JPS5869249A - Nylon-containing liquid composition - Google Patents

Abstract

PURPOSE:To provide the titled compsn. containing alcohol-soluble nylon, hydrophilic urethane prepolymer and a solvent for nylon and exhibiting improved flexibility, film strength and releasability. CONSTITUTION:The compsn. consists of alcohol-soluble nylon, hydrophilic urethane prepolymer and a solvent for the nylon. The amount of the hydrophilic urethane prepolymer should pref. be 0.5-25% of the alcohol-soluble nylon. When the amount of the prepolymer is too small, no sufficient effect is obtained, while when it is too large, the tensile strength of nilon film is lowered. Preferred solvents are lower alcohol such as ethanol, propanol and isopropanol and its blend with water.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a nylon-containing liquid composition that is used by applying it onto a predetermined surface to form a film. ), a nylon-containing liquid composition that is used as an anti-inflammatory analgesic, an insect repellent, a film-forming agent for ventilation fans, etc., and forms a nylon film.

Conventionally, it has been used as pharmaceuticals, quasi-drugs, and cosmetics, such as water bandages, external topical preparations, and Isharnotsuta.
Products that utilize the film-forming properties of polymeric substances to protect affected areas, prolong drug efficacy, and promote absorption are widely used.However, conventionally used products with high film-forming properties The molecular substances include water-insoluble polymers such as acrylic resin, V-nylacetate resin, nitrocellulose, etc., and water-soluble polymers such as I-rivinyl alcohol, polyvinylpyrrolidone, cal-xymethylcellulose, I-lyacrylic acid, and the like. Salts, natural gums, etc., but when water-insoluble polymers are used, H-harmful solvents such as acetatone and ethyl acetate are required to dissolve them. Lj had no sex at all! Generally, it forms a hard and brittle film, which causes a strong discomfort such as a feeling of swelling, has low water vapor permeability, and causes the skin surface to which it is applied to become stuffy.
There's a problem. In addition, when water-soluble polymers are used, there are disadvantages such as the long time it takes to form after application, the strength of the coating being low, the dissolution due to sweat, etc., and stickiness. .

As a solution to these problems, lower grade Alu-
A skin liquid composition using nylon soluble as a film-forming agent has also been proposed], which provides a nylon film having an excellent film 1lIIa without the above-mentioned flaws, but this nylon wall film deteriorates over time. It tends to become brittle and less flexible, and can be removed from the skin as a uniform film, but the adhesive strength may be too strong and it may cause pain when removed. Furthermore, although it has superior water vapor permeability compared to general water-insoluble polymer coatings, it is not necessarily sufficient, and when applied for a long time, it may inhibit normal skin physiological functions such as Ka perspiration. However, it is desirable to solve these problems and further improve the properties of the Nyden coating.

In addition, various types of coating forming agents for ventilation fans have been proposed in the past, but it is desired to have even better performance.

The inventor of the present invention has conducted extensive research to meet the above demands.
Result - Hydrophilic urethane on alcohol-soluble nylon! By incorporating 4 remer, the excellent properties of nylon softening, which solved the nine problems mentioned above, are significantly improved, and the film strength is also very high, and the releasability is improved. For example, it can be peeled off from the skin surface with little force and with almost no pain - and has improved water vapor permeability, so it is a hydrophilic urethane polyester! - has a lubricant-like effect on soluble nylon, and also has a single KWI
We have discovered that nylon has very excellent properties not only as an I agent, but also as a release agent that increases film strength and improves release performance, and has developed the present invention. In total, there are 9 compounds.In addition, 9 N-alkylpenzene sulfona compounds, 78nors, p-toluenesulfona compounds, and oxybenzoic acid esters are conventionally known as opaque agents for cinnylon. The effect of increasing film strength and releasability was not observed, but rather showed the opposite tendency; − is unique to

The present invention will be described in more detail below. The nylon-containing liquid composition according to the present invention contains alcohol-soluble nylon, hydrophilic urethane pre-I reamer, and a solvent that dissolves the nylon.

