JPS5910522A - 血小板粘着阻止蛋白質及びその製造法 - Google Patents
血小板粘着阻止蛋白質及びその製造法Info
- Publication number
- JPS5910522A JPS5910522A JP57118883A JP11888382A JPS5910522A JP S5910522 A JPS5910522 A JP S5910522A JP 57118883 A JP57118883 A JP 57118883A JP 11888382 A JP11888382 A JP 11888382A JP S5910522 A JPS5910522 A JP S5910522A
- Authority
- JP
- Japan
- Prior art keywords
- platelets
- platelet
- protein
- platelet adhesion
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 title claims description 18
- 108090000623 proteins and genes Proteins 0.000 title claims description 18
- 230000005764 inhibitory process Effects 0.000 title description 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 6
- 229920002684 Sepharose Polymers 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004202 carbamide Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 description 11
- 208000007536 Thrombosis Diseases 0.000 description 9
- 239000000872 buffer Substances 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 230000000903 blocking effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 102000016359 Fibronectins Human genes 0.000 description 2
- 108010067306 Fibronectins Proteins 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- ZTVZLYBCZNMWCF-UHFFFAOYSA-N homocystine Chemical compound [O-]C(=O)C([NH3+])CCSSCCC([NH3+])C([O-])=O ZTVZLYBCZNMWCF-UHFFFAOYSA-N 0.000 description 2
- 101100027969 Caenorhabditis elegans old-1 gene Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000220259 Raphanus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000190020 Zelkova serrata Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 206010023497 kuru Diseases 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57118883A JPS5910522A (ja) | 1982-07-07 | 1982-07-07 | 血小板粘着阻止蛋白質及びその製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57118883A JPS5910522A (ja) | 1982-07-07 | 1982-07-07 | 血小板粘着阻止蛋白質及びその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5910522A true JPS5910522A (ja) | 1984-01-20 |
| JPH0359078B2 JPH0359078B2 (enrdf_load_stackoverflow) | 1991-09-09 |
Family
ID=14747490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57118883A Granted JPS5910522A (ja) | 1982-07-07 | 1982-07-07 | 血小板粘着阻止蛋白質及びその製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5910522A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016225A1 (en) * | 1991-03-18 | 1992-10-01 | Brigham And Women's Hospital | Antiplatelet and antithrombotic activity of platelet glycoprotein ib receptor fragments |
-
1982
- 1982-07-07 JP JP57118883A patent/JPS5910522A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016225A1 (en) * | 1991-03-18 | 1992-10-01 | Brigham And Women's Hospital | Antiplatelet and antithrombotic activity of platelet glycoprotein ib receptor fragments |
| US5321127A (en) * | 1991-03-18 | 1994-06-14 | Brigham And Women's Hospital | Antiplatelet and antithrombotic activity of platelet glycoprotein Ib receptor fragments |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0359078B2 (enrdf_load_stackoverflow) | 1991-09-09 |
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