JPS58198353A - Medical tube - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a medical tube containing an X-ray contrast agent.

High calorie infusion tube, cardiac catheter tube, brain h1-
As shown in FIG. 1, an X-ray contrast agent 2t embedded in a part of the tube wall is known as a medical fl-11 such as a chill tube, an artificial endotube, and a urethral insertion tube.

The special bamboo required for medical tubes containing xm artificial dyes must have reliable contrast properties against X-ray irradiation and be transparent so that the presence or absence of blood clots on the inner surface of the tube can be directly observed. For example, it has a part, and does not bend when it comes into contact with blood.

However, in the conventional tube shown in Fig. 1, the contrast agent is embedded in only one place, and the outer wall of this f+- tube is coated with an antithrombotic agent and heat-treated IN! This had the disadvantage that the tube would be curved. When the tube is curved, it is difficult to insert and cover the narrow white tube.

Furthermore, when X* is irradiated, the contrast agent embedded in a linear pattern is directly imaged in a linear pattern, but the tip can be distinguished at a glance from other tissues of the human body, such as bones, which are contrasted by X-rays. The drawback was that it was difficult to do.

Therefore, the present inventor conducted intensive research on the medical tube containing the Xa contrast agent, which is free from the conventional drawbacks, and found that it is sufficient to embed the X-ray contrast agent in a plurality of lines, thereby completing the present invention.

That is, the gist of the present invention resides in a medical tube characterized in that an X-ray contrast agent is embedded inside the tube wall in a plurality of lines in the direction of the tube opening, and the tube is transparent except for the embedded portion.

The present invention will be explained below along with one embodiment shown in the drawings. In Fig. 2.3, 1 is a medical tube,
It can be manufactured from soft transparent synthetic resin, such as polyvinyl chloride. The thickness of the tube 1 varies depending on the use; for example, a high calorie infusion tube inserted into an artery has an outer diameter of 1
~1.5 eia, and an inner diameter of 0.6 to 1.2 ms, and for a 11 heart catheter tube, the outer diameter is around 5-1 and the inner diameter is around 4 mm. In the longitudinal direction of the tube 1, the contrast agent 2 is embedded in three lines inside the tube wall. As this contrast agent 2, barium sulfate, tungsten, etc. are used, and compared to synthetic resin, barium sulfate has a concentration of 40...
60% by weight, 20-40% by weight in the case of tungsten
Embedded by mixing and molding. The contrast agent 2 is embedded at equal intervals, as shown in the cross-sectional view of FIG. Ba1:
It is set to 1.

In the above embodiment, the contrast agent 2 is embedded in three lines, but it is needless to say that the number is not limited to three, and any number of lines of 2 wood fibers may be used.

As described in detail below, the medical tube of the present invention has an X-ray contrast agent embedded inside the tube wall in a plurality of lines. Therefore, when using a medical tube, the tube does not bend even if the outer wall of the tube is coated with an antithrombotic agent and heat treated. This is thought to be because, since a plurality of them are embedded, bending due to expansion or contraction caused by the action of heat, moisture, solvent, etc. can be prevented. Here, the antithrombotic agent is a polynythyl polyurethane or a hydrocarbon polymer in which dialkylaminoethyl methacrylate or dialkylaminoedyl acrylate and vinylpyrrolidone are co-grafted in a heterogeneous system, and then converted into a quaternary salt and then converted into a heparin salt. A heparinized graft polymer molded product obtained by reacting with is used. Furthermore, when inserted into the human body, the bulb inevitably becomes slightly twisted. When exposed to X-rays in a twisted state,
The contrast medium creates a striped pattern, and such striped patterns do not exist in human tissue, making it possible to locate the tube at a glance without mistaking it. Therefore, the present invention provides medical tubes such as high-calorie infusion tubes, cardiac catheter tubes, brain catheter tubes, artificial blood vessels, and urethral insertion tubes, in which high-calorie liquids, white liquids, test reagents, etc. are passed through the tube. It is most suitable as

Next, the present invention will be explained with reference to production examples.

Construction 11@1 1,02φ1IX1.44φ- with three side lines as shown in Figures 2 and 3 using transparent soft vinyl chloride and barium sulfate (mixing ratio 50% by weight) as a contrast agent.
One tube was made.

