JPS58221957A - Hair growth promoting apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to a hair growth promoting device.

Recently, various wigs designed for alopecia have been commercially available and have been well received, but it goes without saying that they are not a fundamental treatment for alopecia.

Various chemical and physical treatments have been attempted for alopecia areata, mid-age alopecia, alopecia alopecia, alopecia atrophicis, symptomatic alopecia, etc., and many efforts have been made to achieve a complete cure. efforts have been made.

Nevertheless, many of the alopecias mentioned above are permanent;
Even when temporary treatment is possible, it usually takes several weeks to several years for a complete recovery.

One reason for this is that hair growth promoters applied to the skin are not efficiently absorbed into the dermal papilla tissue located deep in the scalp, and in some types of alopecia, physical and mental overwork may occur. Since the cause is psychological factors, it is thought that applying chemicals to the affected area or irradiating the affected area with ultraviolet rays cannot easily achieve the goal.

As described above, a few patent applications have attempted to apply electronic therapy to alopecia, which has a wide variety of causes and is extremely difficult to treat. A representative example thereof is disclosed in, for example, Japanese Patent Laid-Open No. 186067/1983. Here, a special hat-shaped treatment tool equipped with electrodes is used to apply low frequency waves to the electrodes to ionize the hair growth promoter and introduce it into the skin, as well as stimulating the autonomic nerves to stimulate hair growth. It is intended to promote The aim of stimulating the autonomic nerves through iontophoresis of hair growth promoters and low-frequency stimulation to completely cure alopecia caused by physical and mental factors is highly praised.
In this attempt, the low frequency for iontophoresis was aOOOO
Since it is a smooth alternating current of 4,000 Hz to 4,000 Hz, and the low frequency for nerve stimulation is an alternating current of 4 Hz to 60 Hz, it is well known that smooth alternating current can easily cause burns that reach deep layers. It has the disadvantage that simple alternating current cannot withstand the stimulation, and in addition, it is difficult to avoid operational inconvenience because the low frequency mentioned above must be switched and applied as needed.
□“The present inventor has carefully investigated hair growth promoters that have even higher therapeutic effects than hair growth promoters such as Pikmin, hormones, and inorganic salts that have been conventionally used in chemotherapy, and has developed a method for using iontophoresis more efficiently. We carefully considered the equipment to carry out the project.

As a result, by applying a certain superimposed low-frequency voltage to ion-transfer aminovinyl-based photosensitive dyes, which have never been used in conventional iontophoresis methods, the waveform of the applied low-frequency voltage can be changed as before. It has been discovered that remarkable hair growth promotion can be easily obtained without switching, and that all the problems of the present invention can be solved.

That is, the present invention generates a waveform that approximates the waveform of a biphasic action potential wave generated in human nerves with a pulse width of 1/200 seconds to 17,600 seconds as a biphasic action potential wave by the first low frequency oscillator at a pulse interval of 1/20. This occurs every 1/800 seconds to 1/800 seconds, which stimulates the skin and stimulates the metabolism. Generates an ultra-low frequency rectangular wave consisting of a zero-potential current and guides it to the conductor, ionizes the aminovinyl photosensitive dye and promotes its penetration into the skin, while at the same time providing appropriate stimulation to the affected area. The present invention provides a hair growth promoting device that is ideal for iontophoresis of aminovinyl photosensitive dyes into hair loss affected areas, which is characterized by alleviating nervous fatigue and promoting the generation of hair roots.

The aminovinyl photosensitive dye, which is subjected to iontophoresis for the first time in the present invention, has aromatic rings bonded to the 1 and 2 positions of the molecule via a vinyl group, and one or both of them is a nitrogen-containing heterocycle. One of the nitrogen atoms is a halide, making it a quaternary salt.

Aminovinyl photosensitive dyes generally exhibit unique coloring and exhibit strong absorption in the ultraviolet region. For example, commercially available 6C2-[(5
-Bromo-2-pyridyl)amine]vinyl]-1-ethyl-2-picolinium iodide and 2-(2-anilinovinyl)-a4-dimethyl-oxacillium iodide (trade name: Kosensen No. 801, No. 401, Nippon Kanko Shiki Co., Ltd.) (manufactured by the company) are particularly advantageously used in the present invention.

