JPS5826223A - Measuring instrument for number of liquid-drop - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to a droplet metering device.

Droplet measuring instruments are widely used for dispensing medicines, particularly eye drops. Eye drops containing active ingredients are becoming more and more widely used, but although they have a high pharmacological effect, they are also toxic, and if the prescribed dosage is not followed, especially when using drop-measuring instruments, it is difficult to dispense the wrong drop. In this case, the problem of side effects arises.

Droplet metering devices currently in use are classified into two types. One has a tube on which a nipple is placed;
This device has a cap that screws onto the container. In this case, the tube, nipple and cap must be disassembled for use as a droplet metering device. This type of device has many drawbacks. In particular, it is extremely complicated as it requires the manufacture and assembly of at least three parts. Additionally, placing the drop metering device on a dirty surface after use risks contaminating the product when it is attached to the bottle. Also, because of the tube, which must be open and held at one end for a very long time, this type of drop metering device is difficult to use for accurately dispensing liquid into the eye.

For this reason, the use of nipple-type droplet metering devices is particularly preferred for the administration of eye drops; Closely mounted.

When using this type of device, turn the bottle upside down and
Liquid thereby fills the nipple and is expelled through a hole in the nipple by pressing on the nipple. Devices currently in common use release liquid by deforming a hollow nipple with a hole in its end. When pressure is applied directly to a liquid, the liquid is generally ejected in a linear manner and does not form droplets. Furthermore, it is extremely difficult to accurately expel a predetermined amount of liquid with this type of device.

On the other hand, in order to prevent the liquid from being discharged in a linear manner as much as possible, the size of the opening of the nipple should be approximately 0.5 to 0.8. Under such conditions, there is a strong possibility that one of the components of the mixture will adhere and cause clogging.

Under these circumstances, the present invention provides a droplet metering device with improved dripping action.

Furthermore, in the device of the invention, a predetermined amount of product can be released by providing a chamber with a predetermined volume. The device of the invention also has a liquid release groove of a fairly large diameter, for example 1 to 1.5 mm.
m, which has the advantage that the risk of clogging is greatly reduced.

To this end, the present invention comprises a nipple suitable for tightly fitting into the opening of a container for liquids, the nipple comprising a substantially undeformable groove communicating with the interior and exterior of the container and at least one of the nipples. The liquid chamber is adjacent to the drainage groove and in contact with the inside of the container, and the liquid chamber and the groove are connected by walls that do not substantially deform. To provide a droplet measuring device suitable for attachment to an opening of a liquid container characterized by being isolated.

The largest dimension of the fluid chamber preferably extends substantially parallel to the axis of the groove, and the fluid chamber is entirely located in one half of the space defined by a plane passing through the axis of the groove.

Furthermore, in order to facilitate gripping the device, the nipple consists of two substantially flat parts, located on either side of the groove, one of which is located in a part of the chamber wall that can be elastically deformed. ing.

In a preferred embodiment of the device of the invention, when used for the administration of a medicament, the volume of the fluid chamber is such that upon full compression, a therapeutic dose of the medicament, or a full submultiple thereof, can be released.

Another advantage of the device of the invention is that it has a scale made of a soft and elastic material, such as natural or synthetic rubber.

In this device, the groove is preferably frustoconical in shape, the widest part of which is located on the side of the interior of the container. Furthermore, the inner diameter of the groove at the end in contact with the outside is 0.8~
It is preferable to read 2 lines, especially 1 to 1-5 meters long.

Other advantages and features of the invention are apparent from the following description and the accompanying drawings.

1 is a cross-sectional view of the device of the present invention taken along line A-A in FIG. 2, FIG. 2 is a left side view of the device of the present invention, and FIG. FIG.

The device of the present invention shown in FIGS. 1 to 3 has a main body (2) and a head (3).
) and a base (1).