In this case, alcohol-soluble nylon includes copolymer type, modified nylon, copolymer-modified nylon, etc. - Copolymer type nylon includes nylon 6766
7610, nylon 6/66/12% nylon 676
9/12, nylon 6/6 12/12, nylon/6
g/6 G/12, nylon 6/66/11/12,
Examples include ternary or higher copolymers such as nylon V66/612/12, nylon 67667 bis(4-adenocyclohexyl)methane-6, and specific examples include CM-4000 and CM- manufactured by Toshi Co., Ltd. 4001, CM-8000,
Dichiru 61t63s6 made by Ji & Poy, 1lAi
iF Ultra Azbee 1m@ICt5At6m, l
O.

Daicel's 〆Iamide, etc. can be used. Also, modified nylon is one in which the hydrogen at the alpha position of nylon 6 is replaced with a dimethylamino group, or the one in which the hydrogen in the aodo group is replaced with an alkoxyal group, etc., manufactured by Teikoku Kagaku Santo. Company made Tregi yF30.
F30C, F3GX, etc. can be used, and copolymerized-modified nylon is a combination of copolymerized type nylon and modified type nylon, manufactured by Daicel Corporation! Those of the Iamide X series, etc. may be used. Note that the nylons exemplified above all have melting points in the range of 80-160°C.

In the present invention, the above-mentioned nylons may be used alone or in combination of two or more.
In addition, the amount of alcohol-soluble nylon blended is not particularly limited, but it is preferably 1 to 20-(weight-1 or less) of the entire composition. If the amount of nylon blended is too small, p will be formed by applying lit. The resulting coating may be too thin, and if the amount of nylon is too large, the composition may have a high viscosity, resulting in poor workability and usability.

Also, hydrophilic urethane! As a monomer, a polyhydric alcohol of 2i1 or more and ethylene oquinide or carbon a3
A polymer or two-molecular copolymer (molecular weight 50
2 or more at the molecular end or in the molecular chain obtained by the reaction of a linear or branched / real polyamide glycol or I-diether 4-liol which is 0 to gooo) with a compound having 2 or more isocyanate groups. A urethane polymer having an isocyanate group can be suitably used, and specifically, Hycel 0H-1 manufactured by Toho Chemical Industries, Ltd., UP-200 manufactured by Lion Corporation, etc. can be used.

In addition, the above-mentioned urethane polymers may be used alone or in combination of two or more.
The amount of the urethane polymer is not necessarily limited, but it is preferably 0.5 to 25% of the alcohol-soluble nylon. ☆ If the amount of the urethane polymer is too small, its effect may not be fully exhibited. If the amount is too large, the tensile strength of the nylon coating may be reduced.Furthermore, in the present invention, any solvent can be used as long as it dissolves soluble nylon, including ethanol, gulononol, iso! Lower alcohols such as Lovanokei and mixed solvents of these lower algol and water can be preferably used. In addition, when using a mixed solvent of lower alcohol and water, the ratio is 9 as a weight ratio.
It is preferable to set it as 5:5-60:4G.

7. The nylon-containing liquid composition of the present invention can be used as a liquid adhesive plaster, general skin medicines (wound medicines, burn medicines, anti-inflammatory analgesics, warming medicines, etc.). It can be used for various purposes such as coatings or film forming agents for ventilation fans, etc., and can be used as a composition for outer skins depending on the type and purpose of use. are bioactive drugs such as bactericides, local narcotics, antihistamines, anti-inflammatory analgesics, astringents, sulfa drugs, vitamines, antifungals, peripheral nerve paralytics, blood circulation enhancers, adrenocortical hormones, and insect repellents; In addition, one or more kinds of fragrances and the like may be added to O to 30 of the total composition.

The following table shows specific examples of the above-mentioned drugs.

Mu) #Sono agents: pendelcoecum chloride, benzethonium chloride, ceterpyridinicum coolide, domino bromide, decalinicum chloride, sulfur #! 7 Radiomycin, homosulfamine, chlorhexidine, chlorhexidine dalconate l) Local narcotics: zigucaine hydrochloride, pyridoxine hydrochloride.

