JPS59501145A - fluid communication device - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] fluid communication device Honbari banquet hill view FIELD OF THE INVENTION The present invention relates to fluid communication devices for mixing and transferring solutions.

More particularly, the present invention relates to a device particularly useful for formulating high calorie infusions.

Hypercaloric fluid therapy involves intravenous administration of a protein-carbohydrate mixture to the patient, for example. be. It is a protein in patients who cannot be satisfied by oral administration and Primarily used to meet caloric needs. Proteins are free amino acids It may be in the form of a protein hydrolyzate, and the carbohydrate is usually dextrose. be. In addition to protein and carbohydrates, vitamins (water-soluble and fat-soluble) and and electrolytes can also be provided in this therapy.

Each of these parenteral ingredients and their combinations are particularly susceptible to pest growth. and it is desirable that they be administered to the patient under sterile conditions. like this These protein and carbohydrate solutions cannot be pre-formulated; They must be formulated under sterile conditions to avoid biological growth. It must be carried out.

Known devices and methods for compounding high calorie infusions include receiving containers and Use a solution transfer system that includes a transfer cent. The 7 character transfer cents are each comprising two separate tubes with one end attached to a common joint; The solution is pumped through the tube through the junction into a receiving vessel. will pass to. The other end of one tube of the set goes into a container containing protein. , and the other end of the other tube is connected to a container containing carbohydrates. to the container The desired volume of each solution being transferred is determined by a clamp attached to each tube. Controlled. The solution may be allowed to flow by gravity flow into the receiving vessel. deer It is useful to transfer the solution under the influence of a vacuum applied to the receiving vessel while It turns out that there is. If the receiving container is a flexible plastic container, vacuum is generated within a vacuum chamber in which the container is placed.

In the past, to ensure pyrogenicity during the formulation of high-calorie infusions, formulations were It is known that it must be carried out under a laminar flow hood. The laminar flow hood used to reduce the risk of airborne contamination of solutions such as these units is to bring in air from the room and remove large contaminants such as lumps and cotton debris. It works by passing it through a pre-filter. The air is then compressed , and is directed in laminar flow through a grouper removal filter in the foot.

Purified air is blown out in parallel lines at a uniform velocity over the entire working surface of the hood. grouper The Terrier Removal Filter removes all bacteria from the air being passed through the mouth. Designed to.

Although compounding under a laminar flow hood helps prevent airborne contamination, it is relatively troublesome. and are expensive and free from other sources of contamination, such as contamination caused by handling. It will not be useful for cleaning. When using the hood, operate the hood on the edge or outside, and $! A small amount of air inside the hood ensures the benefit of the produced air. Work may be inadvertently performed outside the recommended clearance of at least 6 inches. Ru. Take the time to maintain a direct open path between the filter and the blending area. , and must be careful. Solution bottles and other non-sterile objects should be These objects contaminate everything downstream and disrupt the laminar flow pattern of purified air. It can be destroyed and placed after the hood working area leading to the filter. I can't. Additionally, when using a laminar flow hood, the hood must be operated before the formulation is carried out. Routine cleaning of surfaces is necessary.

As such, the prior art devices and methods discussed above are time consuming and error prone. This is disadvantageous due to the large amount of manual labor involved.

Apparatus and methods that utilize filter systems in compounding operations pose new problems. Ru. The viscosity of some of these parenteral fluids can cause filter clogging and Therefore, the transfer through filters and equipment will be avoided. Also, the viscosity of the solution is different. can be, and generally is, and this is due to their inequality or other desirability. This can lead to undesirable mixing. Therefore, the desired mixing of the solutions to be formulated can be achieved. Extra time and care must be taken to ensure that.

Methods and apparatus have been developed that overcome the disadvantages discussed above. This method and apparatus , “High Velocity Bulk”, assigned to the assignee of this invention, and incorporated by reference. in the names of Carl, Miller and Lawrence, Earle, Hogan entitled "Compounding Apparatus" As described and claimed in co-filed U.S. Patent Application No. 391,795 There is.

