JPS5987350A - Method and apparatus for performing full automatic titration analysis of sample - Google Patents

Abstract

PURPOSE:To eliminate errors, etc. due to handling and viewing and to perform exactly an analysis with high precision by automating the stages consisting of picking-up of a sample to a reaction titrating vessel, addition of reaction reagent, etc., reaction, titration, calculation of containing ratio of aimed component, recording, and displaying by using computer. CONSTITUTION:The sample is picked up to the reaction titrating vessel 8 from a sample beaker 1 on a turntable 2 using a nozzle 3 and driving a sucking and compressing pump 30 in an automatic sample picking-up apparatus A in titration analysis such as acid, base, peroxide, e.g. an acid quantitative analyzing apparatus. A washing liquid of the beaker 1 is sucked from a burette 4 to feed it in the vessel 4 along with the washing liquid. Then 1N NaOH solution is fed from a burette 13 and titrated with 1N HCl solution dropping from a burette 17 to detect pH variation in the vessel 8 by an electrode 36. The signal is supplied to a microcomputer 39 through an amplifier 37, an A/D converter 38 to display 40 and print 41 the analyzed value. This operation is all controlled by the computer 39 through an interface 42. Thereby, automatic analysis can be performed exactly.

Description

[Detailed Description of the Invention] This relates to a fully automatic multi-sample titration method using a computer to automate the titration method after reaction, and its apparatus. 1 addition, 1 reaction, 1 titration analysis.

The present invention relates to a method and apparatus for automatically and accurately quantitatively analyzing all of the above using a computer, up to calculating the content of a target component.

In the conventional method of adding excess basic reagent and back titrating with acidic reagent, the basic reagent is added to multiple samples in advance and left until titration, but errors occur due to the influence of carbon dioxide gas in the air. there is a possibility. Conventionally, in iodometry, which quantitatively analyzes peroxide, in order to complete the reaction between peroxide and iodide ions, an appropriate amount of a solvent, acid, etc. is added in addition to iodide, and the mixture is allowed to stand for a certain period of time. However, the addition of these reagents is done manually using instruments such as whole pipettes and graduated cylinders, so errors in setting the reaction time can be avoided. do not have. Furthermore, the end point of the titration is determined by adding a starch solution and visually observing the change in color, and confirming the point at which the purple iodostarch becomes colorless as the equivalence point. However, it cannot be disputed that errors due to human factors may occur in these methods, visual observations, etc.

It is an object of the present invention to deal with and eliminate the drawbacks of conventional methods such as slanting, and to make it possible to perform quantitative analysis automatically and with high precision.

That is, the feature of the present invention is to correct each error caused by the above-mentioned manual method, visual observation, etc. by using a computer,
The test sample set in an automatic sample collection device is supplied to a temperature-controllable reaction titration tank (1), a reaction reagent is added, and a reaction catalyst is added if necessary.
9. Reaction temperature 9. Reaction time limited 9. Addition of a reaction stop solution after the completion of the reaction, etc., are controlled by a microcomputer to automatically terminate the reaction between the sample and the reaction reagent, and furthermore, a titration reagent is added by the microcomputer; The titration end point is detected electrically, the equivalence point is determined by a computer, and the number of electrical pulses at the equivalence point of the sample solution is converted into a titration amount, which is stored in advance in the computer.Blank value 1 titrant solution The point is that calculations, corrections, etc. are automatically performed using concentration, factors, constants, weight values of samples, etc., and the above steps are performed in the same manner sequentially for a plurality of samples.

The apparatus implementing the present invention as described above is characterized by the following configuration.

(1) An automatic sample collection device that automatically collects multiple samples (2) A reaction titration tank equipped with a temperature control device (3) A solvent supply device that supplies a predetermined amount of a solvent for dissolving and/or washing the samples (4) ) A reaction reagent supply device (5) that supplies a reagent to react with the sample in advance.A reaction stop solution supply device (6) that supplies a reaction to stop or slow down the reaction after a set reaction time has elapsed.
A titration reagent supply device (7) that supplies a predetermined amount of a titration reagent that reacts with a compound that is generated by the reaction or remains unreacted; , a detection section (8) equipped with a detection electrode inserted into the titration tank to detect the equivalence point, and a measurement value amplifier for amplifying the above-mentioned electrical measurement parameter values; It is the composition.

Hereinafter, specific embodiments of the present invention will be further described in detail.

