JPS60142911A - Composition for use in oral cavity - Google Patents
Composition for use in oral cavityInfo
- Publication number
- JPS60142911A JPS60142911A JP24576583A JP24576583A JPS60142911A JP S60142911 A JPS60142911 A JP S60142911A JP 24576583 A JP24576583 A JP 24576583A JP 24576583 A JP24576583 A JP 24576583A JP S60142911 A JPS60142911 A JP S60142911A
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- oral cavity
- composition
- filling
- giving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5422—Polymers characterized by specific structures/properties characterized by the charge nonionic
Abstract
Description
【発明の詳細な説明】
発明の利用分野：
本発明は、口腔内組成物に係わり、さらに詳しくは、口
腔内の渇きを抑制し、かつ、口腔内を爽快に保つ口腔内
組成物に関する。DETAILED DESCRIPTION OF THE INVENTION Field of Application of the Invention: The present invention relates to an oral composition, and more particularly to an oral composition that suppresses thirst in the oral cavity and keeps the oral cavity refreshed.
口腔内の異常たとえば歯痛９口出等は、非常な不快感を
与え、正常な判断力をにぶらせる。 歯痛については、
歯科的な治療、ａ瘍剤の使用等により処置されるが、口
渇については、多くの場合、水、清涼飲料、スポーツド
リンク等の大量の水分を摂取して癒している。 しかし
ながら、スポーツ選手等は、ゲームの最中に大量の水分
を摂取すると、発汗を促し逆に体力の消耗の原因となる
。 また、口腔内の異常としての口臭は、本人ばかりで
なく第三者にも不快感を与える。 口臭は、本来口腔科
的に治癒されるべきものであるが、多くの場合、脱臭刻
入のチュウインガムを使用している。 しかしながら、
チュウインガムの人前での常用は決して格好の良いもの
ではない。Abnormalities in the oral cavity, such as toothache, cause extreme discomfort and impair normal judgment. Regarding toothache,
Although it can be treated with dental treatment, anti-inflammatory drugs, etc., dry mouth is often relieved by drinking large amounts of fluids such as water, soft drinks, and sports drinks. However, when athletes and the like ingest a large amount of water while playing a game, this causes them to sweat and conversely causes depletion of their physical strength. In addition, bad breath, which is an abnormality in the oral cavity, causes discomfort not only to the person but also to third parties. Bad breath should originally be treated stomatologically, but in many cases chewing gum with deodorizing inscriptions is used. however,
Regularly using chewing gum in public is never cool.
発明の解決しようとする問題点：
本発明は、口渇や口臭等を抑制し口腔内を爽快にする、
新規なタイプの携帯に便利な口腔内組成物を提供するこ
とを、その目的とする。Problems to be solved by the invention: The present invention suppresses dry mouth, bad breath, etc. and refreshes the oral cavity.
The object is to provide a new type of portable oral composition.
問題点を解決するための手段：
本発明は、ヒドロキシプロピルセルロース、メチルセル
ロースおよびヒドロキシプロピルメチルセルロースから
なる群から選ばれた１４１または２種以上の水溶液を主
成分とし、所望により添加剤を含有し、スプレーボンベ
に加圧充填してなることを特徴とする口腔内組成物であ
る。Means for Solving the Problems: The present invention consists mainly of an aqueous solution of 141 or two or more selected from the group consisting of hydroxypropylcellulose, methylcellulose, and hydroxypropylmethylcellulose, optionally containing additives, and spraying. This is an oral composition characterized by being pressurized and filled into a cylinder.