Normally, aminovinyl photosensitive dyes are dissolved in an alcoholic saline solution to a concentration of several tens to hundreds of ppm, applied to the affected area, or absorbed into a moisturizing therapeutic electrode, and then Iontophoresis is carried out by applying a low frequency voltage for 5°. At this time, the biphasic action potential wave with a frequency of 50 Hz to 300 Hz is converted into an extremely low frequency wave having a current component of zero potential and positive potential with a frequency of 05 Hz to 2 Hz. Apply several tens of volts as a composite wave superimposed on a rectangular wave, and make a current of α1 to 1 milliampere flow.
It is desirable to adjust within this range as appropriate, giving due consideration to the symptoms of the affected area and the patient's condition.

Depending on the symptoms, for adults, for example, 200 ppm
A methanolic saline solution of an aminovinyl photosensitive dye is applied to the affected area to the extent of 1cc per treatment, or absorbed into a roller-shaped moisturizing treatment guide for several minutes.
The above-mentioned superimposed voltage is applied for about several tens of minutes. Then, repeat the process once to several times a day while observing the hair growth situation in the area affected by hair loss. Further, if necessary, iontophoresis may be performed in combination with a hair growth promoter such as acetylcholine, steroids, or DCNH, or may be performed in parallel with ultraviolet irradiation treatment.

Next, a hair growth promoting device according to the present invention suitable for carrying out the above hair growth promoting method will be described.

FIG. 1 shows a block diagram of a hair growth promoting device according to the present invention. (1) is a first low frequency oscillator, which has a pulse width t1 as shown in Figure A of the waveform diagram shown in Figure 2.
"" 1/200 seconds to 1/600 seconds, no (Russ interval t2
= 1/20 second to 1/a 00 second biphasic action potential wave is oscillated. (2) is a second low frequency oscillator, which oscillates an ultra-low frequency rectangular wave with a frequency of 05 Hz to 2 Hz as shown in the fourth waveform diagram in FIG. The currents 7 and 7 are generated alternately.

The waveform of the first low frequency oscillator (1) shown in Figure A and the second
When the waveform of FIG. 1 generated by the low frequency oscillator (2) is superimposed, a waveform as shown in FIG. PM
The waveform part stimulates the skin and nerves to improve metabolism.

The low frequency output voltage obtained in this way, that is, the superimposed wave voltage is the roller electrode (5) connected to the terminal (3) +41.
) and a gripping electrode (6), which guides the therapeutic conductor and applies it to the affected skin. FIG. 3 shows the hair growth promoting device of the present invention, which is a more specific embodiment of the block diagram shown in FIG.

In this exemplified device, the oscillation circuit of the first low frequency oscillator (1) is used as a blocking oscillation circuit to oscillate a biphasic action potential wave, and its output is transmitted via the transformer T to the connection terminal (3) of the therapeutic conductor. ). On the other hand, the oscillation circuit of the second low frequency oscillator (2) is configured by a multivibrator, and the rectangular wave output having current components of zero potential and positive potential of 05 Hz to 2 Hz is generated by the transistor Tr4.
The resulting low impedance output is guided to the secondary side of the transformer T and the first
It is superimposed on the biphasic action potential wave oscillated by the low frequency oscillator (1). Battery B2 is a bias power source.

Further, FIG. 4 illustrates the hair growth promoting device of the present invention in which the oscillation circuits of the first low frequency oscillator +11 and the second low frequency oscillator (2) are constructed by a multivibrator using CR.

The 50 to 300 Hz rectangular wave oscillated by the multi-node oscillator of the first low frequency oscillator (1) is differentiated by the capacitor C9 and the resistor R to become a biphasic action potential wave. This biphasic action potential wave is oscillated by the second low frequency oscillator (2).
It is superimposed on a rectangular wave having current components of zero potential and positive potential of Hz to 2 Hz, resulting in a superimposed low frequency voltage suitable for introducing an image of an aminovinyl photosensitive dye as shown in Fig. 2), which can be used for treatment. It is led to the connection terminals (3) and (4) of the conductor.

That is, the oscillation frequency of the first low frequency oscillator (11) is l/'10 seconds, which has the same period as the pulse interval of the biphasic action potential wave.
1/200 seconds, and its output is connected to the roller electrode (5) of the therapeutic guide via the connection terminal (3), and the other connection terminal (4) is connected to the capacitor of the second low frequency oscillator (2). 9--
Connect to -012.