The inner and outer surfaces of the tip are coated with polyurethane having excellent antithrombotic properties, and the height is 370 mm.
A catheter for indwelling a blood vessel was prepared and tested. As a result, the catheter showed no curvature and exhibited good contrast performance.

Fabrication Example 2 Using transparent soft vinyl chloride and tungsten (mixing ratio 30Φ amount %) as a contrast agent, there are three small side lines in Figures 1 and 2.
A 4φI tube was produced.

11t! Poly 1-?, which has excellent antithrombotic properties, is used on the inner and outer surfaces of the 1-tube. Coating the polyurethane type, the thickness is 3.
A blood vessel indwelling catheter of No. 70-1 was prepared and tested. As a result, the catheter did not have any curvature and exhibited excellent X-ray performance.

[Brief explanation of drawings]

Figure 1 is a partially cutaway perspective view showing a conventional medical tube.
FIG. 2 is a sectional view showing an embodiment of the present invention, and FIG. 3 is a front view of the same side. 1... CH1-B 2... Contrast agent fee Immediate patent attorney Adachi Study Voluntary procedure supplement 11 Yusho l ・It l'l display Showa 57<1 special IF m m'; 12100 +i
2 Title 6 of the invention Medical tube: 3. Mi +l- h Relationship with Elementary III Patent Applicant 4 Agent 8 I amend the full text of the amendment as per the attached document. Details ^ 1. Title of the invention Medical use j+-7 2. Scope of claims I
(Medical J, characterized by being embedded in multiple lines)
1-B. 2 X-ray contrast agent table embedded in three lines 1. 't a
'+-^ Desired range 1st] Oral medical f L-b. 3 The X-ray contrast agent is 1liIi#! The medical f'1-b as described in item 1, which is barium or ljtonguezin. 4. The medical tube according to claim 1, wherein the material of the tube is soft polyvinyl chloride. A medical bulb according to claim 1. 6 In the cross-sectional area of the tube wall of Chini-t-7, the area of the part where the X-ray contrast agent is embedded and the part where the X-ray contrast agent is not embedded > 1
(Item ratio is 1:1) Scope of claim 1
The medical tube described in item 1 (d). ;3 Detailed explanation of the invention The present invention relates to a medical tube containing an X-ray contrast agent J6
There is a C of 0. Medical use such as high blood vessels, urethral tubes, etc. /+-/' I have the first As shown in the figure, it is known that the XwiA contrast agent 2 is embedded in a part of the '. X-ray 1111 medical f: 1-113 required 1
+ 1'l and 1, reliable contrast enhancement against X-ray irradiation, 160J in Jl-/(Iru blood h', etc.) 111 ability to observe directly. The transparent 41 part has to be h', the blood (5) is in contact and does not bend.
Only f1 has the Isho agent embedded, and this f1~
Anti-thrombotic I material is applied to the inner and outer walls of the blood vessel, and there is a drawback: When curved, it can enter small blood vessels. Chi+-,/
It is difficult to insert 4. In addition, when XwA is irradiated, the contrast agent embedded in a line is imaged in a line as it is, but it is different from the ground tissues of the human body such as bones that are imaged by X-rays.
-It's difficult to identify -) It's a drawback.゛Here we developed one, and as a result of intensive research, Akashi developed the X-ray contrast agent containing @requisition cube, which does not have the disadvantages of the previous US.As a result of intensive research, we found that it is possible to prepare the X-ray contrast agent in multiple lines. They discovered this and completed the present invention. In other words, in the present invention, a medical 1-1-b characterized in that X1il contrast agent is embedded in a plurality of lines in a transparent chip facing the right direction. Hereinafter, the present invention will be described in drawings, together with an embodiment, for clarity.
Soft transparent synthetic resins, such as polyvinyl chloride,
Or VJ is made of polyurethane or the like. The thickness of the tube 1 varies depending on the application, and for example, in a high-strength infusion tube 1-1 inserted into an artery or a vein, the outer diameter is 0.8 to 2,516111, and the inner diameter is 0.6 to 2.
．． 31iIl, and the outer diameter of the heart force i-j tube is 5I1.
The contrast medium 2 is embedded in the tube wall in three lines in the direction of the long f horn of -11. IA