First, the first operation of the present invention is to set a sample tube or beaker containing a test sample in an automatic sample collection device, start analysis, and then aspirate and supply the sample to a reaction titration tank. .

At this time, the residual sample is completely transferred to the reaction titration tank by suction while adding a solvent for dissolving the sample.

Next, a reaction reagent of a required concentration is added to the reaction titration tank according to the sample. By reaction, reaction catalyst.

If a reaction stop solution is required, add it as appropriate. Further, the addition of a reaction stop solution after the completion of one reaction, which is limited to one reaction temperature and one reaction time, is controlled by a microcomputer.

Thereafter, a predetermined titration reagent is added to the sample liquid in the tank.Of course, an appropriate titration reagent is selected depending on the type of sample. For example, in the case of a back titration method for an inorganic acid, an acidic reagent such as an aqueous hydrochloric acid solution having a concentration equivalent to that of the reaction reagent; It is a reducing titration reagent such as an aqueous solution.

The titration reagent is sent as electrical pulses from the microcomputer to the pulse motor of the titration reagent supplier, and the titrant is supplied in proportion to the number of pulses. Then, the change in the state of the sample liquid caused by titration of this titration reagent is detected as a change in current or potential difference using an electrode installed in the reaction titration tank, and differential analysis is performed using a microcomputer to determine the equivalence point. Confirm this and stop the titration.

In this way, the number of pulses at the above equivalence point is converted into a titration amount, and the blank value 1 is automatically calculated using the concentration of the titrant, its factors, constants, weight value of the sample, etc. stored in the microcomputer in advance. Perform calculations and corrections on
The results are appropriately displayed using a display device and printed using a printing device.

When the analysis of the sample liquid in the reaction titration tank is completed in this way, the liquid in the tank is drained and washed with water, and a request for analysis of the next sample is awaited, and the request is registered in the microcomputer. If so, perform the analysis again in the same manner.

All of the above operations are controlled by a computer, and titration analysis is performed automatically.

The samples to be subjected to the titration analysis according to the present invention include inorganic acids, inorganic bases, organic acids, organic bases, peroxides, and the like. Examples of peroxides include hydrogen peroxide, hydroperoxide, diacyl peroxide, and the like.

The attached drawings, Figures 1 and 2, systematically schematically show the apparatus used for the titration analysis of each sample as described above. Example of Implementation Apparatus Used FIG. 2 is an example of an implementation apparatus used for quantitative analysis of peroxide.

First, the apparatus shown in Fig. 1 includes an automatic sample collection device (A) that automatically collects multiple samples, a reaction titration tank section (B) that is equipped with a temperature control device, and a solvent that dissolves and/or washes the samples. Solvent supply unit (C) for supplying a fixed amount of titration reagent and reaction reagent supply unit (C) for supplying a predetermined amount of 1 titration reagent (including a part of the reaction reagent)
D) Detection transmitting unit (m, titration unit) that detects the equivalence point by tracking changes in the electrical parameters characterizing the state of the sample liquid when the titration reagent is supplied, and also amplifies the detected value and sends it to the computer. Each part of the computer section (F) manages and controls each drive and valve opening/closing during analysis, and also stores, calculates, and corrects the concentration of the blank value 1 titrant, factors, constants, sample weight values, etc. It becomes more.

The automatic sample collection device (A) is configured by placing a sample beaker (1) on a turntable (2),
By rotating the table (2), the sample beaker (1) is sequentially moved to a predetermined position, that is, a position below the sampling nozzle (3). The sampling nozzle (3) is connected to the solvent supply billet (4) of the solvent supply section (0), and communicates with the solvent inlet (6) via a check valve (5) in the middle.

(8) indicates the reaction titration tank 1~, which is connected to the sample beaker through a solenoid valve (7) ff: contained piping, and is suitably connected by a heat insulation jacket (9) controlled by a temperature control device (not shown). surrounded. and,
A starter (11) rotationally driven by a motor α0)
). In addition to the sample supply pipe from the sample beaker (1), a titrant pipe that connects to the titration billet (]+2o3) in the titration reagent supply section (D) is inserted into the reaction titration tank (8). Further (Solenoid valve (+9)
The pipes are connected to a pure water meter (goods) equipped with a water meter.

The titration burettes (Qx) and Qa) each have a check valve (14) in the middle and communicate with the titrant inlet (17) (113) via a solenoid valve (15) (+6).

In this case, one of the titrants may be used as a reaction reagent.