As described therein, the rapid and accurate transfer of fluids, especially those for compounding sterile fluids, The exchange is performed by a roller operatively connected between the solution container and the receiving container. Data is received regarding the amount by volume of each solution to be blended and its specific gravity. this Comparing the data with the detected weight in the collection container, the controller sequentially controls the pump. allowed to drive. The controller also monitors various process conditions. can be tarred. Failure of these process conditions will result in automatic stoppage of work. Ku.

The device of the present invention provides an integrated sterile system for use with the high speed bulk compounding device. Provides rapid and economical fluid passage. In addition, this device is Provide proper placement.

Honmitsu Tomobe” I1 According to the invention, together with an apparatus for compounding a plurality of /8 liquids, preferably under sterile conditions, A device for fluid communication is provided for use in the present invention. The device of the invention should be formulated multiple fluid containers to be inserted into respective solution containers each containing a solution; Contains connectors.

Fluid lines provide fluid flow from the solution container to each pump tube. and sealingly connect each vessel connector to its respective inlet pump fitting.

Pump tubing fluidly connects each inlet pump fitting to the outlet pump fitting. It is made of elastomer. Pump fittings are used to connect pump lows of peristaltic pumps in compounding equipment. Grid to facilitate placing the pump tube under tension around the around their outer periphery. The tension of the pump tube is compounded with the pump fitting. maintenance by placing them at each inlet and outlet in the equipment housing. held.

Outlet pump fittings connect separate fluid lines to form a fluid path to a common combined block. Sealingly connected to the connector. Combined Pro Tsuk connects each of multiple separate fluid lines. , vertically spaced so that bends in the line do not inhibit fluid flow. are accommodated in substantially parallel manner.

The common docking block has separate fluid connectors to provide passage to the receiving vessel. provides an exit port for sealingly and aseptically containing the The exit port The ports are preferably perpendicular to the inlets of the plurality of fluid lines.

The common coalescing block covers the exit boat and protects it when not in use. It has an associated closure member that protects against contamination. The closure member is A retaining link is connected to the obturator by a flexible member to secure the block to the block. Contains g. In the use of pro-tsuku or uncovered positions, The ring, flexible member and obturator lie substantially in a common plane, and the obturator The inner side faces downward to prevent particulate contaminants from accumulating there. Block In the unused or covered position of the closure, the flexible section is relaxed and the closure Allows you to cover the inside or exit port.

One of each cent of the inlet and outlet pump fittings is connected to the compounding device in accordance with the invention. Color or number to correspond to each pump on the compounding device to provide placement. coded in letters. In addition, the fluid lines are exactly the length required by the compounding equipment. The dimensions shall be as provided. Preferably, the device is capable of combining the three solutions to be combined. configured to accommodate. The apparatus of the present invention comprises a solution containing a solution to be blended. To provide a sterile, integrated and economical fluid path between a liquid container and a receiving container.

nu] Uη single J surplus skin FIG. 1 is a perspective view of the invention according to its application as providing a fluid passageway.

FIG. 2 is a perspective view constructed in accordance with the present invention.

FIG. 3 is a cross-sectional view of a portion of the present invention.

The fourth vinegar is a cross-sectional view of another part of the present invention.

sarakaribada 1 and 2, the fluid communication device 1o of the present invention is best illustrated. ing. Figure 1 shows apparatus 1 in position for use with high speed bulk compounding equipment. 0, while Figure 2 depicts the device 5 after removal from its sterile packaging. . The supply containers 1.2.14 and 16, shown in dotted lines in FIG. It is fluidly connected to a receiving vessel 18 (also shown in dotted lines). indicated by dotted line Supply and receiving vessels will be provided by Torahenol, Laboratories, Deerfield, Illinois. Registered trademark VIAAFFLEX by Leeds, Inc. This is a flexible plastic hanger of the type originally commercially available.