Ethyl ainobenzoate, hydrochloric acid! Lokai N, dimethisoquine hydrochloride, hydrochloric acid! 2 moki Syn, lidocaine Lumin, Maleic acid Rolf, Nirami and isocypennorfuretazole.

Zophenylimidzole D) Anti-inflammatory: salicylic acid, methyl salicylate, salicynia
Agents Glycol tyrate, indomethacin, glycyrrhizin, glycyrrhetinic acid, azulene astringent dichloroaluminum diaminoacetate,
Aluminum phenolsulfonate F) Sulfa drugs: sulfisoxazole, sulfamethoxol, sulfanyl aodo, sulfapyridine, sulfamethoxybiridine, sulfamethoxine, sulfadianone G) pita porridge: vitamine E, M, D H) Anti-odor agents: pentachlorophenol, salicylic acid.

Trichlorophenol caproate.

Trifamphenol cagloate, turyltrif,
Nylphosphonium f-ide, zoantazole hydrochloride, nophenylrodane, thimelonal, tolnaftate, clotrimazole I) Peripheral nerves: t-menthol, camphor, thymol.

Paralytic agent Teshi, To J) Blood circulation promotion: Nonylic acid panillylamide, nicotinic acid, 4
m/-2) xyethyl ester, nicotinic acid pencil ester, ttft4syn.

Synfan, lecithin, chloral hydrate, camphor tincture K)il Renal cortex: Grednisolone, desumenazone,
Foltanluo p mesolone, triamcinolone acetonide, dicloricin L) KunNiIIM: N, N -y etheramide, bisethylenetetrahydrofurfural, butquina 4 P m') -n -7' Lopyruin cincoronate with herbal drug Eyaniji , uki, wekisu, shi, uki, uchisu,
Chinkin dt# Kakkon Extract, Roto Extract.

Sei winged horse chestnut flea extract, hot pepper extract, hot pepper tincture Xunsheng Chin: Oopaku powder, Su/Shishi powder, Shikon powder, Capsicum powder In addition, in the present invention, for the purpose of film adhesion, water permeability of joints, etc. Water-soluble polymers co-dissolved in water and alcohol such as polyvinylpyrrolidone, vinylpyrrolidone/vinyl acetate copolymer, IL-lyacrylic acid/salt, methyl vinyl ether/maleic anhydride copolymer, etc.
s can also be blended. In addition, 1. In order to control moisturizing properties, drug release from the coating, and transdermal absorption,
Polyhydric alcohols such as zorozelendaricol and poly'ethylene glycol, esters such as improbil iristic acid, oils such as 2-norline and vaseline, and surfactants can also be blended in an amount of 1 to 5 ml.

There are no particular restrictions on the method for producing the nylon-containing liquid composition of the present invention, but first, a predetermined amount of nylon is soaked in a solvent and left overnight to sufficiently moisten the nylon.
．． Heat and stir for 5 to 11 hours to dissolve, add a predetermined amount of this dissolved hydrophilic urethane pre-I remer, and further heat at a temperature of 80°C or less for 30 minutes or more (this heating should be done once after production and before use). If there is a period longer than that, it is not necessary to prepare the product), then let it cool to room temperature, then add and dissolve various active ingredients, water-soluble polymers, etc. as necessary, and make the product. Can be adopted.

Therefore, since the nylon-containing liquid composition of the present invention contains alcohol-soluble nylon KiI aqueous tangle zv-v-), the resulting film has excellent flexibility and high strength. Moreover, it is difficult to deteriorate,
For this reason, when applied to the skin surface, it has excellent followability, and even if applied to joints etc. for a long time, it follows the movement of the body, so it can be used suitably on these areas, and for a long time. Even when applied to the skin, it does not become hard and brittle and easily torn, torn, or crumbly.It can maintain the affected area well and can be used without any discomfort. It is something. Furthermore, hydrophilic urethane! The 9-nylon film containing Shisummer has good peelability, and when applied to the skin, it can be peeled off without pain after use.It also has moderate moisture permeability, so it prevents swelling and rashes. It is less likely to occur and has excellent pupil retention on the skin surface, as well as prolonging the medicinal efficacy and promoting absorption due to its appropriate sealing properties.

