JPS59109252A - Device for recovering crushed good of crusher - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to a crushed product recovery device for a crusher.

The process of formulating pharmaceuticals often includes the process of crushing the drug. For example, large crystal particles are made finer to increase the dissolution rate, needle-shaped crystal particles are crushed to improve fluidity, and two or more types of powder are crushed to improve the mixability. Pulverization of drugs is performed for various purposes, such as adjusting the amount of powder, or mixing and pulverizing two or more types of powder to obtain special effects.

Any of these is less than 100 microns, preferably 3
It is required to be finely pulverized to 0 microns or less. Furthermore, due to the special nature of pharmaceuticals, various other conditions must be met.

In other words, no foreign matter should be mixed in during pulverization.

In addition, the pulverization method changes the physicochemical and biological properties of the pulverized drug, so the selection of the pulverization method and the pulverization operation must be carried out so that not only the particle size but also all the characteristics of the pulverized product are always the same. It is necessary to take control. In particular, if the characteristics of a drug differ between the laboratory stage and the production stage, the characteristics of the designed drug and the produced drug will differ, which may cause serious problems. Therefore, crushing of samples in the laboratory must be done carefully, taking into account the crushing during production.

Additionally, drugs are generally very expensive. Therefore, yield is a very important factor in the pulverization process. At the experimental stage, especially for newly created compounds, the amount of the drug to be crushed is small and the price is often extremely high.

As mentioned above, special considerations are required when grinding drugs, and the conditions that should be met by grinding equipment for preparing samples to examine properties such as drug efficacy and stability in the laboratory are summarized as follows. This is Notooshi.

1) Fine pulverization of 100 meshes, preferably 50 meshes or less is possible.

2) There is little risk of contamination with foreign matter.

3) Grinding conditions are easy to control, and pulverized products with desired drug properties can be obtained with good reproducibility.

4) In laboratory milling, a milled product is obtained that is pharmaceutically identical to that obtained by milling in the production field.

5) Small amounts of drugs can be crushed with good yield.

Grinding to obtain pulverized products generally below 100 microns,
In other words, as a pulverizer for fine pulverization, there are ball mills, tube mills, conical mills, rod 1 mills, vibrating ball mills, high swing ball mills, centrifugal ring roller mills, spring type ring roller mills, bottle-type mills, hammer mills for fine pulverization, and attrition mills. The first six models (see Chemical Engineering Handbook, 3rd Edition, Paragraph 17, Grinding), etc., handle the impact and grinding effects caused by falling, tumbling, vibration, rotational movement, etc. of grinding media such as balls and rods. , particles due to compression friction action? Since M is purified, in addition to the contamination of foreign matter from the grinding medium, there is a reduction in yield due to powder adhesion to the surface of the grinding medium. The following two models are also the same except that the grinding media is replaced by a roller. The last type of attrition mill uses the friction and shear generated by the rotation of discs facing each other to crush the drug, and there is concern that the heat generated by friction could damage the drug. The remaining two types crush particles by the impact applied to the particles by the rotation of a bottle or hammer, and they have a cooling effect due to the airflow generated by the centrifugal force caused by rotation, and a Since the powder is pulverized while being classified using a screen, the pulverized fine powder is less likely to be over-pulverized and damage to the drug is extremely small, making it suitable for pulverizing drugs. However, due to the mechanical structure of the bottle-type mill, it is difficult to reduce the Vtrk between the rotating outermost bottle and the liner provided on the peripheral wall of the grinding chamber, so it is difficult to grind the drug to a desired particle size.

Considering the above points, a hammer mill is considered to be the most preferable model for preparing samples for drug testing in the laboratory. In addition, in a hammer mill, there are various factors such as the peripheral speed of the hammer, the distance between the liner and the hammer provided around the crushing chamber, the shape and size of the holes in the classification screen, and the feed rate of the raw material. +m
By cutting, a pulverized product with desired drug properties can be obtained with good reproducibility, regardless of the scale of the pulverizer.

In this sense, hammer mills are believed to be the most suitable crusher for pharmaceutical testing and research.

Next, it passes through a classification screen in a hammer mill.
When collecting crushed products that are discharged on the air current, the first
As shown in the figure, the pulverized products discharged from the hammer mill 1 along with the exhaust flow are sucked by the blower 2 and introduced into the cyclone 4 via the air transport pipe 3, thereby separating the pulverized products from the exhaust gas. There is a known device configured to collect the waste.