本発明において、ヒドロキシプロピルセルロース（以下
、［ＨＩ） ＣＪと称する。）は、日本薬局法に規定さ
れる、ヒドロキシプロポキシル基置換度７５３．１〜７
７．５％、平均付加モル数＝２．０〜４．２、平均分子
ｉｔ ： ２５０，０００〜４０ｏ、０００ 、平均重
合度＝７００〜１ 、０００のＨＰＣである。 メチル
セルロース（以下、「ＭＣＪと称す。）は、メトキシル
基７ ２６．０％〜３３．０％を含み、２０℃における
２％水溶液の粘度： １０００〜１５０００ ｃｐｓの
ＭＣである。 また、ヒドロキシプロピルメチルセルロ
ース（以下、ｒＨＰＭＣＪと称ず。）は、メトキシル基
： １９．０％〜３０．０％およびヒドロキシプロポキ
シル基：４．０％〜１２．０％を含み、２０℃における
２％水溶液の粘度： １０００〜３５０００ ｃｐｓの
ＨＰＭＣである。 本発明においては、ＨＰＣ，ＭＣお
よびＨＰＭＣの１種または２種以上の水溶液に、所望に
より添加剤を添加して用いる。In the present invention, hydroxypropyl cellulose (hereinafter referred to as [HI) CJ]. ) has a degree of hydroxypropoxyl group substitution of 753.1 to 7 as defined by the Japanese Pharmacopoeia Law.
7.5%, average number of added moles = 2.0 to 4.2, average molecular it: 250,000 to 40,000, and average degree of polymerization = 700 to 1,000. Methylcellulose (hereinafter referred to as "MCJ") is MC that contains 26.0% to 33.0% of methoxyl groups 7 and has a viscosity of 2% aqueous solution at 20 ° C.: 1000 to 15000 cps. (hereinafter referred to as rHPMCJ) contains methoxyl groups: 19.0% to 30.0% and hydroxypropoxyl groups: 4.0% to 12.0%, and the viscosity of a 2% aqueous solution at 20°C: HPMC of 1,000 to 35,000 cps. In the present invention, an aqueous solution of one or more of HPC, MC, and HPMC is used, with additives added as desired.
本発明において、所望により添加される添加剤は、ｐ−
メントール、ハツカ油等の着香料、クロロフィル等の着
色料、食塩５ ソルビット、サッカリン等の呈味料、Ｌ
−アスコルビン酸。In the present invention, additives added as desired include p-
Flavoring agents such as menthol and peppermint oil, coloring agents such as chlorophyll, salt 5 Flavoring agents such as sorbitol and saccharin, L
-Ascorbic acid.
デヒドロ−しアスコルビン酸等のビタミン類などである
。These include vitamins such as dehydro-ascorbic acid.
本発明において、口腔内組成物は、前記ＲＰＣ，ＭＣお
よび／またはＨＰＭＧＯ）水溶液に、所望により前記添
加剤の１種または２種以上を添加するか、もしくは、添
加しないで、携帯用のスプレーボンベに加圧充填してな
る。In the present invention, the oral composition is prepared by adding one or more of the additives to the aqueous solution (RPC, MC and/or HPMGO), or by adding or not adding one or more of the additives, as desired. Filled with pressure.
作 用：
本発明において、前記口腔内組成物は、唾液とほぼ同一
の粘度を有し、それを口腔内に適用しても、全く違和感
を感じることなく唾液と混合する。 また、ＨＰＣ，Ｍ
ＣおよびＨＰＭＣは、口腔内粘膜への粘着性を有してお
り、それに添加された添加成分を、長時間に渉って徐放
し、口腔内を長時間に渉り爽快に保持する作用を奏する
。Effect: In the present invention, the oral composition has approximately the same viscosity as saliva, and even when applied to the oral cavity, it mixes with saliva without causing any discomfort. Also, HPC,M
C and HPMC have adhesive properties to the oral mucosa, and have the effect of releasing additive ingredients added thereto over a long period of time and keeping the oral cavity refreshed for a long period of time. .
本発明におい′Ｃ１口腔内組成物は、添加物を含有する
かまたはしないＨＰＣ，ＭＣおよび／またはＨＰＭＣの
水溶液を携帯用のスプレーボンベに加圧充填してなるが
、ボンベ充填することにより携帯が容易となる。The oral composition 'C1 of the present invention is prepared by filling a portable spray cylinder under pressure with an aqueous solution of HPC, MC and/or HPMC containing or not containing additives. It becomes easier.
