JPS59219267A - Phthalazine derivative and its preparation - Google Patents
Phthalazine derivative and its preparationInfo
- Publication number
- JPS59219267A JPS59219267A JP9376083A JP9376083A JPS59219267A JP S59219267 A JPS59219267 A JP S59219267A JP 9376083 A JP9376083 A JP 9376083A JP 9376083 A JP9376083 A JP 9376083A JP S59219267 A JPS59219267 A JP S59219267A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- hydrazinophthalazine
- preparation
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
本発明はフタラジン誘導体およびその製造方法に関する
ものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to phthalazine derivatives and methods for producing the same.
さらに詳しくは、本発明は式（Ｉ）
で示されるフタラジン誘導体、並びに、１−ヒドラジノ
フタラジン又１よその塩と１−ヘキセン−５−オンとを
反応させることを特徴する上：ＵＱＩｌで示されるフタ
ラジン誘導体の製造方法（こ関するものである。More specifically, the present invention is characterized by reacting a phthalazine derivative represented by the formula (I) as well as 1-hydrazinophthalazine or a salt thereof with 1-hexen-5-one. A method for producing the phthalazine derivatives shown in the accompanying drawings.
従来、血圧降下剤としてｌ−ヒドラシッフタラ長）が使
用されているが、本発明者は、その誘導体の開発につき
検討の結果、式（Ｉ）に示されるフタラジン誘導体が薬
理試験により、おだやか、かつ、持続ｆ１．ｆ）る降圧
作用を有することを見出した。Conventionally, l-hydra sifthalazine) has been used as an antihypertensive agent, but as a result of studies on the development of its derivatives, the present inventor found that the phthalazine derivative represented by formula (I) was found to be mild and Duration f1. f) It has been found that it has a hypotensive effect.
式（Ｉ）に示される化合物は新規化合物であり、１−ヒ
トうじノックうジノ又はその塩と１−ヘキセノ−５−４
ノとを不活性溶剤、たとえばメタノール、エタノール、
レオキサノなどの媒体中で反応させることにより、容易
に製造しつる。反応は常温でもよいが、加熱は反応促進
にｒ」効であり、使用溶媒の還流下で実施するのが効率
的である。目的とするフタラジン誘導体は、必要に応じ
て、その有機酸地又は鉱酸塩とすることができる。The compound represented by formula (I) is a new compound, and is a compound consisting of 1-human maggot or a salt thereof and 1-hexeno-5-4.
and an inert solvent such as methanol, ethanol,
It is easily produced by reaction in a medium such as leoxano. Although the reaction may be carried out at room temperature, heating is effective in accelerating the reaction, and it is efficient to carry out the reaction under reflux of the solvent used. The target phthalazine derivative can be an organic acid salt or a mineral acid salt thereof, if necessary.
以下に実施例を挙げて、本発明方法をさらに説明する。The method of the present invention will be further explained with reference to Examples below.
実施例
１−ヒドラジノフタラジン塩酸塩１９７２と１−ヘキセ
ノ−５−オノテニリテノ）−ヒドラジノフタラジンの黄
色柱状結晶をえた。Example 1 Yellow columnar crystals of hydrazinophthalazine hydrochloride 1972 and 1-hexeno-5-onotenyriteno-hydrazinophthalazine were obtained.
収量 １８３ｇ 融点 ８０〜８１３℃元素
分析値 Ｃ、７０，０５％； Ｈ９６，７８％ｉ Ｎ
、 ２３．２９％３１算値 Ｃ，７０，００％； Ｈ，
６，６７％ｉ Ｎ、 ２３．３３％（Ｃ＋ｉＩ■１６Ｎ
＋として）Yield 183g Melting point 80-813℃ Elemental analysis C, 70.05%; H96.78%iN
, 23.29%31 calculated value C, 70,00%; H,
6,67%iN, 23.33%(C+iI■16N
(as +)
Claims (1)
ノ−５−副ンとを反応させることを特徴とする特許請求
の範囲第１項記載のフタラジン誘導体の製造方法[Claims] Claim 1, characterized in that 1) a phthalazine derivative represented by the formula 2) 1-hydrazinophthalazine or a salt thereof and 1-hexeno-5-adryne are reacted Method for producing the described phthalazine derivatives
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9376083A JPS59219267A (en) | 1983-05-26 | 1983-05-26 | Phthalazine derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9376083A JPS59219267A (en) | 1983-05-26 | 1983-05-26 | Phthalazine derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS59219267A true JPS59219267A (en) | 1984-12-10 |
Family
ID=14091383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9376083A Pending JPS59219267A (en) | 1983-05-26 | 1983-05-26 | Phthalazine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59219267A (en) |
-
1983
- 1983-05-26 JP JP9376083A patent/JPS59219267A/en active Pending
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