On the other hand, the pure water meter (goods) connects each solenoid valve 0υ (through 2 hot water), and the solenoid valve (21) is further connected to the solenoid valve (2υ side is pure water population I24) through the pure water pump (23). , and a solenoid valve (the second side is connected to the pure water outlet (25), respectively, and a needle valve (26).

Piping equipped with a solenoid valve (27), a pressure pump C1!8), and a filter (29) is also connected.

In addition, (301 is a suction and pressure pump for sucking the sample into the reaction titration tank (8) through the sampling nozzle (3) and the sample supply piping, and the piping on the suction side and the pressure piping are equipped with , a three-way solenoid valve (3) (33) is interposed. Also, a drain port t33) is connected to the reaction titration tank (8), and a pipe having a solenoid valve C34) (35) is connected to the reaction titration tank (8). It communicates with the bottom and top of (8).

Furthermore, the part shown on the upper right in the figure is the computer section (F)
It is a part that transmits signals to the computer section and signals from the computer section (F) to each drive section while adjusting the voltage and timing. Titration tank (8
), in this case usually a glass-comparison composite electrode, detects changes in the state of the sample in the reaction titration tank (8), and It has become possible to do so, and an amplifier (three power, analog
A digital converter 08) is provided. In addition, the electrical signals from the microcomputer (39) are connected to each drive unit (motor, turntable, solenoid valve, solenoid valve, pump, etc.) through the interface (421e) to determine whether or not to open or close the drive unit. In the figure, (
40), [Shun indicates a display device and a printing device for displaying calculation results by a computer (391), respectively.

The following is a configuration related to Fig. 1. Next, Fig. 2 will be explained. (D
), transmitting section (E), computer section (F) and interface (421 display device (40), printing bag! (
The configuration of each part of 41) is the same as in FIG. 1,
Identical parts are indicated by the same reference numerals, and details thereof will be omitted.

Therefore, the points that differ from Figure 1 will be described below.
First, the titration bilette (12) (
13) and the reaction titration tank (8), but a reaction reagent billet (431 (44)) is provided separately, and the reaction titration tank (8)
On the way, there was a reagent entrance (49).
) and check valves (4 are installed) connected via solenoid valves (46) and (47).

In addition, an example of constant temperature equipment for the reaction titration tank (8), which is not particularly shown in FIG.
3), a constant temperature bath (51) with a built-in heater and a sensor block (52) for temperature detection, and a temperature control device (54) that controls the temperature. A heat insulating jacket (9) surrounding the tank (8) is used to maintain a constant temperature.

In Fig. 2, a sample tube (1) is held on a turntable (2) instead of a beaker (1) in the sample supply section, and its sampling nozzle (3) is connected to a solenoid valve (55) ( 56) and solvent pump (5
7) is provided in the middle and connected to the solvent inlet (6) through piping.

This solvent pipe is connected to a filter (29) that connects to a solenoid valve (551 (56) to the pure water meter).
, a pressure pump (c), a solenoid valve (5), a solenoid valve (58), and a needle valve (59) that are arranged in parallel with the piping including the needle valve (261).

The needle valve (59) and the solenoid valve (6o) in the piping leading to the solvent outlet (61) equipped with the solenoid valve (60)
) is connected to the middle part of the metering tube (62).

Therefore, with the apparatus of the embodiment shown in FIG. 2, titration analysis including reaction for a set time using a reaction reagent, such as quantitative analysis of peroxide, can be easily carried out.

Next, the manner in which titration analysis is carried out using each of the above-mentioned apparatuses, as well as the functions of these apparatuses, will be explained as examples.