On the other hand, since the oscillation low frequency of the second low frequency oscillator (2) is extremely low frequency, if it is performed as charging and discharging of the capacitor C□2 via the resistor R, the distortion of the waveform can be suppressed to a minimum. , the voltage waveforms at both ends of the capacitor C1□ are obtained as approximations to rectangular waves.

The rectangular wave oscillated by the first low frequency oscillator (1) is caused by the capacitor 0 because the biphasic action potential wave differentiated by the capacitor C9 and the resistor R□5 contains many high frequencies.
1□ has almost zero impedance, loss is small, and the voltage of the first low frequency oscillator (1) is connected to the connection terminal (
31(4), it will supply current to the therapeutic conductor.

Next, the hair growth promoting device shown in FIG. 3, the hair growth promoting device shown in FIG.
Alternatively, the effects of the present invention will be specifically explained through experiments using a replacement device using a low frequency oscillator and a synchroscope, and an aminovinyl photosensitive dye.

Experiment 1. Aminovinyl photosensitive dye In the hair growth promoting device shown in FIG. The oscillation frequency of the multivibrator was set to 1 hertz.

At the beginning of the experiment, Silureno (- cream) was applied for a very short time to four symmetrical areas on the backs of rabbits with an area of 5 J, and the marks were thoroughly washed to remove hair so as not to damage the skin.

For this hair loss area, apply Kosensen No. 301 or Kosensen No. 401 manufactured by Nippon Kanko Shiki Co., Ltd. (dissolve it in a glycerin ° solution at a ratio of 105%, add half the amount of 95% alcohol to it, and use it as a test solution. As a control solution, a mixture of 2 parts glycerin and 1 part 95 alcohol was applied, a commercially available acetylcholine preparation was applied, and as a control, nothing was applied. For each, once a day, a superimposed low frequency voltage oscillated by the hair growth promoting device of the present invention was applied for 10 minutes, and a smoothed AC voltage of a, ooo hertz was applied for the same 10 minutes using a known low frequency treatment device. Experiments were conducted with Il applied and with no voltage applied at all, and the effect of aminovinyl photosensitive dyes on hair growth promotion based on ion introduction was investigated.

That is, on the 10th day (1st day) and the 30th day (1st day) from these application tables, I went to a separate house and measured the entire length of each bristles using a microscopic movement device, 100 each, and calculated the average value. Ta. The results are shown in Table 1.

The results in Table 1 confirm that aminovinyl photosensitive dyes slightly promote hair growth when applied to the affected area, but that even more remarkable hair growth promoting effects can be obtained by applying low frequency voltage and iontophoresis. . Furthermore, when applying a superimposed low frequency voltage using the hair growth promoting device of the present invention, the hair growth promoting effect is clearly higher than when measuring iontophoresis by applying a smooth traffic voltage using a known low frequency treatment device. You can check whether you can get it or not.

Experiment 2 Superimposed low frequency The first low frequency oscillator (1) and the second low frequency oscillator (2) are connected as shown in Figure 5, and treatment is performed while observing the waveform of the oscillated superimposed low frequency using a synchroscope Sy. Guided to the guide.

The oscillation frequencies of the first low frequency oscillator (1) and the second low frequency oscillator (2) were changed as shown in Table 2, and photosensitive element No. 301 was dissolved in alcoholic saline to a concentration of 200 ppm. The frequency of the superimposed low frequency to be applied during ion introduction of the aminovinyl photosensitive dye was investigated according to the test method of Experiment 1, except that the test liquid was used. The result is the second
Shown in the table.

As is clear from Table 2, the frequency of the rectangular wave oscillated from the second low frequency oscillator (2) is around 1 Hz, and the frequency of the biphasic action potential wave oscillated from the first low frequency oscillator (1) is approximately 50 Hz. It was confirmed that a remarkable hair growth promoting effect can be obtained in the range of Hz to about 200 Hz.

Referring to the experimental data in Table 2 and above, photosensitive element No. 301, photosensitive element No. 4
No. 01 was used to treat patients with alopecia areata, middle age alopecia, glycosyl alopecia, atrophic alopecia, symptomatic alopecia, etc., and results were shown to be good for all types of alopecia. The results were obtained.

