JPS593964B2 - Solidification method of soybean soapstock - Google Patents
Solidification method of soybean soapstockInfo
- Publication number
- JPS593964B2 JPS593964B2 JP54062038A JP6203879A JPS593964B2 JP S593964 B2 JPS593964 B2 JP S593964B2 JP 54062038 A JP54062038 A JP 54062038A JP 6203879 A JP6203879 A JP 6203879A JP S593964 B2 JPS593964 B2 JP S593964B2
- Authority
- JP
- Japan
- Prior art keywords
- soybean
- soybean soapstock
- soapstock
- powder
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Description
【発明の詳細な説明】
本発明は大豆油の脱臭工程に於いて得られる半固形油状
で揺変性な有する大豆油滓の新規な固形化法(散剤、細
粒剤、錠剤)に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel method for solidifying soybean soapstock (powders, fine granules, tablets) which is a semi-solid oil and has thixotropy obtained in the deodorizing process of soybean oil.
大豆油滓は安全性に優れた植物性の抗脂血症剤として医
薬品に使用されている。Soybean soapstock is used in medicine as a highly safe plant-based antilipidemic agent.
本則は二股に成人1日当り大豆油滓として1200m9
程度投与する必要がある為、服用し易い高単位の製剤が
望まれているが、大豆油滓が半固形の油状物質である為
製剤化が難しく今迄に顆粒化法(特公昭49−4689
9号)が知られているにすぎない。The main rule is 1200 m9 of soybean oil per day for an adult.
Since soybean oil soap needs to be administered in small doses, a high-unit formulation that is easy to take is desired.However, because soybean oil soap is a semi-solid oily substance, it is difficult to formulate a formulation.
No. 9) is only known.
この方法は、大豆油滓な有機溶媒の存在下で吸着剤並び
に崩壊剤等各種の添加物と共に練合し大豆油滓な吸着剤
に吸着させた後押出し造粒機で造粒、乾燥し顆粒化した
ものである。In this method, various additives such as adsorbents and disintegrants are kneaded in the presence of an organic solvent such as soybean soapstock, and the mixture is adsorbed onto the soybean soapland adsorbent, then granulated using an extrusion granulator and dried. It has become.
この方法では大豆油滓含量が50%以上の高濃度になる
と吸着剤への吸着が不完全となり、顆粒表面から経時的
に大豆油滓のにじみを生じ好ましいものは得られなかっ
た。In this method, when the soybean soapland content reached a high concentration of 50% or more, adsorption to the adsorbent became incomplete, and the soybean soapland oozed from the granule surface over time, making it impossible to obtain a desirable product.
また、この方法、例えば前記特公昭49−46899の
実施例1で得られた顆粒(大豆油滓含量47%;嵩密度
0.551?/ml ;粒子平均径361μ)?用いて
錠剤化する場合、打錠時にステッキング等を防止する為
に多量の添加剤な新たに加える必要があり、1銑中大豆
油滓な2001r1g含有するには1錠の重量は550
〜600m9(大豆油滓含量33〜36%)となり大き
くて服用しにくいものであった。Also, this method may be used, for example, the granules obtained in Example 1 of the above-mentioned Japanese Patent Publication No. 49-46899 (soybean soapstock content: 47%; bulk density: 0.551?/ml; average particle diameter: 361μ). In order to prevent sticking during tabletting, it is necessary to add a large amount of additives, and the weight of one tablet is 550.
It was 600m9 (soybean soapstock content 33-36%) and was large and difficult to take.
また、これな粉砕機により粉末化して散剤とする場合、
粉砕機への付着が著しい上に得られた粉末も流動性に於
いて好ましいものは得られなかった。In addition, when pulverizing into powder using a crusher,
The powder adhered to the pulverizer significantly, and the powder obtained did not have favorable fluidity.
本発明者らは以上の欠点な改良すべく大豆油滓の吸着方
法な種々研究した結果、有機溶媒に溶解した大豆油滓と
結合剤を霧化し流動状態にある吸着剤(高純度無水ケイ
酸、商品名アエロジル200〜380)に吸着させると
微細粒子の大豆油滓を吸着剤が包む形で均一に吸着した
粉末が得られ、この粉末な用いれば大豆油滓な高単位に
含有する散剤、細粒剤、顆粒剤及び錠剤を得ることが出
来ることを見い出し本発明を完成した。In order to improve the above drawbacks, the present inventors conducted various studies on adsorption methods for soybean soapstock, and as a result, we atomized soybean soapstock dissolved in an organic solvent and a binder to form an adsorbent (high-purity silicic anhydride) in a fluid state. , (trade name: Aerosil 200-380), a powder is obtained in which fine particles of soybean soapstock are evenly adsorbed in the form of an adsorbent. The present invention was completed by discovering that fine granules, granules, and tablets can be obtained.