The base (1) is substantially cylindrical and has an internal cavity (
4), the cross section of which is similar to the cross section of the opening of the bottle in which the base (1) is installed. The outer diameter of this base (1) is larger than the outer diameter of the main body (2), and the edge of the bottle (
5) and one or more couplings attached to the corresponding parts thereof, allowing the device to be attached to the bottle. Said base (1) rests a body (2) and a head (3), which are in contact with the cavity (4) of the base and communicated with the outside through an outlet tube (7) by means of a groove (6). It is pierced along its vertical axis.

The chambers (8) are present on one side of the body (2) of the device and extend substantially parallel to the groove and are separated from each other by substantially non-deformable partitions (9). The liquid chamber (8) communicates with the hollow part (4) of the base. This room (8)
The outer wall a is thin and can be easily deformed by external pressure.

To improve the grip of this device and to make it easier to position the exit tube during use, especially during eye instillation,
Place the part of the body (2) opposite the chamber (8) on a flat surface.
Similarly, the outer surface of the chamber is made flat at the surface (]2.

In the bottle shown here, the deformable chamber occupies only a limited portion of the entire device, the volume of which is determined by the nature of the liquid to be ejected, and when the chamber is fully compressed. at a predetermined volume of fluid corresponding to the desired therapeutic dose or a full subdivision thereof. Of course, the dimensions of this chamber can be varied as appropriate and can be defined so that a predetermined amount of liquid is released when the chamber is completely deformed.

The device described herein can be attached to a bottle by any suitable means; a variant of the device includes an annular recessed groove in the base of the device that mates directly and closely with an annular boss around the bottle opening. You can also do it.

Experiments carried out with this device have shown excellent dripping effectiveness over a very large viscosity range, and furthermore, when the chamber of the device is pressed, repeatable amounts of product can be released.

[Brief explanation of the drawing]

FIG. 1 is a sectional view taken along line A-A in FIG. 2 of the instrument of the present invention, FIG. 2 is a left side view of the instrument of the present invention, and FIG. 3 is a plan view of the instrument of FIG. 1. . The main symbols in the drawings are as follows. 1...Base, 2...Body, 3...Head, 4...
- Hollow part of base, 6... Groove, 7... Outlet tube, 8... Chamber, 9... Partition, 10... External wall. Patent applicant: Laboratoire Merck Sharp & Dohmouscible Patent attorney Aoyama Aoyama and 2 others FfGj FIG-2 IG-3

Claims (9)

[Claims] (1) Consists of a nipple tightly attached to the opening of a liquid container, the nipple having a substantially undeformable groove (6) communicating from the inside of the container to the outside, and at least one wall (10) of which is elastic under pressure. The liquid chamber is adjacent to the extraction groove and in contact with the inside of the container, and the liquid chamber and the groove have a substantially undeformable wall (8).
9) A droplet metering device suitable for attachment to the opening of a liquid container, characterized in that the drainage groove (6) has a considerably large inner diameter. (2) The device according to item 1 above, wherein the largest dimension of the liquid chamber extends substantially parallel to the axis of the extraction groove. (3) The device according to item (1) or (2) above, wherein the liquid chamber is completely disposed in one half of the space defined by a plane passing through the central axis of the groove. (4) said nipple consists of two substantially flat parts located on opposite sides of the groove, one of said flat parts being located in a part of the chamber wall which is elastically deformable; (
Apparatus according to any one of items 1) to 13). (5) The device according to any one of items (1) to (4) above, wherein the extraction groove has a truncated conical shape, and the widest part thereof is located inside the container. (6) The nipple is integrally molded (1) to
(5) Any one of the appliances. (7) The inner diameter of the exit groove at the contact end with the outside is 0.8~
The device according to any one of items (1) to (6) above, which has 2 votes. (8) The inner diameter of the extrusion groove at the contact end with the outside is 1 to 1.
5 tram. (9) The liquid b to be used (which is a medicine, and the volume of the liquid chamber is determined such that a therapeutic dose of the medicine or a complete sub thereof can be released by complete pressure) (1) to (8) above.
) any one of the appliances. −