JPS5829464A - Serum separator - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an improvement in a plasma separator for separating plasma or some low molecular weight components from blood.

It is well known that dialysis-type artificial kidneys are widely used as a method for removing toxic substances from the blood, and that their therapeutic effects are extremely large. Among this type of dialyzer, the one-way holofiber type has the advantage that the effective area can be significantly larger than the dialysis membrane type, so this type is mainly used in current dialysers. ing. This type of miniaturized module is still being used as a plasma separation pretreatment device for blood component concentration measuring instruments. Note that Holofiber is a tube made of several types of synthetic resin materials.

However, although the hollow fiber module type plasma separator has excellent dialysis performance at the initial stage of use, when used for a long time, coagulated substances accumulate on the inner wall of the hollow fiber, and the efficiency gradually decreases. Also.

By reducing blood flow to increase dialysis efficiency.

As the blood cells flow along the holofiber wall surface, the effective surface area becomes small and the efficiency decreases. That is, there were problems such as a decrease in the proportion of contact with the holofiber wall surface.The present invention aims to solve the problems of the conventional technology and provide a plasma separation device that can significantly improve plasma separation efficiency. The purpose and feature of this method is that an ultrasonic source is installed outside or inside the jacket of the plasma separation module, and the hollow fiber is irradiated with ultrasonic waves.

FIG. 1 is a sectional view of a plasma separator using a holophino module according to an embodiment of the present invention. In this embodiment, a conventional holofiber module 1 is installed in an ultrasonic irradiation tank 8. This tank contains a medium liquid 9 such as water, and ultrasonic waves are irradiated to the module 1 through this tank.The irradiated ultrasonic waves are transmitted to the jacket 3 of the module 1.
The holofiber 2 is irradiated via the external circulating liquid filling between the jacket 3 and the holofiber 2. At this time, it is suitable that the jacket 3 of the module 1 is made of transparent synthetic resin, but it is preferable that it is made as hard as possible. Note that 1.4.5 is the blood inlet and outlet, and 6.7 is the reflux. This is the entrance and exit for liquid.

The ultrasonic element 10 is fixed to the lower part of the ultrasonic tank 12, and is suitable for a frequency band of 10 to 1QQkHz2 and 100 W or less, although it depends on the size of the tank. If this output is too large, the medium liquid 9 and the reflux liquid in the jacket 3, or even the blood in the holographic pallet 2, may be foamed, leading to the risk of damaging the blood cells. 11 is ultrasonic element 1
This is the power supply that operates the 0.

Figure 2 is a diagram comparing the characteristics of the plasma separator shown in Figure 1 with the characteristics of a conventional device, where the horizontal axis shows the usage time and the vertical axis shows the amount of plasma 7six that flows into the perfusion fluid. ml/mjn
Shown in units. When ultrasonic waves are not irradiated, the dialysis ability decreases rapidly as shown in curve B, but it is thought that in the initial stage, blood cells do not adhere to the wall surface of the holofiber 2, so the value is relatively high.

On the other hand, in the case of the straight line A where ultrasonic waves are irradiated, the amount of plasma flux is large because the effective surface area of the holofiber 2 increases and the diffusion layer in the blood becomes thinner due to the ultrasonic irradiation. Also, the reason why the flux does not decrease much even after 1 hour has passed is because the coagulated substances in the blood are holofiber 2.
This is thought to be due to the fact that it no longer deposits on the walls.

In the plasma separator of this example, by irradiating ultrasonic waves from outside the tank in which the module is immersed in the medium liquid, blood cells etc. that adhere to the hollow fibers in the module are separated and flowed out, greatly increasing the plasma separation efficiency. The effect is that it can be improved.

FIG. 3 is a sectional view of a plasma separator according to another embodiment of the present invention, in which the same parts as in FIG. 1 are designated by the same reference numerals. In this case, the ultrasonic element 10 is directly fixed to the lower surface of the module 1 via an ultrasonic permeable membrane 13 made of acrylic resin or the like. In this case, since the ultrasonic waves are also transmitted to the holofiber 2 by the reflux liquid in the jacket 3, the same effect as in the case of FIG. 1 can be obtained, and the structure can be made smaller than this.

The plasma separator of this embodiment has the same effect as the device shown in FIG. 1 by fixing the ultrasonic element directly to the jacket. It has the advantage of being compact and inexpensive.

The plasma separator of the present invention has the effect that plasma separation efficiency can be significantly improved by irradiating the plasma with ultrasonic waves.

[Brief explanation of the drawing]

FIG. 1 is a sectional view of a plasma separator that is an embodiment of the present invention;
FIG. 2 is a diagram comparing the characteristics of the device shown in FIG. 1 with the characteristics of a conventional device, and FIG. 3 is a sectional view of a plasma separator according to another embodiment of the present invention. 1...Module, 2...Holofiber, 3...
・Jacket, 4.5...Blood entrance/exit, 6.7...
Reflux liquid inlet/outlet, 8... Ultrasonic irradiation tank, 9... Medium liquid, IO... Ultrasonic element, 11... Power supply, 12...
Ultrasonic tank, 13 vines 1%3z

Claims (1)

[Claims] 1. Separating plasma or low molecular weight components from blood using a plasma separation module that has a holofiber through which blood flows and a jacket surrounding the holofiber and through which an external reflux liquid flows. In the plasma separation apparatus, an ultrasonic source is installed outside or inside the jacket of the plasma separation module. A plasma separation device characterized in that it is configured to irradiate ultrasonic waves to the above-mentioned hollow fiber. 2. The plasma separation device according to claim 1, wherein the ultrasonic source is an ultrasonic element installed outside an ultrasonic tank in which the module is immersed in a medium solution. 3. The plasma separation device according to claim 1, wherein the ultrasonic source is an ultrasonic element installed on the wall of the jacket via an ultrasonic permeable membrane.