JPS58156856A - Chemical analysis and measurement device - Google Patents

Abstract

PURPOSE:To raise efficiency, by providing a reaction thermostat contg. a rotary disc having plural liquid sample holders arranged along the periphery, and a rotary support having plural partitioned sample chambers arranged along the periphery of said disc. CONSTITUTION:A rotary disc 3 having plural liquid sample holders 2 arranged along the periphery is installed in a reaction thermostat 1, and a rotary ring 42 for supporting plural partitioned sample chambers 100 arranged along the periphery of the disc 3, etc. are provided in a measurement device. In such a constitution, optional samples in the thermostat 1 can be fed to an optional position continuously, and their measurement can be made after an optional time elapsed from that time, so a number of samples capable of being treated for analysis at the same time can be increased, and chemical analysis can be executed with high efficiency.

Description

[Detailed Description of the Invention] This relates to a device for chemically analyzing and measuring a liquid sample using an analytical element impregnated with a drug. In general, for human body fluids and other liquid samples, specific In many cases, it is necessary to know the presence or absence of a component (2) or its content, and for this purpose chemical analysis using a reaction reagent is performed. There are two methods for chemical analysis of liquid samples: the dry method and the wet method. Of these, the dry method uses a liquid sample analysis element consisting of a thin plate impregnated with a specific reagent inserted into a mount. A liquid sample to be analyzed is supplied dropwise to the element, placed in a thermostatic chamber for reaction, and the liquid sample is allowed to react with the reagent. This is a method of measuring and detecting using an optical concentration meter or other means, and is very convenient in that a liquid sample can actually be treated as a solid.

Therefore, in the analysis of such liquid samples, it is usually necessary to analyze each liquid sample for a large number of items, and it is desirable to perform such analysis on a large number of liquid samples with high efficiency.

In conventional chemical analysis and measurement equipment, multiple containers are used to store liquid sample analysis elements of mutually nested types.
(3) A specific liquid sample analysis element is selected from the above-mentioned number of liquid sample analysis elements, and the selected liquid sample analysis element is supplied into the constant temperature chamber. At the same time, the reaction between the liquid sample and the reagent is allowed to proceed in this constant temperature bath, and the analytical elements, after which the reaction time required for each analytical element has elapsed, are transferred to the measurement area by the transfer mechanism and placed in the ff1ll constant area. However, the reaction time required for an analytical element is a unique time that differs depending on the type of reagent for the analytical element, and the precision of In degree is required. In order to measure and detect the progress of the reaction, it is necessary to conduct not only one measurement on the same analytical element, but also a second reaction after the first measurement for a predetermined period of time. It is necessary to perform measurements of Therefore, in the conventional method, it is necessary to measure all the analytical elements with the same measuring device. The number of analytical elements is limited to a small number, and therefore analysis cannot be performed with high efficiency.In addition, in the above chemical analysis method, the analytical elements that can be accommodated are subjected to treatment such as cooling before being measured with a measuring instrument. If such special treatment is carried out using conventional methods, a separate treatment chamber such as a cooling chamber is required, as well as a transfer system from the thermostatic chamber to the υ treatment chamber. The device a becomes extremely complex as it requires a control system to control the transfer system.Furthermore, in conventional devices, as the number of whites increases, the number of storage containers for analytical elements increases, requiring a large installation area. However, it had the disadvantage of being inconvenient especially when conducting clinical tests at this hospital.

SUMMARY OF THE INVENTION An object of the present invention is to provide a chemical analysis and measurement device that is compact and can perform chemical analysis of a liquid sample with high sieving efficiency.

The features and first features of the present invention are a constant temperature chamber for reaction having a disc-shaped holder in which (5) anti-substance sample analysis element holders are arranged along the periphery, and an outer periphery of the holder. a support body in which a plurality of divided element chambers are arranged along the holder; a moving mechanism for relatively moving the support body along the outer periphery of the holding body; and 7! 'A transport mechanism for moving the liquid sample analysis element into and out of the liquid sample analysis element holding portion of the holder, and a measurement chamber provided in the support body in parallel with the element chamber.

The present invention will be explained below with reference to the drawings.

FIG. 1 is a longitudinal sectional side view of a chemical analysis and measurement device according to the present invention;
FIG. 2 shows the collapse plane N of FIG. 1, and 1 in the figure indicates a bath (hereinafter referred to as "thermal chamber") forming a thermostatic chamber for reaction. This thermostatic chamber 1 is supported by a column 11, and inside the thermostatic chamber 1, there are a plurality of analytical element holding parts (hereinafter referred to as "analytical elements") each for holding a liquid sample analytical element (hereinafter referred to as "analytical element").
Hereinafter referred to as the "holding section". ) 2 (2A to 2 ft) on its outer periphery. The holding portion 2 is formed on the holding body 3 as shown in FIG. 1.
) The rotary retaining plate 20 is placed in a state in which the inner side is lowered in the recess 81, and this rotary retaining plate 2° is arranged vertically about the axis P at the outer end of the recess 31. will be moved together. Reference numeral 12 denotes a feeder [1] for moving the analytical element into and out of the thermostatic chamber l, which is opened and closed as appropriate by, for example, a shutter (not shown).