ＨＰＣ，ＭＣおよび／またはＨＰＭＣの水溶液を主成分
とする溶液のスプレーボンベへの充填は、ＨＰＣ，ＭＣ
および／またはＨＰＭＣの水溶液１００ｇに対し、窒素
ガス、炭酸ガス、笑気ガス（ＮｚＯ）等の０．１ｇ以上
を、内圧が１気圧以上、好ましくは、３〜８気圧となる
よう充填するか、もしくは、二重構造容器の内容器にＨ
ＰＣ，ＭＣおよび／またはＨＰＭＣの水溶液を充填し、
外容器に前記した内圧となるように、窒素ガス、炭酸ガ
ス、フロンガス等の加圧ガスを充填する。 ＲＰＣ，Ｍ
Ｃおよび／またはＨＰ Ｍ Ｃの水溶液と加圧ガスを混
合充填する場合、好ましくは、これらの水溶液ｌｏｎｇ
に対し、炭酸ガスであれば０．８〜１．２ ｇ 、窒素
ガスであれば０．２〜０．４ｇを充填する実施例
以下に、本発明を、実施例によりさらに詳細に説明する
。Filling a spray cylinder with a solution whose main component is an aqueous solution of HPC, MC and/or HPMC
and/or filling 100 g of an aqueous solution of HPMC with 0.1 g or more of nitrogen gas, carbon dioxide gas, laughing gas (NzO), etc. so that the internal pressure is 1 atm or more, preferably 3 to 8 atm; Or, put H in the inner container of a double-layered container.
Filled with an aqueous solution of PC, MC and/or HPMC,
The outer container is filled with a pressurized gas such as nitrogen gas, carbon dioxide gas, or chlorofluorocarbon gas to achieve the internal pressure described above. RPC,M
When aqueous solutions of C and/or HPMC and pressurized gas are mixed and filled, preferably these aqueous solutions long
On the other hand, the present invention will be explained in more detail with reference to examples below, in which 0.8 to 1.2 g of carbon dioxide gas and 0.2 to 0.4 g of nitrogen gas are filled.
ただし、本発明の範囲は、下記実施例により何等限定さ
れるものではない。However, the scope of the present invention is not limited in any way by the following examples.
実施例１
ＲＰＣ（日本曹達側型：ＨＰＣ−Ｈ）： ５．Ｏｇを、
蒸溜水に溶解し全量を１０００ｍ １２とし、この５０
ｍ Ａをスプレーボンベに入れ、さらに、炭酸ガスを内
圧が６気圧となるまで充填し、口腔内組成物を製造した
。Example 1 RPC (Nippon Soda side type: HPC-H): 5. Og,
Dissolve in distilled water to make a total volume of 1000 m12, and this 50
mA was placed in a spray cylinder, and further filled with carbon dioxide gas until the internal pressure reached 6 atm to produce an oral composition.
得られた口腔内組成物を、口腔内にスプレーしたところ
、何等の違和感もなく口腔内が湿潤された。When the obtained oral composition was sprayed into the oral cavity, the oral cavity was moistened without any discomfort.
実施例２
実施例１と同様にして、下記組成の溶液を炭酸ガスとと
もに内圧が６気圧となるように、スプレーボンベに充填
し口腔内組成物を製造した。Example 2 In the same manner as in Example 1, an intraoral composition was prepared by filling a spray bomb with a solution having the following composition along with carbon dioxide gas so that the internal pressure was 6 atm.
