JPS59104542A - Measurement device for concentration of gas in blood - Google Patents

Abstract

PURPOSE:To avoid exerting undue stress on a gas-permeable diaphragm of a gas-sensitive electrode by inserting and reinforcing the outside edge of said diaphragm into and by two annular supports, and attaching the reinforcing part to an electrolytic cell of the gas-sensitive electrode by means of a screw, etc. CONSTITUTION:A solid-state type glass electrode 1 as a gas-sensitive electrode formed by attaching a gas-sensitive film 3 to the tip of a supporting cylindrical column 2 and a reference electrode 4 such as a silver-silver chloride electrode are inserted and supported in an electrolytic cell 5. The bottom end of the cell 5 is opened to enclose the electrode 1 and a gas-permeable diaphragm 6 consisting of a fluororesin is attached to the open end of the electrode 5. The attaching of the diaphragm 6 is accomplished by inserting and reinforcing first the outside edge of the diaphragm 6 into and by two annular supports 7a, 7b then bringing the central part of the diaphragm 6 into tight contact with the film 3 at the tip of the electrode 1 and fixing the reinforcing outside edge to the open end of the cell 5 by means of a screw 8.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a blood gas concentration measuring device (5) equipped with a scum-sensitive electrode for detecting the concentration of carbon dioxide gas, oxygen gas, etc. in blood.

Structure of the conventional example and its problems In recent years, measurement of blood gas concentrations such as oxygen gas and carbon dioxide gas has become increasingly popular in the field of clinical medicine. For such blood gas measurements, diaphragms made of fluororesin, polyethylene, polyethylene, polycarbonate, or the like that are permeable to gas are often used.

In a conventional blood carbon dioxide concentration measuring device equipped with such a diaphragm, as shown in FIG.
Glass electrode (1) as a scum-sensitive electrode formed by soaking
01) and a reference electrode (105) such as a silver-silver chloride electrode are supported in a lalastic electrolytic cell (106), and a glass-sensitive membrane (101) has a scum-permeable diaphragm (107) attached to the tip of the glass electrode (1o1). with the outer edge in contact with
- It is attached directly to the outer periphery of the open end of the electrolytic cell (106) with a link (lOS). In addition, (109) and (110) in the figure
) are the lead wires of the comparison electrode (105) and the conductor (104), respectively, and (111) is an electrolytic solution containing heavy metal as a main component. In such a carbon dioxide concentration measuring device, a diaphragm (
The carbon dioxide gas that has permeated through 107) changes the concentration of H+E according to the reaction of Co2+
As a result, a change in electromotive force occurs at the crow electrode (tol), and the carbon dioxide concentration can be determined from this amount of change.

On the other hand, a conventional blood oxygen gas concentration measuring device equipped with a similar diaphragm is shown in FIG. 2, in which the glass electrode (lot) and electrolyte (111) of the device in FIG. The structure is substantially the same as that in Figure 1, except that it is replaced with a gas-sensitive electrode (indicator electrode) (2G1) made of a noble metal such as platinum or gold IJ (202) and an electrolyte (211) made of a phosphate buffer solution. It's the same.

For measurement, first use the indicator electrode (20 liters) and the reference electrode (
205), a voltage of 0.4V to 0.8V is applied between them. As a result, the oxygen gas in the blood that has passed through the diaphragm (20) is electrolyzed according to the reaction: Ru.

In such a blood gas concentration measuring device, it is essential that the response speed is fast and the stability of the measured values is excellent. However, in the conventional structure in which the outer edge of the diaphragm is attached directly to the outer periphery of the upper end of the electrode cell using a 0-link, the tightening of the 0-link over time causes the diaphragm to deteriorate due to a decrease in force and the weight of the electrolyte. As the tension gradually loosens, the diaphragm and the tip of the gas-sensitive electrode separate, and the amount of electrolyte present between them gradually increases, resulting in a slow response speed.

