JPS5982867A - Heat pasturized hollow yarn type mass transfer apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hollow fiber mass transfer device that is heat sterilized in a high temperature, high pressure steam atmosphere.

The hemodialysis device referred to here is a semi-permeable membrane that is interposed between the blood and the dialysate, and utilizes the difference in osmotic pressure to transfer waste materials in the blood to the dialysate. It is used to remove water from the blood through external filtration, and is generally called an artificial kidney. Currently, hemodialysis devices can be generally classified into coil type, flat plate type, and hollow fiber type depending on their mechanical characteristics. It is essential that these items be provided in a sterile condition;
Currently, sterilization methods include ethylene oxide gas, gamma rays, and formalin sterilization, and are broadly divided into dry and wet methods.

Hollow fiber type hemodialysis device r, use hollow fibers such as cellulose acetate with an inner diameter of about 200 to 300μ. Old) Since hemodialysis is performed by passing 0 bundles of V through the hollow fibers and flowing the dialysate through the inside of the hollow fibers and the dialysate outside the hollow fibers, due to the use of the hollow fibers, it is necessary to sterilize them. This causes various problems compared to the coil type and flat plate type. That is,
Dry state when used in hospitals (ethylene oxide gas).

Those sterilized with gamma rays have very thin capillary tubes inside the hollow fibers, which makes it difficult for liquid to pass through, and it is also a hassle to remove air. For this reason, if it is provided in a moist state if possible, there will be no trouble such as inflow of liquid or air removal during use, and damage to the hollow fibers can also be prevented. Therefore, some devices have been sterilized by filling formalin into the device, but this causes another problem such as washing MF during use. In human silk water II
:j Even if you wash the same amount of water, formalin cannot be completely washed away, and it remains behind. ). As described above, each method VC of sterilizing a hollow fiber hemodialysis apparatus has its advantages and disadvantages, and at present there is no established method.

To provide a heat sterilized hollow fiber type hemodialysis device which eliminates the trouble of liquid inflow or air removal during use and can be used without the trouble of cleaning.

That is, the present invention has two chambers, a blood chamber and a dialysate or oxygen chamber, an inlet passage and a discharge passage for blood leading to the blood chamber, and a nozzle for the dialysate or oxygen chamber.
A hollow-fiber tissue transfer device comprising an inflow passage and an outflow passage for dialysate or oxygen, the device comprising an outer barrel, an Ilnln top gearing, the outer barrel and the cap made of polycarbonate or polypropylene. The blood chamber and the dialysate or oxygen chamber of the device are filled with an evaporative filling substance that is harmless to the human body, and the introduction passage, the discharge passage, the inflow passage and the outflow passage are sealed. The entire device is sealed with a high-temperature, high-pressure steam treatment βI! This is a heat sterilized hollow fiber type mass transfer device characterized by:

Hereinafter, the present invention will be explained along with the drawings. In the drawings, the same symbols t and lFi+- are shown. FIG. 1 shows a general hollow fiber type hemodialysis apparatus l.

81'
1: On the other hand, the dialysate (r) 4 flows in through the inflow passage 5, passes through the outside of the hollow fiber 3, flows out through the outflow passage 6, and undergoes dialysis via the hollow fiber 3. 'i
rIru song) α chamber 7 and the dialysate chamber (1 of the artificial lung) through which the dialysate passes.
This will become the oxygen chamber. ) It is divided into two chambers of 8 to prevent leakage.

In the present invention, first, the inside of the liquid chamber 7 is depressurized by filling the blood chamber 7 with a harmless evaporative charge of human body VC, such as physiological saline, water, etc. Then habo]
Fill with fl Oy'o 1 and 4. By using the reduced pressure filling method, it is possible to forcefully fill 7',C<liquid even in a very narrow place such as the inside of a hollow fiber. Next, the dialysate chamber 8 is filled with an evaporative filling material in the same way as the plate/LD chamber 7 until the temperature reaches +C. This one
4,... and:L! It is not necessary to use the vacuum filling method for I'-'i.

After filling is completed, the introduction passage 2. Discharge passage 4. Connect the inflow passage 5 and outflow passage 6 to the sealed part 2a+ 4a+ 5a+ a(
After tightening the evaporative filler material inside the device I to prevent it from leaking (for example, a rubber stopper), the entire device I is placed in high humidity commercial pressure steam in an autoclave for sterilization. Normally, the temperature inside the autoclave is about 100-130"C and the vapor pressure is J~3Ky/CrI, and the free VC humidity temperature and pressure can be adjusted within this range.
It can be reliably sterilized by leaving it in an autoclave at 215 kg/cJ for about 30 minutes. In this case, the outer cylinder 9, the fixed cap 10. Cap l1g Any material that can withstand the temperature inside the autoclave is fine, and is preferably made of synthetic resin such as polycarbonate or polypropylene. Further, the hollow fibers 3 themselves need to be selected from a material that does not undergo changes due to heat, and ancient cellulose or the like is preferable.

In short, the arrangement f(j-1f!) is not particularly limited, as long as the formed combination can withstand the temperature inside the autoclave.

This l, sea urchin hollow fiber type r+? /I quality mobile device allows you to reliably empty the inside of the device VCδ, eliminates the hassle of cleaning 4tt: and q at the start of dialysis, and eliminates the need for liquid or gas in the small device. There are effects such as being able to immediately introduce the dish RY into the inside of the thread while pre-packing one piece.

[Brief explanation of the drawing]

Figure 1 shows a partially broken general hollow fiber hemodialysis machine 111
f 11111 side view. 1...Hollow fiber blood augmentation 7 (V dialysis device, 2...Introduction passage, 4...Outlet 1 "r1 path, 5...Inflow passage, 6...
・Outflow passage, 7... blood chamber, 8... dialysate chamber, 2; I+ /I;

Claims (1)

[Claims] 1 It has two chambers: a fluid chamber and a dialysate or oxygen chamber,
A hollow space consisting of an inlet passage and an outlet passage for blood leading to the blood chamber, and an inlet passage and an outlet passage for dialysate or oxygen leading to the dialysate or oxygen chamber. In a thread-type mass transfer device, 7j, the device if
t includes an outer cylinder and a blood cap, and the outer cylinder and the cap are made of at least one of polycarbonate and polypropylene, and the blood chamber of the apparatus is heated. and the dialysate or oxygen chamber is filled with evaporative filling '12/I, which is harmless to the human body.
The inlet passage, the discharge passage, the inflow passage and the outflow passage are sealed with 75) months, and the whole apparatus is sieved with high pressure steaming (treated with heat). Sterilized hollow fiber i mass transfer device.