JPS5930039A - Thermostatic controller - Google Patents

Abstract

PURPOSE:To retain a thermostatic flow cell at a desired temperature with a high accuracy by a method wherein a desired temperature is inputted into an arithmetic processor to perform a computation in comparison with the temperature of a thermostatic flow cell and the results thereof are inputted into a controller to control voltage and current to be supplied to a thermoelectric element. CONSTITUTION:An arithmetic processor 10 and a controller 8 are attached to a thermostatic system 6 comprising a thermostatic flow cell 1, a thermoelectric element 4, a temperature detection element 5 and the like. A specified temperature of an object to be measured which should be analyzed is inputted into an input unit 11 while the temperature of the thermostatic flow cell 1 is detected with a temperature detection element 5, the detection value is inputted into the arithmetic processor 10 to perform a computation in comparison through a temperature-voltage converter 7 and an A/D converter 9 and the results are inputted into the controller 8 through an A/D converter 13 to control the voltage and current to be fed to the thermoelectric element 4 in the thermostatic system 6. The thermostatic flow cell 1 can be retained at a desired temperature with a high accuracy.

Description

DETAILED DESCRIPTION OF THE INVENTION [Technical Field] The present invention relates to a constant temperature control device that maintains and controls a constant temperature flow cell used in a biochemical analyzer at a constant temperature.

[Background technology and its problems]

Constant temperature fluid cells, which are generally used in biochemical analyzers, maintain the analyte stored in a predetermined container at a set temperature; however, in automatic biochemical analyzers, the analyte (for example, (reagents added to blood)
A constant-temperature 70-cell is needed that can quickly raise the temperature to a predetermined temperature to stabilize the chemical reaction quickly and shorten the processing time, thereby improving the accuracy of the measurement data.

In order to meet such demands, constant temperature flow cells have been conventionally used, for example, in which a thermoelectronic element (for example, a Vertier element) is provided in the flow cell body into which an object to be measured is poured and photometry is carried out.

Conventionally, the set temperature of such a constant temperature flow cell has been one point of 37.degree. C. or three points at most, ie, 25.degree. C., 60.degree. C., and 37.degree. For this reason, the constant temperature 70-cell was manually adjusted and set using a dial or the like while being monitored with a temperature monitor so that the temperature reached the set temperature. However, with the recent advances in biochemical analysis, automated biochemical analyzers are now capable of performing a wide variety of biochemical analyses, allowing measurements not only at the specific set temperature mentioned above but also at any temperature quickly and accurately. It has long been desired to do so.

[Purpose of the invention]

The present invention was developed based on the above-mentioned circumstances, and is capable of maintaining the measured object at the temperature required for biochemical analysis. It is possible to quickly and accurately raise the temperature of a substance to a set temperature, and also to set it at an arbitrary temperature, thereby achieving early stabilization of chemical reactions and shortening processing time. The purpose of the present invention is to provide a constant temperature control device that can improve temperature control.

[Summary of the invention]

In order to achieve the above object, the present invention is provided in a constant temperature flow cell by a processing device and a trap that compares and calculates the output value of the next temperature detection device installed in the constant temperature flow cell and the temperature setting value of the constant temperature flow cell. This is characterized by controlling the output value of a control device z that controls the current supplied to the thermionic element.

〔Example〕

The constant temperature control device of the present invention will be explained below with reference to the drawings.

In the figure, reference numeral 1 denotes a constant-temperature flow cell that accommodates an object to be measured, and its end has a suction pipe 2 for sucking in the object to be measured by pressure waves, and a discharge pipe 3 for discharging the object to be measured.