Further, even when used continuously for a long period of time, reproducibility deteriorates for the same reason, and there is a drawback that it takes time and effort to calibrate the device. When attaching the diaphragm to the electrolytic cell, there is a risk of applying excessive force near the 0-link and creating wrinkles or creases on the diaphragm, which may cause damage or damage to the diaphragm. Easy to invite. Therefore, in the method of directly fixing the diaphragm with O-links, it is necessary to handle the diaphragm carefully, and replacing the diaphragm requires considerable skill.

Furthermore, when a glass sensitive membrane is provided at the tip of the scum-sensitive electrode, since it is thin, there is a risk that it may be damaged due to excessive force applied when attaching the diaphragm.

OBJECT OF THE INVENTION The present invention solves the above-mentioned drawbacks of the conventional technology.It can be easily attached and detached without causing breakage or damage, and once attached, it does not shift from the predetermined mounting position, so that the desired measurement response can always be achieved. It is an object of the present invention to provide a blood sludge concentration measuring device equipped with a diaphragm that can ensure reproducibility.

Structure of the Invention In order to achieve the above object, the present invention provides an electrolytic cell that supports a gas-sensitive electrode and that is in contact with the tip of the scum-sensitive electrode. In a blood sludge concentration measuring device equipped with a sludge-permeable diaphragm attached to an electrolytic cell so as to threshold the opening of the electrolytic cell, the outer edge of the sludge-permeable diaphragm is placed between two annular supports in advance. After holding the diaphragm without sliding using the anti-slip means, connect the outer edge of the diaphragm to the open end of the electrolytic cell via the annular support so that the center part of the diaphragm is in close contact with the tip of the scum-sensitive membrane. To provide a blood gas concentration measuring device characterized in that the blood gas concentration is fixed.

DESCRIPTION OF EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to FIGS. 3 to 6.

In FIG. 3, which shows a blood carbon dioxide concentration measuring device that is an embodiment of the present invention, a solid-state type gas-sensitive electrode consisting of a glass-sensitive membrane (3) attached to the tip of a support cylinder (2) made of resin is shown. A glass electrode (1) and a comparison electrode (4), such as a silver-silver chloride stamp, are inserted and supported in a plastic electrolytic cell (5). The lower end of the electrolytic cell (5) is a glass cap (1)
A gas-permeable diaphragm (6) made of fluororesin is attached to the open end of the electrolytic cell (5) so as to close the opening. When installing the diaphragm (6), first, the outer edge of the diaphragm (6) is held and reinforced in advance by two annular supports (7a) and (7b) having the same outer diameter and inner diameter. The diaphragm (6) is placed directly under the electrolytic cell (5), and the center part of the membrane (6) is placed directly under the glass electrode (1).
) and the diaphragm (6).
The reinforced outer H portion may be fixed to the open end of the electrolytic cell (5) with screws (8). In the figure, (9) and (lυ) are lead wires connected to the comparison electrode (4) and the crow electrode (1), respectively, and (11) is an electrolytic solution whose main component is a heavy metal.

In this embodiment, a solid-state glass electrode is used, which is disclosed in Japanese Patent Publication No. 53-518. Solid-state glass electrodes are significantly superior to generally known liquid-type glass electrodes.

The reason for this is that the solid glass electrode does not contain any liquid, so it can be used even when it is inverted, and its glass-sensitive membrane is sufficiently reinforced with resin, which makes it impermeable to scum. This is because there is almost no risk of damage even if a considerable external force is applied to the crow-sensitive membrane when the diaphragms are brought into close contact with each other.

In the blood carbon dioxide concentration measuring device having the above configuration, the outer edge of the diaphragm (6) is supported by two annular supports (7a) and (7b).
) and then attached to the open end of the electrolytic cell (5), it is easy to install and does not require any skill.Compared to the conventional method, which is attached to the electrolytic cell using an 0-link, Installation is done during work! There is no need to worry about applying excessive force to the outer edge of the diaphragm (6) or creating wrinkles or creases, and the cause of breakage or damage to the diaphragm (6) can be eliminated. In addition, when the diaphragm (6) is attached to the electrolytic cell (5), the screws (8) also have the function of preventing the diaphragm (6) from sliding, so the diaphragm (6) will not loosen during use. There is no deterioration in responsiveness or reproducibility.