Apparatus 10 provides a 1 meter path of sterile fluid from each supply container to a common docking block 20. , a receiving vessel can be placed in fluid communication with the docking block. Mix The liquid is pumped by peristaltic pumps 22, 24 and 26 (indicated by dotted lines). Transferred from supply container to receiving container. The peristaltic pumps 22, 24 and 26 are Each tensioned wall 30,30' of the fluid passage in contact with the rolling roller and 30°, and each pump has a rotatable rotor that compresses the The movement of roller 28 causes supply container 12. ], 4 and 16 through the device 10. to effect fluid flow to the receiving vessel 18.

30° and 30° of the fluid path of the device 10 in contact with each respective pump. and 30” is about 4 inches to about 6 inches in length, preferably 5 inches in tension. An elastomer integral or pump tube that can be placed in the each pong The other ends of the tubes 30, 30° and 30” are connected to their respective inlet and outlet pumps. Connected to fittings 32, 32' and 32'', and 34, 34' and 34'' , the fittings may be installed, for example, in the inlet and outlet slots of the pump housing (not shown). Q is operatively fixed in place to keep the pump tube under tension. Ru.

The fluid passages of device 10 begin at fluid connectors 36, 36' and 36''.

The ends of fluid connectors 36.36" and 36" respectively connect supply containers 12.14 and 16 and is suitable for plugging into connectors and fluid communication Protective sheaths 38, 38' and 38'' (Fig. 2) are used to prevent road contamination. It's covered. Each fluid connector has a respective inlet pump fitting 32. such as vinyl tubing and other sealing connections to 32° and 32” Sealingly connected to respective fluid lines 40, 40' and 40''. Separate fluid lines 42, 42' and 42'' connect to their respective outlet pump fittings 34, 34 ’ and 34” and connect them to a common combined block 20. Continue.

The inlet and outlet pump fittings 32 and 34 seen in FIG. Representative of fittings and tubes. The inlet and outlet pump fittings are It has a ribbed portion 43 around it.

This ribbed portion 43 tensions the pump tube 30 around the roller 28. Make them easy to grasp for placement. inlet and outlet pump fittings 32 and 34 is identical and connects to a cylindrical portion 46 providing a shoulder portion 47 at the other end. It has a dish-shaped portion 44 at one end. The shoulder portion 47 has a pump connected thereto. Inlet and outlet slots in the pump housing to maintain tension on the tube 3°. is pressed against the The pump tube 30 is connected to the cylinders of the fittings 32 and 34. The shaped portions 46 are expanded to form an interference fit therebetween. Cylindrical part 4 6 includes a cylindrical fluid line housing tapered along its length with a shoulder 50; 48. The fluid line passes through the dished portion 44 where it contacts the shoulder 50. into the cylindrical part 46 until it is. The cylindrical portion 46 is then a hollow cylinder. Provide fluid communication through the shaped portion.

Connect each fluid connector 36, 36° and 36” to each inlet pump fitting. Fluid lines 40.40" and 40" connecting to hands 32.32' and 32" are preferably the same length. Outlet pump fitting 34.34’ and 34” common The fluid lines 42, 42' and 42'' connecting to the docking block 20 are preferably or the difference in the positional relationship of each pump 22, 24 and 26 with respect to block 20. Available in different lengths to suit your needs. Additionally for each set of inlet and outlet pump fittings At least one coats each coat to provide proper positioning of the device 10. may be numbered, colored or otherwise coded to correspond to the designated operating position. Ru.

The common coalescing block 20 is best seen in FIG. The block 20 is a combined body 54, a top camp 56 and a membrane 58 therebetween. Body size: 54 With substantially parallel, vertically spaced tapered passages 60.60' and 60'' , each of which accommodates respective fluid lines 42, 42'' and 42''. suitable and does not prohibit the flow of fluid through the line by bending it. It looks like this. Passage 60. 60' and 60'' are sealed therein. fluid lines 42, 42' and 42'' to form a tight fit. It tapers to . Bow) 62.62’ and 62” are the respective aisles and small Provides fluid communication with volume chamber 64. The chamber 64 is connected to the passageway and and substantially perpendicular to the boat and continue into the cylindrical portion 70. It is an inverted truncated cone 66 that continues into a more prominent inverted truncated cone 68.