When the recovery device shown in this conventional example is used in actual production, the amount of pulverization itself is large, so the amount of pulverized products adhering to the cyclone 4 and the pneumatic transport pipe 3 has little effect on the pulverized product recovery rate 1h. The paddle is 100y for testing of medical samples, etc.
When applied to a small pulverizer used for pre- and post-pulverization processing, the amount of pulverized products adhering to the cyclone 4 and the pneumatic transport pipe 3 cannot be ignored, resulting in a disadvantage that the recovery rate of pulverized products is significantly reduced. Especially when only small amounts of crushed materials are available,
Furthermore, if the unit price is extremely high, a reduction in the collection rate becomes a major problem.

As another conventional example of a recovery device, as shown in FIG. Some models have a structure in which the exhaust gas from the mill 1' is extracted, while the pulverized products are collected in a hopper 7 installed at the bottom of the hammer mill 1' and discharged through the rotary valve 8. When applied to a small experimental crusher with a small f1, the collection rate of crushed products to the bag filter 6 etc. is large and the width of the crushed product collection pot is reduced, as in the conventional example. In addition, these conventional methods have problems such as not only is it time-consuming to clean the machine every time the type of grinding material changes, but also the risk of cross-contamination, which is most disliked in the case of pharmaceutical products, is high. .

This invention solves the above-mentioned problems in the conventional methods, has a high recovery rate of crushed products even when processing small quantities, and can easily clean the machine when changing the type of crushed material, greatly reducing the risk of cross-contamination. The object of the present invention is to provide a crushed product recovery device for a crusher that can reduce the amount of waste.

An embodiment of the present invention will be described below based on FIGS. 3 and 4.

As shown in FIG. 3, the crushed product recovery device of this embodiment has the following features:
The pulverized material input from the raw material hopper 9 is fed into the circular pulverizing chamber 11 through the screw feeder 1Of, and the pulverized material is pulverized by the pulverizing hammer 12 installed in the pulverizing chamber 11 and rotating along the peripheral wall of the pulverizing chamber. The pulverized products pulverized to the desired particle size or less pass through the classification screen 13 along with the exhaust flow generated as the pulverizing hammer 12 rotates;
The pulverized product is configured to pass through a pulverized product discharge duct 14, perform solid-gas separation with a cylindrical air filter 16 directly connected to its lower part, and collect the pulverized product into a pulverized product collection pot 17 directly connected to its lower part. Cylindrical air filter 10 - The router 16 may be made of any material that is breathable and can prevent the passage of crushed products. Further, the cylindrical air filter 16 may be removably attached to the inner surface of the reinforcing cell 15 having a suitable ventilation opening,
and the pulverized product collection pot 17 suspended from the pulverized product discharge duct via a spacer 21. The upper and lower ends of the air filter are hermetically connected to the pulverized product discharge duct 14 and the pulverized product collection pot 17, respectively. When the breathable air filter is connected to the discharge duct 14 and the crushed product collection pot 17, the annular packing 18
The seventh flange 16a is held between the seven flange 150 and the seventh flange 15t, and the seventh flange 16b is held between the seventh flange 150 and the annular packing 19.

This will be explained more specifically.

The reinforcing cell 15 is made of a metal plate that does not easily deform or a resin material with a certain rigidity, and has a flat plate-shaped 7 flange portion 15b on the upper opening edge and a cross-section [shaped] on the lower opening edge. The 7 flange portions 150 of the upper opening edge of the discharge duct 14 are formed around the lower opening edge of the discharge duct 14 and the 7 flange portions 14a of the upper opening edge are connected to the 7 flange portions 14a having a cross section of 150 mm. 15b is fitted inside to connect it to the discharge duct 14. At the same time, a flat plate-like 7 flange portion 17a'i provided around the opening edge of the crushed product collection bot 17 is fitted with an annular packing 19 shown in FIG. By fitting into the 7 flange portion 15a of the lower opening edge through the flange, it is connected to the pulverized product collection bot 17. On the other hand, the pot receiver 20 that supports the pulverized product collection pot 17 and the discharge duct 14 are pulled together. Connected by a spring 21, the reinforcing cell A/15 and the crushed product collection bot 17 are held between the discharge duct 14 and the pot receiver 20 under pressure, and the discharge duct 14 is
- The joints between the reinforcing cells 15 and the joints between the reinforcing cells 15 and the crushed product collection pot 17 are made airtight.

As shown in FIG. 4, the cylindrical air filter 16 has seven flat flange portions 16a, 1 at its upper and lower opening edges, respectively.
6b, and this flange portion 16a.

16b on the seven flange portions 15b and 15 degrees of the reinforcing cell 15, the discharge duct 1 of the reinforcing cell 15 is
4 and the crushed product collection pot 17, the annular packing 18 and the 7 flange portion 15b form the 7 flange portion 16a.
The flange 13 part 15c and the annular packing 19 sandwich the seven flange portions 16b, so that the reinforcing cell 15 can be attached to the inner circumferential surface of the reinforcing cell 15 in a detachable manner.