4 to 6 show various embodiments for clamping and reinforcing the outer edge of the diaphragm (6).

In FIG. 4, the diaphragm (6) has at its outer edge two annular supports (7a) similar to those shown in FIG.
, (7b), but the anti-slip screw Oa does not have the function of a screw for attachment to the edge surrounding the electrolytic cell. Such outer edge reinforcement diaphragm (6)
To attach it to the electrolytic cell (5), screws (8) as shown in Fig. 3 may be used separately, but the lower support (7b
) and the side wall of the electrolytic cell (5).
5) may be screwed into the side wall. It is not necessary to use screws to prevent the diaphragm (6) from sliding.
An adhesive may be interposed between the film formation (6) and the respective supports (7a) and (7b). However, in this case, in order to replace the diaphragm (6), the supports (7a) and (7b) must also be replaced.

In the embodiment shown in FIG. 5, one support (7a) has a groove o.
r<, and the other support (7b) is provided with a protrusion α→ that fits into this groove 03 at a corner corresponding to the thickness of the diaphragm (6),
By fitting these grooves 03 and projections 04 through the diaphragm (6), the diaphragm (6) is prevented from sliding.

The embodiment shown in Figure 6 is substantially the same as that in Figure 5, but with a septum (6) and a respective support (7a).

(7b) is interposed with resin α9 to completely eliminate leakage of gas and liquid from this location. Particularly in the case of blood dregs concentration determination, the presence of ventilation points other than in the thickness direction of the diaphragm (6) is undesirable, so it is preferable to support the outer edge of the KWX in this manner.

Effects of the Invention As described above, in the blood dregs concentration measuring device according to the present invention, the sludge permeable diaphragm is clamped and reinforced in advance by two annular supports at its outer edge, and is then reinforced with screws or the like. Since it is a type that can be installed indirectly on the electrolytic cell, it is easy to install, and the installation process does not cause excessive force to be applied to the diaphragm during installation, or wrinkles or creases may occur, which may cause breakage or damage. Furthermore, when the diaphragm is attached, the screws, grooves, protrusions, adhesives, etc. act to prevent the diaphragm from sliding, which may cause the diaphragm to loosen during measurement, deteriorating the responsiveness and reproducibility of the measurement. can be prevented.

[Brief explanation of drawings]

FIG. 1 is a longitudinal sectional view showing a conventional blood carbon dioxide concentration measuring device, FIG. 2 is a longitudinal sectional view showing a conventional blood oxygen sludge concentration measuring device, and FIG. 3 is a blood gas concentration according to the present invention. The longitudinal cross-sectional views of the measuring device, FIGS. 4 to 6, are longitudinal cross-sectional views showing various methods of clamping and reinforcing the outer edge of the diaphragm. (1) Solid glass electrode () 5-sense sensitive electrode), (5
)・Electrolytic cell, 16)・-Cass permeable diaphragm, (7a) (7
b) (7a,) (7b) cyclic support, (8) OJ
Q314) - Anti-slip means 2- Fig. 1 "' Fig. 3 7) /ρ4 da l'

Claims (1)

[Claims] 1. An electrolytic cell that supports a 15-gas-sensitive electrode and has an opening surrounding the tip of the gas-sensitive electrode, and is attached to the electrolytic cell so that the opening of the electrolytic cell is closed while in contact with the tip of the gas-sensitive electrode. In a blood scum concentration measuring device equipped with a gas-permeable diaphragm, the outer edge of the gas-permeable diaphragm is
After holding the diaphragm between two annular supports without sliding using a sliding means, the outer edge of the diaphragm is inserted into the electrolytic cell through the annular support so that the center of the diaphragm is in close contact with the tip of the scum-sensitive electrode. A blood sludge concentration measuring device, characterized in that it is indirectly fixed to an open end of a blood scum concentration measuring device.