JPS60181024A - Composition for dermatologic administration - Google Patents

Abstract

PURPOSE:A composition for dermatologic administration containing at least one selected from dried bark of phellodendoron amurense RUPRECUT of the family Rutaceae and dried rhizome of Coptis Japonica MAKINO of the family Ranunculaceae and the dried whole plant of Chelidonium majus L. subsp. asoaticum HARA of the family Papaveraceae. CONSTITUTION:At least one of dried bark of Phellodendoron amurense RUPRECUT of the family Rutaceae and dried rhizome of coptis Japonica MAKINO of the family Ranunculaceae is blended with the dried whole plant of Chelidonium majus L. subsp. asoaticum HARA of the family Papaveraceae in a weight ratio of 1:10, preferably 1:2- 4 to give a composition for dermatologic administration to be added to a remedy for skin diseases, bothing agent, shampoo, soap, etc. An amount of each component in a base, etc. is 0.01-20wt% in case of dried powder of the whole plant of Chelidonium majus L. subsp. asoaticum HARA of the family Papaveraceae, 0.003-10wt% in case of extract of it, 0.01-10wt% in case of dried powder of dried bark of Phellodendoron amurense RUPRECUT of the family Rutaceae, 0.003-5wt% in case of extract of it, and an amount of dried rhizome of coptis Japonica MAKINO of the family Ranunculaceae is almost the same as that of dried bark of Phellodendoron amurense RUPERCUT of the family Ranunculaceae. A dose for remedy for trauma, humid tetter, etc. is 50-200mg in case of powder, and 5-20mg in case of extract.

Description

[Detailed Description of the Invention] [Technical Field] The present invention relates to a composition for dermal administration containing Chinese herbal medicine as a main component,
In particular, the present invention relates to a composition that can be used for the treatment and prevention of external skin diseases such as trauma and eczema.

[Prior art]

A large number of synthetic external drugs such as steroidal anti-inflammatory agents, non-steroidal anti-inflammatory agents, local anesthetics, bactericides, and fungicides have been on the market as therapeutic agents for skin diseases such as trauma and eczema. There is.

However, synthetic drugs are not always preferable, as steroids and the like can have side effects if used repeatedly, and local anesthetics, bactericides, fungicides, and the like can cause allergic symptoms.

On the other hand, Chinese herbal medicines for treating skin diseases, such as Zhonghuang-yang and Shiyun-yang, have extremely few allergic symptoms and other side effects, and their effects are gradual but certain.
However, most of these Chinese herbal medicines are extremely inferior in terms of their quick-acting ability to quickly stop pain (
do not have.

Under these circumstances, the present inventors have developed a herbal herbal medicine system that has analgesic, anti-inflammatory, antibacterial, and local analgesic effects (analgesic, ring-stopping, etc.) on affected skin areas that are comparable to synthetic drugs. , and to obtain a composition for dermal administration with fewer allergic symptoms and other side effects (after repeated research,
The active ingredient is at least one selected from the Chinese herbal medicines Huangbai and Huangsu, and Chinese cabbage is administered to the skin to provide anti-inflammatory and bactericidal effects on abrasions, cuts, eczema, redness, etc. In addition to this, they also showed local anesthetic effects (analgesic and ring-locking effects), and also had few side effects.

The present invention was completed based on this knowledge, and relates to a composition for administration to the skin, which contains at least one selected from Oriental cypress and Oriental chinensis and Chinese cabbage.

The Chinese cabbage used in the present invention belongs to the Papaveaceae family (Family Pa.
ρ-averaceae) plant, Che
lidonium tsa-jus L, 5ubsp
It is the dried whole plant of Asoaticum Ithahe^). White cabbage can be extracted with a fine powder or a dry extract extracted with an organic solvent such as alcohol such as methanol or ethanol, ketone such as acetone, ether, or Hensen, or with acidic water made by adding citric acid, hydrochloric acid, etc. to water. It is preferable to use it in the form of a prepared dry extract.

In addition, the yellow oak used in the present invention is of the family Rutaceae (Fami-1).
y Rutaceae) plant, yellowfin (Phell)
odendoronamurense RUPRECI
IT) is the dried bark of the tree. It is preferable to use the yellow oak in the form of a fine powder or a dry extract extracted with a relatively highly polar solvent such as water, alcohol such as methanol or ethanol, or ketone such as acetone.