A top cap 56 is sealed to the top of the body, such as by welding, and A membrane 58 is fixed to the surface. Top cap 56 includes a passageway 74 that provides communication with membrane 58. It is provided with a dish-shaped open lower lower part 2 that continues to. Membrane 58 is closed at the passageway extending therethrough. It has a slit 76 that can be elastically deformed. The slit 76 allows flow to the receiving container. Fluid connectors in sump providing body passageways Sealed sterile sump in other inlets Provide fluid passageway. This deforms the membrane 58 and closes around the connector. This is achieved by When the connector is pulled out, the membrane 58 immediately closes on itself. , thereby continuing to protect the fluid path of the device IO. top cap Cup, Membrane and Suri 7th are Scotto, Tee, Gearet, Rohart, Earl. , U.S. Patent No. 4, issued in the name of Fasana and William, Elle, Lucena. 197°848.

A closure or bulge cover 78 is provided to protect the fluid passageway of device 10 when not in use. is provided. The cover 78 is a closure member 80. Connecting member 82 and flexibility therebetween Includes arm 84. The connecting member 82 has a ring shape and is an upper end portion of the combined body 54. fits around the outer periphery of the The top cap has a member 82 detached from the combined body 54. a lip 86 to prevent leakage and provide a sealed connection with member 80; is provided.

A flexible arm 84 connects connecting member 82 and closure member 80 .

Arm 84 protects device 10 but provides easy access when needed. This allows members 80 and 82 to lie substantially coplanar and functional areas when not in use. Keep it off.

Closure member 80 forms a sealed closure around the top cap, thereby lip 88 and lip 8 of top cap 56 to protect the fluid passageway of device 10. 6 and a complementary undercut 90. The member 80 is a particulate material. To protect the device 10 when not in use, to prevent particles from building up on it. , is arranged so that its inner surface 92 faces downward. Seal the top cap 56 When covering, member 80 maintains the correct orientation of closure member 80 with respect to top camp 56. Rotating or twisting flexible arm 84 about its axis to provide It takes. Member 80 also includes a tab 9 to facilitate cover removal of the top cap. 4 includes a pull tab 94 with a raised gripping area 94 for easy gripping. I'm reading.

The apparatus 10 of the invention described above comprises a plurality of containers containing a solution to be transferred to a receiving container. Provides an integrated, sterile and economical fluid path between multiple solution containers. The device is fast A high-speed compounding device that provides an efficient, precise, dense, and sterile solution compounding method. Particularly suitable for use with Furthermore, the device 10 is configured to Provide proper placement of the device with respect to the combined device.

Modifications and variations of the present invention are possible in light of the above teachings. therefore within the scope of the claim It should be understood that the invention may be practiced otherwise than as specifically described. It is possible.

FIG.3 FIG.4 international metrology report

Claims (1)