本発明に使用される結合剤としては、ヒドロキシグロピ
ルセルロース、ポリビニルピロリドン等の有機溶媒に可
溶なものが、また、有機溶媒としては、クロロホルム、
クロロセン、メチレンクロライド等が使用される。Binders used in the present invention include those soluble in organic solvents such as hydroxyglopylcellulose and polyvinylpyrrolidone; examples of organic solvents include chloroform,
Chlorocene, methylene chloride, etc. are used.
この方法によれば霧化条件、例えば噴霧空気圧(0,3
〜2.0 kg/crA ) 、液速度(大豆油滓20
(1’使用時10〜60m1Z分)等な変化することに
より粉末状から顆粒状のもの(大豆油滓含量が最高75
%まで)を得ることが出来る。According to this method, the atomization conditions, for example, the atomization air pressure (0,3
~2.0 kg/crA), liquid velocity (soybean soapstock 20
(for 10 to 60 mL when used)
%) can be obtained.
例えば、■バッチ200グの大豆油滓を使用して第9改
正日本薬局方に規定する散剤、細粒剤、及び顆粒剤な得
る場合、各々の噴霧空気圧条件は、0.6〜2.0 k
g/cwt、 0.3〜0.6 kg/ci。For example, when preparing powders, fine granules, and granules specified in the 9th revised Japanese Pharmacopoeia using a batch of 200 g of soybean oil soapstock, the atomizing air pressure conditions for each are 0.6 to 2.0. k
g/cwt, 0.3-0.6 kg/ci.
0、3〜0.5 kg/ctA、また、各々の滴速度条
件は、30〜50m1Z分、30〜60m1Z分、40
〜60rul/分が用いられる。0, 3 to 0.5 kg/ctA, and each droplet velocity condition is 30 to 50 m1Z min, 30 to 60 m1Z min, 40
~60 rul/min is used.
得られた粉末もしくは顆粒は大豆油滓な含む微細粒子が
相互に凝集し合った状態で存在し、しかもアエロジルが
濡れ易い為大豆油滓を高濃度に含有しているにも拘らず
水中への分散は良好で、したがって崩壊剤や活面活性剤
な添加する必要がなく、しかも、経時的にその流動性、
付着性が悪化することはなかった。The obtained powder or granules exist in a state in which fine particles containing soybean soapstock aggregate with each other, and since Aerosil is easily wetted, it does not soak into water even though it contains a high concentration of soybean soapstock. The dispersion is good, so there is no need to add disintegrants or surfactants, and the fluidity improves over time.
Adhesion did not deteriorate.
更に、本発明は吸着、乾燥な同−密閉系で行う為工程の
簡略化並びに吸着剤の粉じん、揮発溶媒等の人体に及ぼ
す影響の軽減に果す役割は太きい。Furthermore, since the present invention uses a closed system for adsorption and drying, it plays a significant role in simplifying the process and reducing the effects of adsorbent dust, volatile solvents, etc. on the human body.
この吸着粉末から散剤、細粒剤、顆粒剤を得るには一般
に知られている酸化防止剤が用いられる。Generally known antioxidants are used to obtain powders, fine granules, and granules from this adsorbed powder.
また、錠剤の場合には賦形剤として乳糖、デンプン、微
結晶セルロース、水酸化アルミニウムマグネシウム、ケ
イ酸アルミニウム等が又滑沢剤としてタルク、無水ケイ
酸等が好んで用いられる。In the case of tablets, lactose, starch, microcrystalline cellulose, magnesium aluminum hydroxide, aluminum silicate, etc. are preferably used as excipients, and talc, silicic anhydride, etc. are preferably used as lubricants.
また、これら添加剤は大豆油滓200〜を含む吸着粉末
に対し散剤、細粒剤、及び顆粒剤の場合5〜15η(大
豆油滓含量62,1〜64.1%)、錠剤の場合120
〜150■(大豆油滓含量43.8〜46.8%)の量
が用いられる。In addition, these additives are 5 to 15 η for powders, fine granules, and granules (soybean soapstock content 62.1 to 64.1%), and 120 for tablets, for adsorbed powder containing 200 to 200 η of soybean soapstock.
An amount of ˜150 μm (soybean soapstock content 43.8-46.8%) is used.
次に、本発明の構成を実施例により説明する。Next, the configuration of the present invention will be explained using examples.
実施例 1
大豆油滓200 f?にメチレンクロライド11!に溶
解し、また、ポリビニルピロリドン2oyv−c。Example 1 Soybean soapstock 200 f? Methylene chloride 11! Also dissolved in polyvinylpyrrolidone 2oyv-c.
タノール100m1に溶解し両者な混和攪拌し噴霧液と
する。Dissolve in 100 ml of tanol, mix and stir to form a spray solution.
流動造粒コーチイング装置(フロイント産業型FLI
O型)にアエロジル38o(商品名)(組成:無水ケイ
酸99.8%以上、酸化アルミニウム0.05%以下、
籾粒0.05%以下、その他の成分0.1%以下;BE
T表面積380±30m2/ ? ;液性酸性)87.
