JPS60112711A - Dentifrice - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a toothpaste, which, based on its composition, is particularly suitable for cleaning mountains and removing plaque, maintaining the health of teeth and gums, and preventing gum diseases. It also exhibits a beautiful appearance when dispensing the toothpaste on a toothbrush in the form of a string, and, in connection with this, exhibits optimal fluidity.

Toothpastes with divine ingredients are already known. This way 5. 'zM Risono polish contains a series of essential ingredients such as abrasives, moisture retention agents, preservatives, aromas, fragrances, binders and water as a base. Cali
Fluorine compounds, which were no longer suspected of having a preventive effect, have also become almost indispensable as ingredients in tooth pastes and toothpastes.

The formulation contains a wide range of additives, including antibacterial substances that are effective against plaque, blood circulation promoters, anti-inflammatory agents, enzymes that are effective in decomposing plaque, plant extracts, amino acids, etc. has been added to.

One group of additives that are often utilized are synthetic surfactants, which may be particularly helpful in foaming when using toothpastes. Widespread evaluation suggests that these substances, such as lauroyl sulfate, sodium lauroyl sulfate, or sodium lauroyl sarconate, can contribute to tooth cleaning, but this is, of course, not an uncontested opinion.

However, on the other hand, many authors have confirmed that adding too much of such surfactants can harm cells and have negative effects on the gums.

Therefore, careful attention must be paid to the formulation of all toothpaste ingredients, ensuring that the toothpaste is effective in maintaining the health of teeth and gums, but also has an optical appearance that is pleasing to the user. In order to obtain toothpastes exhibiting good flow properties, great care must be taken in the formulation of the additives and active substances as well as the basic substances.

The present invention can solve the above-mentioned roughness by combining completely special ingredients and conditions in the polishing composition.

The purpose of the present invention σ) is to provide abrasives, moisture retainers,
fck toothpaste based on a water-soluble base containing other known base substances, active substances, auxiliaries and binders, where the binder is 0.2fx for the whole toothpaste by, vr. 2.0, especially KO05 to 1.017
Cup percent methylcellulose and 0.1 or so,
0, especially KO03 to 1.5 weight percent hydroxyethyl cellulose.

The use of this special binder combination allows for flow conditions and
A toothpaste is obtained which has a particularly favorable and stable appearance in the form of a toothpaste string when extruded onto a brush, and which also exhibits optimum properties with regard to compatibility with various active substances.

A 2 percent aqueous solution of methylcellulose added as a component of the binder has a temperature of 50 to io, o o o at 25°C.
Centiboise mainly indicates a Prutskfeel F viscosity of 100 to 1.00 [1 centimeter/centiboise, while a 2 percent aqueous solution of hydroxyethyl cellulose has a viscosity range of 2
20 to 100,000 centivoise at 5℃, mainly 15
It is 0 to 30,000 ce/chiboise.

The combination of methylcellulose and hydroxyethylcellulose binder in the quantities described above contains calcium carbonate as the sole or main abrasive and is therefore an additive to toothpastes exhibiting...values in the alkaline range. Pass (
ing.

The value of such toothpastes usually ranges from about 7.5 to about 9.
It is between 5 and 5.

According to a currently preferred embodiment, methylcellulose and hydroxyethylcellulose as binders are
The total composition does not contain urea as an active substance in a maximum concentration of 10% by weight, mainly 81% by weight, especially 5% by weight.

The combination of the constituent calcium carbonate, urea and both surfactants provides good fluidity, which has been particularly appreciated for the superior gingival-protecting properties of urea and for its ability to improve the keratinization index of the gingiva. A significantly more stable toothpaste was created.

According to a currently preferred embodiment of the present invention, the toothpaste contains little or no synthetic surfactants, or higher fatty acids or For the alkali salts of such fatty acid mixtures, up to a maximum weight percentage of 0.5
and 1.5 weight percent, especially K O, 65 to 0
．． In particular, it contains between 75i and 75i weight percent of coconut fatty acids or animal fatty acids.

This type of stone is listed in the German Medical Dictionary (D6nzsches).
Arzneibuch, 6th edition (DABVI) 6
6 Medizinis on pages 07-608
K 85 is listed below the che 5eipe) display.

It is obvious that the toothpaste according to the present invention may contain other known active substances in addition to urea.

The knowledge of such agents includes, first of all, the various fluorine compounds proposed for the prevention of caries, such as alkali fluorides, especially sodium and -potassium fluoride, sodium monofluorophosphate, -potassium, -lithium and - Monofluorophosphates such as calcium and fluorine compounds such as zinc fluoride.