The reason why such good results are obtained due to the hair growth promoting effect of the present invention is that the iontophoresis of amino/vinyl photosensitive dyes is extremely effective in promoting hair growth, and also because the iontophoresis of the amide/vinyl photosensitive dye is extremely effective in promoting hair growth. It is understood that this is because biphasic action potential waves stimulate the skin and promote metabolism, and also act effectively on nerves and other organs to promote recovery from nervous fatigue, allowing treatment to be carried out from both the mind and body at the same time. Ru.

In addition, when performing hair growth promoting treatment using the hair growth promoting device of the present invention, it is recommended to If a low frequency voltage, especially a superimposed low frequency voltage emitted by the hair growth promoting device of the present invention, is applied simultaneously or sequentially with the application of the superimposed low frequency voltage to the hair loss affected area, even higher hair growth can be achieved. Provides a hair-promoting effect. and,
The low-frequency voltage applied to this acupuncture point can be applied appropriately using a separately prepared known low-frequency treatment device, the hair growth promoting device of the present invention, or a part of the superimposed low frequency emitted by the hair growth promoting device of the present invention. It is obtained by connecting to an auxiliary electrode having therapeutic elements, and these therapeutic elements are preferably provided with strings, bands, or rubber band attachments for fixing them at the acupuncture points.

[Brief explanation of the drawing]

In the figures, Fig. 1 shows a block diagram of the hair growth promoting device of the present invention, Fig. 2 shows the waveform of the oscillated low frequency wave in the hair growth promoting device of the present invention, and Fig. A shows the output waveform of the first low frequency oscillator. is the output waveform of the second low-frequency oscillator, Figure C is the waveform of their superimposed low-frequency waves, and Figure 3 shows the first low-frequency oscillator as a Brockinog-type oscillation circuit and the second low-frequency oscillator as a multivibrator-type oscillation circuit. Figure 4 is a circuit diagram when both frequency oscillators are multivibrator type oscillation circuits, and Figure 5 is a block diaphragm of an experimental device in which a synchroscope is connected to both frequency oscillators. The symbols in the figure are explained as follows. (1) is the first low frequency oscillator (2) is the second low frequency oscillator (3) (4) is the connection terminal (5) is the roller electrode (6) is the grip electrode B is the battery C is the co/denoser R is the Resistor S is a switch Sg is a shift cross scope T is a transformer Tr is a transistor

Claims (1)

Claims: (11) A first low-frequency oscillator that oscillates a biphasic action potential wave with a pulse width of 1/200 seconds to 1/600 seconds and a pulse interval of 1/!20 seconds to 1/300 seconds; A second low frequency oscillator that oscillates an ultra-low frequency rectangular wave having a current component of zero potential and positive potential of ~2 Hz, a therapeutic guide consisting of a roller electrode and a grip electrode, and a power source thereof. The output hot side terminal of the first low frequency oscillator is connected to the roller electrode, and the other return terminal is connected to the very low frequency output circuit of the second low frequency oscillator, and the return terminal of the second low frequency oscillator is connected to the roller electrode. The first low frequency oscillator and the second low frequency oscillator are connected in series to the therapeutic guide by connecting to the grip electrode, and the first low frequency oscillator is connected between the roller electrode of the therapeutic guide and the grasp electrode. By applying a superimposed wave voltage of the output of a low frequency oscillator and the output of a second low frequency oscillator, and applying an aminovinyl photosensitive dye to the roller electrode, the roller electrode is brought into contact with the skin by holding the gripper electrode. A hair growth promoting device characterized by applying stimulation with a superimposed wave voltage to the skin and measuring ion introduction of an aminovinyl photosensitive dye. (2) The oscillation circuit of the first low frequency oscillator is a blocking oscillation circuit. The hair growth promoting device according to claim 1. (3) The oscillation circuit of the first low frequency oscillator and the second low frequency oscillator is a multi-vibration two circuit. The hair growth promoting device according to item 1. (4) The aminovinyl photosensitive dye is 6-(2-4(5)
-bromo-2-pyridyl)amine]vinyl]-1-ethyl-2-picolinium iodide or 2(2-anilinovinyl) -a4-dimethyl-oxacillium
The oscillation promoting device according to claim 1, 2 or 3, characterized in that it is iodide.