31ニー投入し空気を流体として流動化し、そこに噴霧
空気圧0.8kg/crA、滴速度30m11分、吸気
温度50〜60℃で噴霧液な連続的に噴霧して大豆油滓
ケアエロジル380に吸着させ、吸着終了後40〜50
℃で乾燥し吸着粉末(大豆油滓含量65.1%;嵩密度
0.54y−/ml:粒子平均径223μ)な得た。Fluid granulation coaching equipment (Freund industrial type FLI)
O type) and Aerosil 38o (trade name) (composition: silicic anhydride 99.8% or more, aluminum oxide 0.05% or less,
Rice grain 0.05% or less, other ingredients 0.1% or less; BE
T surface area 380±30m2/? ;liquid acidic)87.
31 Knee injection to fluidize the air as a fluid, and then continuously spray the spray liquid at a spray air pressure of 0.8 kg/crA, a droplet speed of 30 ml for 11 minutes, and an intake air temperature of 50 to 60°C to adsorb it on the soybean soapstock Care Erosil 380. , 40-50 minutes after completion of adsorption
It was dried at 0.degree. C. to obtain an adsorbed powder (soybean soapstock content: 65.1%; bulk density: 0.54 y/ml; average particle diameter: 223 .mu.m).
この吸着粉末に酸化防止剤としてビタミンC8,5す、
クエン酸4.2P&添加添加口て大豆油滓62.5%な
含有する水中への分散性並びに流動性良好な散剤な得た
。This adsorbed powder contains vitamin C8,5 as an antioxidant.
A powder containing 4.2 P of citric acid and 62.5% of soybean soapstock with good dispersibility and fluidity in water was obtained.
実施例 2
実施例1と同様の方法で製した吸着粉末な下記の処方に
なるように混合し、直径10間、厚さ5、4 mmの錠
剤に圧縮成形した。Example 2 Adsorbed powder prepared in the same manner as in Example 1 was mixed to the following formulation and compressed into tablets with a diameter of 10 mm and a thickness of 5.4 mm.
得られた錠剤のうち10個k S chleunige
r錠剤硬度計により測定したところ平均硬度は3.0k
gであった。10 of the resulting tablets
The average hardness is 3.0k as measured by a tablet hardness meter.
It was g.
また、錠剤10個について崩壊時間な第9改正日本薬局
方に基づいて測定したところ平均崩壊時間は10分であ
った。Further, when the disintegration time of 10 tablets was measured based on the 9th edition Japanese Pharmacopoeia, the average disintegration time was 10 minutes.
1錠中
吸着粉末(大豆油滓200嘘有)307.3〜微結晶セ
ルロース 46.0rn9水酸化アル
ミニウムマグネシウム 70.0〜ケイ酸アルミニウ
ム 4.0〜ビタミンC8,5〜
クエン酸 4.2〜すリ
5.07Q無水
ケイ酸 5. OW19計
450.0〜Adsorbed powder in 1 tablet (Soybean soapstock 200%) 307.3 ~ Microcrystalline cellulose 46.0rn9 Aluminum magnesium hydroxide 70.0 ~ Aluminum silicate 4.0 ~ Vitamin C 8.5 ~ Citric acid 4.2 ~ Li
5.07Q silicic anhydride 5. OW19 total
450.0~
Claims (1)
.08〜0.16重量部な適当な有機溶媒5〜20重量
部に溶解せしめ、この液を噴霧空気圧が0.3〜2 k
g/crti、且つ液速度が前記使用の大豆油滓1ky
につき50〜300 wtl/分の条件下で霧化し、流
動層中で流動状態にある0、2〜2重量部の高純度無水
ケイ酸に吸着させることな特徴とする大豆油滓の固形化
法。1 1 part by weight of soybean soapstock and 0 organic solvent-soluble binder
.. 08 to 0.16 parts by weight of a suitable organic solvent, and this liquid was sprayed at an air pressure of 0.3 to 2 k.
g/crti and the liquid speed is 1 ky of soybean soapstock used as above.
A method for solidifying soybean soapstock characterized by atomizing it under conditions of 50 to 300 wtl/min and adsorbing it to 0.2 to 2 parts by weight of high-purity silicic anhydride in a fluidized state in a fluidized bed. .
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54062038A JPS593964B2 (en) | 1979-05-18 | 1979-05-18 | Solidification method of soybean soapstock |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54062038A JPS593964B2 (en) | 1979-05-18 | 1979-05-18 | Solidification method of soybean soapstock |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55153716A JPS55153716A (en) | 1980-11-29 |
JPS593964B2 true JPS593964B2 (en) | 1984-01-27 |
Family
ID=13188591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54062038A Expired JPS593964B2 (en) | 1979-05-18 | 1979-05-18 | Solidification method of soybean soapstock |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS593964B2 (en) |
-
1979
- 1979-05-18 JP JP54062038A patent/JPS593964B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS55153716A (en) | 1980-11-29 |
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