JPS593964B2 - Solidification method of soybean soapstock - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel method for solidifying soybean soapstock (powders, fine granules, tablets) which is a semi-solid oil and has thixotropy obtained in the deodorizing process of soybean oil.

Soybean soapstock is used in medicine as a highly safe plant-based antilipidemic agent.

The main rule is 1200 m9 of soybean oil per day for an adult.
Since soybean oil soap needs to be administered in small doses, a high-unit formulation that is easy to take is desired.However, because soybean oil soap is a semi-solid oily substance, it is difficult to formulate a formulation.
No. 9) is only known.

In this method, various additives such as adsorbents and disintegrants are kneaded in the presence of an organic solvent such as soybean soapstock, and the mixture is adsorbed onto the soybean soapland adsorbent, then granulated using an extrusion granulator and dried. It has become.

In this method, when the soybean soapland content reached a high concentration of 50% or more, adsorption to the adsorbent became incomplete, and the soybean soapland oozed from the granule surface over time, making it impossible to obtain a desirable product.

Also, this method may be used, for example, the granules obtained in Example 1 of the above-mentioned Japanese Patent Publication No. 49-46899 (soybean soapstock content: 47%; bulk density: 0.551?/ml; average particle diameter: 361μ). In order to prevent sticking during tabletting, it is necessary to add a large amount of additives, and the weight of one tablet is 550.
It was 600m9 (soybean soapstock content 33-36%) and was large and difficult to take.

In addition, when pulverizing into powder using a crusher,
The powder adhered to the pulverizer significantly, and the powder obtained did not have favorable fluidity.

In order to improve the above drawbacks, the present inventors conducted various studies on adsorption methods for soybean soapstock, and as a result, we atomized soybean soapstock dissolved in an organic solvent and a binder to form an adsorbent (high-purity silicic anhydride) in a fluid state. , (trade name: Aerosil 200-380), a powder is obtained in which fine particles of soybean soapstock are evenly adsorbed in the form of an adsorbent. The present invention was completed by discovering that fine granules, granules, and tablets can be obtained.

Binders used in the present invention include those soluble in organic solvents such as hydroxyglopylcellulose and polyvinylpyrrolidone; examples of organic solvents include chloroform,
Chlorocene, methylene chloride, etc. are used.

According to this method, the atomization conditions, for example, the atomization air pressure (0,3
~2.0 kg/crA), liquid velocity (soybean soapstock 20
(for 10 to 60 mL when used)
%) can be obtained.

For example, when preparing powders, fine granules, and granules specified in the 9th revised Japanese Pharmacopoeia using a batch of 200 g of soybean oil soapstock, the atomizing air pressure conditions for each are 0.6 to 2.0. k
g/cwt, 0.3-0.6 kg/ci.

0, 3 to 0.5 kg/ctA, and each droplet velocity condition is 30 to 50 m1Z min, 30 to 60 m1Z min, 40
~60 rul/min is used.

The obtained powder or granules exist in a state in which fine particles containing soybean soapstock aggregate with each other, and since Aerosil is easily wetted, it does not soak into water even though it contains a high concentration of soybean soapstock. The dispersion is good, so there is no need to add disintegrants or surfactants, and the fluidity improves over time.
Adhesion did not deteriorate.

Furthermore, since the present invention uses a closed system for adsorption and drying, it plays a significant role in simplifying the process and reducing the effects of adsorbent dust, volatile solvents, etc. on the human body.

Generally known antioxidants are used to obtain powders, fine granules, and granules from this adsorbed powder.

In the case of tablets, lactose, starch, microcrystalline cellulose, magnesium aluminum hydroxide, aluminum silicate, etc. are preferably used as excipients, and talc, silicic anhydride, etc. are preferably used as lubricants.

In addition, these additives are 5 to 15 η for powders, fine granules, and granules (soybean soapstock content 62.1 to 64.1%), and 120 for tablets, for adsorbed powder containing 200 to 200 η of soybean soapstock.
An amount of ˜150 μm (soybean soapstock content 43.8-46.8%) is used.

Next, the configuration of the present invention will be explained using examples.

Example 1 Soybean soapstock 200 f? Methylene chloride 11! Also dissolved in polyvinylpyrrolidone 2oyv-c.

Dissolve in 100 ml of tanol, mix and stir to form a spray solution.

Fluid granulation coaching equipment (Freund industrial type FLI)
O type) and Aerosil 38o (trade name) (composition: silicic anhydride 99.8% or more, aluminum oxide 0.05% or less,
Rice grain 0.05% or less, other ingredients 0.1% or less; BE
T surface area 380±30m2/? ;liquid acidic)87.
31 Knee injection to fluidize the air as a fluid, and then continuously spray the spray liquid at a spray air pressure of 0.8 kg/crA, a droplet speed of 30 ml for 11 minutes, and an intake air temperature of 50 to 60°C to adsorb it on the soybean soapstock Care Erosil 380. , 40-50 minutes after completion of adsorption
It was dried at 0.degree. C. to obtain an adsorbed powder (soybean soapstock content: 65.1%; bulk density: 0.54 y/ml; average particle diameter: 223 .mu.m).

This adsorbed powder contains vitamin C8,5 as an antioxidant.
A powder containing 4.2 P of citric acid and 62.5% of soybean soapstock with good dispersibility and fluidity in water was obtained.

Example 2 Adsorbed powder prepared in the same manner as in Example 1 was mixed to the following formulation and compressed into tablets with a diameter of 10 mm and a thickness of 5.4 mm.

10 of the resulting tablets
The average hardness is 3.0k as measured by a tablet hardness meter.
It was g.

Further, when the disintegration time of 10 tablets was measured based on the 9th edition Japanese Pharmacopoeia, the average disintegration time was 10 minutes.

Adsorbed powder in 1 tablet (Soybean soapstock 200%) 307.3 ~ Microcrystalline cellulose 46.0rn9 Aluminum magnesium hydroxide 70.0 ~ Aluminum silicate 4.0 ~ Vitamin C 8.5 ~ Citric acid 4.2 ~ Li
5.07Q silicic anhydride 5. OW19 total
450.0～

Claims (1)

[Claims] 1 1 part by weight of soybean soapstock and 0 organic solvent-soluble binder
．． 08 to 0.16 parts by weight of a suitable organic solvent, and this liquid was sprayed at an air pressure of 0.3 to 2 k.
g/crti and the liquid speed is 1 ky of soybean soapstock used as above.
A method for solidifying soybean soapstock characterized by atomizing it under conditions of 50 to 300 wtl/min and adsorbing it to 0.2 to 2 parts by weight of high-purity silicic anhydride in a fluidized state in a fluidized bed. .