Example 1) First, the apparatus shown in FIG. 1 is used to carry out back titration. In FIG. 1, a beaker (1) containing a weighed test sample is set in advance at a predetermined position on the turntable (2) of an automatic sample collection device. Then, the turntable (2) is rotated completely so that the beaker (1) is positioned below the sampling nozzle (3). suction,
Open the reaction titration tank (8) side valve of the three-way solenoid valve C31) on the suction side of the pressure pump (30), and open the sampling nozzle (3
) and open the solenoid valve (7) ft to aspirate the sample.
Transfer into the reaction titration tank (8). The solvent feeder (4) filled with water is driven to eject water from around the sampling nozzle (3), dissolving the sample remaining in the beaker (1), and simultaneously sucking the sample. Transfer the entire amount to the reaction titration tank (8). Open the outside air intake valve side of the three-way solenoid valve (31), close the solenoid valve (7), and drive the motor (1o) to rotate the stirrer (11)'. IN-Titration burette containing aqueous sodium hydroxide solution (!3)
The motor is driven, and a constant voltage of an appropriate concentration is applied as a reaction reagent depending on the acid concentration of the sample, for example, 15, OO++l.
Add e to the reaction titration tank (8). The reaction time was set to zero, the reaction temperature was room temperature, and no reaction catalyst 9 reaction stop solution was used. Open the solenoid valves (15) and (16) and start the titration burette).
(12) Return θ8) to the starting point and fill with the titrant. Close the solenoid valve (15) (+6), drive the pressure pump (28), open the solenoid valve (2'l) (19> C3 clause), and pour the water from the Pure Water Meter Co., Ltd. (for example, 40 ml) into the reaction titration tank. (
In addition to step 8), stop the pressure pump (28) and close the solenoid valve (27).
1 (1!1) Close (35). The motor of the titration billet αη filled with an aqueous N-hydrochloric acid solution is driven by an electric pulse, and the aqueous hydrochloric acid solution having the same concentration as the reaction reagent is titrated. Changes in the state inside the reaction titration tank (8)
The potential difference of the comparative composite electrode (36) is detected as a change in the electrical parameter and transmitted to the microcomputer Kasumi via the amplifier (37) and the analog-to-digital converter. The microcomputer (39) analyzes changes in electrical parameters, confirms the equivalence point, stops the titration, stops driving the motor θ0), and turns the stirrer (11) on.
) stops rotating. A blank value is obtained by converting the electrical Hals number up to the equivalence point into a titer and storing it in the microcomputer (39) in advance.

Calculations are made using the concentration of the titrant, its factors, constants, the weight of the sample, etc., and the results are displayed on the display device (40) and printed on the printing device (41). Raise the sampling nozzle (3) and rotate the turntable (2) by one beaker. The titrated liquid is drained from the reaction titration tank (8) by opening the solenoid valve (34) and suctioning it, and by opening the reaction titration tank (8) side of the three-way solenoid valve on the pressurizing side of the pressure pump (30). Then, r(, the pure water pump (231) is driven, and the solenoid valve (2
Open valves n and I2a to fill the pure water meter (goods) and allow it to overflow. After draining, open the atmosphere release side of the three-way solenoid valve (132), drive the solenoid valve (34) and (close 221, motor 00) to rotate the stirrer (1]), and then open the solenoid valve (19).
(35), add water to the reaction titration tank (8) for cleaning, add enough water to overflow from the solenoid valve (35), close the solenoid valves (19), (21), and C351 to purify the water. Water pump (2
31f: Stop.

Thus, the solenoid valve C34) is opened, and the reaction titration tank (8) side of the three-way solenoid valve 02 is opened to drain the liquid. After draining, stop the motor (1o), stop the rotation of the starter (1υ),
Solenoid valve (34)'! r Close, open the atmosphere release side of the three-way solenoid valve, and return the solvent supply device (4) to the starting point to complete one analysis cycle. If the next analysis request is registered in the microcomputer c39, analysis is performed in the same manner.

In addition, in the above explanation, motor, turntable,
The operation and opening/closing of each electromagnetic valve and pump is determined by supplying electrical signals from a microcomputer (391) via an interface (421).

(Example 2) Next, an example will be described in which the present invention is applied to quantitative analysis of peroxide by iodometry using the apparatus N shown in FIG.

First, the sample, each reagent, and the conditions in this application example will be briefly listed before giving a specific explanation. For example, suppose that a sample containing hydroperoxide is weighed and set in an automatic sample collection device, and the solvent is as follows. Water or alcohol is used, preferably methanol. In addition, an iodide aqueous solution such as potassium iodide, sodium iodide, or hydrogen iodide is used as a reaction reagent. Among them, an aqueous potassium iodide solution is preferably used, and a 30% to saturated aqueous solution, more preferably a 40% aqueous solution is used for the reaction. 0.5 to 2 as a reagent. oml, preferably 5.0ml. Furthermore, acetic acid, hydrochloric acid, or sulfuric acid, preferably acetic acid, is used as a reaction catalyst to react with 0.5~zo, preferably 2o
, o+++A' is used. On the other hand, the external heating jacket of the reaction titration tank (8) is maintained at a set temperature of 40 to 90°C, preferably around 60°C, using a temperature controller using a heating medium mainly composed of ethylene glycol or glycerin, or water. 9) to serve as a heat source to maintain the reaction temperature.

