JPS5867624A - Veterinary drug composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to novel veterinary drug compositions for the prevention of feline urinary syndromes in cats, such as urolithiasis and related diseases found in cats. The invention further relates to a method of administering the veterinary composition to cats.

Associated urological pathologies include urethritis, prostatitis, cystitis, ureteritis, pyelonephritis, interstitial and glomerulonephritis, and urinary tract atresia.

Urinary diseases seen in cats, especially cats, account for approximately 35% of hospitalizations at veterinary hospitals. Sometimes these diseases are fatal to animals. These urinary diseases are currently prevented using expensive drugs that are difficult and dangerous to administer.

The purpose of the present invention is to provide a novel veterinary drug composition for preventing urinary system syndromes in cats, and to provide a novel veterinary drug composition for preventing urinary system syndromes in cats. Substantial cost savings are achieved. Particularly preferred veterinary compositions according to the invention include, based on the total weight of the composition, 25-75% by weight of green leafy plant powder, 15-45% by weight of uric acid, 9.5-28% by weight of mild diuretic. 511G and a calcium chelator by weight of 0.5-1.5.

Equivalent amounts of synthetic polychlorophyll can be used in place of green leafy plant powder, and among other things, this book contains substantial amounts of IIC for animals and plants! This is the source of the other oligo-elements that are included. Preferably, about 50 weight of green leafy plant powder is used in the composition.

Also preferably, DL-methionine is used as the uric acid north. However, this compound can be replaced with ammonium chloride, etheredian dihydrochloride, mandelic acid, ascorbic acid, sodium biphosphate or any other urinary acid salt. The uric acid base preferably constitutes about 30% by weight of the total composition.

Sodium chloride is preferably used as a mild diuretic. However, in Canada, the product name is L.
A8IX], hydrofusyl thiazide or acetoacylamide (trade name DI in Canada)
[commercially available as AMOX] can also be used. The diuretic preferably constitutes about 19% by weight of the total composition.

Ethylenecyadenetetraacetic acid can advantageously be used as calcium chelating agent. The liquid solution preferably constitutes about 1 weight of the composition.

According to a particularly preferred embodiment of the invention, the veterinary composition comprises, based on the total weight of the composition, a green leafy plant powder of 50 g by weight,
DL-Methionine approx. 30% by weight - 1 Sodium chloride approx. 19%
and about 1% by weight of ethylenedianetetraacetic acid.

The veterinary drug composition according to the present invention obtained as a result of the synergistic mixing of the four components of sweetfish has the following advantages:

That is, it acidifies the urine, helps prevent inflammation of the urinary tract system, reduces the depth of the animal's urine and feces,
It provides livestock with a better respiratory tract, reduces the amount of dry matter in the urine by at least 45%, and helps prevent urolithiasis and related urinary diseases mentioned above.

Another object of the invention is to provide a new method of administering a drug to an animal, more particularly a veterinary pharmaceutical composition as defined above.

Every animal breeder knows that turtles have a very difficult time administering drugs orally to the animals. In fact, animals commonly become panicked, fight, bite, claw, and spit out drugs.

If a drug tablet is crushed and mixed with an animal's food or a liquid mixture is injected into its food, the animal will either refrain from eating or swallow only a portion of its meal and therefore only a portion of its drug.

To overcome this deficiency, it was specifically designed to prevent urolithiasis and related urinary diseases in fil.

A novel animal litter is provided. This new litter contains 0.1 of the veterinary drug composition based on the total weight of the particles.
The term "litter" as used in the text includes particles of wood or wood derivatives coated with a weight of ~4% by weight, placed in a container or tray, and intended for domestic or captive cats. All objects used as latrine locations for other animals in
bstaixce).

The main advantage of the litter according to the invention, in which the particles are coated with an outer layer of the drug, is that the animal unknowingly impregnates its paws, parts of its fur and muzzle with the drug, with which the animal cleanses itself and This is where the animal involuntarily ingests the drug when it licks its paws and fur. In this regard, it should be noted that cats are known to be very clean animals, licking the inside of their urinary and defecation channels.

