component.

Examples of animals used in the present invention include mammals such as cows, pigs, horses, sheep, dogs, rabbits, and goats; birds such as chickens, ducks, turkeys, and guinea fowl; oysters, mysids, krill, lampreys, small fish, etc. Examples include fish and shellfish; reptiles such as stinging turtles and turtles. As the animal tissue, any of the whole animal and its organs such as liver and blood can be used, but in the case of large animals, it is particularly preferable to use the whole liver or blood. The product can be produced by extracting the entire bulk, for example, by boiling it in hot or boiling water for a long time, or by extracting it while enzymatically decomposing it by allowing protease or protease and lipase to act at 35 to 45C. Examples of the pulverized animal product include, in addition to the pulverized animal itself, those pulverized after freezing with liquid nitrogen, and pulverized freeze-dried products. An enzymatically decomposed product of an animal is a product obtained by decomposing an animal or its pulverized product with protease or protease and lipase.N proteases include, for example, animal-derived bezucin, pancreatic soloidease, and microorganism-derived asbergyl x (Aspcrgi).
llus), Bacillus and Streptomyces
genus grotease, papain of plant origin, promethiine 4
It can be used for 1ffl.

The t-tryptophan derivatives used in the present invention include:
Examples include 1]-acetyl-tryptophan, 5-hydroxytryptophan, and the like.

Animal tissue extracts, etc. and t-) IJ butophane or its derivatives used as active ingredients of the anemia preventive agent of the present invention are extremely safe and are used as food materials or food additives. The lethal dose of 50 y/mt in acute toxicity tests for mice was 50 y/mt or more when administered intraperitoneally to males.

The blending ratio of the animal tissue extract, etc. used in the present invention and t-)ligtophan or its derivative can be appropriately selected depending on the anemia condition, administration method, etc., but in general, the ratio of A- ) Ligtophan or its derivative 't-0.01 to 100, especially 0.1 to 20
It is preferable to mix and formulate the anemia prophylactic agent of the present invention in a ratio of .

The anemia preventive agent of the present invention can be prepared by mixing an animal tissue extract, etc. with t-)liptophan or a derivative thereof and additives necessary for formulation, and preparing tablets, pills, granules, etc. according to a conventional method. It can be formulated into oral preparations such as capsules and parenteral preparations such as injections.

The dosage of the anemia preventive agent of the present invention varies depending on the degree of anemia and the administration method, but is preferably 0.5 to 10 F per day for adults, for example.

Example I SD rats (male, 6 weeks old, weight around 3502, 7 rats per group) wo, stupon powder, t-) liptophan, or stupon powder! - After being fed a powdered feed containing trigtophan (Table 1) for 10 days, while continuing to be fed the same feed, the jugular vein was fed once a day, approximately 1/200 of the body weight.
(approximately 1.75 m) of blood was collected for 20 days to create an experimental anemia state, and the red blood cell count, hematocrit value, and hemoglobin value were measured from time to time. The results are shown in FIGS. 1 to 3.

As is clear from Fig. M1 to Fig.
When used in combination with t-1 liptophan, the anemia preventive effect was enhanced compared to when used alone.

Example 2 [Composition] 66.7% frozen and crushed stupon 1 tryptophan 16.6 corn starch 4.9 crystalline cellulose & 3 carboxymethyl cellulose calcium 3.5 Anemic 26-35 year olds with hematocrit values of 30-35% Tablets with the above composition (o, 5?) were given to 10 women? ! - When the patients were given 4 tablets a day for 1 month, their hematocrit values were 35-40% after 1 month, and their anemia status was significantly improved.

Example 3 [Composition] Lyophilized eagle hemoglobin 50.0% t-trigtophan 5. θ Medium-chain fatty acid triglyceride 44.5 Natural tocopherol o5 Mix each of the above ingredients well and place in a soft gelatin capsule.
Take 3 tablets per day.

Example 4 Anemia prevention and improvement drink: P+: [Composition] ■Apple cider vinegar 10.0 parts by weight■Quen'' 4.0 ■Vitamin Bl O,05 ■'n2o,os ■'B3 0.2 ■“B6 0. 05 ■ Ascorbic acid 0.3 ■ Caffeine 0.5 ■ Granulated sugar 120.0 [Phase] Honey 30.0 ■ Ethanol 10.0' ■ Frozen crushed stupon 10.0 @n-acetyl-6-) ribtofa 7 2 .0■Drink/flavor 4,5 q9 mineral water Balance meter 1000 [Production method] ■～Q? After thoroughly stirring and dissolving, the mixture is filtered and bottled to produce a sterilized product.

[Brief explanation of the drawing]

Figures 1 to 3 are diagrams showing oral changes in blood components when rats are subjected to total experimental anemia. Figure 1 is the red blood cell count, Figure 2 is the hematocrit value, and Figure 3 is the It shows the change in hemoglobin value over time. -Q: Control group ---- ) f, 1
Figure Number of days after blood collection started Figure 2 (%) 0 10 20 Figure 3 (?/dll)

Claims (1)

[Claims] 1. An anemia preventive agent which effectively contains a substance selected from the group consisting of animal tissue extracts, pulverized products, and enzymatically decomposed products, and t-)liptophan or its derivatives.