[Claims] 1. Each person should connect their respective fluid connector to their respective first pump fitting. a plurality of first fluid lines forming fluid passageways between the first fluid lines; connecting said respective first pump couplings to respective second pump couplings; a plurality of pump tube segments forming a fluid passageway to the a plurality of pumps each connecting a respective said second pump coupling to a common dock a second fluid line, wherein the common combined block connects each of the second fluid lines. a fluid passageway in fluid communication with the fluid passageway; and a fluid passageway in communication with and further in fluid communication with the fluid passageway; and exit boat means including means for providing a passageway for the exit boat. A fluid communication device characterized by: 2. To cover the front ejection robot means and prevent particulate matter from accumulating on it. 2. The device of claim 1, comprising a closure member of. 3. The closing member has a protection for fixing the closing member to the common combined block. The device of clause 2 comprising a ring. 4. the closure member includes a flexible member connecting the retaining ring to the closure member; The closure member, flexible member and retaining ring cover the outlet port means. 3. The apparatus of clause 3 which lies substantially in the same plane when not in contact with the apparatus. 5. The inner portion of said closure member is closed when not covering said outlet port means. 4. Apparatus according to paragraph 4, facing downwardly to prevent build-up of granular contaminants on top. 6. said flexible member covers said exit boat means with said closure member; 5. The apparatus of clause 5, which is rotated to enable 7. The apparatus of clause 1, wherein the fluid passageway is sealingly connected. 8. The pump tube segment is connected to the pump fitting by an interference fit therebetween. 7. The device according to paragraph 7, which is connected to 9. The apparatus of clause 1, wherein each of said second fluid lines is of a different length. 10. Each pump tube segment is made of elastomer suitable for being placed under tension. The device of paragraph 1, which is an integral part of the device. 11. Each pump tube segment is connected to the associated peristaltic port. placed under tension around a roller to achieve fluid flow through it 10. Apparatus according to paragraph 10 suitable for. 12. Each pump tube segment has a length of about 4 inches to about 6 inches. A device according to item 1. 13. The length of each said pump tube segment is approximately 5 inches. Device. 14. The pump fitting places the pump tube segment under tension. Apparatus according to claim 1, comprising gripping means around their periphery suitable for assisting the . 15, at least one of each cent of the first and second pump couplings is The cord is tagged to provide proper placement into the operative position. The device of paragraph 1. 16, the fluid passageway for accommodating the second fluid line and for carrying the second fluid line; 2. The apparatus of claim 1 comprising substantially parallel separate boats. 17. said outlet port means is located at an upper end portion of said common unitary block; 16, wherein said exit boat means is substantially perpendicular to said remote boat. Place. 18, said outlet port means being connected to a further fluid connector providing a passageway for fluid communication; A device according to claim 1, which is suitable for sealingly receiving nectar. 19, the plurality of first fluid lines includes three first fluid lines, each first A fluid line connects the respective fluid connector to the respective first pump fitting. a plurality of pump tube segments connected to and forming a fluid passageway therebetween; connecting said respective first pump fittings to said respective second pump fittings; three pump tube segments defining a fluid passageway therebetween; The number of second fluid lines includes three second fluid lines, and the number of second fluid lines includes three second fluid lines. each of the members connects said respective second pump coupling to said common combination block. The device of paragraph 1. 20. Each person seals their respective fluid connector to their respective first pump fitting. a plurality of first fluid lines that connect to each other and define fluid passages therebetween; sealingly connecting said respective first pump couplings to respective second pump couplings; a plurality of pump tube segments connected to each other and forming a fluid passageway therebetween; Th+ said pump fitting places said pump tube segment under tension; including gripping means around their periphery suitable to assist in At least one of each cent of the first and second pump tubes must be Cords to provide proper placement into each corded operating position. and further each person connects said respective second pump coupling to a common combination block. a plurality of second fluid lines sealingly connecting to the lock; A lock includes a fluid passageway in fluid communication with each said second fluid line and said fluid passageway. and means for forming a passageway for further fluid communication. and an outlet port means. 21, the plurality of first fluid lines includes three first fluid lines, each first A fluid line connects the respective fluid connector to the respective first pump fitting. a plurality of pump tube segments connected to and forming a fluid passageway therebetween; connecting said respective first pump couplings to said respective second pump couplings; including three pump tube segments forming a fluid passageway therebetween; the number of second fluid lines including three second fluid lines; each of which connects said respective second pump coupling to said common combination block; 20. 22, said pump tube segment is connected to the associated load of each peristaltic pump. suitable for placing under tension around a roller to achieve fluid flow through it. Item 20 or Apparatus according to paragraph 21. 23, said fluid passageway houses said second fluid line and said second fluid line substantially parallel to maintain a substantially parallel apart relationship to prevent bending of the a separate boat, said outlet port means providing a passageway for fluid communication; Additionally, a twenty fluid connector suitable for sealingly receiving another fluid connector is provided. Apparatus according to paragraph or paragraph 21. 24. The apparatus of paragraph 20 or paragraph 21, wherein each said second fluid line is of a different length.