A plurality of compartments 4 are provided outside the thermostatic chamber 1, which are sequentially divided and connected along the outer periphery of the holder 8. In this example, it is not guided by a guide member 41 extending along a circle centered on the central axis , a plurality of cylindrical bodies 40 each having a notch 401 formed on the inner side of the bottom wall are sequentially vertically provided along the outer periphery of the rotating body 42, and these cylindrical bodies ↓0 form the partitions. Chamber 4 (4A-4H) is formed fN.

In the figure, 43 indicates a wheel. In this example, the compartments 4A to 4F of the compartments 4 are configured as an element chamber 100 for storing analytical elements, and the compartment 4G is configured to contain optical analyzers, etc. 7) Pf is used as the measurement chamber 200 for measuring the concentration of the reagent of the analytical element and the reactant of the liquid sample. It is configured as a discharge compartment 300 for discharging the analytical elements.

On the outside of the rotating body 42, the rotating body 42 is connected to a gear 'F
A motor 5 is provided for rotation via M'fllt.

This motor 5 constitutes a movement @ groove that moves the compartment 4 along the outer periphery of the holding body 8 by rotating the rotating body 42 . The constant temperature bath l and the rotating body 42
A transport mechanism 6 (indicated by a dot @il line in Figs. .) will be established. This conveyance Fl is carried out by the motor 61 through the gear Fl! It is attached to a rotating plate 62 that rotates around the 111J iiL support column 11 via Im, and as shown in FIG. A belt 64 provided, supports 15, 65' that support the rollers 68 and 63' respectively and are moved forward and backward in the vertical direction, and a drive section 66 that moves the support shafts 65.f!5' forward and backward. The belt 64 consists of: 01) the notch 40 of the cylindrical body 4o;
1, there is a raised position (indicated by a solid line) located at the same level as the inner surface of the bottom wall of the cylindrical body Φ0, and a lowered position (indicated by a two-dot chain line) located at the same level as the −L plane of the holder 3. ). 7 in the figure is the element 100.
This is a liquid sample source that is moved along with the movement of the transport mechanism 6 and drops a liquid sample onto the analysis element that is sent to the holding section 2 at the same timing as the analysis element is sent.

To explain an example of the operation of a chemical analysis and measurement apparatus having such a configuration, first, analytical elements S of the same type and the same W number are stacked and stored in the element chamber 100 as shown by the dashed line in FIG. . The type of analytical element S stored is element chamber 10.
Each 0 is different. And for example - element chamber 1
A liquid sample is dropped onto the analytical element S of 00 (4A) and sent to the two holding parts of -, and then transferred to the element chamber 100 described above.
Analysis of the element chamber 100 (ΦB) adjacent to (4A) (9) Drop a liquid sample onto the element S and feed it into the holding part 2B adjacent to the two holding parts described above, and form a circle in this way. Analytical elements S housed in each element chamber 100 along the
A liquid sample is sequentially dropped into the holding parts 2 and sent to each of the holding parts 2. This operation first begins with - element chamber 1.00 (4
A) and the opposing holding section 2A, the conveyance machine Il#6 is positioned, the belt 64 of the conveyance mechanism 6 is placed in the raised position, and the belt 64 is driven to move the element chamber 100 ( 4A) is sent out by friction with the belt 64, and at this time, a liquid sample is dripped onto the analysis element S from the liquid sample source 7, and then the support shaft 65.65' is retracted. By lowering the belt 64 and placing it on the
slides down on the rotary holding plate 20 through the supply port 12 of the constant temperature bath 1, comes into contact with the wall surface of the recess 31, and is held by two holding members. Thereafter, by driving the motor 61, the circulation plate 62 is rotated clockwise in FIG.
l O) Position it between the adjacent element chamber 100 (4B) and the holding part 2B facing it, and hold the analytical element S in the element chamber 1.00 (4B) in the holding part 2B by the same operation. By sequentially performing such operations, the analytical elements S stored in each element chamber 100 are transferred to the holding unit 2.
send it to each of them.

After each analytical element S held in the holding section 2 is maintained at a constant temperature in the constant temperature bath l for a specific reaction time for each analytical element S, each analytical element S is measured by a measuring instrument. This operation is performed as follows. For example, when measuring the analytical element S held by the - holding part 21G, the rotating body 42 is rotated by driving the motor 5 to stop the measurement chamber tG at a position 1a facing the - holding part 2A. [
- At the same time, the rotating plate 62 is driven by the motor 61.
is rotated to stop the transport mechanism 6 at a position opposite to the - holding part 2A, and then the rotary holding plate 20 associated with the holding part 2A is rotated around the axis P by a drive mechanism (not shown). 3, and thereby slide the analyte (11) S on the co-moving holding plate 2o and feed it onto the belt 64 placed in the lowered position of the transport mechanism 6. Thereafter, the analytical element S is sent into the measurement chamber 200 by placing the belt 64 in the raised position. When the measurement here is completed, the analytical element S is discharged to the discharge compartment 800 via the carrier 11176.