A thermionic element 4 made of a one-Berthier element or the like is provided near the constant temperature flow cell 1, and heats or cools the constant temperature flow cell 1. Reference numeral 5 denotes a temperature detecting element such as a twister that detects the temperature inside the constant temperature flow cell 1. These constant temperature flow cells1. A constant temperature system 6 is formed by the thermoelectric element 4 and the temperature detection element 5. 7 is a temperature-voltage converter that converts the change in resistance value of the temperature detection element 5 into voltage; the output of the temperature-voltage converter 7 is input to the thermionic element 4, and a control device 8 that controls the pressure and current. Ru. Temperature-voltage converter 7 is A-D
A converter 9 converts the output voltage into a digital value. Reference numeral 10 denotes an arithmetic processing unit that performs arithmetic processing on the outputs from the input device 11 and the A-D converter 9.

Reference numeral 12 denotes a display section, which is composed of a cathode ray tube or the like, and displays the results of the arithmetic processing performed by the arithmetic processing device 10.

Reference numeral 16 denotes a DA converter that converts the result of the arithmetic processing by the arithmetic processing device 10 into an analog value and outputs it to the control device 8.

The operation of the constant temperature control device configured as described above will be explained below.

The relationship between the temperature and resistance of the thermistor constituting the temperature detection element 5 is expressed by the following equation.

The absolute temperature here at VCRo is 7°. The resistance value when , similarly KR
1: Resistance value at absolute temperature T, B is a constant unique to the thermistor.

First, input device 111 K, l B, Ro, T
o, enter the To value. Next, the output from the rc input device 11 is input to the processing device 10, and the value of R is determined based on the above-mentioned calculation formula. - After converting the resistance value change of the temperature detection element 5 into a voltage by the temperature-voltage converter 7 and further converting it into a digital value by the A-D converter 9, this digital value is input to the arithmetic processing unit 10. . This arithmetic processing device 10 performs arithmetic processing using the conversion coefficient determined by the temperature-voltage converter 7, outputs the result of the arithmetic processing to the DA converter 16, and the control device 13 generates a comparison voltage. The control device 16 compares the output voltage from the temperature-voltage converter 7 with the output voltage of the D-A converter 13 that generates a comparison voltage, and accordingly controls the thermionic element 4 consisting of a Bertier element into the constant temperature system 1. is controlled to maintain a constant temperature.

Here, the Bertier element is known as the Bertier effect, which means that when two materials, for example two metals or a metal and a semiconductor are bonded together and a current is passed there, heat is generated in addition to Joule heat at the bonding point. This method takes advantage of the effect that occurs in the generation or absorption of .

The present invention is not limited to the above-mentioned embodiments, but can be implemented with appropriate modifications within the scope of the gist.For example, in the embodiments, the output voltage of the temperature-voltage converter 7 is converted into analog Although a method of performing control using a voltage difference from a comparison voltage was used, a digital control method that controls the output data of the A-D converter 9 to a predetermined temperature may be used in the same manner.

〔Effect of the invention〕

As mentioned above, according to the misfire FII, the set temperature of the constant temperature 70-cell is set to an arbitrary temperature using the input device, and the object to be measured is maintained at the temperature state required for biochemical analysis. This makes it possible to quickly stabilize the chemical reaction and shorten the processing time.

In particular, since the temperature of the constant-temperature flow cell can be set using the input device, the temperature within the constant-temperature flow cell can be changed arbitrarily, and biochemical analysis can be performed in an extremely short time.

[Brief explanation of drawings]

The figure is a schematic configuration diagram showing an embodiment of the constant temperature control device of the present invention. 1... Constant temperature flow cell, 4... Thermionic Yonago,
5...Temperature detection element, 7...Temperature-voltage converter, 8...Control device, 9...A-D converter,
10... Arithmetic processing device, 11... Input device, 12... Display section.

Claims (1)

[Claims] By supplying current to a thermionic element placed in contact with the flow cell body into which the object to be measured is poured, heat is transferred, and the object to be measured is heated or cooled and maintained at a constant temperature. a constant temperature flow cell, a control device that controls the current supplied to the heat 1 element, a temperature detection device that detects the temperature of the flow cell main body, an input device that inputs the set temperature of the flow cell, etc.; A constant temperature control device comprising an arithmetic processing device that compares and calculates an input value from the device and an output from a temperature detection device, and outputs the result to the control device.