ＨＰＣ−ＨＯ，５ｗｔ％
クロロフィル ０．０５ 鍔（％
ａミーメントール ０．Ｏｌ 葬ｔ％以下Ｄソルビット
５．Ｑ ｗｔ％
蒸溜水 残り
得られた口腔内組成物を、口腔内にスプレーしたところ
、口腔内に爽快感を得た。HPC-HO, 5 wt% Chlorophyll 0.05 Tsuba (% a Mementhol 0.Ol t% or less D Sorbitol 5.Q wt% Distilled water When the remaining oral composition was sprayed into the oral cavity, the oral cavity I felt refreshed inside.
実施例３
実施例１と同一の組成のＨＰＣ水溶液を、二重構造式の
スプレー容器の内容器に充填し、外容器にフロンガスを
２５°Ｃにおける内圧が５．８気圧となるよう充填し、
口腔内組成物を製造した。Example 3 An HPC aqueous solution having the same composition as in Example 1 was filled into the inner container of a double structure spray container, and the outer container was filled with fluorocarbon gas so that the internal pressure at 25°C was 5.8 atm.
An oral composition was produced.
得られた口腔内組成物は、実施例１と同様に良好にスプ
レーできた。The obtained oral composition could be sprayed well as in Example 1.
実施例４
実施例２において、ＨＰＣに替えて、ＭＣ（信越化学工
業側型メトローズＳＭ−１５００）を用いた以外には、
同一の組成の口腔内組成物を製造した。Example 4 In Example 2, except that MC (Shin-Etsu Chemical's Metrose SM-1500) was used instead of HPC,
Oral compositions of the same composition were prepared.
得られた口腔内組成物を、口腔内にスプレーしたところ
、実施例２と同様に口腔内に爽快感を得た。When the obtained oral composition was sprayed into the oral cavity, a refreshing feeling was obtained in the oral cavity as in Example 2.
発明の効果：
本発明において、ＨＰＣ，ＭＣおよび／またはＨＰＭＣ
を主成分とする溶液は、唾液の代用となる人口唾液とし
て使用することができ、放射線療法等により唾液分泌障
害を起こしている患者が、携帯して使用できる口腔内組
成物として極めて有用である。Effect of the invention: In the present invention, HPC, MC and/or HPMC
A solution containing as a main component can be used as artificial saliva as a substitute for saliva, and is extremely useful as a portable oral composition for patients suffering from salivary secretion disorders due to radiation therapy, etc. .
また、添加剤を適宜選択することにより、口出を癒すと
共に口腔内に爽快感を与え、口臭を防除することができ
る。In addition, by appropriately selecting additives, it is possible to soothe dry mouth, give a refreshing feeling to the oral cavity, and control bad breath.
本発明は、医学上また日常生活上にも使用し得る口腔内
組成物を提（Ｊ目゛るものであり、その産業的意義は極
めて大きい。The present invention provides an oral composition that can be used medically and in daily life, and has extremely great industrial significance.
特許出願人 日本曹達株式会社 小池化学株式会社 代理人 （６２８６）伊藤晴之 （７１２５）横山吉美Patent applicant: Nippon Soda Co., Ltd. Koike Chemical Co., Ltd. Agent (6286) Haruyuki Ito (7125) Yoshimi Yokoyama
Claims (1)
およびヒドロキシプロピルメチルセルロースからなる群
から選ばれた１種または２種以上の水溶液を主成分とし
、所望により添加剤を含有し、スプレーボンベに加圧充
填してなることを特徴とする口腔内組成物 ２ 所望により着香料９着色料、呈味料、ビタミン類、
塩類を添加含有してなる特許請求の範囲第１項記載の口
腔内組成物[Scope of Claims] 1 The main component is an aqueous solution of one or more selected from the group consisting of hydroxypropylcellulose, methylcellulose, and hydroxypropylmethylcellulose, optionally containing additives, and filled into a spray cylinder under pressure. Oral composition 2 Optionally flavoring agent 9 Coloring agent, flavoring agent, vitamins,
Oral composition according to claim 1, which additionally contains salts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24576583A JPS60142911A (en) | 1983-12-29 | 1983-12-29 | Composition for use in oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24576583A JPS60142911A (en) | 1983-12-29 | 1983-12-29 | Composition for use in oral cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS60142911A true JPS60142911A (en) | 1985-07-29 |
Family