The cylindrical air filter 16 is of a cartridge type and is replaced or discarded every time the pulverizer is operated.

The filtration area of the cylindrical air filter 16 needs to be set in accordance with the amount of air produced from the pulverizer. If this area is set large, the recovery rate of pulverized products will drop significantly, as in the conventional example using a bag filter. On the other hand, if the filtration area is too small, air escape will be difficult, reducing the capacity of the pulverizer and increasing the temperature inside the pulverizer.

When the amount of pulverization processed at one time is as small as 50 to 100 y, the continuous operation time is as short as several minutes to several tens of minutes. should be small. Therefore, a small and inexpensive air filter is sufficient.

Although the specific examples have been explained above, the present invention is a small-sized crusher that crushes particles by impact action and frictional action caused by a rotating hammer and its surrounding wall surface. At the bottom of the product outlet,
A device that satisfies the necessary conditions for pulverizing pharmaceuticals by arranging a cylindrical air filter, connecting directly to the bottom of the air filter, and removably connecting pots for collecting pulverized products in an airtight manner. It was completed as

The features of the device according to the present invention are listed below.

(a) The cylindrical reinforced cell 15 with the cylindrical air filter 16 attached to the inner periphery is connected to the pulverized product outlet, and a pulverized product collection box 17' (
Because it is directly connected to the cylindrical air filter 16, the pulverized products that are separated from the exhaust air can be efficiently collected in the pulverized product collection bot 17, making it suitable for small models such as laboratory pulverizers that require a small amount of pulverization. Even when applied to a crusher, a sufficient recovery rate can be obtained.

In the above example, Sample: Force 7 Ain treatment charge j 100y Supply speed: 20 f/min Operating time: 5 minutes Pulverizer specifications: Main motor output 0.4KW Spindle rotation speed
16000r, p, m classification screen mesh diameter 0.
According to the results of pulverization under the conditions of 7 words φ air filter area 0.025 m'', the yield of pulverized caffeine was 98.0%, and compared to the conventional example shown in Figure 2, the above It was confirmed that the recovery rate was significantly improved compared to the recovery rate of about 60% when the pulverization treatment was performed under these conditions.

(b) Since the cylindrical reinforced cell 15 covered with the cylindrical air filter 16 is removably sandwiched between the pulverized product outlet and the pulverized product collection pot 17, it is easy to assemble and remove it from the pulverizer. is extremely simple and easy to use. In particular, as in the embodiment, the flange portion 14 is connected between the crushed product discharge port (discharge duct 14), the 15 cylindrical reinforced cells, the cylindrical reinforced cell 15, and the crushed product collection bot 1717- through the annular packing 1B+19.
a + 15 b and 15 o + 17 a, and the crushed product outlet (
Cylindrical reinforced cell 15 with discharge duct 14) and pot holder 2o
By squeezing the crushed product collection bot 17, it is possible to simultaneously maintain the connection of each member, airtight each joint, and attach the cylindrical air filter 16 to the cylindrical reinforcing cell 15.・Easier to remove.

(c) The cylindrical air filter 16 to which the crushed product adheres is
Since it is configured to be removably attached to the inner circumferential side of the cylindrical reinforcing cell 15, it can be easily replaced with another cylindrical air filter 16 whenever the type of crushing material is changed. This can help prevent cross-contamination, which is most disliked in many cases.

[Brief explanation of the drawing]

1 and 2 are schematic diagrams of a conventional example, FIG. 3 is a partially cutaway front view showing an embodiment of the present invention, and FIG. 4 is an exploded perspective view of a main part thereof. 14...Discharge duct (pulverized product outlet), 14a...
7 rung portion, 15...cylindrical reinforcement cell, 15a...
Ventilation hole (ventilation window), 15 b r 15 c...7 rung part, 16...cylindrical air filter, 16ay1
6b...7 rung part, 17...crushed product collection box),
17a...7 rung part, 18.19...ring-shaped packing, 20...pot holder, 21...tension spring Applicant: Takeda Pharmaceutical Company Limited Fuji Baudal Co., Ltd. 19 -

Claims (1)

[Claims] In a crusher that crushes particles by impact and friction generated by a rotating hammer and its surrounding wall surface, a cylindrical air filter is installed at the bottom of an outlet for crushed products discharged through a classification screen. A pulverized product recovery device for a pulverizer, characterized in that a pot for collecting pulverized products is arranged below the air filter, and each pot is removably connected in an airtight manner.