In general, when applied as a liquid agent, the degree of nylon #1 is required to be 5- or more to make it a peelable type, but according to the present invention, as a result of increased coating strength and improved peelability,
The composition can be made into a peelable type even with a single dose, and the composition can therefore be prepared to have a low viscosity, so it can be easily prepared into a dosage form such as a spray or squeeze type.

Next, the effects of the present invention will be specifically explained using experimental examples.

[Experiment example]

A liquid composition for skin with the formulation shown in Table 1 was prepared by the following method)
Prepared.

Preparation method: Dissolve soluble nylon in a solvent by heating at 40 to 70°C, then add a predetermined amount of water-visible polyurethane pre-I remer or polyvinylpyrrolidone, stir to form a uniform solution, and then heat at 70°C for 1 hour. The mixture was allowed to cool to room temperature to prepare a liquid composition tlI, which was used as a sample for the following experiment.

Next, using the above sample, pull 314 by the following method.
11 Properties, release properties, water vapor permeability - Check.

Tensile strength Each sample was spread on an acrylic plate and melted.
Volatilize and form a film tlI9, press this film, width 1c x nelis point distance 3 cm, tension p
The stress-strain curve 1IIt side was added using a tensilon meter at a speed of 21/min at room temperature. Tested on films left at room temperature for 2 hours and films stored at 50°C for 1 month. 9. Peeling characteristics Sample 1@18■ was applied to a glass plate and the skin of a person's arm, and after drying and film formation, it was tested at room temperature. The film was then peeled off at 110° (to the glass plate) and at 90° (to the human skin) using a force tensilon meter (tensile f = 231/min).
51 hitl is the Heikyo value at the time of dross] was calculated.

On the front side, to prevent the film from stretching when peeled off, use a cellophane cheese with a width of 18 cm on the film! I added an ID.

Water Vapor Permeability Each sample was formed into a film with a thickness of 3120 μm, and this film was filled with water and run at 35 μm.
The mouth tube of the tube was sealed, and the tube was left in a thermostat at 137° C. for 30 hours [24 hours], and the water loss was measured. The value was converted into film 1-1, and this was defined as the water vapor permeability.

The above results are shown in Tables 2 and 3.

Iris Table 1 Sample Prescription Note: All ils indicate weight parts.
/weight at (the same applies below).

From the above results, it was found that the hydrophilic urethane preform can form nylon*me with excellent properties by adding a remer. In other words, wood-friendly urethane prepoly! The nylon coating containing - had a lower yield strength, a moderately strong tensile strength (ft), and exhibited a tensile strength (ft) that was approximately twice as high as that of one without the addition of urethane blemishers. Also, 50℃,
Even in a forced deterioration test after storage for one month, the strength and flexibility did not deteriorate at all, and the material changed to become more elastic, in fact heading in a better direction. On the other hand, urethane pre-I remer without additives tends to deteriorate and become hard and brittle (), therefore, hydrophilic urethane pre-I remer has the effect of making the nylon coating more flexible and tough. Recognized 9 times.

Furthermore, % hydrophilic urethane! The nylon coating containing Rayrimer also has improved releasability and can be used with less force than II; it also has excellent water vapor permeability. The nylon-coated wA containing O has water vapor permeability, but has poor releasability.
In addition, the film strength did not improve, but rather showed a tendency to become brittle.

Examples will be shown below, but the present invention is not limited to the following examples.

[Act j11f11) The following removable bandages were manufactured.

Soluble nylon (Ultraamide IC) 15
9 to 1 polyurethane prepolymer (UP-200)
110G, 0% This bandage is used by applying it to the specified affected area and allowing it to dry, so the film is extremely flexible, has good followability even when used indirectly, and does not cause any discomfort. Ta.