Huangren is a family of Ranunculaceae (Family Ranunculaceae).
laceae) plant, Coptis Ja
powica M^KINO), and Huangren is used in the form of a fine powder or a dried extract extracted with a relatively polar solvent such as water, alcohol such as methanol or ethanol, or ketone such as acetone. It is preferable.

The composition ratio of each component is Huanglian/White cabbage - 1/10 ~
10 (particularly 1/2 to 4) is preferable.

Each component in the composition of the present invention is a Chinese herbal medicine that has been commonly used since ancient times, and its safety has already been established.

The composition of the present invention can be used as a therapeutic agent for skin diseases (in particular, a therapeutic agent for abrasions, cuts, eczema, etc.), and can also be added to bath salts, shampoos, soaps, etc. to have bactericidal, anti-inflammatory, and anti-inflammatory properties.
Used for ring-stopping and analgesic properties.

The composition of the present invention is mixed with pharmaceutical agents such as pharmaceutically acceptable carriers, excipients, diluents, and bases to form ointments, liquids, and the like. Furthermore, by adding it to conventional bath additives, soaps, shampoos, etc., it is possible to impart sterilizing properties to these.

As the base for the ointment, conventionally known bases may be used, such as oil bases (e.g. sesame oil), semi-oil bases (e.g.
Emulsifying bases such as olive oil, beeswax, water, and sucrose fatty acid esters) and water-soluble bases (e.g., macrogol, acrylic gels) are preferably used, but in general, semi-oily bases are used. A water-soluble base is preferred.

As a base for liquid preparations, preferably water, glycerin, and alcohol (eg, ethanol) are used.

The amount of each component added to the base etc. in the composition of the present invention is as follows.

In the case of the dry powder of Chinese cabbage, the ratio of the base to the base is 0.
1-20% by weight of O, preferably 0.5-8% by weight, in the case of its extract, 3-10% by weight of O,OO, preferably 0
．． It is 1 to 5% by weight.

In the case of its dry powder, the ratio of Huangbai to the base is 0.0.
It is about 1-10% by weight, preferably about 0.1-5% by weight, and in the case of its extract, about 0.003-5% by weight, preferably about 0.01-2% by weight.

The amount of Huanglian added may be approximately the same as that of Huangbai.

When the composition of the present invention is used, for example, for the treatment of trauma, eczema, etc., the dosage is generally 50 to 20 mg in the case of powder.
In the case of 0 Mong2 extract, it is 5 to 20 mg. The frequency of administration can be appropriately selected within the range of 1 to 3 times a day.

EXAMPLES Hereinafter, the present invention will be explained more specifically using Examples and Experimental Examples, and the effects of the present invention will be clarified.

In addition, the number of grams of crude drugs in the following Examples and Comparative Examples represents the amount blended with respect to 100 g of base.

Example 1 For hydrophilic ointment (base) listed in the 10th revised Japanese Pharmacopoeia,
An ointment was obtained by blending 5 g of white cabbage powder and 2 g of white powder.

Example 2 An ointment was obtained by blending 5 g of Chinese cabbage powder and 2 g of Huanglian powder with the parent tree ointment (base) used in Example 1.

Example 3 An ointment was obtained by blending 4 g of Huangbo ethanol extract and 2 g of 1% citric acid extract of Chinese cabbage with the parent tree ointment (base) used in Example I.

Example 4 Ethanol 10g Glycerin 20g Propylene glycol 5g Purified water 65g The above liquid preparation base was made to contain 2 g of Chinese cabbage ethanol extract and 2 g of Huang Rensui extract to obtain a liquid preparation.

Comparative Example 1 In Example 1, the white cabbage powder was removed to obtain an ointment containing 7 g of Huangbao powder.

Comparative Example 2 Huanglian powder was removed from the formulation of Example 2 to obtain an ointment containing 7 g of Chinese cabbage.

Experimental Example 1 The formulations of Examples and Comparative Examples are shown in Table 1 and locally administered to the affected disease, and the average number of days required for healing (13 cases) is shown in Table 1.

The numbers in Table 1 are more than the average number of days taken for mice to heal, which proves that the composition of the present invention is excellent.

Claims (1)

[Claims] A composition for rind administration, comprising at least one selected from Huangbo and Huangsu and Chinese cabbage.