The reaction time is set in advance to 0 to 999 seconds, for example about 180 seconds, depending on the sample, and during that time, after the reaction, a reaction stop solution, such as water or methanol, is added to stop the reaction from proceeding excessively due to air oxidation, etc. The reaction is stopped by adding about 20 to 4 ounces of an organic solvent, preferably water. The peroxide contained in the sample reacts with iodide under the above reagent 1 conditions to produce iodine.

of iodine as a reducing titration reagent, preferably with an aqueous sodium thiosulfate solution.

Continuing to explain the mode of titration analysis based on each of the above conditions, in comparison with the apparatus shown in Fig. 2, in Fig. Set the turntable (2) at the specified position and rotate the turntable (2) so that the sampling tube (1) is located at the bottom of the sampling nozzle (3). Add 20.0 ml of the filled reagent, for example acetic acid, into the reaction titration tank (8). At this time, the reaction titration tank (8) circulates a heating medium of ethylene glycol thread through its heating jacket (9) from the temperature control device (54) VC to maintain the temperature at, for example, 60°C.

Therefore, the suction and pressurization pumps are driven, the reaction titration tank (8) side of the suction side solenoid valve L31) is opened, and the atmosphere discharge side of the three-way solenoid valve (32) on the application side is opened. Fully open the valve, open the solenoid valve (7), and open the sampling nozzle (8).
descend and aspirate the sample into the reaction titration tank (8). For example, by driving the pressure pump (28) and opening the solenoid valves (58) and (55), a 3 ml measuring tube (62) is filled with methanol in advance, and the sampling nozzle (3
) and while dissolving the sample remaining in the sample tube (1), it is suctioned from the sampling nozzle (3) and the entire amount of the sample is transferred to the reaction titration tank (8).
Move to.

Stop the pressure pump (2), open the outside air suction valve of the three-way solenoid valve (31), and close the solenoid valves (7), (58), and (55). Drive the motor (10) and start the stirrer 01). Rotate. 40 filled with reagent billet (44)
For example, 5.0 ml of % potassium iodide aqueous solution is added to the reaction titration tank (8).

At the same time, the reaction time is measured and the reaction is allowed to occur for the set time. At the end of the set time, drive the pressure pump (28), open the solenoid valve (2n), and add water, e.g.
In addition to step 8), the concentration of the reaction solution is lowered, the circulation pump 50) is stopped, and the heat medium in the heat insulation jacket (9) is returned to the thermostat (51) to lower the temperature of the reaction solution and prevent excessive reaction. Stop progress. During the above reaction, a solenoid valve (15),
(16), (46), and (47) are opened, and the reagent biulet (43), (441, titration biulet (b), Qa) are each returned to the starting point, and each is filled with one reagent titrant. After a certain time, the pressure pump (28) is stopped and the solenoid valve (27) is turned off.
, (1111) is closed. Titration is performed by driving the titration burette (12) or α3) motor specified in advance for each sample with electrical pulses. Titration billet (
For example, 0.05N-sodium thiosulfate aqueous solution is added to 13), and 0.5N-sodium thiosulfate is added to titration bilette (B).
By filling it with an aqueous sodium thiosulfate solution and specifying it as a sample hood for each sample in advance, titrations with two different concentrations can be used. A change in the state in the reaction titration tank (8) is thus detected as a change in the electrical parameter, e.g. current or potential difference, in the bidirectional gold electrode μs) and in the amplifier 07) and the digital-to-analog converter (
2) to the microcomputer (39).The microcomputer (3!ll) analyzes changes in electrical parameters, confirms the equivalence point, and stops the titration.Electrical pulses up to the equivalence point Convert the number into a titration amount, calculate it using the blank value stored in the caulking microcomputer (39), the concentration of the specified titrant, its factor, constant, weight value of the sample, etc. The results are displayed on the display device (40) and printed on the printing device (4υ).The sampling nozzle (3) is raised and the turntable (2) is rotated by one sample tube.

Open the solenoid valve c34) and transfer the titrated liquid to the three-way solenoid valve (3).
The reaction titration tank (8) side of No. 2 is opened to drain the reaction titration tank (9), and the pure water pump (c) is driven.