In addition, even when used for a long time, it does not smear easily, does not become hard and crumbly, and does not lose any peeling after use (it can be removed smoothly as a single film).・Ma-#-1 This removable bandage can also be used as a composition for forming a film for ventilation fans, and when it is used as a film for ventilation fans by forming a film with Ventilation 11Kj!, it is resistant to oil stains. (Moreover, the film did not deteriorate and remained stable even after being left for a long period of time, over 6 months. After use, it could be easily removed as a single film along with dirt.

C*Example 2 ] Fourteen facial tubes were manufactured according to the prescribed recipe.

Soluble nylon (Tart 2 Eye i'lc) Is
@Hydrophilic urethane pre-I”?-1,5 (Toho Chemical Industry Co., Ltd. Hi-Shichiru 0H-1) Fragrance
O,S This no, the M is very flexible and there is no feeling during use, so there is no pain at all after using it (smooth and smooth). 119. [Example 3] The following formulation 0** was produced by peeling it off as a film.

Cetylpyridinium chloride PO,
116 pendelkonium chloride
O,OS Glucon Shun Dichlorhexinone
O,OS pyridoxine hydrochloride
1.0 Didecaine hydrochloride
0.1 Nahuazoline hydrochloride
0.1! Rain Shun Chlorpheniramine
0.2 Soluble Nylon (Ultraamide Ic
) 4.0 Hydrophilic urethane! Repolymer (UP
-200) When 0.41G0.0 was applied to the finger of a mango and formed into a 4t-
The coating that followed the movement of the finger well and was stable over a long period of time completely preserved the wound WJ and did not peel off.

[Example 4] An anti-inflammatory analgesic agent tlliI was prepared with the following formulation.

Methyl nalicylate 35
Glycol naritilate
1.81-Menthol
4.0 Riichi Kanfur 2
・O nonylic acid paerylamide) P
Q, 01 Glycyrrhetinic acid
a1 bitan I
0.5 soluble nylon (Akebono CM- manufactured by Toshisha Co., Ltd.
8000) 10.0 moth aqueous 0 rethane I remer (Hicel 0H-1 mu) 1.2 kernels:
Due to the retention effect of the coating), the medicinal efficacy is sustained, and it also exhibits fast-acting properties as a liquid, and exhibits good 1* properties, such as peeling off as a single film even after use. Even after 8 hours or more, the coating did not become tattered, and no calculus appeared on the surface to which it was applied.

[Example 5] An insect repellent tll with the following formulation was prepared: N,N-diethylamide 2.
051 Bisethylenetet 2hydrofurfur 2-
0. stokiside 1
．． 0G1-propyl incincoronate 0
．． 5 Soluble Nyan (CM-8000)
2.0 urethane prepoly? -(UP-200)
0.1100.011 This was placed in a squeeze-type container and used as a spray to remove adult insects. This central repellent is easy to use, has a long-lasting insect repellent effect due to its film effect, and has a strong 1 film despite the low am content of nylon.

Applicant Lion Co., Ltd. Agent: Patent attorney: Hajime Kojima 〃〃　Patent Attorney Hanyo Takahata

Claims (1)

[Scope of Claims] 1. A nylon-containing liquid composition comprising alcohol-soluble nylon, hydrophilic urethane gray rimer, and a solvent that dissolves the nylon. 2,! I water-based kuritan! The amount of repolymer distributed is 0.0 compared to alcohol-soluble nylon. The composition according to claim 1, which has a weight of s to 2s - 3! ll Aqueous Fretanbre 4 Limer Divalent or higher polyhydric alcohol and ethylene oxide or alkylene oxide having 3 or more carbon atoms O
Linear or branched 04-real medium rangelicol or I-ether glycol which is a polymer or Tsunodum copolymer (molecular weight sOθ ~ 200G) obtained by addition reaction with one type or two or more types, and an isocyanate group having a valence of 2 or more. The composition according to claim 1 or 2, which has two or more incyanate groups at the molecular end or in the molecular chain obtained by reaction with a compound having the following. 4. The composition according to claim 1, 2 or 3, wherein the lll agent is a lower alcohol or a mixed solvent of this and water.