II barium, tangethnon, bismuth, etc. are used,
In the case of barium IIIt acid, 4 (1 = 6 (-3Φ%), in the case of tangesnon, 2040% is mixed and molded. Contrast agent 2 is embedded in the paleointerval C, as shown in the cross-sectional view of Fig. 2, and the cross-sectional area of the tube wall is f''-11, ',
The ratio of the area of the part where the contrast medium is embedded and the area of the part to be implanted is 1:1. Although it is embedded in the form of three lines, it is not limited to three lines, but several lines of 2 wood fibers and 1 C.
- Of course it's a good thing to have. As described above, the medical tube of the present invention has an X-ray contrast agent embedded in a plurality of lines in the fi-1 direction.
It's a gift. Therefore, when the medical tube f is used, an antithrombotic agent A is inked on the inner and outer walls of the tube for post-treatment so that the tube does not bend. By embedding multiple wires symmetrically, heat, moisture, and
The curvature due to expansion or contraction, which decreases by -1 due to n use such as 11, can be transformed into an anti-I[r-kirukaraguru. Here, antithrombotic bamboo heat 4-litoji (poly 1-nor type polyurethane,
Or by co-grafting hydrocarbon-based poly((J)-(J)-(J-di)-(N)))-[f-(-)-(-)-)-(-)-)-(-)-)-(-)-]-)-]-]-(-)-)-(-)-)-(-)-)-)-(-)-)-)-)-)-(-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)-)->> or [---(-)-(-)-(-)-)-]->->>). A heparinized granodoporin molded product is used which is then converted into a quaternary chloride and then reacted with a heparin salt to form a heparinized granodoporin.Furthermore, when inserted into the human body, the tube inevitably becomes twisted.
When the line is irradiated, the contrast agent forms a striped pattern, and since stripes like A are not found in human tissue, the location of the tip can be confirmed at a glance without misreading the tube. Therefore, the present invention provides a high-force lever for X-ray imaging by passing liquid, blood, test reagents, etc. into the lever 1 by attaching it to the lever 1-1 having a plurality of side lines. It is most suitable for medical use such as infusion tubes 1-7, heart tubes, cerebral collar tubes, human blood vessels, and urethral insertion tubes. Next, the present invention will be explained using examples. n Rope manufacturing 1 Transparent 41 soft vinyl chloride and barium chain acid (contrast medium)
Figures 2 and 2 using a mixing ratio of 50Φ-%; IJ, 1, 02ψnvx to h the three lateral lines of the eel
1, 1-1-bu of 44φl1lIll was prepared.
-1 The antithrombotic properties of the inner and outer walls of the
+J <',) Koriho-Nor type polyurethane"-Fing (7, IX 3701111n vascular retention 117J
j −=y ) Lt Wotake L/, experiment (l < h
J/: As a result, there was no cuff-norm bending, and X-ray contrast properties and antithrombotic properties were exhibited. 1/I Preparation Example 2 Transparent soft vinyl chloride and contrast agent tungesnon (U
1,02φn1m×144φ1
11111 f-corps were made. 1. A polyurethane with anti-thrombotic properties was applied to the inside and outside of the 11-#. Experiment bench (■na) J Excellent Xv with no bending of the catheter
A: Demonstrated contrast enhancement and antithrombotic properties. 4. Brief explanation of the drawings Figure 1 shows a conventional medical tube, with 11 parts cut away and a perspective view.
FIG. 2 shows an embodiment of the present invention, 111i and top view, and FIG. 3 shows 1111 examples of 11 and C. 1...f:] -”7 2...Contrast agent agent Patent attorney 1 Tsutomu Tsutomu

Claims (1)

[Scope of Claims] A medical tube, characterized in that an I Xli contrast agent is embedded inside the tube wall in a plurality of lines in the longitudinal direction of the tube, and is transparent except for the embedded portions. 2. The medical tube according to claim 1, in which the Xl1lyli stimulant is embedded in three linear lines. 3. The medical tube according to claim 1, wherein the XIi contrast agent is barium sulfate or tungsten. 4. The medical tube according to claim 1, wherein the material of the tube L-1 is soft polyvinyl chloride. 5. The medical tube according to claim 1, wherein the outer wall of the tube is coated with an antithrombotic agent. 6. The medical tube according to claim 1, wherein in the cross-sectional area of the tube wall, the ratio of the area of the part where the XIl contrast agent is embedded to the area of the part not embedded is approximately 1:1.