(22) is opened to fill the pure water meter (22) and overflow, the circulation pump 15 (11) is driven to circulate the heat medium in the thermostatic chamber (51) into the heat insulation jacket (9). Titration After discharging the finished liquid, open the atmosphere release side of the three-way solenoid valve 020, close the solenoid valves (34) and (22), open the three solenoid valves (19) and C, and open the reaction titration tank (8) V for cleaning. (Add water,
Flow to the extent that it overflows from solenoid valve 0■, and then close solenoid valve (19).
, (21), (Close clause 13 and stop the pure water pump (23). Open the solenoid valve t34) and drain the liquid from the side of the reaction titration tank (8) of the three-way solenoid valve 02. Solenoid valve C3 after draining
4), close the three-way solenoid valve t3, open the atmospheric release side of the hot water, and -
This is the end of the analysis cycle. If the next sample analysis request is registered in the microcomputer 0α, the same analysis is performed as in the first embodiment.

In this embodiment, the drive, opening and closing of the motor, turntable, solenoid valve, and pumps are all controlled by electrical signals from the microcomputer (39) through the interface (4).
This will be done after making adjustments via step 21.

As described above, according to the present invention, a computer is used to automatically perform everything from collecting a sample to a reaction titration tank, adding reaction reagents, etc. to one reaction, one titration analysis, and calculating the content of the target substance. There is no error or influence from the surrounding environment as with conventional manual methods or visual observation, and the accuracy of analysis is significantly improved.
The entire operation process is carried out reliably without the need for complicated manual operations, and has the remarkable effect of streamlining the titration analysis method or apparatus.

[Brief explanation of the drawing]

1 and 2 are schematic road diagrams showing each side of an apparatus for carrying out the analysis method according to the present invention. (A)... Automatic sample collection device, (B)...
...Reaction titration tank section. (0)... Solvent supply section, (D)...
Titration reagent and reaction reagent supply section. (E)...Detection transmitter, (F)...
・Computer Department. (1)...Sample beaker, (],)...
...sample tube. (2)・・・・・・Turntable, (3)・・・
...Sampling nozzle. (4)... Solvent supply buret), (6)
・・・・・・Solvent inlet. (8)・・・・・・Reaction titration tank, (9)・・・・Heat insulation jacket. (+2) (13)...titration burette), (1
7) (113)...Titrant inlet. (Foundation)...Pure water measuring instrument, (24)...
...Pure water inlet. (25)...Pure water outlet, (30)...-
...Suction, pressure pump. (33)...Drain port, (36)...
...Detection electrode. C37)...Amplifier, 08)...Analog/digital converter. (39)・・・・・・Microcomputer, (
４２）・・・・・・Interface. (43) (44)...Reagent bullet), (4
8)(49)・・・Reagent inlet. (51)... Constant temperature bath, (54)... Temperature control device. (57)...Solvent pump, (61)...Solvent outlet. (62)...Measuring tube.

Claims (1)

[Claims] 1. Supply of sample to reaction titration tank and addition of reaction reagent 1
Setting the reaction temperature and reaction time 9. Preparation of the sample solution in the reaction titration tank, such as adding titration reagents, is automatically performed by computer control, and changes in the state of the generated sample solution in the tank are detected electrically. Then, calculate the equivalence point using a computer, convert the number of electric pulses at the equivalence point of the sample liquid to the titration amount, and calculate the blank value 1 titrant concentration, its factor, constant, and weight of the sample, which has been memorized and input into the computer in advance. A fully automatic sample titration analysis method characterized by automatically performing calculations and corrections using values, etc. to perform the required titration analysis. 2. A reaction titration tank, an automatic sample collection device that automatically collects multiple samples and supplies them to the reaction titration tank, a solvent supply device that supplies the required amount of solvent for dissolving and/or washing the samples to the sample system; a reaction reagent supply device that supplies a reagent that reacts with the sample in advance to the reaction titration tank; a titration reagent that supplies a required amount of a titration reagent that reacts with a compound that is generated by the reaction or remains unreacted to the reaction titration tank; feeder,
A detection electrode inserted into the reaction titration tank and amplifying the detected electrical measurement parameter value are used to electrically track the state change of the sample liquid in the reaction titration tank when the titration reagent is supplied, and to detect the equivalence point. Increase @ device to send to Funpyuta,
1. A fully automatic sample titration analyzer comprising a detection transmitting device including a converter, each of the devices being connected to a computer that controls and performs calculations so as to be able to operate automatically.