By rotating the rotating body 42 in this way to sequentially move the measurement chambers 200 and moving the transport @ structure 6 accordingly, the analytical elements S held in the holding sections 2 can be measured sequentially. 2) It will happen. Each analytical element S
If measurements are to be made for each of these two or more times, the above-mentioned operations will be repeated. In this way, the analytical element S
When the measurement of the element Y is completed, the empty holding part 2 is filled with the element Y.
A new analysis element S is sent in from 100. Here, when sending the analytical purple fS in the element chamber 100 to the holding part 2, instead of placing the analytical elements S in each holding part 2 in the order corresponding to the arrangement of the element chambers 100 as described above, It is also possible to select the chamber 100 and send the analytical element S to - of the holding section 2 from there. In this case,
Analytical elements S from arbitrarily selected element chambers 100 are placed in each holding section 2, and the analytical elements S are sent into the measurement chambers 200 in accordance with the unique reaction time of each analytical element S. Measurements will be taken.

Therefore, in the present invention, the holding parts for the number of membranes are arranged side by side on the outer periphery of the holder in a constant temperature room, and the element chamber and the measurement chamber are moved relative to the holder along the outer periphery of the holder. Since the analytical elements can be freely installed and moved in and out between these compartments and the holding part, it is possible to select any analytical element and send it to any holding part in the thermostatic chamber, and also to place it in the thermostatic chamber. You can send any analytical element out of the existing analytical elements to the measurement chamber at any time, and you can also place a new selected analytical element into the empty holding section after the measurement of the analytical element has been completed. It can be positioned immediately. Therefore, it is possible to continuously supply arbitrary analytical elements to arbitrary positions in a thermostatic chamber and measure these analytical elements after an arbitrary reaction time has elapsed (18).This means that simultaneous analysis can be performed. The number of analytical elements that can be processed can be increased, and chemical analysis of liquid samples can be achieved with high efficiency. Furthermore, since the element chambers are arranged sequentially along the outer periphery of the holder, the installation area of the device can be made small while increasing the number of element chambers. Therefore, for example, the number of inspection items can be reduced. Even if the number of analytical elements increases, the device can be made smaller.

Furthermore, in the above embodiment, since the analytical element is not moved within the thermostatic chamber, the analytical element can be prevented from being cooled by relative air flow, and the temperature of the analytical element can be maintained at a constant temperature. Therefore, highly reliable measurement results can be obtained.

In the present invention, some of the membrane compartments are
It may also be configured as a compartment for processing such as cooling with an atmosphere at a temperature different from the temperature inside the constant temperature chamber.In this way, the configuration of the apparatus can be simplified and any analytical element inside the constant temperature chamber can be connected to any The analytical element can be fed into or taken out from the processing compartment (14) at any time, and various treatments can be performed on the analytical element with high efficiency.

In the present invention, a conveyance mechanism for the number of membranes may be provided,
With such a configuration, analysis processing can be performed with higher efficiency when the number of compartments is large.

As described above, according to the present invention, it is possible to provide a chemical analysis and measurement device that is small in size and can perform chemical analysis of a liquid sample with high efficiency.

[Brief explanation of drawings]

FIG. 1 is a vertical cross-sectional side view showing a chemical analysis and measurement device according to the present invention, FIG. 2 is a cross-sectional plan view of FIG. 1, and FIG. 8 is a partially enlarged view of FIG. FIG. 1... Constant temperature chamber 2... Analytical element holding part 3
... Holding body 81 ... Recess 4.4l-4
H... Compartment chamber 40... Cylindrical body t2... Rotating body 5... Motor 6... Transport mechanism
62... Rotating plate 100... Element chamber 200.
...Measurement room (15) 300...Discharge compartment S...Analytical element agent Patent attorney Tomohiko Ooi JP-A BH5B-1568
56(5) Lai 3 figure

Claims (1)

[Claims] 1) A thermostatic reaction chamber including a disk-shaped holder in which a plurality of liquid sample analysis element holders are arranged along the periphery, and a plurality of divided element chambers arranged along the outer periphery of the holder. a support, a moving mechanism for relatively moving the support along the outer periphery of the holder, and a liquid sample analysis element stored in an element chamber of the support to a liquid sample analysis element holding part of the holder. A chemical analysis and measurement device characterized by comprising a conveyor groove for entry and exit, and a measurement chamber provided in the support body in parallel with an element chamber.