ID=17138467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24576583A Pending JPS60142911A (en) | 1983-12-29 | 1983-12-29 | Composition for use in oral cavity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60142911A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63233908A (en) * | 1987-03-23 | 1988-09-29 | Pijiyon Kk | Bubble-like tooth wash |
| JPH07258053A (en) * | 1994-02-03 | 1995-10-09 | Kao Corp | Composition for oral cavity |
| EP0679390A2 (en) * | 1994-04-29 | 1995-11-02 | Zyma SA | Sprayable topical pharmaceutical compositions |
| US5576306A (en) * | 1991-03-01 | 1996-11-19 | Dow Chemical Company | Pharmaceutical compositions and uses of water-soluble, high-viscosity grade cellulose ethers |
| US5585366A (en) * | 1991-03-08 | 1996-12-17 | Regents Of The University Of Minnesota | Lowering blood cholesterol levels using water soluble cellulose ethers |
-
1983
- 1983-12-29 JP JP24576583A patent/JPS60142911A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63233908A (en) * | 1987-03-23 | 1988-09-29 | Pijiyon Kk | Bubble-like tooth wash |
| US5576306A (en) * | 1991-03-01 | 1996-11-19 | Dow Chemical Company | Pharmaceutical compositions and uses of water-soluble, high-viscosity grade cellulose ethers |
| US5585366A (en) * | 1991-03-08 | 1996-12-17 | Regents Of The University Of Minnesota | Lowering blood cholesterol levels using water soluble cellulose ethers |
| JPH07258053A (en) * | 1994-02-03 | 1995-10-09 | Kao Corp | Composition for oral cavity |
| EP0679390A2 (en) * | 1994-04-29 | 1995-11-02 | Zyma SA | Sprayable topical pharmaceutical compositions |
| EP0679390A3 (en) * | 1994-04-29 | 1995-12-13 | Zyma SA | Sprayable topical pharmaceutical compositions |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4954170B2 (en) | Sublingual, cheek foam | |
| JP5378270B2 (en) | Orally soluble film | |
| US9161909B2 (en) | Adhesive compositions for the treatment of xerostomia | |
| JP5841151B2 (en) | Nasal spray | |
| TWI243687B (en) | Pharmaceutical composition for application to mucosa | |
| US20110206621A1 (en) | Oral transmucosal nicotine dosage form | |
| JP2014037415A (en) | Disintegrable oral film | |
| MX2008000848A (en) | Oral, quickly disintegrating film, which cannot be spit out, for an antiemetic or antimigraine agent. | |
| MX2012009586A (en) | Nicotine-containing soft gelatin pastilles. | |
| JP2001288074A (en) | Film-formed troche | |
| US20090053309A1 (en) | Adhesive compositions for the treatment of xerostomia | |
| US20110217246A1 (en) | Denture care composition | |
| JPS60142911A (en) | Composition for use in oral cavity | |
| US8187659B2 (en) | Solid medicament dosage form consumption aid | |
| JP2006347958A (en) | Antiinflammatory spray for pharyngeal mucosa | |
| JP2001010977A (en) | Composition for oral administration | |
| JPH08295637A (en) | Local administrative agent for oral cavity | |
| AU777234B2 (en) | Pharmaceutical effervescent formulation containing metamizol | |
| KR100344198B1 (en) | Composition of sildenafil citrate dosage form | |
| JPS60501311A (en) | Composition for oral dental treatment | |
| TW202033221A (en) | Film coating composition and solid preparation | |
| JP2006083100A (en) | Oral care formulation | |
| JP2019156721A (en) | Edible composition for improving blood flow | |
| RU2782018C1 (en) | Remedy for those quitting smoking | |
| JPS60237018A (en) | Composition having adhesivity to interior of oral cavity |