As an example, a domestic cat requires approximately 250M of litter to defecate and urinate in a hygienic manner over a period of 3 to 4 days. When spread out, this amount of bedding will cover a surface of approximately 1000 mm.

Considering that the average surface area covered by a domestic cat's paws is approximately 40 kg, cats using litter are expected to receive 5 to 15 doses of the drug added to their litter every day.
Become.

- The particles used as a support for the drug to be taken up by the animal when using the litter are preferably made of wood sawdust or shavings, blotting paper or other forms of pulp. Each particle size is preferably 0.1~
It has a volume of 5-.

For example, diameter 0.2~2cm and length 0.2~5cst
A small cylinder of commercially available sanitary paper can be used. Particles may also have any geometric shape. Natural sawdust or treated sawdust from which small particles have been removed are particularly useful. This is because sawdust is very readily available, inexpensive to purchase, and weighs only half the weight per volume of the finely ground soil normally used as bedding. Furthermore, one piece of sawdust absorbs 50 g more water than a bedding of the same volume made of finely ground clay. Its liquid absorption capacity 130
Vapor paste 4 treated with sodium polyacrylate for doubling can also be used.

A very advantageous feature of the litter according to the invention is that its particles are less dusty than the finely divided soil particles used in conventional litter.

For illustrative purposes, the litter mentioned in the preamble is capable of absorbing a larger amount of cat urine and defecation in the same period of time than any known litter due to its refreshing absorbent capacity. It turned out that this was sufficient.

In addition, the porous particles used in the bedding button according to the present invention can advantageously carry and retain drugs without affecting their therapeutic efficacy prior to ingestion and elongation by the animal.

The invention will be better understood in consideration of the following non-limiting examples.

Example A veterinary drug composition for preventing urolithiasis in the urinary tract of cats was prepared by adding 5 parts by weight of green leafy plant powder, 3 parts by weight of DL-methionine, 1.9 parts by weight of sodium chloride, and ethylenedianetetraacetic acid. 0.1 parts by weight were mixed intimately. The resulting composition was ground into a fine powder.

A thin coating of the powder thus obtained is applied to sawdust using 52 powder/sawdust IKt (approximately 5000 cli) to make animal bedding, and this bedding is then used for feeding animals between 1 and 3 years of age. Six domestic cats (4 males and 2 females, all of which had been sterilized, ie, castrated and ovohysterectomized) were tested. Urine samples were collected from each cat after a two week adaptation period on "normal litter" and the proportion of dry matter contained in each sample was determined. Thereafter, the cats were allowed to use the previously prepared animal litter for 3 weeks. At the end of the three week period, another urine sample was taken from each cat and the proportion of dry matter in the sample was determined. Nine data obtained from the test are shown in the table below.

1 0.09 fm/d O,02 fm/d2
0:04 tm/ml
O,04tm/wd3 0.14 fm/d
O,03far/wd4 0.08 fm/
vd O,07fm/d5 0.13 tm/
d O,07fm/d6 0.11 fm/w
d O,015fm/wl average 0.098 f
m/d O,048tIl/d From the table above, it can be seen that before using the animal bedding according to the invention, cat urine contains an average amount of Group 1 - Dry substance 0.098f. I understand. After using the bedding according to the invention for 3 weeks, the urine of the same urine contained an average amount of only 0.05 ml of dry matter per liter of urine.
Contains 048F. The proportion of dry matter in the urine on each side is determined by complete/IC evaporation of the entire urine.

Another experiment! J! The amount of dry matter in the urine was determined by centrifuging the urine, separating suspended solids, and evaporating the sediment. The control, untreated cat had a ratio of 3.33 W dry matter/urine, while the cat using the litter according to the invention had a ratio of 1.81 v dry matter/urine.
It had a ○ ratio. It is therefore clear that the inventive lJK bedding reduces by about 45 inches the proportion of solid materials that can cause irritation and thus obstruct the urinary tract.