Further suitable agents include, for example (Azul). That is, α-bisporol (α
Guajaazul, from which Bisabolol is excreted, or chamomile extract (Ka
mi], 1eneXT, rakt) (mainly 0.001 to 0.1 weight percent of the total toothpaste composition), allantoin (A11ant, ion)
Chlorhexidine digluconate (predominantly 0.05 to 0.5 percent by weight of the total composition)
and dihydrochloride alechinschiff (Alexidind)
antibacterial substances, vitamins, etc. for reducing or preventing plaque formation, such as the hydrochloric salts of Chlorhexidjn and Alexidin;
For example, β-pyridyl carpenol (β-Pyridyl
blood circulation enhancers such as carbenol) or nicotinic acid esters, roskastania extract (RozkasZa
njenexzrakt) and its active substances aestine (Aescjn), hesperetene () (esper
ez'in) and hesperid ()lesperid
) or glycyrrhetinic acid (0], ycyrrhe
zinsAure) or Labarbel extract (R11a
1) Flavonoids, such as ArdereXf+rakZ), have anti-inflammatory effects.

As already explained, the toothpaste according to the invention already contains V
In addition to transparent substances, auxiliary agents such as moisture retaining agents, preservatives, fragrances, dyes, etc. are utilized.

An overview of toothpaste production and potential additives by M. S. Balsam and E. Sagrin.
Cosmeiies-8science and T”e
chnology”ν, 2nd edition, Volume 1, pp. 423-532 (
1972) VC. This publication clarifies this relationship.

Three examples of toothpastes corresponding to the invention are described below.

Example 1 Urea 8.00 weight Birsen Aradoin 0.05 Guayazul (25%) 0.02 Medicinal soap 0.72 (Deut, 5ches Arzneibuch, No. 6
Version) Sodium monofluorophosphate 0.76 Benzoic acid D, 15 Methyl p-hydroxybenzoate 0.10 Sankali/-
Sodium 0.04 Colloidal Silica 0.20 Methylcellulose 0.50 Hydroxyethylcellulose 0.50 Cal/Rum Silicate 0.20 Sorbit (70%) 4.20 1.2 Propylene Glycol 0.80 Aroma Mixture
1.00 Calcium carbonate 42.00 Water 40.76 Example 2 Urea 5.000 wt. 0.500 Sodium myristic acid 0.400 Guayazul 0.005 Sodium saccharin 0.030 E-menthol 0.250 Aroma mixture 1.000 Nonionic emulsifier 0.020 (Ethoxylated castor oil) Colloidal silica 0.200 Methylcellulose 0.800 Deuteroproperce/hydroxyethylcellulose X' 0.400 Sorbit (7
0%') 13.000 Precipitated calcium carbonate 4,2
．． 000 Water 35.795 Example 6 Urea 5.0 Ofk Needle Percent Bromochlorophene 0.10 Allantoy 7 0.20 Daayazur 0.02 β-Biridylcarpenol 0.10 Sodium Benzoate 0.60 Sodium Salt of Coconut Oil Fatty Acid 0.60p-methyl hydroxybenzoate [1,10 saccharin-sodium
0.04 Methylcellulose 0.65 Hydroxyethylcellulose 0.37 Calcium silicate 0.50 Sorbit 10.00 Aroma mixture 1.00 Calcium carbonate [), OO] Type A of synthetic theolide 2 .00 (according to German Patent Publication No. 105.612 (1980) r) Wednesday 39.02 Agent Akira Asamura

Claims (1)

[Claims] Contains an abrasive of +1118 or higher, a water retention agent, water, a surface-active substance, and five auxiliary agents known per se, such as a working agent and a binder. , water-soluble, characterized in that it contains as a binder a mixture of 0.2 to 2.0 Mk percent methylcellulose and 0.1 to 3.01 digit percent hydroxyethyl cellulose based on the total toothpaste composition. Neri-eima made from the base material. (2) 0.5 to 1.01 for the total composition of the paste
Needle percent methylcellulose and 0.3 to 1.5
The toothpaste according to claim 1, characterized in that it contains hydroxyethyl cellulose of i < it y' neat. (3) A 2% aqueous solution of 50 to 10% at 25°C.
Claims 1. Methyl cellulose exhibiting a viscosity of 1,000 centivoids. and/or 2. The toothpaste described in . (4) An aqueous solution of 2 persate has a concentration of 100 to 1 at 25°C.
．． Claim 3. The cellulose is methyl cellulose having a Brookfield viscosity of 0.007 mm. The toothpaste described in . (5) 2% water WI solution at 25℃
Claims 1. Hydroxyethyl cellulose exhibiting a Solzkfield viscosity of 0.000 centivoise. or 4. The training *calendar written in *. (6) 2% aqueous solution is 150 to 30 at 25°C.
．． Claim 5. Hydroxyethyl cellulose exhibiting a Brookfield viscosity of 0,000 centivoids. The toothpaste described in . (7) Claims 1 to 6 characterized in that calcium carbonate is contained as the sole or main abrasive.
The toothpaste described in . (8) Claim 1 characterized in that urea is contained in an amount not exceeding 10% by weight based on the total composition.
．． or 7. , Toothpaste to vc. . (9) Claim 1. does not contain a synthesized compound that supports surface activity. to 8°
Toothpaste on pi. Toothpaste according to claim 9, characterized in that it contains an alkali salt of a fatty acid of the group 012 to C1B, or a mixture thereof, of not more than 2N percent based on the total composition.