In this context, studies of cats suffering from urinary tract syndromes have shown that the average proportion of solid matter in the urine was approximately 5.61 we/urine.
It is noteworthy that this was the case.

The advantages of this novel method of administering veterinary drug compositions to cats include that the sick animal is not subjected to any stress, that the drug is administered in a continuous and regular manner, and that the cat owner does not have to worry about being bitten or scratched. This includes the benefit of reducing the risk of exposure.

This method of administering a veterinary drug product to an animal should not be limited to cats or the highly defined veterinary drug compositions disclosed in the preamble. In fact, this method does not require the use of topical or oral insecticides, antibiotics, vitamins,
Ovulation suppressants, and any other preparations or compositions for preventing certain diseases, may also be used for administering KS or for any other reason.

The foregoing description of the tortoise shell is merely illustrative of the present invention and is not intended to be limiting.

Since modifications of the disclosed embodiments that embody the spirit and substance of the invention will occur to those skilled in the art, the scope of the invention should be limited only with respect to the claims that follow.

Claims (1)

[Claims] 1. Based on the total weight of the composition, green leafy plant powder 25 to 75%
Weight: Excellent, Urine acidifying agent: 15-45 Weight: Mild diuretic: 9
．． 5-28.5 weight and calcium chelating agent 0.
A veterinary drug composition for preventing feline strict urinary system syndrome in cats, characterized by comprising a weight ratio of 5 to 1.5. 2. The veterinary medicine composition according to claim 1, wherein the green herbal medicine constitutes about 50% by weight based on the total weight of the composition. 3. The veterinary drug composition according to claim 1, wherein the uric acid north is selected from the group consisting of DL-methionine, ammonium chloride, ethylene cyano dihydrochloride m, mantelic acid, ascorbic acid, and sodium diphosphate. 4. The veterinary drug composition according to claim 3, wherein the uric acid component is DL-methionine. 5. The veterinary drug composition according to claim 1.3 or 4, wherein the uric acid content constitutes about 30 kg based on the total weight of the composition. 68. The veterinary drug composition according to claim 1, wherein the mild diuretic is selected from the group consisting of sodium chloride, fork, human tetrachlorothiazide, and acetoacyl. 7. Mild. 7. The veterinary composition of claim 6, wherein the mild diuretic is sodium chloride. The veterinary drug composition according to claim 1.6 or 7. 9. The veterinary composition according to claim 1, wherein the calcium chelating agent is ethylenedianetetraacetic acid. 10. Claim 1 constitutes about 1 part by weight based on the total weight of the composition.
or the veterinary drug composition according to item 9. 11. Group ``Based on the total weight of the parallax, the final 50 of green leafy plants
2. A composition according to claim 1, comprising about 30 parts by weight of DL-methionine, about 19 parts by weight of sodium chloride, and about 1 part by weight of ethylenecyanetetraacetic acid. 12. Prevention of urinary system syndrome in cats consisting of particles of a wood derivative coated with 0.1 to 4 weight doses of the veterinary drug composition according to claim 1 based on the weight of the particles. Veterinary medicated bedding for use. 13. A veterinary litter according to claim 12, wherein the particles are made from wood sawdust, wood shavings or blotting paper. 14. Each particle is in the range of 0.1 to 5. The veterinary medicinal bedding according to claim 12 and claim 13, wherein the veterinary medicinal composition has a volume of .
13. The veterinary bedding according to claim 12, which is coated with 5% by weight. 16. Claim 12, wherein the veterinary drug composition comprises a green leafy plant, approximately 50% by weight, about 30% by weight of DL-methionine - about 19% by weight of sodium chloride, and about 1% by weight of ethylenethiadentetraacetic acid. or the veterinary medicinal bedding described in item 15.